TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T20251	Voltage-gated potassium channel Kv11.1	D00FGR	Miltefosine	Approved	3599	C21H46NO4P	407.6	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D00JAU	Irbesartan	Approved	3749	C25H28N6O	428.5	CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5	IC50 = 194984.46 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D00UYE	Meperidine	Approved	4058	C15H21NO2	247.33	CCOC(=O)C1(CCN(CC1)C)C2=CC=CC=C2	IC50 = 74131.02 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D01KPV	Fexofenadine	Approved	3348	C32H39NO4	501.7	CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O	IC50 = 65000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D01ZSO	Moclobemide	Approved	4235	C13H17ClN2O2	268.74	C1COCCN1CCNC(=O)C2=CC=C(C=C2)Cl	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D03CQE	Gatifloxacin	Approved	5379	C19H22FN3O4	375.4	CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F	IC50 = 128824.96 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D03IGH	Darunavir	Approved	213039	C27H37N3O7S	547.7	CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D04MSM	Carbamazepine	Approved	2554	C15H12N2O	236.27	C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N	IC50 = 104712.85 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D04OSE	Nifedipine	Approved	4485	C17H18N2O6	346.3	CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D04XGT	Benznidazole	Approved	31593	C12H12N4O3	260.25	C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D05LYX	Glibenclamide	Approved	3488	C23H28ClN3O5S	494	COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3	IC50 = 74000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D05MQK	Tadalafil	Approved	110635	C22H19N3O4	389.4	CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D09MWJ	Alfuzosin	Approved	2092	C19H27N5O4	389.4	CN(CCCNC(=O)C1CCCO1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC	IC50 = 125892.54 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0B5LF	Ximelegatran	Approved	448042	C14H21N3O	247.34	C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N	Ki = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0BP9C	Etravirine	Approved	193962	C20H15BrN6O	435.3	CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N	IC50 = 158489.32 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0C9SY	Vardenafil	Approved	135400189	C23H32N6O4S	488.6	.	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0DK8V	Cetirizine	Approved	2678	C21H25ClN2O3	388.9	C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl	IC50 = 108000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0DV3O	Epinastine	Approved	3241	C16H15N3	249.31	C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N	IC50 = 91201.08 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0E4DW	Phenytoin	Approved	1775	C15H12N2O2	252.27	C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0E6XR	Dasatinib	Approved	3062316	C22H26ClN7O2S	488	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0F0YZ	Pentobarbital	Approved	4737	C11H18N2O3	226.27	CCCC(C)C1(C(=O)NC(=O)NC1=O)CC	IC50 = 131825.67 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0I1FQ	Raltegravir	Approved	54671008	C20H21FN6O5	444.4	.	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0JL2K	Grepafloxacin	Approved	72474	C19H22FN3O3	359.4	CC1CN(CCN1)C2=C(C(=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)C)F	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0K6GZ	Sparfloxacin	Approved	60464	C19H22F2N4O3	392.4	C[C@@H]1CN(C[C@@H](N1)C)C2=C(C(=C3C(=C2F)N(C=C(C3=O)C(=O)O)C4CC4)N)F	IC50 = 127600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0M4YC	Disopyramide	Approved	3114	C21H29N3O	339.5	CC(C)N(CCC(C1=CC=CC=C1)(C2=CC=CC=N2)C(=O)N)C(C)C	IC50 = 91201.08 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0NR6S	Maraviroc	Approved	3002977	C29H41F2N5O	513.7	CC1=NN=C(N1C2C[C@H]3CC[C@@H](C2)N3CC[C@@H](C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0O1WX	Ciprofloxacin XR	Approved	2764	C17H18FN3O3	331.34	C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0U2JP	Sitagliptin	Approved	4369359	C16H15F6N5O	407.31	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 158489.32 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0U5SI	Procainamide	Approved	4913	C13H21N3O	235.33	CCN(CC)CCNC(=O)C1=CC=C(C=C1)N	IC50 = 138038.43 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0WO8W	Mepivacaine	Approved	4062	C15H22N2O	246.35	CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C	IC50 = 154881.66 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0Z7ZM	Rhucin	Approved	135398744	C22H30N6O4S	474.6	CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0W8WB	Berberine	Phase 4	2353	C20H18NO4+	336.4	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC	IC50 = 66069.34 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0X5LR	BMN-673	Phase 3	135565082	C19H14F2N6O	380.4	.	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D00SWQ	Mitoglitazone	Phase 2	10429242	C19H18N2O4S	370.4	CCC1=CN=C(C=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D01NUR	ASTX660	Phase 2	118169620	C30H42FN5O3	539.7	C[C@@H]1CN([C@H](CN1)CN2CCOC[C@H]2C)CC(=O)N3CC(C4=C3C=C(C(=N4)CO)CC5=CC=C(C=C5)F)(C)C	IC50 = 69000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D01UBY	JNJ-41443532	Phase 2	46208367	C22H25F3N4O3S	482.5	C1CC(CCC1N2CC(C2)NC(=O)CNC(=O)C3=CC(=CC=C3)C(F)(F)F)(C4=CN=CS4)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D01ZAQ	AZD5363	Phase 2	25227436	C21H25ClN6O2	428.9	C1CN(CCC1(C(=O)N[C@@H](CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D02WFN	MK-7622	Phase 2	46207733	C25H25N3O2	399.5	CC1=NC=C(C=C1)CC2=CC3=C(C4=CC=CC=C42)N=CN(C3=O)[C@H]5CCCC[C@@H]5O	IC50 = 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D07HZG	PF-00734200	Phase 2	11516136	C17H24F2N6O	366.4	C1CN(CC1(F)F)C(=O)[C@@H]2C[C@@H](CN2)N3CCN(CC3)C4=NC=CC=N4	IC50 = 126000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D08QGT	GDC0941	Phase 2	17755052	C23H27N7O3S2	513.6	CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6	IC50 = 64000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0DL8A	Clarithromycin	Phase 2	84029	C38H69NO13	748	CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O	IC50 = 58884.37 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0LQ3L	GSK2982772	Phase 2	77108121	C20H19N5O3	377.4	CN1C2=CC=CC=C2OC[C@@H](C1=O)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4	IC50 = 195000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0M7CB	MK-0873	Phase 2	9919680	C25H18N4O3	422.4	C1CC1NC(=O)C2=CN(C3=C(C2=O)C=CC=N3)C4=CC=CC(=C4)C#CC5=C[N+](=CC=C5)[O-]	IC50 = 65700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0O8BS	AZD1656	Phase 2	16039797	C24H26N6O5	478.5	CC1=CN=C(C=N1)NC(=O)C2=CC(=CC(=C2)O[C@@H](C)COC)OC3=NC=C(N=C3)C(=O)N4CCC4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0R8IU	AZD-4017	Phase 2	24946280	C22H33N3O3S	419.6	CCCSC1=C(C=CC(=N1)N2CCC[C@H](C2)CC(=O)O)C(=O)NC3CCCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0SG7B	GLPG-0634	Phase 2	49831257	C21H23N5O3S	425.5	C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5	IC50 = 85000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D05LPW	DA-1229	Phase 1	25022354	C19H26F3N3O3	401.4	CC(C)(C)OC[C@@H]1C(=O)NCCN1C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N	IC50 = 79600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0O1ZI	AZD8329	Phase 1	25006684	C25H31N3O3	421.5	CC(C)(C)C1=C(C=NN1C2=CC=C(C=C2)C(=O)O)C(=O)NC3C4CC5CC(C4)CC3C5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0U8QH	GDC-0349	Phase 1	59239165	C24H32N6O3	452.5	CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D04MAZ	Pyrimidine derivative 33	Patented	71731606	C23H24ClN5O2	437.9	CC#CCN1C(=CC(=O)N(C1=O)CC2=NC3=C(C=CC(=C3)Cl)C=C2)N4CCC[C@H](C4)N	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0D4OW	PMID25435285-Compound-15	Patented	57338826	C15H15Cl2NO6	376.2	C1=CC(=C(C=C1CO[C@@H]2[C@H]([C@H]3[C@@H]([C@H]3[C@@]2(C(=O)O)N)C(=O)O)O)Cl)Cl	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0HG2S	Sulfonamide derivative 10	Patented	86294663	C19H10ClFN4O3S	428.8	C1=CC(=C(C=C1OC2=C(C=C(C=C2)S(=O)(=O)NC3=NC=C(C=C3)F)C#N)Cl)C#N	IC50 = 67000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0PJ8X	2-(substituted ethynyl)quinoline derivative 1	Patented	71562840	C18H13NO	259.3	COC1=CC=CC2=C1C=CC(=N2)C#CC3=CC=CC=C3	IC50 = 61700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D08SOF	Terfenadine	Withdrawn from market	5405	C32H41NO2	471.7	CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O	IC50 = 56000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D04BQR	Acecainide	Discontinued in Phase 3	4342	C15H23N3O2	277.36	CCN(CC)CCNC(=O)C1=CC=C(C=C1)NC(=O)C	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D09EVZ	BMS-488043	Discontinued in Phase 2	507806	C22H22N4O5	422.4	COC1=CN=C(C2=C1C(=CN2)C(=O)C(=O)N3CCN(CC3)C(=O)C4=CC=CC=C4)OC	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D03KWN	AZD-6703	Discontinued in Phase 1	11373432	C24H27N5O2	417.5	CC1=C(C=C(C=C1)C(=O)NC2CC2)N3C=NC4=C(C3=O)C=C(C=C4)N5CCN(CC5)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0IY0R	Viquidacin	Preclinical	11591505	C25H29FN2O4S2	504.6	COC1=CC2=C(C(=CN=C2C=C1)F)[C@H](CC[C@@H]3CCN(C[C@@H]3C(=O)O)CCSC4=CC=CS4)O	IC50 = 124000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B01BHO	2-(2-(2,6-Dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)-N-(5-isopropyl-2-methylphenyl)acetamide	Investigative	73673505	C26H25Cl2N3O	466.4	CC1=C(C=C(C=C1)C(C)C)NC(=O)CN2C3=CC=CC=C3N=C2CC4=C(C=CC=C4Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B01STX	(2S)-2-[1-(2,6-Dichlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-(5-methylpyrazin-2-yl)propanamide	Investigative	46175520	C22H20Cl2N8O3	515.299	CC1=CN=C(C=N1)NC(=O)[C@H](CN2CC(C2)O)OC3=NC=NC4=C3C=NN4C5=C(C=CC=C5Cl)Cl	IC50 = 62000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B05KSF	4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-1-hydroxy-N-(6-methoxyquinolin-4-yl)cyclohexane-1-carboxamide	Investigative	57394056	C25H28N4O5	464.5	COC1=CC2=C(C=CN=C2C=C1)NC(=O)C3(CCC(CC3)NCC4=CC5=C(C=N4)OCCO5)O	IC50 = 200000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B07HPA	[4-[[3-(Hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenyl] 4-methoxybenzoate	Investigative	72948995	C24H28N2O7S	488.6	COC1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)S(=O)(=O)C3(CCC4(C3)CCNCC4)C(=O)NO	IC50 = 63400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B07RFK	[(2R,3Ar,6aR)-2-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71530223	C24H32F3N3O3	467.5	CO[C@@H]1COCC[C@@H]1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B08IER	N-[4-[2-[(5R)-5-(2,4-Difluorophenyl)-2-methyl-1,5-dihydro-2,4-benzodiazepin-3-yl]ethyl]phenyl]methanesulfonamide;hydrochloride	Investigative	54580954	C25H26ClF2N3O2S	506	CN1CC2=CC=CC=C2[C@@H](N=C1CCC3=CC=C(C=C3)NS(=O)(=O)C)C4=C(C=C(C=C4)F)F.Cl	IC50 = 85000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B08VTN	(1S,2R,5S)-5-(4,7,8,12-Tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	24951733	C20H20F3N5	387.4	C1C[C@@H]([C@H](C[C@H]1N2CC3=C4N=CC=CN4N=C3C2)N)C5=CC(=C(C=C5F)F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B09QPG	1-Propan-2-yl-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143591	C18H29N3O4S	383.5	CC(C)NC(=O)NS(=O)(=O)C1=CC=C(C=C1)OCCCCN2CCCC2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B09TZS	4-[[5-[2-[4-[(5-Cyano-6-methylpyridin-3-yl)methylamino]piperidin-1-yl]ethyl]-6-oxo-1,5-naphthyridin-3-yl]oxy]benzenesulfonamide	Investigative	122187096	C29H31N7O4S	573.7	CC1=C(C=C(C=N1)CNC2CCN(CC2)CCN3C(=O)C=CC4=C3C=C(C=N4)OC5=CC=C(C=C5)S(=O)(=O)N)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0AL2H	Benzeneacetamide, 3-chloro-alpha-(cyclopentylmethyl)-N-(5-((1S)-1,2-dihydroxyethyl)-2-pyrazinyl)-4-(methylsulfonyl)-, (alphaR)-	Investigative	10073306	C21H26ClN3O5S	468	CS(=O)(=O)C1=C(C=C(C=C1)[C@@H](CC2CCCC2)C(=O)NC3=NC=C(N=C3)[C@@H](CO)O)Cl	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0ANT5	4-(3-Fluorophenyl)-2-(2-hydroxyethyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrile	Investigative	11382160	C19H15FN2O3	338.3	COC1=CC2=C(C=C1)C(=O)N(C(=C2C3=CC(=CC=C3)F)C#N)CCO	IC50 = 62000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0B3ZL	N-[1-[2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]-N-methyl-3-oxo-4H-pyrido[3,2-b][1,4]oxazine-6-carboxamide	Investigative	122186034	C27H28FN5O5	521.5	CN(C(=O)C1=NC2=C(C=C1)OCC(=O)N2)C34CCC(CC3)(OC4)CCC5=C6C(=NC=C5F)C=CC(=N6)OC	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0BFA4	N-(2-((1S,2R,4R)-4-(Isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide	Investigative	46865774	C27H34F3N3O4S	553.6	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C2=CC=CC=C2)NC(=O)CNC(=O)C3=CC(=CC=C3)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0CUO6	N-(3-Chloro-4-methylphenyl)-3-(2-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide	Investigative	44605617	C19H16Cl2N2O2	375.2	CC1=C(C=C(C=C1)N(C)C(=O)C2=C(ON=C2C3=CC=CC=C3Cl)C)Cl	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0F6QE	(2S)-2-[1-(2-Chloro-6-cyanophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-[(2R)-1-hydroxypropan-2-yl]oxy-N-(5-methylpyrazin-2-yl)propanamide	Investigative	46175611	C23H21ClN8O4	508.9	CC1=CN=C(C=N1)NC(=O)[C@H](CO[C@H](C)CO)OC2=NC=NC3=C2C=NN3C4=C(C=CC=C4Cl)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0GQM1	3-[4-[2-[3-(2-Methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzoic acid	Investigative	54583051	C36H40N4O3	576.7	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC(=CC=C6)C(=O)O)C7=CC=CC=C7	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0HRA1	4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(1H-pyrazol-5-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide	Investigative	117769346	C19H25N7O	367.4	C[C@@]1(CC[C@H](C1(C)C)NC2=C(C=NN3C2=CC(=C3)C4=CC=NN4)C(=O)N)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0I2GH	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70281073	C19H25N5O2S	387.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC=CS4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0I3MR	5-Amino-4-morpholino-6-(neopentylamino)pyrimidine-2-carbonitrile	Investigative	44565796	C14H22N6O	290.36	CC(C)(C)CNC1=C(C(=NC(=N1)C#N)N2CCOCC2)N	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0J8DA	(2S)-2-[4-[[4-(4-Fluoro-2-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)propanoic acid	Investigative	71451391	C27H34F2N2O3	472.6	CC1=C(C=CC(=C1)F)OC2CCN(CC2)CC3CCN(CC3)[C@@H](CC4=CC=C(C=C4)F)C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0JF9B	[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-pyrimidin-2-yl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	72946384	C27H33F3N6O3	546.6	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C6=NC=CC=N6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0JKZ8	N-[4-[(1R,5S)-3-Azabicyclo[3.1.0]hexan-1-yl]phenyl]-N-methylbenzenesulfonamide	Investigative	49865589	C18H20N2O2S	328.4	CN(C1=CC=C(C=C1)[C@@]23C[C@@H]2CNC3)S(=O)(=O)C4=CC=CC=C4	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0K4YO	1-Phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145630	C19H23N3O4S	389.5	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0MA5D	Chembl4209994	Investigative	145966369	C15H17F3N2OS	330.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3C(F)(F)F)N	IC50 = 55400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0MN7P	(3R,3'S)-N-Cyclopropyl-5,6-difluoro-N-(quinolin-4-ylmethyl)spiro[1H-2-benzofuran-3,4'-piperidine]-3'-carboxamide	Investigative	57394344	C26H25F2N3O2	449.5	C1CC1N(CC2=CC=NC3=CC=CC=C23)C(=O)[C@H]4CNCC[C@]45C6=CC(=C(C=C6CO5)F)F	Ki = 55000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0MPW7	5-[4-(Dimethylamino)phenyl]-N-(pyridin-2-ylmethyl)-2-pyrimidin-5-ylquinazolin-4-amine	Investigative	68204921	C26H23N7	433.5	CN(C)C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CN=CN=C5	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0OVM1	Chembl4206035	Investigative	118613653	C31H42N4O3	518.7	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CC5(C4)CCN(CC5)C)OC)OCCCN6CCCC6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0PDL2	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-[5-(2-cyanopropan-2-yl)-1,3-thiazol-2-yl]piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70697225	C23H30N6O2S	454.6	CC(C)(C#N)C1=CN=C(S1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0PED3	Levobupivacaine hydrochloride	Investigative	117965	C18H29ClN2O	324.9	CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C.Cl	IC50 = 83000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0PK8T	(3Ar,5R,6aR)-Benzyl 5-((3-methoxytetrahydro-2H-pyran-4-yl)amino)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)hexahydrocyclopenta-[c]pyrrole-2(1H)-carboxylate	Investigative	72946982	C31H37F3N4O5	602.6	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OCC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0QV5H	N-[4-(1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-4-(2,2,2-trifluoro-ethanesulfonylamino)-benzenesulfonamide	Investigative	44360787	C20H29F3N4O5S2	526.6	C1CCN(C1)C(=O)[C@H](C2CCC(CC2)NS(=O)(=O)C3=CC=C(C=C3)NS(=O)(=O)CC(F)(F)F)N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0R4VQ	Chembl4241584	Investigative	131985489	C26H32N6O2	460.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)N5C=CN=N5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0RMG6	Methylecgonidine	Investigative	119478	C10H15NO2	181.23	CN1[C@H]2CC[C@@H]1C(=CC2)C(=O)OC	IC50 = 169824.37 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0TH5P	(R)-2-Methyl-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline	Investigative	46890564	C17H22N2	254.37	C[C@@H]1CCCN1CCC2=CC3=C(C=C2)N=C(C=C3)C	Ki = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0U1FB	(2S,3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-6a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,3a,4,5,6-hexahydro-1H-pentalene-2-carboxamide	Investigative	71716742	C25H33F3N4O4	510.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0UF7X	1-(4-Methoxyphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60144088	C22H29N3O5S	447.5	COC1=CC=C(C=C1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0URV3	N-(1,3-Dimethylpyrazol-4-yl)-2-[2-methoxy-4-(7-methoxyquinolin-4-yl)oxyphenyl]acetamide;sulfuric acid	Investigative	67304696	C24H26N4O8S	530.6	CC1=NN(C=C1NC(=O)CC2=C(C=C(C=C2)OC3=C4C=CC(=CC4=NC=C3)OC)OC)C.OS(=O)(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0WMP9	1-(((3R)-3-Methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclopropanecarboxamide	Investigative	11442292	C19H26F3N3O4S	449.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(C=C2)C(C)(C(F)(F)F)O)CC3(CC3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0WNK1	[(2R,3Ar,6aR)-2-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-(3-nitro-7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone	Investigative	71519050	C23H32N4O5	444.5	COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0XE3B	1-Propan-2-yl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60145775	C17H27N3O4S	369.5	CC(C)NC(=O)NS(=O)(=O)C1=CC=C(C=C1)OCCCN2CCCC2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B0XL2S	Benzamide, N,N-diethyl-4-(5-hydroxyspiro(2H-1-benzopyran-2,4'-piperidin)-4-yl)-	Investigative	11417954	C24H28N2O3	392.5	CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC(=C42)O	IC50 = 78000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B10OCU	2,4-Dichloro-3-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]benzenesulfonamide	Investigative	54583059	C35H38Cl2FN5O3S	698.7	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=C(C=CC(=C6Cl)S(=O)(=O)N)Cl)C7=CC(=CC=C7)F	IC50 = 52480.75 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B19UJX	CID 44454371	Investigative	44454371	C23H26N6OS	434.6	CC1=NC2=C(O1)C=C3CCN(CCC3=C2)CCCSC4=NN=C(N4C)C5=CN=CC=C5	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1A8KN	(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-methylpyrazin-2-yl)-3-propan-2-yloxypropanamide	Investigative	90667868	C22H22ClN7O3	467.9	CC1=CN=C(C=N1)NC(=O)[C@H](COC(C)C)OC2=NC=NC3=C2C=NN3C4=CC=CC=C4Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1B3HE	Example 19 [PMID: 23886683]	Investigative	71818575	C18H21ClFN3OS	381.9	C[C@H]1CCCN([C@H]1C)C(=O)C2=C(SC(=N2)NC3=C(C=C(C=C3)Cl)F)C	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1CR7I	Rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)hex-4-ynoic acid	Investigative	53248846	C20H15F5O4	414.3	CC#CC(CC(=O)O)C1=CC=C(C=C1)OC2=C(C=C(C=C2)C(F)(F)F)OC(F)F	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1D9PO	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-propan-2-yloxypropanamide	Investigative	57504361	C22H19ClN8O3	478.9	CC(C)OC[C@@H](C(=O)NC1=NC=C(C=C1)C#N)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1EMT4	[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-[[6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]methyl]piperazin-1-yl]methanone	Investigative	137649223	C32H36N6O3	552.7	CC1=NOC(=N1)C2=CC=CC(=N2)CN3CCN(CC3)C(=O)C4=CC=C(C=C4)C[C@@H]5CC[C@@H](N5)[C@@H](C6=CC=CC=C6)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1ENI2	4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide	Investigative	53311230	C27H26N4O3	454.5	C1CN2CCC1[C@@](C2)(C#CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)NCC5=NC=NC=C5)O	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1G9CF	CID 68768923	Investigative	68768923	C27H39F4N3O4S	577.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C(C)(C)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC(=C3)F)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1HA7B	4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylmethylamino)-1-hydroxy-N-(6-methoxy-1,5-naphthyridin-4-yl)cyclohexane-1-carboxamide	Investigative	57394046	C24H27N5O5	465.5	COC1=NC2=C(C=CN=C2C=C1)NC(=O)C3(CCC(CC3)NCC4=CC5=C(N=C4)OCCO5)O	IC50 = 52000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1M4IN	Ethyl 1-[4-[4-(phenylcarbamoylsulfamoyl)phenoxy]butyl]piperidine-4-carboxylate	Investigative	60143923	C25H33N3O6S	503.6	CCOC(=O)C1CCN(CC1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1NQY5	6-[[[1-[(1S,2R)-2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1,2-dihydroxyethyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	127037593	C26H28FN5O6	525.5	COC1=NC2=C(C(=CN=C2C=C1)F)[C@H]([C@@H](C34CCC(CC3)(CO4)NCC5=NC6=C(C=C5)OCC(=O)N6)O)O	IC50 = 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1OUN7	(E)-3-[8-[4-[2-[4-[3-(Azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]quinolin-2-yl]prop-2-enoic acid	Investigative	57780016	C33H42N4O3	542.7	C1CCCN(CC1)CCCOC2=CC=C(C=C2)CCN3CCN(CC3)C4=CC=CC5=C4N=C(C=C5)/C=C/C(=O)O	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1PJH2	1-[(2R)-4-Benzoyl-2-methylpiperazin-1-yl]-2-(1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione	Investigative	507783	C21H20N4O3	376.4	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=C2C=CN=C3)C(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1UM7F	4-(3-Piperidin-1-ylpropoxy)benzenesulfonamide	Investigative	70685675	C14H22N2O3S	298.4	C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)N	IC50 = 93200 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1UMF6	N-[4-((S)-1-Amino-2-oxo-2-pyrrolidin-1-yl-ethyl)-cyclohexyl]-4-(3,3-dimethyl-ureido)-benzenesulfonamide	Investigative	44360724	C21H33N5O4S	451.6	CN(C)C(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2CCC(CC2)[C@@H](C(=O)N3CCCC3)N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1V3XD	4-[6-(1H-Indazol-4-yl)-2-[(4-methylsulfonylpiperazin-1-yl)methyl]imidazo[1,2-a]pyrazin-8-yl]morpholine	Investigative	57328247	C23H28N8O3S	496.6	CS(=O)(=O)N1CCN(CC1)CC2=CN3C=C(N=C(C3=N2)N4CCOCC4)C5=C6C=NNC6=CC=C5	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1VS4U	1-[2-[(3R,4R)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-hydroxypiperidin-1-yl]ethyl]-7-methoxyquinoxalin-2-one	Investigative	71449750	C24H29N5O5	467.5	COC1=CC2=C(C=C1)N=CC(=O)N2CCN3CC[C@H]([C@@H](C3)O)NCC4=CC5=C(C=N4)OCCO5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1VY6N	N-Hydroxy-3-[4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzamide	Investigative	54584056	C36H41N5O3	591.7	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC=CC(=C6)C(=O)NO)C7=CC=CC=C7	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1X0GF	(4-Cyclopropylpiperazin-1-yl)(isoindolin-2-yl)methanone	Investigative	44418473	C16H21N3O	271.36	C1CC1N2CCN(CC2)C(=O)N3CC4=CC=CC=C4C3	IC50 = 52500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1X4ES	6-[[[1-[2-(2-Oxo-7-pyridin-3-yloxy-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187100	C28H29N7O4	527.6	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=N5)OC6=CN=CC=C6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1YCQ6	1-(((3R)-3-Methyl-4-(4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclobutanecarboxamide	Investigative	11155482	C20H28F3N3O4S	463.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(C=C2)C(C)(C(F)(F)F)O)CC3(CCC3)C(=O)N	IC50 = 65000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1YL5U	4-[[2-[(3,4-Dichlorophenyl)carbamoylamino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide	Investigative	127046489	C21H15Cl2N5O3S	488.3	CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC(=O)NC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1YMA5	Ceralasertib	Investigative	54761306	C20H24N6O2S	412.5	C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)[S@](=N)(=O)C)C4=C5C=CNC5=NC=C4	IC50 = 166000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B1Z2LM	3-[[(3R)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]amino]propanoic acid	Investigative	49836187	C22H25NO2	335.4	C1C[C@]2(CC1NCCC(=O)O)CC3=CC=CC=C3CC4=CC=CC=C24	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B20ICK	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797110	C23H27F4N3O5	501.5	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2CO)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B20QDW	1-(1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-[(1-hydroxycyclopentyl)methylamino]ethanone	Investigative	59396252	C23H34N2O2	370.5	C1CCC(CC1)C2C3=CC=CC=C3CCN2C(=O)CNCC4(CCCC4)O	IC50 = 78600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B21AVJ	4-Methyl-5-[2-[4-[2-[3-methyl-5-(tetrazol-1-yl)pyridin-2-yl]acetyl]piperazin-1-yl]ethyl]-3H-2-benzofuran-1-one	Investigative	69087452	C24H27N7O3	461.5	CC1=CC(=CN=C1CC(=O)N2CCN(CC2)CCC3=C(C4=C(C=C3)C(=O)OC4)C)N5C=NN=N5	IC50 = 52000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B21TOV	[(2R,3As,5R,6aS)-2-chloro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517401	C24H31ClF3N3O3	502	COC1COCCC1N[C@@H]2C[C@H]3C[C@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)Cl	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B23FKC	(3-Chlorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86274964	C16H15ClN6OS	374.8	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=CC=C3)Cl)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B24UXN	(1R)-1-[2-(3,5-Dichlorophenyl)pyridin-3-yl]-2,2-dipyridin-3-ylethanol	Investigative	16722295	C23H17Cl2N3O	422.3	C1=CC(=CN=C1)C(C2=CN=CC=C2)[C@H](C3=C(N=CC=C3)C4=CC(=CC(=C4)Cl)Cl)O	IC50 = 128000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B25FDA	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-(3-hydroxyazetidin-1-yl)propanamide	Investigative	57504462	C21H18ClFN8O3	484.9	C1C(CN1C[C@@H](C(=O)NC2=NC=C(C=C2)F)OC3=NC=NC4=C3C=NN4C5=C(C=CC=N5)Cl)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B26CVM	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	Investigative	743974	C16H19NO3S	305.4	CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B29NBO	7-((R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	9885754	C20H25N3O4	371.4	C[C@@H]([C@@H]1CCN(C1)C2=C(C3=C(C=C2)C(=O)C(=CN3C4CC4)C(=O)O)OC)N	Ki = 62000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B29XAN	6-[7-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2,7-diazaspiro[3.5]nonan-2-yl]-2-methylpyridazin-3-one	Investigative	137661489	C23H28N4O4	424.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CN(C4)C5=NN(C(=O)C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2A0FE	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one	Investigative	121313969	C24H28N4O5	452.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4=O)C5=NN(C(=O)C=C5)C)O	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2CE7W	5-[3-(2,4-Bis-trifluoromethyl-phenyl)-isoxazol-5-ylmethyl]-2-(2,3-difluoro-phenyl)-5H-imidazo[4,5-d]pyridazine	Investigative	25138344	C23H11F8N5O	525.4	C1=CC(=C(C(=C1)F)F)C2=NC3=CN(N=CC3=N2)CC4=CC(=NO4)C5=C(C=C(C=C5)C(F)(F)F)C(F)(F)F	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2EG6P	9-[3-(4-Fluorophenyl)-1-Methyl-1h-Pyrazol-4-Yl]-2,3,4,5-Tetrahydropyrido[2,3-F][1,4]oxazepine	Investigative	57382553	C18H17FN4O	324.4	CN1C=C(C(=N1)C2=CC=C(C=C2)F)C3=C4C(=NC=C3)CNCCO4	IC50 ~ 79600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2GR7X	2-[(7R)-7-[(4-Fluorophenyl)methyl-(4-fluorophenyl)sulfonylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid	Investigative	53317718	C27H24F2N2O4S	510.6	C1CC2=C(C3=CC=CC=C3N2C[C@@H]1N(CC4=CC=C(C=C4)F)S(=O)(=O)C5=CC=C(C=C5)F)CC(=O)O	Ki ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2H5LW	10-(3-Benzyl-3,6-diazabicyclo[3.1.1]heptane-6-carbonyl)-19-cyclohexyl-N-(dimethylsulfamoyl)-5-methoxy-12-azapentacyclo[10.7.0.02,7.08,10.013,18]nonadeca-1(19),2(7),3,5,13(18),14,16-heptaene-15-carboxamide	Investigative	75276948	C41H47N5O5S	721.9	CN(C)S(=O)(=O)NC(=O)C1=CC2=C(C=C1)C(=C3N2CC4(CC4C5=C3C=CC(=C5)OC)C(=O)N6C7CC6CN(C7)CC8=CC=CC=C8)C9CCCCC9	EC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2I6ZY	(3R)-3-[[4-[(5-Chloro-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736682	C27H27ClFN3O5	528	C1CC2(CCC1(CO2)NCC3=C(C4=C(C=C3)OCCO4)Cl)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2J4VC	4-Methyl-1-((3-(5-(3-phenoxyprop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazol-6-yl)methyl)piperazin-2-one	Investigative	16221375	C29H26N4O2S	494.6	CN1CCN(C(=O)C1)CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CSC(=C5)C#CCOC6=CC=CC=C6	IC50 = 53000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2JHO6	trans-4-({1-[5-(5-Fluoro-1H-benzimidazol-2-yl)pyridin-2-yl]piperidin-4-yl}oxy)cyclohexanecarboxylic acid	Investigative	71078482	C24H27FN4O3	438.5	C1CC(CCC1C(=O)O)OC2CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)F	Ki ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2JR4V	CID 15950540	Investigative	15950540	C17H15Cl2N3O3	380.2	CC1=C(C(=C2CN(C(=O)C2=N1)CC(=O)O)C3=C(C=C(C=C3)Cl)Cl)CN	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2K0VB	8-[4-[2-[4-[3-(Azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]quinoline-4-carboxylic acid	Investigative	134133571	C31H40N4O3	516.7	C1CCCN(CC1)CCCOC2=CC=C(C=C2)CCN3CCN(CC3)C4=CC=CC5=C(C=CN=C54)C(=O)O	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2K5EC	(2S)-2-(1-(3-Chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-N-(5-fluoropyridin-2-yl)-3-((S)-1-hydroxypropan-2-yloxy)propanamide	Investigative	57504420	C21H19ClFN7O4	487.9	C[C@@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)F)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2KOR7	CID 57606048	Investigative	57606048	C25H35N3O3	425.6	CNC(=O)CCCN(C)C(=O)C1=CC2=C(C=C1)N(C3=C2C[C@@H](CC3)C4CCOCC4)C	IC50 = 105000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2LB1G	6-[[[1-[2-[7-(1,2-Oxazol-3-yloxy)-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187099	C26H27N7O5	517.5	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=N5)OC6=NOC=C6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2MC0D	(6R,8S)-6-((4-o-Tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol	Investigative	24894531	C22H28N2O	336.5	CC1=CC=CC=C1C2CCN(CC2)C[C@H]3C[C@@H](C4=C(C3)C=CC=N4)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2N9AQ	6-[[[1-[2-[2-Oxo-7-(pyridazin-3-ylmethoxy)-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187105	C28H30N8O4	542.6	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=N5)OCC6=NN=CC=C6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2O0CI	[4-[[2-(2,2-Difluoroethyl)tetrazol-5-yl]methyl]piperazin-1-yl]-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]methanone	Investigative	137656598	C27H33F2N7O2	525.6	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)C(=O)N3CCN(CC3)CC4=NN(N=N4)CC(F)F)[C@@H](C5=CC=CC=C5)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2OF6Z	Ilotycin	Investigative	3255	C37H67NO13	733.9	CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O	IC50 = 72443.6 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2PX7G	1-(2,5-Dichlorophenyl)-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143758	C21H25Cl2N3O4S	486.4	C1CCN(C1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2R1KO	1-[3-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-3,4-dihydro-1,7-naphthyridin-2-one	Investigative	62705174	C23H27N5O2	405.5	C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C=NC=C5	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2SKM9	3-[1-(4-Chlorophenyl)cyclopropyl]-8-Cyclopropyl[1,2,4]triazolo[4,3-A]pyridine	Investigative	118709259	C18H16ClN3	309.8	C1CC1C2=CC=CN3C2=NN=C3C4(CC4)C5=CC=C(C=C5)Cl	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2UD5M	4-[[7-Oxo-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]-1,8-naphthyridin-2-yl]oxy]benzenesulfonamide	Investigative	122187093	C29H31N7O6S	605.7	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4N=C(C=C5)OC6=CC=C(C=C6)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B2WH1E	2-Methyl-5-[[[1-[2-[2-oxo-7-methoxy-1,5-naphthyridine-1(2H)-yl]ethyl]-4-piperidinyl]amino]methyl]-3-pyridinecarbonitrile	Investigative	90644100	C24H28N6O2	432.5	CC1=C(C=C(C=N1)CNC2CCN(CC2)CCN3C(=O)C=CC4=C3C=C(C=N4)OC)C#N	IC50 = 50600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B31GIH	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-pyridin-2-ylpropanamide	Investigative	57504356	C20H18ClN7O3	439.9	CCOC[C@@H](C(=O)NC1=CC=CC=N1)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B34EHJ	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-2-oxopyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one	Investigative	137633091	C25H29N3O5	451.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4=O)C5=CC(=O)N(C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B34YNT	5-Cyano-N-[1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]-6-methylpyridine-3-carboxamide	Investigative	90644104	C24H26N6O3	446.5	CC1=C(C=C(C=N1)C(=O)NC2CCN(CC2)CCN3C(=O)C=CC4=C3C=C(C=N4)OC)C#N	IC50 = 74000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B35VON	(2S,3As,6aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712788	C18H20F3N3O	351.4	C1C[C@H]2C[C@H](N([C@H]2C1)C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N)C#N	IC50 = 55300 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B37OFQ	CID 81689815	Investigative	81689815	C15H13FN6OS	344.4	CC1=NSC(=N1)C2=NN=C3N2CCN(C3)C(=O)C4=CC=C(C=C4)F	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B38HLS	3-(Aminomethyl)-4-(2,4-Dichlorophenyl)-6-(2-Methoxyethyl)-2-Methyl-5,6-Dihydro-7h-Pyrrolo[3,4-B]pyridin-7-One	Investigative	15950615	C18H19Cl2N3O2	380.3	CC1=C(C(=C2CN(C(=O)C2=N1)CCOC)C3=C(C=C(C=C3)Cl)Cl)CN	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3A9TL	CID 42606792	Investigative	42606792	C24H34F3N3O4S	517.6	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3AGV8	4-(Spiro[chromene-2,4''-piperidine]-4-yl)benzoic acid	Investigative	25129436	C20H19NO3	321.4	C1CNCCC12C=C(C3=CC=CC=C3O2)C4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3F5YT	2-(Oxan-4-yl)ethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72946198	C31H43F3N4O6	624.7	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OCCC6CCOCC6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3GLZ5	N-((3S,4S)-4-(4-(5-Fluoropyridin-2-yl)phenyl)tetrahydrofuran-3-yl)propane-2-sulfonamide	Investigative	52948827	C18H21FN2O3S	364.4	CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1C2=CC=C(C=C2)C3=NC=C(C=C3)F	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3GRA8	6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione	Investigative	4687521	C22H19N3O4	389.4	CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3GX7T	(2S)-N-(5-Chloropyridin-2-yl)-2-[1-(3-chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(2-hydroxyethoxy)propanamide	Investigative	57504389	C20H17Cl2N7O4	490.3	C1=CC(=C(N=C1)N2C3=C(C=N2)C(=NC=N3)O[C@@H](COCCO)C(=O)NC4=NC=C(C=C4)Cl)Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3HWZ1	(R)-1-(4-Benzoyl-2-methylpiperazin-1-yl)-2-(1H-indol-3-yl)-ethane-1,2-dione	Investigative	3008866	C22H21N3O3	375.4	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=CC=CC=C32)C(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3KPY9	(1S,3R)-3-[8-Amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-1,3-dimethylcyclohexane-1-carboxylic acid	Investigative	137649218	C28H27F3N6O3	552.5	C[C@]1(CCC[C@](C1)(C)C(=O)O)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC(=C5)C(F)(F)F	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3KVX7	Bupivacaine hydrochloride	Investigative	64737	C18H29ClN2O	324.9	CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl	IC50 = 95000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3KWG8	6-[(3R)-3-[(1S)-2-Cyano-1-(methylamino)ethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	11452706	C21H23FN4O4	414.4	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CC[C@H](C4)[C@H](CC#N)NC)F)C(=O)O	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3N7HZ	7-(2-Fluorophenyl)-3-(4-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one	Investigative	78321115	C19H13FN2O2S	352.4	COC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC=C3C4=CC=CC=C4F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3NJD5	4-[1-Methyl-3-(4-fluorophenyl)-1H-pyrazole-4-yl]pyridine	Investigative	22037373	C15H12FN3	253.27	CN1C=C(C(=N1)C2=CC=C(C=C2)F)C3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3PJU5	Tert-butyl 4-[3-(1H-benzimidazol-2-ylamino)propylcarbamoyl]piperidine-1-carboxylate	Investigative	122179075	C21H31N5O3	401.5	CC(C)(C)OC(=O)N1CCC(CC1)C(=O)NCCCNC2=NC3=CC=CC=C3N2	IC50 ~ 50100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3POD9	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70276830	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)N=CC=C5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3Q2SI	Chembl4251444	Investigative	145982905	C27H33N5O2	459.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)N5C=CC=N5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3RBM6	(3R)-3-[[4-[(5,8-Dichloro-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736685	C27H26Cl2FN3O5	562.4	C1CC2(CCC1(CO2)NCC3=CC(=C4C(=C3Cl)OCCO4)Cl)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3RGA7	6-(Bis(4-chlorophenyl)methyl)-4-((1-((trifluoromethyl)sulfonyl)piperidin-4-yl)amino)quinolin-2(1H)-one	Investigative	91844670	C28H24Cl2F3N3O3S	610.5	C1CN(CCC1NC2=CC(=O)NC3=C2C=C(C=C3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl)S(=O)(=O)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3SU4Q	4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyridin-3-ylpyrrolo[1,2-b]pyridazine-3-carboxamide	Investigative	91755097	C21H26N6O	378.5	C[C@@]1(CC[C@H](C1(C)C)NC2=C(C=NN3C2=CC(=C3)C4=CN=CC=C4)C(=O)N)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3T8ER	1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid	Investigative	46872626	C18H17Cl2NO3	366.2	C1C(CN1CC2=CC=C(C=C2)OCC3=CC(=C(C=C3)Cl)Cl)C(=O)O	IC50 = 77000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3TS8R	Fezolinetant	Investigative	117604931	C16H15FN6OS	358.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3U7BY	Chembl4248589	Investigative	121245322	C31H42N4O3	518.7	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC(=C4)C5CC5)N6CCOCC6	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3W0YL	(2S,4S)-1-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	118712775	C15H15F4N3O	329.29	C1[C@@H](CN([C@@H]1C#N)C(=O)C[C@@H](CC2=CC(=C(C=C2F)F)F)N)F	IC50 = 97700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3WOY8	3-Oxo-4-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]-1,4-benzoxazine-6-carboxylic acid	Investigative	56672433	C24H27N5O6	481.5	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)COC5=C4C=C(C=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3XHQ7	[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-methyl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	76335990	C24H33F3N4O3	482.5	CN1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3Z4IU	CID 68767109	Investigative	68767109	C25H36F3N3O4S	531.6	CC1=C(C=C(C=C1)C(=O)N[C@H]2CCN(C2=O)[C@H]3CC[C@H](C[C@H]3CS(=O)(=O)C)N(C)C(C)C)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B3Z7IB	2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine	Investigative	25070582	C15H17N3	239.32	C1CNCCC2=NC(=NC=C21)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B42WON	(R)-(+)-Bupivacaine Hydrochloride	Investigative	117964	C18H29ClN2O	324.9	CCCCN1CCCC[C@@H]1C(=O)NC2=C(C=CC=C2C)C.Cl	IC50 = 84000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B43ZWT	2-Methoxyethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72946200	C27H37F3N4O6	570.6	COCCOC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B46XEP	N-[3-(1H-Benzimidazol-2-ylamino)propyl]-4-(pyrrolidin-1-ylmethyl)benzamide	Investigative	122179074	C22H27N5O	377.5	C1CCN(C1)CC2=CC=C(C=C2)C(=O)NCCCNC3=NC4=CC=CC=C4N3	IC50 ~ 50100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B47AZN	3-(1-Methylpyrazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;hydrochloride	Investigative	127025891	C30H27ClF3N5O3	598	CN1C=C(C=N1)C2=CC(=CC(=C2)C(F)(F)F)C(=O)N[C@@H]3CCC4=C(C3)C=C(C=C4)OC5=C6CCC(=O)NC6=NC=C5.Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B48ZMI	N-[(2s,4s)-1-({4-[2-(3,5-Dimethyl-1,2-Oxazol-4-Yl)ethyl]piperidin-1-Yl}sulfonyl)-4-(5-Fluoropyrimidin-2-Yl)-2-Methylpentan-2-Yl]-N-Hydroxyformamide	Investigative	50990921	C23H34FN5O5S	511.6	CC1=C(C(=NO1)C)CCC2CCN(CC2)S(=O)(=O)C[C@](C)(C[C@H](C)C3=NC=C(C=N3)F)N(C=O)O	IC50 = 65000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4B5GV	CID 60199965	Investigative	60199965	C25H25FN6O3	476.5	C1CN(C[C@@H]([C@@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)F)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 168000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4BA2Z	Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-	Investigative	16727109	C22H20ClFN2O6	462.9	CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC(=C(C=C3)F)CN(CC(=O)O)C(=O)OC	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4CN2U	N-[2-[2-[4-Bromo-3-[(3R,4R)-4-(3,4-difluorophenyl)-4-(2,3-dihydroxypropoxy)piperidin-3-yl]-1,2-oxazol-5-yl]phenyl]ethyl]acetamide	Investigative	46932704	C27H30BrF2N3O5	594.4	CC(=O)NCCC1=CC=CC=C1C2=C(C(=NO2)[C@H]3CNCC[C@@]3(C4=CC(=C(C=C4)F)F)OCC(CO)O)Br	Ki ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4DTJ5	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(1-methyl-6-oxopyridin-3-yl)-2,8-diazaspiro[4.5]decan-1-one	Investigative	130449733	C25H29N3O5	451.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4=O)C5=CN(C(=O)C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4FX6A	6-Fluoro-4-[[1-[(5-chloro-1-methyl-1H-pyrazole-4-yl)carbonyl]-4-piperidinyl]amino]quinoline-2(1H)-one	Investigative	90644462	C19H19ClFN5O2	403.8	CN1C(=C(C=N1)C(=O)N2CCC(CC2)NC3=CC(=O)NC4=C3C=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4KPA0	1-Ethyl-3-[3-[[[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinolin-5-yl]amino]methyl]phenyl]urea	Investigative	90667600	C25H29F3N6O	486.5	CCNC(=O)NC1=CC=CC(=C1)CNC2=CC(=CC3=C2C=C(C=N3)N4CCN(CC4)C)C(F)(F)F	IC50 = 81700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4LN5V	1-[4-[3-(Azepan-1-yl)propoxy]phenyl]-4-(2,4-difluorobenzoyl)piperazin-2-one;formic acid	Investigative	24749726	C27H33F2N3O5	517.6	C1CCCN(CC1)CCCOC2=CC=C(C=C2)N3CCN(CC3=O)C(=O)C4=C(C=C(C=C4)F)F.C(=O)O	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4LT9B	1-[4-(2-Piperidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60145773	C21H24F3N3O4S	471.5	C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4QE0G	(trans-4-{2-[(1r)-1-Hydroxyethyl]imidazo[4,5-D]pyrrolo[2,3-B]pyridin-1(6h)-Yl}cyclohexyl)acetonitrile	Investigative	58395078	C18H21N5O	323.4	C[C@H](C1=NC2=CN=C3C(=C2N1C4CCC(CC4)CC#N)C=CN3)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4RT8Y	(1R,3R)-3-[8-Amino-1-[4-[[4-(trifluoromethyl)pyridin-2-yl]carbamoyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-3-methyl-1-propan-2-ylcyclopentane-1-carboxylic acid	Investigative	137655281	C29H29F3N6O3	566.6	CC(C)[C@]1(CC[C@@](C1)(C)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC(=C5)C(F)(F)F)C(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4S1WU	(3R)-3-[[4-(2,3-Dihydro-1,4-benzodioxin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736679	C27H28FN3O5	493.5	C1CC2(CCC1(CO2)NCC3=CC4=C(C=C3)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4SJW5	CID 68767802	Investigative	68767802	C26H42N4O4S	506.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C)N2CC[C@@H](C2=O)NC(=O)C3=NC(=CC=C3)C(C)(C)C	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4SUW3	4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]-2,6-dimethylphenoxy]butanoic acid	Investigative	134132142	C19H18ClF3O4	402.8	CC1=CC(=CC(=C1OCCCC(=O)O)C)C2=C(C=CC(=C2)OC(F)(F)F)Cl	IC50 = 54570 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4U5DJ	(R)-1-(1-((S)-Tetrahydro-2H-pyran-3-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)ethanol	Investigative	58394783	C15H18N4O2	286.33	C[C@H](C1=NC2=CN=C3C(=C2N1[C@H]4CCCOC4)C=CN3)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4U8LM	Chembl4204215	Investigative	145977049	C12H16N2OS2	268.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CS3)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4UN1Q	6-[[[1-[2-[7-(1,2-Oxazol-3-yloxy)-2-oxo-1,8-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187098	C26H27N7O5	517.5	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4N=C(C=C5)OC6=NOC=C6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4VXG7	[(2R,3Ar,5R,6aR)-2-[(3-methoxyoxan-4-yl)amino]-5-(trifluoromethyl)-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517403	C25H31F6N3O3	535.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4WEG5	Chembl4238909	Investigative	118978102	C28H38N4O3	478.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)N5CCOCC5	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4XB0O	7-Fluoro-4-oxo-N-(1-((2-oxo-1,2-dihydroquinolin-7-yl)methyl)piperidin-4-yl)-4H-chromene-2-carboxamide	Investigative	11719291	C25H22FN3O4	447.5	C1CN(CCC1NC(=O)C2=CC(=O)C3=C(O2)C=C(C=C3)F)CC4=CC5=C(C=C4)C=CC(=O)N5	IC50 = 85500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B4XLG5	(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(2H-tetrazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797060	C23H24F4N6O3	508.5	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C3=NNN=N3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 = 59000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B50CGK	1-(3-Chlorophenyl)-3-[2-[methyl-[(3-methyl-1,2-oxazol-5-yl)methyl]amino]ethyl]imidazolidin-2-one	Investigative	45270916	C17H21ClN4O2	348.8	CC1=NOC(=C1)CN(C)CCN2CCN(C2=O)C3=CC(=CC=C3)Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B54DOB	2-(4-((6,7-Dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide	Investigative	11517980	C24H25N5O4	447.5	CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC	IC50 = 137000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B56ONR	(3R)-5-Fluoro-3-hydroxy-3-[[4-[(4-methyl-2,3-dihydropyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736763	C27H30FN5O4	507.6	CN1CCOC2=C1N=C(C=C2)CNC34CCC(CC3)(OC4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B58KPU	Morpholino(4-(spiro[chromene-2,4''-piperidine]-4-yl)phenyl)-methanone	Investigative	44254584	C24H26N2O3	390.5	C1CNCCC12C=C(C3=CC=CC=C3O2)C4=CC=C(C=C4)C(=O)N5CCOCC5	IC50 = 54256 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B58SMF	N-(1-(4-((2-(Piperidin-1-yl)ethyl)carbamoyl)benzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide	Investigative	11692293	C30H35FN4O4	534.6	C1CCN(CC1)CCNC(=O)C2=CC=C(C=C2)CN3CCC(CC3)NC(=O)C4=CC(=O)C5=C(O4)C=C(C=C5)F	IC50 = 66000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B59LBY	3-Anilino-1-[(1S,2S)-2-cyanocyclohexyl]pyrazole-4-carboxamide	Investigative	89471082	C17H19N5O	309.4	C1CC[C@@H]([C@H](C1)C#N)N2C=C(C(=N2)NC3=CC=CC=C3)C(=O)N	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5B2QS	6-[[[1-[2-[7-[(1-Methylpyrazol-3-yl)methoxy]-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187106	C28H32N8O4	544.6	CN1C=CC(=N1)COC2=CC3=C(C=CC(=O)N3CCN4CCC(CC4)NCC5=NC6=C(C=C5)OCC(=O)N6)N=C2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5DJ7X	CID 25008593	Investigative	25008593	C26H29N5O4	475.5	CO[C@H]1CN(CC[C@@H]1NCC2=CC3=C(C=N2)OCCO3)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 176000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5E3ND	9-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-4-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-5-one	Investigative	121313866	C24H28N4O6	468.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)C(=O)N(CCO4)C5=NN(C(=O)C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5FR4B	TGR5 Receptor Agonist	Investigative	44605616	C18H14Cl2N2O2	361.2	CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)N(C)C3=CC=C(C=C3)Cl	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5G2SW	6-[[[1-[[(3R)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7-trien-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728080	C26H28FN5O5	509.5	C1CC(=O)N2C[C@](C3=C2C1=NC=C3F)(CC45CCC(CC4)(CO5)NCC6=NC7=C(C=C6)OCC(=O)N7)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5GR6Q	5-[(E)-2-(2-Chloro-6-fluorophenyl)ethenyl]-N,N-dimethylpyridin-2-amine	Investigative	118707602	C15H14ClFN2	276.73	CN(C)C1=NC=C(C=C1)/C=C/C2=C(C=CC=C2Cl)F	IC50 = 59500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5HFU8	1-[(3S)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]azetidine-3-carboxylic acid	Investigative	49836633	C23H25NO2	347.4	C1C[C@@]2(CC1N3CC(C3)C(=O)O)CC4=CC=CC=C4CC5=CC=CC=C25	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5HI3Q	4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-pyridin-4-ylpyrrolo[1,2-b]pyridazine-3-carboxamide	Investigative	117769349	C21H26N6O	378.5	C[C@@]1(CC[C@H](C1(C)C)NC2=C(C=NN3C2=CC(=C3)C4=CC=NC=C4)C(=O)N)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5HNZ6	N-Hydroxy-3-[4-[[4-(methylcarbamoyl)phenyl]methoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide	Investigative	118179817	C25H31N3O6S	501.6	CNC(=O)C1=CC=C(C=C1)COC2=CC=C(C=C2)S(=O)(=O)C3(CCC4(C3)CCNCC4)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5J4FN	Chembl4242732	Investigative	130454024	C29H39N3O4	493.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)OC5CCOCC5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5JD6I	Chembl4127458	Investigative	145961500	C22H22ClN5O	407.9	CC1=CN=CC(=N1)C2=CC=C(C=C2)C(=O)N([C@@H]3CCCNC3)C4=C(C=CC=N4)Cl	IC50 = 59800 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5JYK3	4-Amino-N-(1-(4-chlorophenyl)-4-(dimethylamino)butyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	42602264	C24H32ClN7O	470	CN(C)CCCC(C1=CC=C(C=C1)Cl)NC(=O)C2(CCN(CC2)C3=NC=NC4=C3C=CN4)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5KPH1	2,2-Difluoro-4-[[7-fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxy]butanoic acid	Investigative	71153035	C29H30F3N5O6	601.6	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CCC5=C6C(=NC=C5F)C=CC(=N6)OCCC(C(=O)O)(F)F	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5KWI0	6-[[[(3S,4R)-1-[2-[2-Oxo-7-fluoro-1,5-naphthyridine-1(2H)-yl]ethyl]-3-fluoro-4-piperidinyl]amino]methyl]-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one	Investigative	90644113	C23H24F2N6O3	470.5	C1CN(C[C@@H]([C@@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)F)CCN4C(=O)C=CC5=C4C=C(C=N5)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5MIV7	(1S)-2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethanol	Investigative	57402816	C24H28FN5O4	469.5	COC1=NC2=C(C(=CN=C2C=C1)F)[C@@H](CN3CCC(CC3)NCC4=CC5=C(C=N4)OCCO5)O	IC50 = 63100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5N4BH	(3R)-3-[[4-(3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736760	C26H28FN5O4	493.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCCN4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5NF7B	CID 25008249	Investigative	25008249	C25H31N5O5	481.5	CO[C@H]1CN(CC[C@@H]1NCC2=CC3=C(C=N2)OCCO3)CCN4C5=C(C=CC(=C5)OC)N=CC4=O	IC50 = 93000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5NXR3	Chembl420197	Investigative	45272695	C19H29NO2	303.4	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CC[C@@H]4[C@@]3(C=CC(=O)N4C)C	Ki = 130000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5PC3O	3-[4-(Azetidine-1-carbonyl)phenoxy]-N-(1-ethylpyrazol-3-yl)-5-[(2S)-1-hydroxypropan-2-yl]oxybenzamide	Investigative	11626833	C25H28N4O5	464.5	CCN1C=CC(=N1)NC(=O)C2=CC(=CC(=C2)O[C@@H](C)CO)OC3=CC=C(C=C3)C(=O)N4CCC4	IC50 = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5PHQ9	8-[(8-Fluoro-2,3-dihydro-1,4-benzoxazin-4-yl)methyl]-N,N-dimethyl-2-morpholin-4-yl-4-oxochromene-6-carboxamide	Investigative	127046317	C25H26FN3O5	467.5	CN(C)C(=O)C1=CC(=C2C(=C1)C(=O)C=C(O2)N3CCOCC3)CN4CCOC5=C4C=CC=C5F	IC50 = 94000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5TVG4	GPR120 agonist 4x	Investigative	90418278	C20H12ClF6NO3S	495.8	C1=CC(=C(C=C1Cl)F)C2=NSC(=C2COC3=C(C=C(C=C3F)CCC(=O)O)F)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5VP9J	1-[(2S)-3-(4-Fluorophenoxy)-2-hydroxy-2-methylpropanoyl]-2,3-dihydroindole-4-carbonitrile	Investigative	86276216	C19H17FN2O3	340.3	C[C@](COC1=CC=C(C=C1)F)(C(=O)N2CCC3=C(C=CC=C32)C#N)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5WU7L	CID 11496746	Investigative	11496746	C27H28N6OS	484.6	CC1=NC2=CC=CC(=C2C=C1)C3=NN=C(N3C)SCCN4CCC5=CC6=C(C=C5CC4)OC(=N6)C	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5X0MQ	(4-Chloro-3-fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86274490	C16H14ClFN6OS	392.8	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=C(C=C3)Cl)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B5Z9IG	Chembl4246111	Investigative	121246911	C26H32N6O2	460.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)N5C=NN=C5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B60LKM	2-[(7R)-4-Fluoro-7-[(4-fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid	Investigative	53325908	C21H20F2N2O4S	434.5	CN([C@@H]1CCC2=C(C3=C(N2C1)C(=CC=C3)F)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	Ki ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B60UJH	Chembl4214785	Investigative	145974600	C11H15N3OS2	269.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=NC=CS3)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B62WJG	[(2S,3As,5R,6aS)-2-fluoro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517240	C24H31F4N3O3	485.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B63BPI	CID 86274489	Investigative	86274489	C16H15ClN6OS	374.8	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)Cl)C4=NC(=NS4)C	IC50 = 66000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B63ZUV	(R)-6-(2-(4-Fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)-2-(o-tolyl)pyridazin-3(2H)-one	Investigative	136173253	C24H22FN5O2	431.5	CC1=CC=CC=C1N2C(=O)C=CC(=N2)C3=C4NC[C@H](CN4N=C3C5=CC=C(C=C5)F)CO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B64GYX	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4,5-dimethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70688897	C21H29N5O2S	415.6	CC1=C(SC(=N1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B64PEZ	(S)-4-((5-((1-(2-Aminonicotinoyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile	Investigative	44592987	C22H21N7O2	415.4	C1CN(C(=O)[C@H]1NCC2=CN=CN2CC3=CC=C(C=C3)C#N)C(=O)C4=C(N=CC=C4)N	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B64WZI	1-[3-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-3,4-dihydro-1,5-naphthyridin-2-one	Investigative	62705172	C23H27N5O2	405.5	C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C=CC=N5	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B65JOF	6-[[[1-[2-[7-(5-Fluoropyridin-3-yl)oxy-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187101	C28H28FN7O4	545.6	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=N5)OC6=CC(=CN=C6)F	IC50 = 79000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B67MOX	CID 57400418	Investigative	57400418	C27H35F3N4O7S	616.7	COC1=NC=C(C=C1)C2(CCC(CC2)N3CC[C@H](C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O.CS(=O)(=O)O	IC50 = 84000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B67UKE	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70695171	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)C=CN=C5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B69LZM	(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-methyl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide	Investigative	72948001	C25H34F3N5O4	525.6	CNC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B69UGZ	6-[[[1-[[(3S)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728075	C26H26FN5O5	507.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6B8GM	US8552017, 1.1(3).HCl	Investigative	44476436	C17H19N5O2S	357.4	CNC1=NN2C3=C(CN(CC3)C)C=NC2=C1S(=O)(=O)C4=CC=CC=C4	IC50 = 54200 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6C9XK	[(2R,3As,5R,6aS)-2-hydroxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517574	C24H32F3N3O4	483.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6DX0H	6-[(1R,3R)-3-[5-(4-Fluorophenyl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]pyridine-3-carboxylic acid	Investigative	118710536	C30H24FN7O2	533.6	CN1C=C(C=N1)[C@@]2(C3=C(C[C@@H](N2)C4=NC=C(N4)C5=CC=C(C=C5)F)C6=CC=CC=C6N3)C7=NC=C(C=C7)C(=O)O	IC50 = 95600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6HL0I	4-[[5-[2-[4-[(5-Chloro-6-methylpyridin-3-yl)methylamino]piperidin-1-yl]ethyl]-6-oxo-1,5-naphthyridin-3-yl]oxy]benzenesulfonamide	Investigative	122187095	C28H31ClN6O4S	583.1	CC1=C(C=C(C=N1)CNC2CCN(CC2)CCN3C(=O)C=CC4=C3C=C(C=N4)OC5=CC=C(C=C5)S(=O)(=O)N)Cl	IC50 = 82000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6IL0V	1-[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]ethanone	Investigative	72947413	C25H33F3N4O4	510.5	CC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6LS7Z	5-(4-Cyano-2-Methyl-1h-Benzimidazol-1-Yl)-N-Cyclopropylthiophene-2-Carboxamide	Investigative	53494972	C17H14N4OS	322.4	CC1=NC2=C(C=CC=C2N1C3=CC=C(S3)C(=O)NC4CC4)C#N	IC50 = 53000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6LU2V	6-{[(1-[2-[6-(1-Hydroxyethyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	Investigative	15982019	C25H31N5O5	481.5	CC(C1=CC2=C(C=C1)OCC(=O)N2CCN3CCC(CC3)NCC4=NC5=C(C=C4)OCC(=O)N5)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6M0BZ	7-Cyclopropyl-4-[3-(methylamino)azetidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine	Investigative	71519674	C14H18N6	270.33	CNC1CN(C1)C2=NC(=NC3=C2N=CC(=C3)C4CC4)N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6OBC4	(3R)-3-[[4-[(4,4-Dioxo-2,3-dihydro-[1,4]oxathiino[3,2-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736675	C26H27FN4O6S	542.6	C1CC2(CCC1(CO2)NCC3=CC4=C(C=N3)S(=O)(=O)CCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6P7LQ	(2S)-2-[4-[[4-(4-Chloro-3-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)propanoic acid	Investigative	71453204	C27H34ClFN2O3	489	CC1=C(C=CC(=C1)OC2CCN(CC2)CC3CCN(CC3)[C@@H](CC4=CC=C(C=C4)F)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6RDV1	CID 12001832	Investigative	12001832	C27H33Cl2FN2O3	523.5	CC1=C(C=CC(=C1Cl)Cl)OC2CCN(CC2)CC3CCN(CC3)[C@@H](CC4=CC=C(C=C4)F)C(=O)O	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6RQZ7	4-[4-[2-(4-Acetylpiperazin-1-yl)ethoxy]phenyl]-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol	Investigative	59149828	C25H30F3N7O3	533.5	CC(=O)N1CCN(CC1)CCOC2=CC=C(C=C2)C3(CCN(CC3)C4=NN5C(=NN=C5C(F)(F)F)C=C4)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6RYJ1	Chembl4237868	Investigative	137480037	C28H36N6O2	488.6	CC1=NN(C(=N1)C)C2=CC=CC(=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6T7PW	1-[4-(4-Methylcyclohexyl)butyl]alpha,alpha-diphenyl-4-piperdinemethanol	Investigative	45485462	C29H41NO	419.6	CC1CCC(CC1)CCCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6TQU3	(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-(5-methylpyrazin-2-yl)propanamide	Investigative	57504328	C21H20ClN7O3	453.9	CCOC[C@@H](C(=O)NC1=NC=C(N=C1)C)OC2=NC=NC3=C2C=NN3C4=CC=CC=C4Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6VU8R	(3R)-3-[[4-(6,7-Dihydro-[1,4]dioxino[2,3-c]pyridazin-3-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736677	C25H26FN5O5	495.5	C1CC2(CCC1(CO2)NCC3=CC4=C(N=N3)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6WB1P	Ethyl 1-[3-(4-sulfamoylphenoxy)propyl]piperidine-4-carboxylate	Investigative	60145490	C17H26N2O5S	370.5	CCOC(=O)C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)N	IC50 = 76500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6X0HE	6-((2R,5R)-2-Methyl-5-phenylmorpholino)-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	Investigative	54592009	C18H19N3O3	325.4	C[C@@H]1CN([C@@H](CO1)C2=CC=CC=C2)C3=NC4=C(C=C3)OCC(=O)N4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B6ZDG5	N-Methyl-4-[4-[[3'-(hydroxycarbamoyl)spiro[piperidine-4,1'-cyclopentane]-3'-yl]sulfonyl]phenoxy]benzamide	Investigative	72720906	C24H29N3O6S	487.6	CNC(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)C3(CCC4(C3)CCNCC4)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B70BHN	Chembl4214603	Investigative	145974594	C13H16FN3OS	281.35	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=C(C=CC=N3)F)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B70THD	3-[4-(5-Aminomethyl-2-fluoro-phenyl)-piperidine-1-carbonyl]-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoic acid	Investigative	44396541	C26H23FN4O4S	506.5	C1CN(CCC1C2=C(C=CC(=C2)CN)F)C(=O)C3=CC(=CC(=C3)C4=NC(=NO4)C5=CC=CS5)C(=O)O	IC50 = 76800 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B72NYB	4-[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl]benzonitrile	Investigative	86275450	C17H15N7OS	365.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)C#N)C4=NC(=NS4)C	IC50 = 59000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B74KPY	4-Benzoyl-1-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazin-2-one;hydrochloride	Investigative	24749606	C25H32ClN3O3	458	C1CCN(CC1)CCCOC2=CC=C(C=C2)N3CCN(CC3=O)C(=O)C4=CC=CC=C4.Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B74TEG	CID 71768899	Investigative	71768899	C29H32F3N3O4	543.6	C1CN(CCC1C2=CC=C(C=C2)C(=O)O)[C@@H]3C[C@@H]4[C@](C3)(CCO4)C(=O)N5CCC6=C(C5)C=C(C=N6)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B76WSX	3-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-4-sulfonamide	Investigative	68205062	C25H20N6O2S	468.5	C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=C(C=CN=C5)S(=O)(=O)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7B9QM	[(2R,3Ar,5S,6aR)-2-[(3-methoxyoxan-4-yl)amino]-5-(trifluoromethyl)-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517402	C25H31F6N3O3	535.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7BN0D	2-[5-Chloro-3-[(3,4-dichlorophenyl)sulfonylamino]pyridin-2-yl]oxy-N-(2-hydroxyethyl)benzamide	Investigative	49798437	C20H16Cl3N3O5S	516.799	C1=CC=C(C(=C1)C(=O)NCCO)OC2=C(C=C(C=N2)Cl)NS(=O)(=O)C3=CC(=C(C=C3)Cl)Cl	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7BSK4	6-[[[1-[[(3R)-5,10-Difluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728967	C26H25F2N5O5	525.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@@]5(CN6C7=C5C(=CN=C7C=C(C6=O)F)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7GH2C	2-(2-Aminopyrimidin-5-yl)-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine	Investigative	51030920	C24H19N7	405.5	C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CN=C(N=C5)N	IC50 = 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7GH3J	Chembl4130214	Investigative	145961840	C19H23N3O2	325.4	C1C[C@H](CN(C1)[C@@H]2C[C@@H]3[C@H]([C@H]2OC4=CC=C(C=C4)C#N)CC3=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7H4YN	3-(2-Methylpyridin-3-yl)-8-[6-(trifluoromethoxy)-1H-benzimidazol-2-yl]-1-oxa-3-azaspiro[4.5]decan-2-one	Investigative	25072568	C22H21F3N4O3	446.4	CC1=C(C=CC=N1)N2CC3(CCC(CC3)C4=NC5=C(N4)C=C(C=C5)OC(F)(F)F)OC2=O	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7HSP2	(3Ar,5R,6aR)-N'-cyano-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboximidamide	Investigative	72946387	C25H32F3N7O3	535.6	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=NC#N)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7KOL3	N-{[1-(4-Hydroxy-4-oxazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide	Investigative	46241121	C22H25F3N4O4	466.5	C1CC(CCC1N2CC(C2)NC(=O)CNC(=O)C3=CC(=CC=C3)C(F)(F)F)(C4=NC=CO4)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7MH2B	3-[(2R)-2-Methylpiperidin-1-yl]-N-[[4-[[3-[(2S)-2-methylpiperidin-1-yl]propylamino]methyl]phenyl]methyl]propan-1-amine;hydrochloride	Investigative	71456968	C26H47ClN4	451.1	C[C@@H]1CCCCN1CCCNCC2=CC=C(C=C2)CNCCCN3CCCC[C@@H]3C.Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7NQ0P	6-[[[1-[[(3S)-5-Fluoro-3-hydroxy-9-methyl-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728971	C27H28FN5O5	521.5	CC1=CC(=O)N2C[C@@](C3=C2C1=NC=C3F)(CC45CCC(CC4)(CO5)NCC6=NC7=C(C=C6)OCC(=O)N7)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7OSJ1	8-[4-[2-[4-[3-(Azepan-1-yl)propoxy]phenyl]ethyl]piperazin-1-yl]quinoline-5-carbonitrile	Investigative	134143913	C31H39N5O	497.7	C1CCCN(CC1)CCCOC2=CC=C(C=C2)CCN3CCN(CC3)C4=C5C(=C(C=C4)C#N)C=CC=N5	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7QIF6	N-(1,1-Dioxothian-3-yl)-4-[4-[2-[(3S)-3-hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]benzamide	Investigative	57391205	C27H30N2O5S	494.6	C1CC(CS(=O)(=O)C1)NC(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)C#C[C@@]4(CN5CCC4CC5)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7QTZ3	N-[4-[[(5S)-2-Methyl-5-(4-methylsulfanylphenyl)-1,5-dihydro-2,4-benzodiazepin-3-yl]oxymethyl]phenyl]methanesulfonamide;hydrochloride	Investigative	118718808	C25H28ClN3O3S2	518.1	CN1CC2=CC=CC=C2[C@@H](N=C1OCC3=CC=C(C=C3)NS(=O)(=O)C)C4=CC=C(C=C4)SC.Cl	IC50 = 56000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7S6VD	1-{3-[6-(1-Hydroxy-1-methyl-ethyl)-1-oxy-pyridin-3-ylethynyl]-phenyl}-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid cyclopropylamide	Investigative	10206059	C28H24N4O4	480.5	CC(C)(C1=[N+](C=C(C=C1)C#CC2=CC(=CC=C2)N3C=C(C(=O)C4=C3N=CC=C4)C(=O)NC5CC5)[O-])O	IC50 = 89400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7SIN9	N-Hydroxy-3-[4-[[4-(trifluoromethoxy)phenyl]methoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide	Investigative	118734983	C24H27F3N2O6S	528.5	C1CC(CC12CCNCC2)(C(=O)NO)S(=O)(=O)C3=CC=C(C=C3)OCC4=CC=C(C=C4)OC(F)(F)F	IC50 = 50300 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7TYI4	1-[6,6-Bis(4-fluorophenyl)hexyl]-4-[[4-methoxy-3,5-bis[(2-methylpropan-2-yl)oxy]phenyl]methyl]piperazine-2,5-dione	Investigative	118721374	C38H48F2N2O5	650.8	CC(C)(C)OC1=CC(=CC(=C1OC)OC(C)(C)C)CN2CC(=O)N(CC2=O)CCCCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7U5YB	Chembl4284935	Investigative	117715778	C19H28N6O2S	404.5	CCCC[C@@H](CCO)NC1=NC(=NC2=C1CN(CC2)C(=O)C3=CSC(=N3)C)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7UBM1	1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]anilino]pyrazole-4-carboxamide	Investigative	89470730	C18H18F3N5O3	409.4	C1COC[C@@H]([C@H]1C#N)N2C=C(C(=N2)NC3=CC=C(C=C3)[C@@H](C(F)(F)F)O)C(=O)N	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B7XEP5	Chembl4215377	Investigative	129085361	C27H35ClN4O2	483	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)Cl)OCCCN5CCCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B80OPE	Ethyl 1-[2-[4-(phenylcarbamoylsulfamoyl)phenoxy]ethyl]piperidine-4-carboxylate	Investigative	60145774	C23H29N3O6S	475.6	CCOC(=O)C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B82ITR	(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)(4-isopropylpiperazin-1-yl)methanone	Investigative	44418497	C19H29N3O3	347.5	CC(C)N1CCN(CC1)C(=O)N2CCC3=CC(=C(C=C3C2)OC)OC	IC50 = 115000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B83JKX	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide	Investigative	57504311	C20H18ClN7O3	439.9	CC1=CN=C(C=C1)NC(=O)[C@H](COC)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B83QJZ	1-[(2R)-4-Benzoyl-2-methylpiperazin-1-yl]-2-(1H-pyrrolo[3,2-c]pyridin-3-yl)ethane-1,2-dione	Investigative	507751	C21H20N4O3	376.4	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=C2C=NC=C3)C(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B83VEM	(2S)-2-[4-[[4-(4-Chloro-3-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)-2-methylpropanoic acid	Investigative	71462100	C28H36ClFN2O3	503	CC1=C(C=CC(=C1)OC2CCN(CC2)CC3CCN(CC3)[C@@](C)(CC4=CC=C(C=C4)F)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B85FQY	(2,4-Difluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86274966	C16H14F2N6OS	376.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=C(C=C(C=C3)F)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8B7WR	(3-Fluorophenyl)-[2-(5-fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]methanone	Investigative	74222036	C18H13F2N3O2	341.3	C1CN(CC2=C1OC(=N2)C3=NC=C(C=C3)F)C(=O)C4=CC(=CC=C4)F	IC50 = 74000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8C7KE	1-Phenyl-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143592	C21H27N3O4S	417.5	C1CCN(C1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8DAO0	5-Methoxy-2-(2-pyridin-3-ylethynyl)quinoline	Investigative	71562957	C17H12N2O	260.29	COC1=CC=CC2=C1C=CC(=N2)C#CC3=CN=CC=C3	IC50 = 65300 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8DT6V	2-(1-Hydroxy-1-methylethyl)-5-[3-[3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridine-1(4H)-yl]phenyl]pyridine 1-oxide	Investigative	10297996	C26H24N4O4	456.5	CC(C)(C1=[N+](C=C(C=C1)C2=CC(=CC=C2)N3C=C(C(=O)C4=C3N=CC=C4)C(=O)NC5CC5)[O-])O	IC50 = 50100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8DXV5	CID 57663637	Investigative	57663637	C23H24F3N5O2	459.5	C1CN(CCC1(F)F)CCCNC2=NN=C(O2)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4F	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8EOB1	(R)-(4-(1-Amino-2-(2,4,5-trifluorophenyl)ethyl)piperidin-1-yl)(3-methylpyrazin-2-yl)methanone	Investigative	44591849	C19H21F3N4O	378.4	CC1=NC=CN=C1C(=O)N2CCC(CC2)[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 = 55000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8EWY2	5-[[(2R)-2-Amino-3-methylsulfonylpropyl]amino]-3-[(4,6-dimethylpyridin-2-yl)amino]pyridine-2-carboxamide	Investigative	118733349	C17H24N6O3S	392.5	CC1=CC(=NC(=C1)NC2=C(N=CC(=C2)NC[C@H](CS(=O)(=O)C)N)C(=O)N)C	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8FCJ6	(1R,2S)-2-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxymethyl]cyclopropane-1-carboxylic acid	Investigative	122186197	C30H32FN5O6	577.6	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CCC5=C6C(=NC=C5F)C=CC(=N6)OC[C@H]7C[C@H]7C(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8FGQ3	8-[(1R,2S)-1-Hydroxy-1-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)propan-2-yl]-2-(1-methyl-6-oxopyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one	Investigative	121314036	C25H30N4O5	466.5	CC1=C(C=CC2=C1COC2=O)[C@H]([C@H](C)N3CCC4(CC3)CCN(C4=O)C5=NN(C(=O)C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8FU5D	1-[4-(Dimethylamino)phenyl]-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60144084	C22H30N4O4S	446.6	CN(C)C1=CC=C(C=C1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8G9PY	5-[1-Methoxy-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one	Investigative	68094634	C24H27N7O4	477.5	CC1=C(C=CC2=C1COC2=O)C(CN3CCN(CC3)C(=O)CC4=CN=C(C=C4)N5C=NN=N5)OC	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8GOM4	6-[(3R)-3-[(1S)-1-Aminoethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	44425437	C19H22FN3O4	375.4	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CC[C@H](C4)[C@H](C)N)F)C(=O)O	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8HGE9	1-(2,5-Dichlorophenyl)-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145632	C19H21Cl2N3O4S	458.4	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8HMX5	1-Propan-2-yl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145629	C16H25N3O4S	355.5	CC(C)NC(=O)NS(=O)(=O)C1=CC=C(C=C1)OCCN2CCCC2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8IAO7	[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-[[6-(5-methyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]methyl]piperazin-1-yl]methanone	Investigative	137653127	C32H36N6O3	552.7	CC1=NN=C(O1)C2=CC=CC(=N2)CN3CCN(CC3)C(=O)C4=CC=C(C=C4)C[C@@H]5CC[C@@H](N5)[C@@H](C6=CC=CC=C6)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8IG1M	(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	49797198	C22H26F4N4O6S	550.5	CS(=O)(=O)C1=CC=C(C=C1)C2=NOC(=N2)[C@@H](CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8IQ0E	Cxcr2-IN-1	Investigative	127020968	C19H20Cl2FN3O4S	476.3	CN1CCC(CC1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8LXE7	(2S)-2-[1-(2-Chloro-6-cyanophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-(3-hydroxyazetidin-1-yl)propanamide	Investigative	46175610	C23H18ClFN8O3	508.9	C1C(CN1C[C@@H](C(=O)NC2=NC=C(C=C2)F)OC3=NC=NC4=C3C=NN4C5=C(C=CC=C5Cl)C#N)O	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8LYA4	(NE,4S)-N-(1-aminoethylidene)-5-(4-chlorophenyl)-N'-(4-chlorophenyl)sulfonyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide	Investigative	137653051	C24H21Cl2N5O2S	514.4	C/C(=N\\C(=N/S(=O)(=O)C1=CC=C(C=C1)Cl)\\N2C[C@@H](C(=N2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)/N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8MI1V	2-(Diethylamino)-2-phenyl-1,1-di(pyridin-3-yl)ethanol	Investigative	46885587	C22H25N3O	347.5	CCN(CC)C(C1=CC=CC=C1)C(C2=CN=CC=C2)(C3=CN=CC=C3)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8MPK1	N-[(3S,4R)-4-[4-(3-Acetylphenyl)phenyl]oxolan-3-yl]propane-2-sulfonamide	Investigative	49870853	C21H25NO4S	387.5	CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1C2=CC=C(C=C2)C3=CC(=CC=C3)C(=O)C	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8MS7T	CID 71768688	Investigative	71768688	C23H30F3N3O4	469.5	COC1COCCC1N[C@@H]2C[C@@H]3[C@](C2)(CCO3)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8MT3N	6-[[[4-[(1R)-1-Amino-2-(7-fluoro-2-oxoquinoxalin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	46205674	C24H27FN6O3	466.5	C1CC(CCC1[C@H](CN2C3=C(C=CC(=C3)F)N=CC2=O)N)NCC4=NC5=C(C=C4)OCC(=O)N5	IC50 = 174000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8PQ7T	4-(4-{2-[(2,2-Dimethylpropanoyl)amino]ethyl}piperidin-1-Yl)thieno[3,2-D]pyrimidine-6-Carboxamide	Investigative	71304814	C19H27N5O2S	389.5	CC(C)(C)C(=O)NCCC1CCN(CC1)C2=NC=NC3=C2SC(=C3)C(=O)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8R9GA	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid	Investigative	11541314	C24H25F5N6O4	556.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=NC3=CC=NN3C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8S9CW	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-6-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797111	C22H24F5N3O4	489.4	C[C@@H](C1=CC=C(C=C1)C2=C(N(C(=O)C=C2)C)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8TFX7	CID 68867935	Investigative	68867935	C30H41N3O4S	539.7	CCS(=O)(=O)C[C@@H]1C[C@@H](CC[C@@H]1N2CC[C@@H](C2=O)NC(=O)C3=CC=CC(=C3)C4=CC=CC=C4)N(C)C(C)C	IC50 = 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8WP9V	(E)-1-(2-Hydroxy-4,5-dimethoxyphenyl)-3-(3-methoxyphenyl)prop-2-en-1-one	Investigative	137639661	C18H18O5	314.3	COC1=CC=CC(=C1)/C=C/C(=O)C2=CC(=C(C=C2O)OC)OC	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B8Y6IG	7-((R)-3-((S)-1-Amino-2-cyanoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425431	C21H23FN4O4	414.4	COC1=C2C(=CC(=C1N3CC[C@H](C3)[C@H](CC#N)N)F)C(=O)C(=CN2C4CC4)C(=O)O	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B92QCI	1-[4-(4-Piperidin-1-ylbutoxy)phenyl]sulfonyl-3-propan-2-ylurea	Investigative	60143760	C19H31N3O4S	397.5	CC(C)NC(=O)NS(=O)(=O)C1=CC=C(C=C1)OCCCCN2CCCCC2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B93KYB	3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49797089	C23H24F4N2O5	484.4	C[C@@H](C1=CC=C(C=C1)C2=CC(=CC=C2)C(=O)O)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B97GOP	(3-Methoxyphenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86275448	C17H18N6O2S	370.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=CC=C3)OC)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B97SGK	N-(1-(1-Isopropylpiperazine-4-carbonyl)piperidin-4-yl)cyclopentanecarboxamide	Investigative	16049886	C19H34N4O2	350.5	CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)NC(=O)C3CCCC3	IC50 = 156666.67 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B97ZDL	5-[[[1-[2-(7-Fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile	Investigative	90644099	C23H25FN6O	420.5	CC1=C(C=C(C=N1)CNC2CCN(CC2)CCN3C(=O)C=CC4=C3C=C(C=N4)F)C#N	IC50 = 69000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9A4YR	CID 86274732	Investigative	86274732	C17H17FN6O2S	388.4	CC1=NSC(=N1)C2=NN=C3N2CCN([C@@H]3CCO)C(=O)C4=CC=C(C=C4)F	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9AGF4	2-[(2R)-2,3-Dihydroxypropyl]-6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile	Investigative	11995522	C20H18N2O4	350.4	COC1=CC2=C(C=C1)C(=O)N(C(=C2C3=CC=CC=C3)C#N)C[C@H](CO)O	IC50 = 76000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9B5KA	5-(2-Fluoro-4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carbonitrile	Investigative	132471744	C12H9FN2O	216.21	CN1C(=CC=C1C2=C(C=C(C=C2)O)F)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9DUX8	(3R)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-b]pyridin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736676	C26H27FN4O5	494.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9EGY7	N-(2-[(2-Aminoethyl)(methyl)amino]-5-{[3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl]amino}phenyl)acetamide	Investigative	56946894	C21H25N9O	419.5	CC(=O)NC1=C(C=CC(=C1)NC2=NC3=C(C=NN3C(=C2)NC4CC4)C#N)N(C)CCN	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9F6AJ	1-(4-Methylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60143926	C21H27N3O4S	417.5	CC1=CC=C(C=C1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9FO2R	Chembl4203179	Investigative	124114343	C30H36F2N8	546.7	CCN1CCC(CC1)N2CCC3=C(C2)C=CC(=N3)NC4=NC=C(C(=N4)C5=CC6=C(C(=C5)F)N=C(N6C(C)C)C)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9FQ1S	Chembl4209354	Investigative	145965420	C15H20N2O2S	292.4	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3OC)N	IC50 = 85600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9HFL8	[4-(3-Aza-bicyclo[3.2.2]nonane-3-carbonyl)-piperidin-1-yl]-(4-isopropyl-piperazin-1-yl)-methanone	Investigative	16049887	C22H38N4O2	390.6	CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)C(=O)N3CC4CCC(C3)CC4	IC50 = 115000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9J2YB	2-[[3-[[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]methoxy]phenyl]methyl-(4-methylphenoxy)carbonylamino]acetic acid	Investigative	46198107	C28H25ClN2O5S	537	CC1=CC=C(C=C1)OC(=O)N(CC2=CC(=CC=C2)OCC3=C(N=C(S3)C4=CC=C(C=C4)Cl)C)CC(=O)O	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9LGH6	(2S)-N-(5-Chloropyridin-2-yl)-2-(1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-((R)-1-hydroxypropan-2-yloxy)propanamide	Investigative	46175432	C21H19Cl2N7O4	504.3	C[C@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)Cl)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9LNJ5	5-Methyl-3-[[(2R)-4 (2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine	Investigative	52938764	C14H18N8OS	346.41	CC1=NC(=C2C(=N1)N(N=N2)C[C@H]3CN(CCO3)CC4=NC=CS4)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9LNZ4	[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-[[1-(2,2,2-trifluoroethyl)-1,2,4-triazol-3-yl]methyl]piperazin-1-yl]methanone	Investigative	137634334	C28H33F3N6O2	542.6	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)C(=O)N3CCN(CC3)CC4=NN(C=N4)CC(F)(F)F)[C@@H](C5=CC=CC=C5)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9N7HO	2-[[(2R)-4-(2,4-Dimethyl-1,3-thiazol-5-yl)-2-methylpiperazin-1-yl]methyl]-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine	Investigative	122182842	C21H26N8OS	438.6	C[C@@H]1CN(CCN1CC2=NN3C(=N2)C4=C(C(=CC=C4)OC)N=C3N)C5=C(N=C(S5)C)C	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9R1PN	PF-05175157	Investigative	52934180	C23H27N5O2	405.5	CC1=NC2=C(N1)C=C(C=C2)C(=O)N3CCC4(CC3)CC5=C(C(=O)C4)N(N=C5)C(C)C	IC50 = 141000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9UFD8	5-[(3S,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one	Investigative	117690396	C24H25N7O4	475.5	CC1=C(C=CC2=C1COC2=O)[C@H]3CN4CCN(C[C@@H]4CO3)C(=O)CC5=CN=C(C=C5)N6C=NN=N6	IC50 = 53400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9X2YV	(2,3-Dimethylpiperidin-1-yl)-[2-(4-methylanilino)-1,3-thiazol-4-yl]methanone	Investigative	71818431	C18H23N3OS	329.5	CC1CCCN(C1C)C(=O)C2=CSC(=N2)NC3=CC=C(C=C3)C	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9XQ4I	5-[1-Fluoro-2-[4-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]piperazin-1-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one	Investigative	69087545	C23H24FN7O3	465.5	CC1=C(C=CC2=C1COC2=O)C(CN3CCN(CC3)C(=O)CC4=CN=C(C=C4)N5C=NN=N5)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	B9ZC5U	N-(1-(4-Hydroxy-4-(2-methylthiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide	Investigative	68004012	C24H27F3N6O2S	520.6	CC1=NC=C(S1)C2(CCC(CC2)N3CC(C3)NC(=O)CNC4=NC=NC5=C4C=C(C=C5)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA1C3D	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-cyclopropyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70274815	C22H29N5O2S	427.6	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC(=CS4)C5CC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA4I2G	(S)-6-(Piperidin-3-yloxy)-2H-isoquinolin-1-one	Investigative	16124479	C14H16N2O2	244.29	C1C[C@@H](CNC1)OC2=CC3=C(C=C2)C(=O)NC=C3	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA4I3R	(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-1,5,7,9,11,13-hexamethyl-15-[1-(1,8-naphthyridin-4-ylmethyl)azetidin-3-yl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone	Investigative	45482735	C42H61N5O10	796	CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)N(C(=O)O2)C4CN(C4)CC5=C6C=CC=NC6=NC=C5)C	IC50 = 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA4P6Y	[(2S,3As,5R,6aS)-2-(dimethylamino)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517577	C26H37F3N4O3	510.6	CN(C)[C@H]1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA8QE7	(E)-4-(Dimethylamino)-1-[4-[5-[(3-nitrophenyl)methylamino]-7-(trifluoromethyl)quinolin-3-yl]piperazin-1-yl]but-2-en-1-one	Investigative	90667424	C27H29F3N6O3	542.6	CN(C)C/C=C/C(=O)N1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC(=CC=C4)[N+](=O)[O-])C(F)(F)F)N=C2	IC50 = 92100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA97RD	(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-15-[1-[(3-hydroxy-1,5-naphthyridin-4-yl)methyl]azetidin-3-yl]-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone	Investigative	136123532	C42H61N5O11	812	CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)N(C(=O)O2)C4CN(C4)CC5=C6C(=NC=C5O)C=CC=N6)C	IC50 = 67000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA9SE8	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-3-one	Investigative	117852239	C25H29N3O6S	499.6	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CC(=O)N(C4)C5=CN=C(C=C5)S(=O)(=O)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BA9YT1	N-((3R,4R)-1-Methyl-4-(4-(thiophen-2-yl)phenyl)pyrrolidin-3-yl)propane-2-sulfonamide	Investigative	11537876	C18H24N2O2S2	364.5	CC(C)S(=O)(=O)N[C@H]1CN(C[C@@H]1C2=CC=C(C=C2)C3=CC=CS3)C	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BABO46	3-Methyl-2-morpholino-1,1-di(pyridin-3-yl)butan-1-ol	Investigative	11702625	C19H25N3O2	327.4	CC(C)C(C(C1=CN=CC=C1)(C2=CN=CC=C2)O)N3CCOCC3	IC50 = 75000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAC46G	2-Fluoro-N-[3-methoxy-4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide	Investigative	57663405	C24H28FN5O4	469.5	COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=C2F)C3=NN=C(O3)NCCCCN4CCOCC4	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAD1H8	6-[[[1-[[(3R)-5-Chloro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728974	C26H26ClN5O5	524	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)Cl)O	IC50 = 53300 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAD51W	CID 69285465	Investigative	69285465	C23H34F3N3O3	457.5	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CCOC)NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAFP92	6-[[2alpha-[(S)-2-(1,2-Dihydro-2-oxo-7-methoxy-1,8-naphthyridine-1-yl)-1-aminoethyl]-tetrahydro-2H-pyran-5beta-yl]aminomethyl]-2H-pyrido[3,2-b][1,4]oxazine-3(4H)-one	Investigative	44594174	C24H28N6O5	480.5	COC1=NC2=C(C=C1)C=CC(=O)N2C[C@@H]([C@@H]3CC[C@H](CO3)NCC4=NC5=C(C=C4)OCC(=O)N5)N	IC50 = 52000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAI82F	alpha-Amino acid pyrrolidide 28	Investigative	11603996	C17H21ClN4O4S	412.9	C[C@H](C1=NC(=NO1)C2=C(C=C(C=C2)S(=O)(=O)C)Cl)[C@@H](C(=O)N3CCCC3)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAIU90	CID 60200280	Investigative	60200280	C24H28N6O5	480.5	COC1=CC2=C(C=C1)N=CC(=O)N2CCN3CC[C@H]([C@H](C3)O)NCC4=NC5=C(C=C4)OCC(=O)N5	IC50 = 152000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAM3K4	2-[[3-[[2-(2-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-(4-methylphenoxy)carbonylamino]acetic acid	Investigative	46198109	C28H25ClN2O6	521	CC1=CC=C(C=C1)OC(=O)N(CC2=CC(=CC=C2)OCC3=C(OC(=N3)C4=CC=CC=C4Cl)C)CC(=O)O	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BANB23	N-[(2R,3Ar,6aR)-6a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,3a,4,5,6-hexahydro-1H-pentalen-2-yl]oxane-4-carboxamide	Investigative	71518573	C24H30F3N3O3	465.5	C1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC(=O)C5CCOCC5	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAPY49	1(2H)-Isoquinolinone, 5,8-dichloro-2-((1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl)-3,4-dihydro-7-((R)-methoxy-3-oxetanylmethyl)-	Investigative	118572065	C22H24Cl2N2O5	467.3	CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)[C@@H](C4COC4)OC)Cl)OC	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAR9X7	CID 68769744	Investigative	68769744	C29H47N3O4S	533.8	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C(C)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)C(C)(C)C	IC50 = 77000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BATS20	Chembl4240155	Investigative	121247103	C28H35N5O2	473.6	CC1=CC(=NN1)C2=CC(=CC=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAU1N3	[4-[(2-Ethyltetrazol-5-yl)methyl]piperazin-1-yl]-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]methanone	Investigative	137631487	C27H35N7O2	489.6	CCN1N=C(N=N1)CN2CCN(CC2)C(=O)C3=CC=C(C=C3)C[C@@H]4CC[C@@H](N4)[C@@H](C5=CC=CC=C5)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAUB04	7-((R)-3-((S)-1-(2-Cyanoethylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425430	C23H27FN4O4	442.5	C[C@@H]([C@@H]1CCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F)NCCC#N	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAW89L	4-[4-(Dimethylcarbamoyl)phenoxy]-2-methyl-N-(5-methylpyrazin-2-yl)-1-benzofuran-6-carboxamide	Investigative	90665739	C24H22N4O4	430.5	CC1=CC2=C(O1)C=C(C=C2OC3=CC=C(C=C3)C(=O)N(C)C)C(=O)NC4=NC=C(N=C4)C	IC50 = 59000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAY53K	2-(2-Aminoimidazol-1-yl)-1-(4-chloro-2-fluorophenyl)ethanol	Investigative	90644779	C11H11ClFN3O	255.67	C1=CC(=C(C=C1Cl)F)C(CN2C=CN=C2N)O	IC50 = 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAYL96	N-[(3S)-1-[(1S,2R,4R)-2-(Tert-butylsulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethoxy)benzamide	Investigative	89845025	C27H40F3N3O5S	575.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C(C)(C)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)OC(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BAZ3T5	(2S)-N-(5-Chloropyridin-2-yl)-2-[1-(3-chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)propanamide	Investigative	46175430	C21H18Cl2N8O3	501.3	C1C(CN1C[C@@H](C(=O)NC2=NC=C(C=C2)Cl)OC3=NC=NC4=C3C=NN4C5=C(C=CC=N5)Cl)O	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB06US	6-[[[1-[2-[3-Oxo-6-(tetrazol-1-yl)-1,4-benzoxazin-4-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	56668949	C24H27N9O4	505.5	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)COC5=C4C=C(C=C5)N6C=NN=N6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB0X4M	3-(1-Methylimidazol-4-yl)-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide;dihydrochloride	Investigative	127025889	C30H28Cl2F3N5O3	634.5	CN1C=C(N=C1)C2=CC(=CC(=C2)C(F)(F)F)C(=O)N[C@@H]3CCC4=C(C3)C=C(C=C4)OC5=C6CCC(=O)NC6=NC=C5.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB1E5Z	(S)-3-Chloro-N-isobutyl-2-methyl-N-(pyrrolidin-3-yl)benzamide	Investigative	46882910	C16H23ClN2O	294.82	CC1=C(C=CC=C1Cl)C(=O)N(CC(C)C)[C@H]2CCNC2	IC50 = 52400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB1HO6	6-[[[1-[[(3S)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7-trien-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728081	C26H28FN5O5	509.5	C1CC(=O)N2C[C@@](C3=C2C1=NC=C3F)(CC45CCC(CC4)(CO5)NCC6=NC7=C(C=C6)OCC(=O)N7)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB1X6S	4-(4-Fluorobenzoyl)-1-[4-(3-piperidin-1-ylpropoxy)phenyl]piperazin-2-one;formic acid	Investigative	24748805	C26H32FN3O5	485.5	C1CCN(CC1)CCCOC2=CC=C(C=C2)N3CCN(CC3=O)C(=O)C4=CC=C(C=C4)F.C(=O)O	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB4YH5	[(2S,3As,5R,6aS)-2-hydroxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517573	C24H32F3N3O4	483.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB5G0J	(E)-3-[4-[7-Hydroxy-3-[2-methyl-4-(trifluoromethoxy)phenyl]-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid	Investigative	118737794	C26H17F3O7	498.4	CC1=C(C=CC(=C1)OC(F)(F)F)C2=C(C3=C(C=C(C=C3)O)OC2=O)OC4=CC=C(C=C4)/C=C/C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB5JZ4	2,6-Di(4-biphenylylethynyl)pyridine	Investigative	71605896	C33H21N	431.5	C1=CC=C(C=C1)C2=CC=C(C=C2)C#CC3=NC(=CC=C3)C#CC4=CC=C(C=C4)C5=CC=CC=C5	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB67HJ	4-[[[[1-[(1R)-3-[(6-Chloro-2,4-dimethyl-pyridine-3-carbonyl)amino]-1-methyl-propyl]-4-piperidyl]-(3-thienylmethyl)carbamoyl]amino]methyl]benzoic acid	Investigative	15940498	C31H38ClN5O4S	612.2	CC1=CC(=NC(=C1C(=O)NCC[C@@H](C)N2CCC(CC2)N(CC3=CSC=C3)C(=O)NCC4=CC=C(C=C4)C(=O)O)C)Cl	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB79EF	(3,4-Dihydroisoquinolin-2(1H)-yl)(4-isopropylpiperazin-1-yl)methanone	Investigative	44418491	C17H25N3O	287.4	CC(C)N1CCN(CC1)C(=O)N2CCC3=CC=CC=C3C2	IC50 = 115000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB96HC	(3R)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]methyl]-5-fluoro-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	24872164	C24H26FN5O3	451.5	C1CN(CCC1NCC2=CC3=C(C=N2)OCCO3)C[C@@H]4CN5C(=O)C=CC6=NC=C(C4=C65)F	IC50 = 58000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BB98OR	[(3As,5S,6aR)-5-[3-hydroxypropyl-(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	90656026	C26H36F3N3O5	527.6	COC1COCCC1N(CCCO)[C@@H]2C[C@@H]3[C@](C2)(CCO3)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBD6C2	2-Pyrrolidin-1-ylethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72946381	C30H42F3N5O5	609.7	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OCCN6CCCC6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBF04T	CID 57750321	Investigative	57750321	C26H34ClN7O	496	C1CCN(C1)CCCC(C2=CC=C(C=C2)Cl)NC(=O)C3(CCN(CC3)C4=NC=NC5=C4C=CN5)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBG4O2	Ethyl 1-[3-[4-(phenylcarbamoylsulfamoyl)phenoxy]propyl]piperidine-4-carboxylate	Investigative	60143590	C24H31N3O6S	489.6	CCOC(=O)C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 78700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBGJ89	2-[5-(7-Ethoxy-6-methoxyquinolin-4-yl)oxy-3-methoxypyridin-2-yl]-N-(5-ethyl-4-methyl-1H-pyrazol-3-yl)acetamide	Investigative	70691981	C26H29N5O5	491.5	CCC1=C(C(=NN1)NC(=O)CC2=C(C=C(C=N2)OC3=C4C=C(C(=CC4=NC=C3)OCC)OC)OC)C	IC50 = 76000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBJ1K2	Chembl4205373	Investigative	145978072	C30H40N4O3	504.7	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CC5CCC(C4)N5C)OC)OCCCN6CCCC6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBP03U	N-[3-[(6,7-Dimethoxy-4-methylquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide	Investigative	53321473	C20H28N4O4	388.5	CC1=NC(=NC2=CC(=C(C=C12)OC)OC)N(C)CCCNC(=O)C3CCCO3	IC50 = 83176.38 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBQ7D9	Tert-butyl 1-(1-isopropylpiperazine-4-carbonyl)piperidine-4-carboxylate	Investigative	44418482	C18H33N3O3	339.5	CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)C(=O)OC(C)(C)C	IC50 = 101111.11 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBSZ75	Chembl4245829	Investigative	121246982	C27H33N5O2	459.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)CC(CC(=O)O)C4=CC(=CC=C4)N5C=CN=C5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBYA59	5-[[[(3S,4R)-3-Methoxy-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile	Investigative	90644112	C25H30N6O3	462.5	CC1=C(C=C(C=N1)CN[C@@H]2CCN(C[C@@H]2OC)CCN3C(=O)C=CC4=C3C=C(C=N4)OC)C#N	IC50 = 151000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBYQ31	CID 25118804	Investigative	25118804	C22H34N2O3	374.5	CC(C)[C@H]1C2=C(CCN1C(=O)CNCC3(CCCCC3)O)C=C(C=C2)OC	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BBZ0C5	7-Fluoro-4-oxo-N-(1-((2-oxobenzo[d][1,3]dioxol-5-yl)methyl)piperidin-4-yl)-4H-chromene-2-carboxamide	Investigative	44417936	C23H19FN2O6	438.4	C1CN(CCC1NC(=O)C2=CC(=O)C3=C(O2)C=C(C=C3)F)CC4=CC5=C(C=C4)OC(=O)O5	IC50 = 85200 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC02JX	(2S,4S)-1-[(2S)-2-Amino-3-(1,3-thiazol-4-yl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile	Investigative	76318342	C11H13FN4OS	268.31	C1[C@@H](CN([C@@H]1C#N)C(=O)[C@H](CC2=CSC=N2)N)F	IC50 = 176600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC0L9S	(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide	Investigative	44590696	C22H27FN6O2	426.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(C=C2)N=CN3)[C@@H](C(=O)N4CC[C@@H](C4)F)N	IC50 = 86000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC0WS6	CID 25008767	Investigative	25008767	C24H28N6O5	480.5	COC1=CC2=C(C=C1)N=CC(=O)N2CCN3CC[C@@H]([C@@H](C3)O)NCC4=NC5=C(C=C4)OCC(=O)N5	IC50 = 172000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC0XB2	N-Methyl-pyrimidinone derivative, 11	Investigative	54712015	C20H24FN5O5	433.4	CC(C)(C1=NC(=C(C(=O)N1C)O)C(=O)NCC2=CC=C(C=C2)F)NC(=O)C(=O)N(C)C	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC1A9M	CID 57750315	Investigative	57750315	C20H22ClN7O2	427.9	C1CN(CCC1(C(=O)NC(C2=CC=C(C=C2)Cl)C(=O)N)N)C3=NC=NC4=C3C=CN4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC3B2W	(S)-1-((3R,4R)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	44443354	C20H24N6O2	380.4	CC1=NN=C(O1)C2=CC=C(C=C2)CN3C[C@H]([C@H](C3)N)C(=O)N4CCC[C@H]4C#N	IC50 = 165000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC3LF7	2,6-Dichloro-N-[(2R)-2-(8-fluoro-5-methyl-4-oxo-3H-quinazolin-2-yl)-2-(3-fluorophenyl)ethyl]-4-(3-methyl-1,2,4-triazol-1-yl)benzamide	Investigative	137028369	C27H20Cl2F2N6O2	569.4	CC1=C2C(=C(C=C1)F)N=C(NC2=O)[C@@H](CNC(=O)C3=C(C=C(C=C3Cl)N4C=NC(=N4)C)Cl)C5=CC(=CC=C5)F	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC4IE3	(2S)-2-(1-(3-Chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-N-(5-cyanopyridin-2-yl)-3-((R)-1-hydroxypropan-2-yloxy)propanamide	Investigative	57504418	C22H19ClN8O4	494.9	C[C@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)C#N)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC56FW	(3R)-5-Fluoro-3-[[4-[(6-fluoro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736680	C27H27F2N3O5	511.5	C1CC2(CCC1(CO2)NCC3=CC4=C(C=C3F)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC69RH	Pyrrolidine, 1,5-dimethyl-3,3-diphenyl-2-ethylidene-	Investigative	115159	C20H23N	277.4	CC=C1C(CC(N1C)C)(C2=CC=CC=C2)C3=CC=CC=C3	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC6R0H	(3R)-5-Fluoro-3-hydroxy-3-[[4-[(2-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736669	C27H29FN4O5	508.5	CC1COC2=C(O1)C=C(N=C2)CNC34CCC(CC3)(OC4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC6V9K	1-[4-(4-Piperidin-1-ylbutoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60143922	C23H28F3N3O4S	499.5	C1CCN(CC1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC8KG1	(3R)-3-[[4-(2,3-Dihydro-[1,4]oxathiino[3,2-c]pyridin-7-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736673	C26H27FN4O4S	510.6	C1CC2(CCC1(CO2)NCC3=CC4=C(C=N3)SCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC9DQ2	N-[(3S,4R)-4-(4-Thiophen-3-ylphenyl)oxolan-3-yl]propane-2-sulfonamide	Investigative	52941684	C17H21NO3S2	351.5	CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1C2=CC=C(C=C2)C3=CSC=C3	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BC9FH2	[(2R,3As,6aS)-5,5-difluoro-2-[(3-methoxyoxan-4-yl)amino]-1,2,3,4,6,6a-hexahydropentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71519227	C24H30F5N3O3	503.5	COC1COCCC1N[C@@H]2C[C@H]3CC(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCI1Z4	8-[(3-Methylpyridin-2-yl)methyl]-1-(6-oxo-1H-pyrimidin-4-yl)-3-[4-(2-oxo-1H-pyrimidin-5-yl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione	Investigative	136069563	C28H26N8O4	538.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=O)NC=N4)C5=CC=C(C=C5)C6=CNC(=O)N=C6	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCJ16Q	[(1S,3R)-3-[[(3S,4S)-3-Methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[4-[2-(trifluoromethyl)pyridin-4-yl]piperazin-1-yl]methanone	Investigative	54585107	C25H37F3N4O3	498.6	CC(C)[C@@]1(CC[C@H](C1)N[C@H]2CCOC[C@H]2OC)C(=O)N3CCN(CC3)C4=CC(=NC=C4)C(F)(F)F	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCJ59K	6-[(3R,9As)-8-[2-[2-(tetrazol-1-yl)pyrimidin-5-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one	Investigative	89633392	C23H24N8O4	476.5	C1COC(=O)C2=C1C=C(C=C2)[C@@H]3CN4CCN(C[C@H]4CO3)C(=O)CC5=CN=C(N=C5)N6C=NN=N6	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCQ29F	7-[(3S)-3-[(2-Cyanoethylamino)methyl]pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid	Investigative	44425429	C22H25FN4O4	428.5	COC1=C2C(=CC(=C1N3CC[C@H](C3)CNCCC#N)F)C(=O)C(=CN2C4CC4)C(=O)O	Ki = 106000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCRL46	Pde10A-IN-8	Investigative	56596230	C23H19N3O2	369.4	CN(C1=CC=C(C=C1)OCC2=NC3=CC=CC=C3C=C2)C(=O)C4=CC=NC=C4	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCS5A3	2-[3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-7-oxo-5H-pyrrolo[3,4-b]pyridin-6-yl]-N-(pyridin-3-ylmethyl)acetamide	Investigative	57403171	C23H21Cl2N5O2	470.3	CC1=C(C(=C2CN(C(=O)C2=N1)CC(=O)NCC3=CN=CC=C3)C4=C(C=C(C=C4)Cl)Cl)CN	IC50 = 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCU93D	N-[4-[[4-[2-(3,5-Dimethyl-1,2-oxazol-4-yl)ethyl]piperidin-1-yl]sulfonylmethyl]oxan-4-yl]-N-hydroxyformamide	Investigative	53242178	C19H31N3O6S	429.5	CC1=C(C(=NO1)C)CCC2CCN(CC2)S(=O)(=O)CC3(CCOCC3)N(C=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BCWY53	4-[4-[2-Chloro-5-(trifluoromethoxy)phenyl]phenoxy]butanoic acid	Investigative	134150245	C17H14ClF3O4	374.7	C1=CC(=CC=C1C2=C(C=CC(=C2)OC(F)(F)F)Cl)OCCCC(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD1V3I	Chembl4245368	Investigative	131985523	C29H37N5O2	487.6	CC1=CN(C(=N1)C2=CC(=CC=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4)C	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD25GL	Chembl4212905	Investigative	129085358	C30H42N4O3	506.7	CCC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NCC4CCN(CC4)C)OC)OCCCN5CCCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD27HW	(4r)-3-Fluoro-4-Hydroxy-4-{[(1r,4r)-4-{[(3-Oxo-3,4-Dihydro-2h-Pyrido[3,2-B][1,4]oxazin-6-Yl)methyl]amino}-2-Oxabicyclo[2.2.2]oct-1-Yl]methyl}-4,5-Dihydro-7h-Pyrrolo[3,2,1-De][1,5]naphthyridin-7-One	Investigative	91801175	C26H26FN5O5	507.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD31ZR	Chembl4127600	Investigative	138319685	C22H29N3O2	367.5	C[C@]12CCC(=O)C[C@H]1C[C@H]([C@@H]2OC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD3GM2	N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide	Investigative	68004002	C23H25F3N6O2S	506.5	C1CC(CCC1N2CC(C2)NC(=O)CNC3=NC=NC4=C3C=C(C=C4)C(F)(F)F)(C5=CN=CS5)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD6FV8	N-((cis)-4-Aminocyclohexyl)-N-(3-chlorobenzyl)-1-methyl-1H-imidazole-4-carboxamide dihydrochloride	Investigative	90665166	C18H26Cl4N4O	456.2	CN1C=C(N=C1)C(=O)N(CC2=CC(=CC=C2)Cl)C3CCC(CC3)N.Cl.Cl.Cl	IC50 = 65600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD7P6A	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-(5-fluoropyridin-2-yl)propanamide	Investigative	57504355	C20H17ClFN7O3	457.8	CCOC[C@@H](C(=O)NC1=NC=C(C=C1)F)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD84FB	1-Cyclopentyl-6-{(1r)-1-[3-(Pyrimidin-2-Yl)azetidin-1-Yl]ethyl}-1,5-Dihydro-4h-Pyrazolo[3,4-D]pyrimidin-4-One	Investigative	135566744	C19H23N7O	365.4	C[C@H](C1=NC2=C(C=NN2C3CCCC3)C(=O)N1)N4CC(C4)C5=NC=CC=N5	IC50 = 53500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD9V8Y	N-[7-[Acetyl(ethyl)amino]-4-methoxy-1,3-benzothiazol-2-yl]-2-methylpyrazole-3-carboxamide	Investigative	46911060	C17H19N5O3S	373.4	CCN(C1=C2C(=C(C=C1)OC)N=C(S2)NC(=O)C3=CC=NN3C)C(=O)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BD9WG2	[(2S,3S,4R,6S)-6-[(2R,3S,4R,5R,6S)-6-[[(4R,5S,6S,7R,9R,10R,11Z,13E,16R)-4-Acetyloxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy]-4-(dimethylamino)-5-hydroxy-2-methyloxan-3-yl]oxy-4-hydroxy-2,4-dimethyloxan-3-yl] 3-methylbutanoate	Investigative	53325596	C42H69NO15	828	C[C@@H]1C/C=C/C=C\\[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O	IC50 = 102329.3 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDAJ86	N-[[(3S)-1-Oxo-7-(3-oxomorpholino)-3abeta,4-dihydro-1H,3H-2,5-dioxa-9b-aza-2H-benzo[e]indene-3beta-yl]methyl]-5-chlorothiophene-2-carboxamide	Investigative	76685067	C20H18ClN3O6S	463.9	C1COCC(=O)N1C2=CC3=C(C=C2)N4[C@@H](CO3)[C@@H](OC4=O)CNC(=O)C5=CC=C(S5)Cl	IC50 = 79750 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDAK81	Chembl4126938	Investigative	145961922	C23H33N3O2	383.5	C[C@]12CCC(C[C@H]1C[C@H]([C@@H]2OC3=CC=C(C=C3)C#N)N4CCC[C@H](C4)N)(C)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDEG38	1-Cyclohexyl-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143762	C22H35N3O4S	437.6	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCCN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDF8W1	N,N-Diethyl-5-(spiro[chromene-2,4''-piperidine]-4-yl)pyrimidine-2-carboxamide	Investigative	44255043	C22H26N4O2	378.5	CCN(CC)C(=O)C1=NC=C(C=N1)C2=CC3(CCNCC3)OC4=CC=CC=C42	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDHA63	6-[(3R)-3-[(1S)-1-Amino-2-cyanoethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	44425439	C20H21FN4O4	400.4	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CC[C@H](C4)[C@H](CC#N)N)F)C(=O)O	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDJL25	4-[[2-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide	Investigative	127047275	C22H15ClF3N5O3S	521.9	CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC(=O)NC4=CC(=C(C=C4)Cl)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDR8N5	6-[(3R)-3-[(1S)-1-(2-Cyanoethylamino)ethyl]pyrrolidin-1-yl]-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid	Investigative	44425438	C22H25FN4O4	428.5	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CC[C@H](C4)[C@H](C)NCCC#N)F)C(=O)O	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDS7K3	N-Hydroxy-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide	Investigative	118179819	C23H25F3N2O6S	514.5	C1CC(CC12CCNCC2)(C(=O)NO)S(=O)(=O)C3=CC=C(C=C3)OC4=CC=C(C=C4)OC(F)(F)F	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDTI83	6-[[[1-[(10-Chloro-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl)methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728969	C26H25ClFN5O5	542	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CC5(CN6C7=C5C(=CN=C7C=C(C6=O)Cl)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BDX89Y	N-[1-[4-(1,3-Thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide	Investigative	56671795	C22H25F3N6OS	478.5	C1CC(CCC1C2=CN=CS2)N3CC(C3)NC(=O)CNC4=NNC5=C4C=C(C=C5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE06HK	5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-c]pyridin-6-yl)pyridin-2-amine	Investigative	45482746	C21H26N6S	394.5	C1CCN(CC1)C2CCN(CC2)C3=NC4=CN=C(C=C4S3)C5=CN=C(C=C5)N	IC50 = 190000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE13MI	N-((1S,4r)-4-((2S,3S)-3-Amino-4-((S)-3-fluoropyrrolidin-1-yl)-4-oxobutan-2-yl)cyclohexyl)acetamide	Investigative	44433617	C16H28FN3O2	313.41	C[C@@H](C1CCC(CC1)NC(=O)C)[C@@H](C(=O)N2CC[C@@H](C2)F)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE18IF	N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-N-methylacetamide;hydrochloride	Investigative	17748274	C17H31ClFN3O2	363.9	C[C@@H](C1CCC(CC1)N(C)C(=O)C)[C@@H](C(=O)N2CC[C@@H](C2)F)N.Cl	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE20HV	(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-1,5,7,9,11,13-hexamethyl-15-[1-(1,5-naphthyridin-4-ylmethyl)azetidin-3-yl]-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone	Investigative	45482734	C42H61N5O10	796	CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)N(C(=O)O2)C4CN(C4)CC5=C6C(=NC=C5)C=CC=N6)C	IC50 = 196000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE3AH7	CID 68769143	Investigative	68769143	C25H36F3N3O4S	531.6	CCS(=O)(=O)C[C@@H]1C[C@@H](CC[C@@H]1N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)C(F)(F)F)N(C)C(C)C	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE3FT1	2-[[[4-[(1R)-1-Amino-2-(7-methoxy-2-oxoquinolin-1-yl)ethyl]cyclohexyl]amino]methyl]-8H-pyrimido[5,4-b][1,4]oxazin-7-one	Investigative	118720929	C25H30N6O4	478.5	COC1=CC2=C(C=C1)C=CC(=O)N2C[C@@H](C3CCC(CC3)NCC4=NC=C5C(=N4)NC(=O)CO5)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE7N5K	Chembl4215326	Investigative	129072680	C28H36N4O3	476.6	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OC5CC6(C5)CN(C6)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE8XG6	6-((1H-1,2,4-Triazol-1-yl)methyl)-3-(5-(3-(2-methoxyethoxy)-prop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	11676364	C23H21N5O2S	431.5	COCCOCC#CC1=CC(=CS1)C2=NNC3=C2CC4=C3C=CC(=C4)CN5C=NC=N5	IC50 ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE9I6S	(E)-3-[4-[3-(4-Fluoro-2-methylphenyl)-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid	Investigative	118737807	C25H17FO5	416.4	CC1=C(C=CC(=C1)F)C2=C(C3=CC=CC=C3OC2=O)OC4=CC=C(C=C4)/C=C/C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BE9W0I	1-Cyclohexyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145771	C20H31N3O4S	409.5	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEBZ83	TLR7-agonist-1	Investigative	86346192	C17H16N6O2	336.3	CC1=CC(=NO1)COC2=NC(=NC3=C2N(C=C3)CC4=CC=CC=N4)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEC70B	N-[1-[2-(3-Fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl]-2-oxabicyclo[2.2.2]octan-4-yl]-3-oxo-4H-pyrido[3,2-b][1,4]oxazine-6-carboxamide	Investigative	122186033	C26H26FN5O5	507.5	COC1=NC2=C(C(=CN=C2C=C1)F)CCC34CCC(CC3)(CO4)NC(=O)C5=NC6=C(C=C5)OCC(=O)N6	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEH04S	(3R)-3-[[4-[(6-Chloro-2,3-dihydro-1,4-benzodioxin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736681	C27H27ClFN3O5	528	C1CC2(CCC1(CO2)NCC3=CC4=C(C=C3Cl)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEI5Y6	2-Morpholino-1,1-di(pyridin-3-yl)propan-1-ol	Investigative	11688027	C17H21N3O2	299.37	CC(C(C1=CN=CC=C1)(C2=CN=CC=C2)O)N3CCOCC3	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEI7F1	1-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]sulfonyl-3-[3-(trifluoromethyl)phenyl]urea	Investigative	60143924	C21H24F3N3O4S	471.5	C1CCN(C1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC(=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEJ56B	5-[(1R)-1-Hydroxy-2-[2-(6-methylsulfonylpyridin-3-yl)-2,8-diazaspiro[4.5]decan-8-yl]ethyl]-4-methyl-3H-2-benzofuran-1-one	Investigative	117852205	C25H31N3O5S	485.6	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4)C5=CN=C(C=C5)S(=O)(=O)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BEN84G	[1-(2,3-Dihydroxypropyl)piperidin-4-yl]methyl 3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxylate	Investigative	91754444	C21H28N2O5	388.5	C1CN2C3=CC=CC=C3C(=C2OC1)C(=O)OCC4CCN(CC4)CC(CO)O	IC50 = 81000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BER0H1	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6-methylsulfonyl-1,3-benzothiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70276990	C24H29N5O4S2	515.7	CS(=O)(=O)C1=CC2=C(C=C1)N=C(S2)N3CCN(CC3)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF07KJ	5-(2-Fluorophenyl)-4-oxo-N-[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-6-yl]-1H-pyridine-3-carboxamide	Investigative	71763463	C25H17FN4O3	440.4	C1=CC=C(C(=C1)C2=CNC=C(C2=O)C(=O)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF0DE7	3-[4-(Azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-1H-pyrazol-3-ylbenzamide	Investigative	11662060	C23H24N4O5	436.5	C[C@@H](CO)OC1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N3CCC3)C(=O)NC4=CC=NN4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF0NU9	(E)-3-[4-[3-(4-Fluoro-2-methylphenyl)-7-hydroxy-2-oxochromen-4-yl]oxyphenyl]prop-2-enoic acid	Investigative	118737793	C25H17FO6	432.4	CC1=C(C=CC(=C1)F)C2=C(C3=C(C=C(C=C3)O)OC2=O)OC4=CC=C(C=C4)/C=C/C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF3S6I	Irak4-IN-28	Investigative	131839619	C21H31N5O2	385.5	C1CC(CCC1NC2=NC=NC3=C2C(=CN3)C4CCOCC4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF41PW	2-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxy]acetic acid	Investigative	122186268	C27H28FN5O6	537.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CCC5=C6C(=NC=C5F)C=CC(=N6)OCC(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF43OZ	2,2-Dimethylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72946010	C29H41F3N4O5	582.7	CC(C)(C)COC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF4HU8	CID 89844945	Investigative	89844945	C23H33F3N4O4S	518.6	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C)N2CC[C@@H](C2=O)NC(=O)C3=NC(=CC=C3)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF5N2S	(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796938	C27H38F3N3O7	573.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C(C3CCCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF6J4Z	2-[[(3R,4R)-3-Aminooxan-4-yl]amino]-4-(4-methoxyanilino)pyrimidine-5-carboxamide	Investigative	56666238	C17H22N6O3	358.4	COC1=CC=C(C=C1)NC2=NC(=NC=C2C(=O)N)N[C@@H]3CCOC[C@@H]3N	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF73OM	[(2R,3As,5R,6aS)-2-methoxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517576	C25H34F3N3O4	497.5	CO[C@@H]1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF8BT2	(2S)-N-(5-Chloropyridin-2-yl)-2-[1-(3-chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-propan-2-yloxypropanamide	Investigative	57504360	C21H19Cl2N7O3	488.3	CC(C)OC[C@@H](C(=O)NC1=NC=C(C=C1)Cl)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BF9OQ1	Chembl4203293	Investigative	71542927	C25H24N2O4	416.5	COC1=CC(=CC(=C1)NC(C2=CC=CC=C2)C(=O)C3=CNC4=CC=CC=C43)OCCO	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFDH49	CID 68767577	Investigative	68767577	C26H38F3N3O4S	545.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C(C)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFH02A	4-Pyridin-3-yl-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol	Investigative	44125830	C16H15F3N6O	364.32	C1CN(CCC1(C2=CN=CC=C2)O)C3=NN4C(=NN=C4C(F)(F)F)C=C3	IC50 = 95499.26 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFJ63U	4-Amino-N-(1-(4-chlorophenyl)-2-hydroxyethyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	42602176	C20H23ClN6O2	414.9	C1CN(CCC1(C(=O)NC(CO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFK28O	1-[4-Chloro-2-hydroxy-3-(1-methylpiperidin-4-yl)sulfonylphenyl]-3-(2,3-dichlorophenyl)urea	Investigative	127049047	C19H20Cl3N3O4S	492.8	CN1CCC(CC1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)Cl)Cl)Cl	IC50 ~ 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFND29	(S)-7-(3-((2-Cyanoethylamino)methyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425433	C22H26N4O4	410.5	COC1=C(C=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)N4CC[C@H](C4)CNCCC#N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFO8P7	6-[[[1-[[(3S)-5,10-Difluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728968	C26H25F2N5O5	525.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@]5(CN6C7=C5C(=CN=C7C=C(C6=O)F)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFR8O6	1-[4-(3-Piperidin-1-ylpropoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60143589	C22H26F3N3O4S	485.5	C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFS15L	(2S)-2-(1-(3-Chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-N-(5-fluoropyridin-2-yl)-3-((R)-1-hydroxypropan-2-yloxy)propanamide	Investigative	57504419	C21H19ClFN7O4	487.9	C[C@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)F)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFTK45	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-3-(1-methyl-6-oxopyridazin-3-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one	Investigative	121313965	C23H26N4O6	454.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CN(C(=O)O4)C5=NN(C(=O)C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BFX8G7	N-{2-[1-(6-Carbamoylthieno[3,2-D]pyrimidin-4-Yl)piperidin-4-Yl]ethyl}-N'-Ethylthiophene-2,5-Dicarboxamide	Investigative	71304813	C22H26N6O3S2	486.6	CCNC(=O)C1=CC=C(S1)C(=O)NCCC2CCN(CC2)C3=NC=NC4=C3SC(=C4)C(=O)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG0AM3	(3-Fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86274963	C16H15FN6OS	358.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=CC=C3)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG0FZ4	7-(3-((2-Cyanoethylamino)methyl)-3-ethylazetidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	11281738	C23H27FN4O3	426.5	CCC1(CN(C1)C2=C(C=C3C(=C2C)N(C=C(C3=O)C(=O)O)C4CC4)F)CNCCC#N	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG1CJ4	2-Fluoro-N-[4-[5-(4-morpholin-4-ylbutylamino)-1,3,4-oxadiazol-2-yl]phenyl]benzamide	Investigative	57663596	C23H26FN5O3	439.5	C1COCCN1CCCCNC2=NN=C(O2)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4F	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG42ZQ	CID 46187356	Investigative	46187356	C22H21ClN4O3	424.9	COC1=C(C=CC(=C1)N2CC3=CN(N=C3C2=O)C4=CC=C(C=C4)Cl)N5CC[C@H](C5)O	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG4I3P	7-Fluoro-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118736656	C26H25F2N5O5	525.5	C1CC2(CCC1(CO2)NCC3=C(C=C4C(=N3)NC(=O)CO4)F)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG4UW8	1-[3-[[[3-(4-Methylpiperazin-1-yl)-7-(trifluoromethyl)quinolin-5-yl]amino]methyl]phenyl]ethanone	Investigative	90667590	C24H25F3N4O	442.5	CC(=O)C1=CC=CC(=C1)CNC2=CC(=CC3=C2C=C(C=N3)N4CCN(CC4)C)C(F)(F)F	IC50 = 93600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG68QX	(1S,4R)-1-(((S)-4-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)-3-methylpiperazin-1-ylsulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]heptan-2-one	Investigative	44570180	C21H27F4N3O3S	477.5	C[C@H]1CN(CCN1C2=C(C=C(C=N2)C(F)(F)F)F)S(=O)(=O)C[C@@]34CC[C@@H](C3(C)C)CC4=O	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG80BD	(3R)-3-[[4-(1,3-Benzodioxol-5-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736766	C26H26FN3O5	479.5	C1CC2(CCC1(CO2)NCC3=CC4=C(C=C3)OCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG8DB3	[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-(oxetan-3-yl)-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	72946204	C26H35F3N4O4	524.6	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C6COC6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG8JN9	7-((R)-3-((S)-1-Amino-2-cyanoethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425435	C21H24N4O4	396.4	COC1=C(C=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)N4CC[C@H](C4)[C@H](CC#N)N	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG8K3Z	[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(3,4,5-trifluorophenyl)methanone	Investigative	86274728	C16H13F3N6OS	394.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=C(C(=C3)F)F)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG94OD	FC(OC=1C=C(C=CC=1F)C=1C=NN(C=1)CC1=Nnc=C1)F	Investigative	118864337	C14H11F3N4O	308.26	C1=CC(=C(C=C1C2=CN(N=C2)CC3=CC=NN3)OC(F)F)F	IC50 = 135000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BG9IB6	N-[5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridin-2-yl]acetamide	Investigative	68205000	C27H22N6O	446.5	CC(=O)NC1=NC=C(C=C1)C2=NC3=CC=CC(=C3C(=N2)NCC4=CC=CC=N4)C5=CC=CC=C5	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGA9Z2	CID 11662194	Investigative	11662194	C23H31N5O2S	441.6	CC1=NC2=C(O1)C=C3CCN(CCC3=C2)CCCSC4=NN=C(N4C)C5CCOCC5	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGE06L	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride	Investigative	49797358	C24H35ClF2N4O3	501	CN(C)C(=O)[C@@H](C1CCC(CC1)N(C)C(=O)C2=CC(=CC=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.Cl	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGI0F1	(S)-6-(2-Hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one	Investigative	44476893	C28H32N2O4	460.6	C[C@@H](C1=CC=C(C=C1)C2=CC(=O)N(C=C2)C)N3CC[C@](OC3=O)(CC(C)(C)O)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGJ1E7	7-(3-(Aminomethyl)-3-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425440	C19H22FN3O3	359.4	CC1=C2C(=CC(=C1N3CC(C3)(C)CN)F)C(=O)C(=CN2C4CC4)C(=O)O	Ki = 112000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGKW43	4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-N-(8-fluoro-6-methoxyquinolin-4-yl)-1-hydroxycyclohexane-1-carboxamide	Investigative	57401040	C25H27FN4O5	482.5	COC1=CC2=C(C=CN=C2C(=C1)F)NC(=O)C3(CCC(CC3)NCC4=CC5=C(C=N4)OCCO5)O	IC50 = 113000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGM0Z4	(3R)-5-Fluoro-3-hydroxy-3-[[4-[(3-methyl-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736668	C27H29FN4O5	508.5	CC1COC2=C(O1)C=NC(=C2)CNC34CCC(CC3)(OC4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGQ0I1	(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid	Investigative	11649741	C24H25F5N6O4	556.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGQ2M7	Chembl4292234	Investigative	145988531	C23H22F4N2O	418.4	CC1=C(C=C(N1C2=CC=C(C=C2)F)C3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BGZ0I2	6-[[[1-[2-[2-Oxo-7-[(3S)-oxolan-3-yl]oxy-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187103	C27H32N6O5	520.6	C1COC[C@H]1OC2=CC3=C(C=CC(=O)N3CCN4CCC(CC4)NCC5=NC6=C(C=C5)OCC(=O)N6)N=C2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH1OS4	(2s)-2-{[1-(3-Chloropyridin-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-4-Yl]oxy}-N-(5-Methylpyridin-2-Yl)-3-(Propan-2-Yloxy)propanamide	Investigative	57504313	C22H22ClN7O3	467.9	CC1=CN=C(C=C1)NC(=O)[C@H](COC(C)C)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH1YX9	[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(2,3,4-trifluorophenyl)methanone	Investigative	86274729	C16H13F3N6OS	394.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=C(C(=C(C=C3)F)F)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH27XI	5-[[[1-[2-(7-Methoxy-2-oxopyrido[2,3-b]pyrazin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile	Investigative	90644108	C23H27N7O2	433.5	CC1=C(C=C(C=N1)CNC2CCN(CC2)CCN3C4=C(N=CC(=C4)OC)N=CC3=O)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH35FL	2-[[3-[[2-(4-Cyanophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl-(4-methylphenoxy)carbonylamino]acetic acid	Investigative	46198325	C29H25N3O6	511.5	CC1=CC=C(C=C1)OC(=O)N(CC2=CC(=CC=C2)OCC3=C(OC(=N3)C4=CC=C(C=C4)C#N)C)CC(=O)O	IC50 = 53000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH3NI2	[(2R,3As,5R,6aS)-2-fluoro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517241	C24H31F4N3O3	485.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH4J3Y	5-[(3S,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one	Investigative	117689963	C24H25N7O4	475.5	CC1=C(C=CC2=C1COC2=O)[C@H]3CN4CCN(C[C@H]4CO3)C(=O)CC5=CN=C(C=C5)N6C=NN=N6	IC50 = 56500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH59SQ	2-[4-[4-[6-[[2-Phenyl-5-(trifluoromethyl)-1,3-oxazole-4-carbonyl]amino]-1H-benzimidazol-2-yl]phenyl]cyclohexyl]acetic acid	Investigative	71812623	C32H27F3N4O4	588.6	C1CC(CCC1CC(=O)O)C2=CC=C(C=C2)C3=NC4=C(N3)C=C(C=C4)NC(=O)C5=C(OC(=N5)C6=CC=CC=C6)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH6U2P	Chembl4224807	Investigative	134537158	C14H16N6O	284.32	CN([C@@H]1CCN(C1)C(=O)CC#N)C2=NC=NC3=C2C=CN3	IC50 = 93000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH6ZW8	CID 45279680	Investigative	45279680	C22H20ClN5O2	421.9	C1CN(CCC1O)C2=NC=C(C=C2)N3C=NN4C=C(C=C4C3=O)C5=CC=C(C=C5)Cl	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH79ZX	N-((3R,4R)-1-Methyl-4-(3''-(methylsulfonyl)biphenyl-4-yl)pyrrolidin-3-yl)propane-2-sulfonamide	Investigative	11611844	C21H28N2O4S2	436.6	CC(C)S(=O)(=O)N[C@H]1CN(C[C@@H]1C2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)C	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH7DX1	N-({1-[4-Hydroxy-4-(2-isopropyl-thiazol-5-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide	Investigative	46240585	C25H31F3N4O3S	524.6	CC(C)C1=NC=C(S1)C2(CCC(CC2)N3CC(C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH8IM9	1-{[(3R)-3-Methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide	Investigative	24856362	C19H26F3N3O4S	449.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(C=C2)[C@@](C)(C(F)(F)F)O)CC3(CC3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH8W0F	(2S)-N-(5-Chloropyridin-2-yl)-2-(1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)-3-((S)-1-hydroxypropan-2-yloxy)propanamide	Investigative	57504421	C21H19Cl2N7O4	504.3	C[C@@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)Cl)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BH95TR	3-{4-[(Dimethylamino)carbonyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-1H-pyrazol-3-ylbenzamide	Investigative	11704809	C23H26N4O5	438.5	C[C@@H](COC)OC1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N(C)C)C(=O)NC3=CC=NN3	IC50 ~ 95000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHB26E	N2-(Benzo[d][1,3]dioxol-5-ylmethyl)-N4-(pyridin-4-yl)-6-(trifluoromethyl)pyrimidine-2,4-diamine	Investigative	46226027	C18H14F3N5O2	389.3	C1OC2=C(O1)C=C(C=C2)CNC3=NC(=CC(=N3)NC4=CC=NC=C4)C(F)(F)F	IC50 = 135000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHDR30	N-Cyclohexyl-N2-[4-(dimethylamino)benzoyl]-N2-[4-(hydroxycarbamoyl)benzyl]glycinamide	Investigative	132515052	C25H32N4O4	452.5	CN(C)C1=CC=C(C=C1)C(=O)N(CC2=CC=C(C=C2)C(=O)NO)CC(=O)NC3CCCCC3	IC50 = 52119.47 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHG62Y	N-[2,4-Difluoro-5-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]phenyl]methanesulfonamide	Investigative	54584296	C36H40F3N5O3S	679.8	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC(=C(C=C6F)F)NS(=O)(=O)C)C7=CC(=CC=C7)F	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHMA62	Edifenphos	Investigative	28292	C14H15O2PS2	310.4	CCOP(=O)(SC1=CC=CC=C1)SC2=CC=CC=C2	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHNJ06	N-({1-[4-(2-Ethyl-thiazol-5-yl)-4-hydroxy-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide	Investigative	46240785	C24H29F3N4O3S	510.6	CCC1=NC=C(S1)C2(CCC(CC2)N3CC(C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHP9Z2	CID 60201265	Investigative	60201265	C26H28N6O4	488.5	CO[C@H]1CN(CC[C@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 189000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHSM64	[(2R,3Ar,6aR)-2-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-(7,8-dihydro-5H-1,6-naphthyridin-6-yl)methanone	Investigative	71518896	C23H33N3O3	399.5	COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCC5=C(C4)C=CC=N5	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHV28K	4-(4-Pyrrolidin-1-ylbutoxy)benzenesulfonamide	Investigative	60145492	C14H22N2O3S	298.4	C1CCN(C1)CCCCOC2=CC=C(C=C2)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHVC49	1-[2-[(3S,4S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-fluoropiperidin-1-yl]ethyl]-2-oxoquinoline-7-carbonitrile	Investigative	60201946	C25H26FN5O3	463.5	C1CN(C[C@@H]([C@H]1NCC2=CC3=C(C=N2)OCCO3)F)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 57000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHWB09	1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(2-fluoropyridin-4-yl)amino]pyrazole-4-carboxamide	Investigative	89470690	C15H15FN6O2	330.32	C1COC[C@@H]([C@H]1C#N)N2C=C(C(=N2)NC3=CC(=NC=C3)F)C(=O)N	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHXP97	1-(1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-[(1-hydroxycycloheptyl)methylamino]ethanone	Investigative	59396641	C25H38N2O2	398.6	C1CCCC(CC1)(CNCC(=O)N2CCC3=CC=CC=C3C2C4CCCCC4)O	IC50 = 50100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BHXS32	cis-((3S,4R)-3,4-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone	Investigative	44565892	C17H24F2N6O	366.4	C1CN(CCN1[C@H]2C[C@H](NC2)C(=O)N3C[C@H]([C@H](C3)F)F)C4=NC=CC=N4	IC50 = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI0BM7	(4-Tert-butylpiperidin-1-yl)(4-isopropylpiperazin-1-yl)methanone	Investigative	44418490	C17H33N3O	295.5	CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)C(C)(C)C	IC50 = 66923.08 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI0BO3	[(8R)-8-Methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(2,3,4,5-tetrafluorophenyl)methanone	Investigative	86274731	C16H12F4N6OS	412.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=C(C(=C3F)F)F)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI1B0M	4-[2-[4-[[(1-Propan-2-ylindazole-3-carbonyl)amino]methyl]piperidin-1-yl]ethyl]benzoic acid	Investigative	68490431	C26H32N4O3	448.6	CC(C)N1C2=CC=CC=C2C(=N1)C(=O)NCC3CCN(CC3)CCC4=CC=C(C=C4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI34ZG	2-Methyl-7-[4-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]butyl]-5,6,8,9-tetrahydro-[1,3]oxazolo[4,5-h][3]benzazepine	Investigative	44454402	C23H28N6O2S	452.6	CC1=C(OC=N1)C2=NN=C(N2C)SCCCCN3CCC4=CC5=C(C=C4CC3)OC(=N5)C	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI6KH5	CID 86275207	Investigative	86275207	C16H16N6OS	340.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=CC=C3)C4=NC(=NS4)C	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI6PY0	2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-benzo[e][1,2]thiazin-2-yl)-1-phenyl-ethanone	Investigative	5436342	C23H17NO5S	419.5	C1=CC=C(C=C1)C(=O)CN2/C(=C(\\C3=CC=CC=C3)/O)/C(=O)C4=CC=CC=C4S2(=O)=O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI73LJ	1-(2,5-Dichlorophenyl)-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143921	C22H27Cl2N3O4S	500.4	C1CCN(CC1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI7BN5	1-(4-(2-(4-(1-(3-(Trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone	Investigative	46893585	C25H32F3N7O2	519.6	CC(=O)N1CCN(CC1)CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5C(F)(F)F)CC4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI8F1W	(2S)-2-[1-(2-Chloro-6-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-pyridin-2-ylpropanamide	Investigative	57504444	C22H19ClFN7O3	483.9	C1C(CN1C[C@@H](C(=O)NC2=CC=CC=N2)OC3=NC=NC4=C3C=NN4C5=C(C=CC=C5Cl)F)O	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI91ES	Phenyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72945827	C30H35F3N4O5	588.6	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BI9FQ2	5-[[[(3S,4R)-3-Fluoro-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile	Investigative	90644111	C24H27FN6O2	450.5	CC1=C(C=C(C=N1)CN[C@@H]2CCN(C[C@@H]2F)CCN3C(=O)C=CC4=C3C=C(C=N4)OC)C#N	IC50 = 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIA0B3	ClC1=C(C=C(C=C1)C=1C=NN(C=1)CC=1C=NN(C=1)C)OC(F)F	Investigative	118864476	C15H13ClF2N4O	338.74	CN1C=C(C=N1)CN2C=C(C=N2)C3=CC(=C(C=C3)Cl)OC(F)F	IC50 = 52400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIA4D6	CID 25008771	Investigative	25008771	C26H29N5O4	475.5	CO[C@H]1CN(CC[C@H]1NCC2=CC3=C(C=N2)OCCO3)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 174000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIB60Z	4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-(1-methylpiperidin-4-yl)benzamide	Investigative	57394711	C28H33N3O3	459.6	CN1CCC(CC1)NC(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)C#C[C@@]4(CN5CCC4CC5)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIES75	4-[4-Amino-5-(trifluoromethyl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-2-[(5S,6R)-2,2,5,6-tetramethyl-3-oxomorpholin-4-yl]benzonitrile	Investigative	137653443	C22H21F3N6O2	458.4	C[C@H]1[C@H](OC(C(=O)N1C2=C(C=CC(=C2)C3=CC(=C4N3N=CN=C4N)C(F)(F)F)C#N)(C)C)C	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIQF79	(4-Fluorophenyl)-[(8R)-3-(3-methyl-1,2,4-thiadiazol-5-yl)-8-propyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86275211	C18H19FN6OS	386.4	CCC[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)F)C4=NC(=NS4)C	IC50 = 61000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIR1N7	2-Fluoro-N-[4-[5-[3-(4-methylpiperazin-1-yl)propylamino]-1,3,4-oxadiazol-2-yl]phenyl]benzamide	Investigative	57663581	C23H27FN6O2	438.5	CN1CCN(CC1)CCCNC2=NN=C(O2)C3=CC=C(C=C3)NC(=O)C4=CC=CC=C4F	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIUR47	1-(2,5-Dichlorophenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60143413	C20H23Cl2N3O4S	472.4	C1CCN(C1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIWL90	(S)-5-(4-(Butoxycarbonyl)piperazin-1-yl)-5-oxo-4-(6-phenyl-4-(4-(pyrrolidine-1-carbonyl)piperidin-1-yl)picolinamido)pentanoic acid	Investigative	44631974	C36H48N6O7	676.8	CCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(=O)O)NC(=O)C2=CC(=CC(=N2)C3=CC=CC=C3)N4CCC(CC4)C(=O)N5CCCC5	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIX1Z2	7-((R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	10044868	C20H24FN3O3	373.4	CC1=C2C(=CC(=C1N3CC[C@H](C3)[C@H](C)N)F)C(=O)C(=CN2C4CC4)C(=O)O	Ki = 51000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIY83D	3-(1-Cyclohexylpiperidin-4-yl)-1H-benzimidazol-2-one	Investigative	44253016	C18H25N3O	299.4	C1CCC(CC1)N2CCC(CC2)N3C4=CC=CC=C4NC3=O	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BIYL68	1-(3-Bromophenyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide	Investigative	22391985	C15H10BrN3O2	344.16	C1=CC(=CC(=C1)Br)N2C=C(C(=O)C3=C2N=CC=C3)C(=O)N	IC50 ~ 94500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ2EQ0	3-[[(3S)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]amino]propanoic acid	Investigative	52945978	C22H25NO2	335.4	C1C[C@@]2(CC1NCCC(=O)O)CC3=CC=CC=C3CC4=CC=CC=C24	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ35FD	3-(3,5-Diethyl-1H-pyrazol-4-yloxy)-5-methylbenzonitrile	Investigative	21949901	C15H17N3O	255.31	CCC1=C(C(=NN1)CC)OC2=CC(=CC(=C2)C#N)C	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ42KA	1-[2-[(3S,4R)-4-[(5-Cyano-6-methylpyridin-3-yl)methylamino]-3-fluoropiperidin-1-yl]ethyl]-2-oxoquinoline-7-carbonitrile	Investigative	90644109	C25H25FN6O	444.5	CC1=C(C=C(C=N1)CN[C@@H]2CCN(C[C@@H]2F)CCN3C(=O)C=CC4=C3C=C(C=C4)C#N)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ4U5B	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[5,4-c]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70682584	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)C=NC=C5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ50OV	1-Benzhydryl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60144245	C28H33N3O4S	507.6	C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ61YL	4-[3-Chloro-4-(hydroxymethyl)phenoxy]-3-cyano-N-(5-fluoropyridin-2-yl)benzenesulfonamide	Investigative	86271138	C19H13ClFN3O4S	433.8	C1=CC(=C(C=C1OC2=C(C=C(C=C2)S(=O)(=O)NC3=NC=C(C=C3)F)C#N)Cl)CO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ65KB	3-Chloro-4-[4-[1-(6-methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]benzoic acid	Investigative	57386785	C32H29ClN6O5	613.1	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)Cl	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ6G3E	[(1S,3R)-3-[[(3S,4S)-3-Methoxyoxan-4-yl]-methylamino]-1-propan-2-ylcyclopentyl]-[4-[5-(trifluoromethyl)pyridazin-3-yl]piperazin-1-yl]methanone	Investigative	54583112	C25H38F3N5O3	513.6	CC(C)[C@@]1(CC[C@H](C1)N(C)[C@H]2CCOC[C@H]2OC)C(=O)N3CCN(CC3)C4=NN=CC(=C4)C(F)(F)F	IC50 = 52800 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ6Q8M	2-Methylpropyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72947193	C28H39F3N4O5	568.6	CC(C)COC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ72UQ	2-[5-[1-[3-Cyclobutyloxy-4-(difluoromethoxy)phenyl]-2-(1-oxidopyridin-1-ium-4-yl)ethyl]-1,3-thiazol-2-yl]propan-2-ol	Investigative	10162604	C24H26F2N2O4S	476.5	CC(C)(C1=NC=C(S1)C(CC2=CC=[N+](C=C2)[O-])C3=CC(=C(C=C3)OC(F)F)OC4CCC4)O	Ki = 58400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJ84XB	(3R,4R)-1-[3-(2,5-Difluorophenyl)cyclobutyl]-4-[(3S)-3-(3-fluoro-6-methoxyquinolin-4-yl)-3-hydroxypropyl]piperidine-3-carboxylic acid	Investigative	25114847	C29H31F3N2O4	528.6	COC1=CC2=C(C(=CN=C2C=C1)F)[C@H](CC[C@@H]3CCN(C[C@@H]3C(=O)O)C4CC(C4)C5=C(C=CC(=C5)F)F)O	IC50 = 85900 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJAZ13	8-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-2-(4-methyl-5-oxopyrazin-2-yl)-2,8-diazaspiro[4.5]decan-1-one	Investigative	121313972	C24H28N4O5	452.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CCN(C4=O)C5=CN(C(=O)C=N5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJD9C4	1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(1-methylpyrazol-4-yl)anilino]pyrazole-4-carboxamide	Investigative	137651256	C20H21N7O2	391.4	CN1C=C(C=N1)C2=CC=C(C=C2)NC3=NN(C=C3C(=O)N)[C@H]4COCC[C@@H]4C#N	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJI79D	1-Naphthalen-1-yl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	46893542	C24H27N3O4S	453.6	C1CCN(C1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC4=CC=CC=C43	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJI7G6	N-[2-[[(1S,2R,4R)-2-(Methoxymethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide	Investigative	69285563	C22H32F3N3O3	443.5	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)COC)NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJLD76	2-[(2R)-2-(Pyridin-3-yloxymethyl)piperazin-1-yl]-[1,3]oxazolo[4,5-b]pyridine;hydrochloride	Investigative	66797369	C16H18ClN5O2	347.8	C1CN([C@H](CN1)COC2=CN=CC=C2)C3=NC4=C(O3)C=CC=N4.Cl	IC50 = 72000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJQO46	ClC1=C(C=C(C=C1)C=1C=NN(C=1)CC=1C=NNC=1)OC(F)F	Investigative	118864482	C14H11ClF2N4O	324.71	C1=CC(=C(C=C1C2=CN(N=C2)CC3=CNN=C3)OC(F)F)Cl	IC50 = 52600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BJSZ09	1-[4-(3-Piperidin-1-ylpropoxy)phenyl]sulfonyl-3-propan-2-ylurea	Investigative	60143415	C18H29N3O4S	383.5	CC(C)NC(=O)NS(=O)(=O)C1=CC=C(C=C1)OCCCN2CCCCC2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK20YA	7-Cyclopentyl-4-[3-(methylamino)azetidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine	Investigative	71525681	C16H22N6	298.39	CNC1CN(C1)C2=NC(=NC3=C2N=CC(=C3)C4CCCC4)N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK25AG	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-propan-2-yloxy-N-pyridin-2-ylpropanamide	Investigative	57504362	C21H20ClN7O3	453.9	CC(C)OC[C@@H](C(=O)NC1=CC=CC=N1)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK28AV	Chembl4208519	Investigative	130282636	C27H32N4O6S	540.6	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)S(=O)(=O)N(C)C4(CN(C4)C(=O)CC(C)C)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK73TA	US10087188, Example 1	Investigative	121454909	C26H23F3N6O3	524.5	C1C[C@H](C[C@H](C1)C(=O)O)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC(=C5)C(F)(F)F	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK7C0I	1-(4-Acetylphenyl)-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60143925	C22H27N3O5S	445.5	CC(=O)C1=CC=C(C=C1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK7TD1	1-[4-(3-Piperidin-1-ylpropoxy)phenyl]sulfonyl-3-[2-(trifluoromethyl)phenyl]urea	Investigative	60144086	C22H26F3N3O4S	485.5	C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BK9MD2	6-{[(1-{2-[6-(Ethylsulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	Investigative	15982150	C25H31N5O6S	529.6	CCS(=O)(=O)C1=CC2=C(C=C1)OCC(=O)N2CCN3CCC(CC3)NCC4=NC5=C(C=C4)OCC(=O)N5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKE7A3	N-((3r,5s)-1-(Benzofuran-3-Carbonyl)-5-(Ethylcarbamoyl)pyrrolidin-3-Yl)-3-Ethyl-1-Methyl-1h-Pyrazole-5-Carboxamide	Investigative	72725792	C23H27N5O4	437.5	CCC1=NN(C(=C1)C(=O)N[C@@H]2C[C@H](N(C2)C(=O)C3=COC4=CC=CC=C43)C(=O)NCC)C	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKJ56H	(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-propan-2-yloxy-N-pyridin-2-ylpropanamide	Investigative	57504348	C22H21ClN6O3	452.9	CC(C)OC[C@@H](C(=O)NC1=CC=CC=N1)OC2=NC=NC3=C2C=NN3C4=CC=CC=C4Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKN60T	ADL-5747 free base	Investigative	11200189	C24H28N2O3	392.5	CCN(CC)C(=O)C1=CC(=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC=C42)O	IC50 = 56700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKOI83	Oxan-4-ylmethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72946199	C30H41F3N4O6	610.7	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OCC6CCOCC6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKQ74I	1-Cyclohexyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145631	C19H29N3O4S	395.5	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKRO53	CID 60202107	Investigative	60202107	C25H27N5O4	461.5	C1CN(C[C@@H]([C@@H]1NCC2=CC3=C(C=N2)OCCO3)O)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 117000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKSD10	N-Methyl-3-[4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzenesulfonamide	Investigative	54585971	C36H43N5O3S	625.8	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC(=CC=C6)S(=O)(=O)NC)C7=CC=CC=C7	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKWU14	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-ethoxy-N-(5-methylpyridin-2-yl)propanamide	Investigative	57504326	C21H20ClN7O3	453.9	CCOC[C@@H](C(=O)NC1=NC=C(C=C1)C)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKY08F	Chembl4208812	Investigative	118613658	C31H42N4O3	518.7	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCC45CCN(CC5)C)OC)OCCCN6CCCC6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKY4B0	N-(1-(4-(3-(Dimethylamino)propoxy)-3-fluorobenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide	Investigative	44438740	C27H31F2N3O4	499.5	CN(C)CCCOC1=C(C=C(C=C1)CN2CCC(CC2)NC(=O)C3=CC(=O)C4=C(O3)C=C(C=C4)F)F	IC50 = 65000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BKY57T	(S)-4-((5-((1-(2-Hydroxynicotinoyl)-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile	Investigative	44592988	C22H20N6O3	416.4	C1CN(C(=O)[C@H]1NCC2=CN=CN2CC3=CC=C(C=C3)C#N)C(=O)C4=CC=CNC4=O	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL3AK0	(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	44590735	C29H34F5N3O7	631.6	CC(C)[C@@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C[C@@H](CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 76000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL47FX	5-Amino-4-(isobutylamino)-6-(piperazin-1-yl)pyrimidine-2-carbonitrile	Investigative	25256833	C13H21N7	275.35	CC(C)CNC1=C(C(=NC(=N1)C#N)N2CCNCC2)N	IC50 = 52000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL57DE	N'-(1-Piperidin-4-yl-2,3-dihydroindol-5-yl)thiophene-2-carboximidamide	Investigative	25014630	C18H22N4S	326.5	C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N	IC50 = 160000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL68HN	Methyl 2-[3-[(3,5-dichlorobenzoyl)amino]propylamino]-3H-benzimidazole-5-carboxylate	Investigative	122179076	C19H18Cl2N4O3	421.3	COC(=O)C1=CC2=C(C=C1)N=C(N2)NCCCNC(=O)C3=CC(=CC(=C3)Cl)Cl	IC50 ~ 50100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL6AU3	6-[9-[(2R)-2-Hydroxy-2-(4-methyl-1-oxo-3H-2-benzofuran-5-yl)ethyl]-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl]-2-methylpyridazin-3-one	Investigative	130449749	C24H30N4O5	454.5	CC1=C(C=CC2=C1COC2=O)[C@H](CN3CCC4(CC3)CN(CCO4)C5=NN(C(=O)C=C5)C)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL6X0K	4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-fluoropyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide	Investigative	117769217	C21H25FN6O	396.5	C[C@@]1(CC[C@H](C1(C)C)NC2=C(C=NN3C2=CC(=C3)C4=C(C=NC=C4)F)C(=O)N)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL76DF	3-[4-(Dimethylcarbamoyl)phenoxy]-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)benzamide	Investigative	11495849	C23H26N4O5	438.5	C[C@@H](CO)OC1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N(C)C)C(=O)NC3=NN(C=C3)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL7CU8	1-(1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl)-2-[2-(2,6-dichlorophenyl)ethylamino]ethanone	Investigative	118721376	C25H30Cl2N2O	445.4	C1CCC(CC1)C2C3=CC=CC=C3CCN2C(=O)CNCCC4=C(C=CC=C4Cl)Cl	IC50 = 54700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BL7M0E	[(2R)-1-[3-[1-[[1-[2-(2,3-Difluoroanilino)-2-oxoethyl]pyrazol-4-yl]amino]phthalazin-6-yl]oxypropyl]pyrrolidin-2-yl]methyl dihydrogen phosphate	Investigative	44447866	C27H30F2N7O6P	617.5	C1C[C@@H](N(C1)CCCOC2=CC3=CN=NC(=C3C=C2)NC4=CN(N=C4)CC(=O)NC5=C(C(=CC=C5)F)F)COP(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLF2V0	JTZ-951 HCl	Investigative	67049587	C17H17ClN4O4	376.8	C1=CC=C(C=C1)CCC2=CC(=O)C(=C3N2NC=N3)C(=O)NCC(=O)O.Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLH14X	Chembl4243686	Investigative	131985420	C26H32N6O2	460.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)N5C=NC=N5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLP2H7	N-[1-(4-Aminocyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide	Investigative	56668413	C19H25F3N6O	410.4	C1CC(CCC1N)N2CC(C2)NC(=O)CNC3=NNC4=C3C=C(C=C4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLQ3I1	6-[4-[(2,3-Difluorophenyl)methyl]piperazin-1-yl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazine	Investigative	71719561	C17H15F5N6	398.33	C1CN(CCN1CC2=C(C(=CC=C2)F)F)C3=NN4C(=NN=C4C(F)(F)F)C=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLQ9V6	Bradanicline	Investigative	25147644	C22H23N3O2	361.4	C1CN2CCC1[C@H]([C@@H]2CC3=CN=CC=C3)NC(=O)C4=CC5=CC=CC=C5O4	IC50 = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLUE24	Abelcet	Investigative	118705500	C47H73NO17	924.1	C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLVR12	1-(4-Methylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60144244	C22H29N3O4S	431.6	CC1=CC=C(C=C1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BLZ63X	4-[[(1R,3S)-3-Amino-2,2,3-trimethylcyclopentyl]amino]-6-(3-methylpyridin-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide	Investigative	117769464	C22H28N6O	392.5	CC1=C(C=CN=C1)C2=CN3C(=C2)C(=C(C=N3)C(=O)N)N[C@@H]4CC[C@](C4(C)C)(C)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM0O2J	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(7,7-dimethyl-4,6-dihydropyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70686822	C24H33N5O3S	471.6	CC1(COCC2=C1N=C(S2)N3CCN(CC3)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM2PL4	N-[1-[4-Hydroxy-4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]-2-[[6-(trifluoromethyl)quinazolin-4-yl]amino]acetamide	Investigative	68004034	C23H25F3N6O2S	506.5	C1CC(CCC1N2CC(C2)NC(=O)CNC3=NC=NC4=C3C=C(C=C4)C(F)(F)F)(C5=NC=CS5)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM3IE0	(3,4-Difluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone	Investigative	86274730	C16H14F2N6OS	376.4	C[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC(=C(C=C3)F)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM3L1V	2-[(2S)-2,3-Dihydroxypropyl]-6-methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile	Investigative	11995420	C20H18N2O4	350.4	COC1=CC2=C(C=C1)C(=O)N(C(=C2C3=CC=CC=C3)C#N)C[C@@H](CO)O	IC50 = 135000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM5YX8	4-[[2-[[3,5-Bis(trifluoromethyl)phenyl]carbamoylamino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide	Investigative	127047276	C23H15F6N5O3S	555.5	CNC(=O)C1=NC=CC(=C1)OC2=CC3=C(C=C2)N=C(S3)NC(=O)NC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM64NW	(2S)-2-[4-[[4-(4-Fluoro-2-methylphenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)-2-methylpropanoic acid	Investigative	71456722	C28H36F2N2O3	486.6	CC1=C(C=CC(=C1)F)OC2CCN(CC2)CC3CCN(CC3)[C@@](C)(CC4=CC=C(C=C4)F)C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BM91ZH	N-Tert-butyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamide	Investigative	24964190	C26H26N2O2	398.5	CC(C)(C)NC(=O)C1C2=CC=CC=C2C(=O)N1CC3=CC=CC=C3C4=CC=CC=C4	IC50 = 62000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMAS68	4-[[(3S,4R)-1-(5-Cyano-2-pyridyl)-3-fluoropiperidine-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	Investigative	59292007	C19H18FN7O	379.4	C1CN(C[C@@H]([C@@H]1NC2=C3C=CNC3=NC=C2C(=O)N)F)C4=NC=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMC29L	(-)-(3R,4R)-4-(2-Chloro-4-fluorophenyl)-3-hydroxy-1-{[(6R,8S)-8-hydroxy-5,6,7,8-tetrahydroquinolin-6-yl]methyl}piperidinium Chloride	Investigative	11326750	C21H24ClFN2O2	390.9	C1CN(C[C@@H]([C@H]1C2=C(C=C(C=C2)F)Cl)O)C[C@H]3C[C@@H](C4=C(C3)C=CC=N4)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMED42	6-[[[1-[[(3R)-6-Chloro-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12),9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728973	C26H25ClFN5O5	542	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@@]5(CN6C(=O)C=CC7=C6C5=C(C(=N7)Cl)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMEK46	N-[(3S)-1-[(1S,2R,4R)-4-[Methyl(propan-2-yl)amino]-2-(methylsulfonylmethyl)cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethoxy)benzamide	Investigative	89845031	C24H34F3N3O5S	533.6	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)OC(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMF2Y7	(2R,3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-6a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-2,3,3a,4,5,6-hexahydro-1H-pentalene-2-carboxamide	Investigative	71719764	C25H33F3N4O4	510.5	COC1COCCC1N[C@@H]2C[C@H]3C[C@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMI5V8	N-(3,4-Dichlorophenyl)-4-{[(2R)-4-isopropylpiperazin-2-yl]carbonyl}piperazine-1-carboxamide	Investigative	57656833	C19H27Cl2N5O2	428.4	CC(C)N1CCN[C@H](C1)C(=O)N2CCN(CC2)C(=O)NC3=CC(=C(C=C3)Cl)Cl	IC50 = 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMK3S6	(6R,8S)-6-(((3R,4R)-3-Hydroxy-4-o-tolylpiperidin-1-yl)methyl)-5,6,7,8-tetrahydroquinolin-8-ol	Investigative	24894783	C22H28N2O2	352.5	CC1=CC=CC=C1[C@H]2CCN(C[C@@H]2O)C[C@H]3C[C@@H](C4=C(C3)C=CC=N4)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BMRZ52	[4-[[(2S,5R)-5-[(R)-Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[(1S,5R)-6-(1,3,4-oxadiazol-2-yl)-3-azabicyclo[3.1.0]hexan-3-yl]methanone	Investigative	67972107	C26H28N4O3	444.5	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)C(=O)N3C[C@@H]4[C@H](C3)C4C5=NN=CO5)[C@@H](C6=CC=CC=C6)O	IC50 = 55000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN06RX	2-[4-[[4-(3,4-Dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carbonyloxymethyl)piperidin-1-yl]methyl]phenyl]-2-methylpropanoic acid	Investigative	46935743	C29H34N2O5	490.6	CC(C)(C1=CC=C(C=C1)CN2CCC(CC2)COC(=O)C3=C4N(CCCO4)C5=CC=CC=C53)C(=O)O	IC50 = 69000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN08UF	1-[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-3-phenylpropan-1-one	Investigative	72947191	C32H39F3N4O4	600.7	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)CCC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN0T6U	CID 44517795	Investigative	44517795	C22H15F3N4O5	472.4	C1CN(C2=C1C=C(C=C2)C3=NOC(=N3)C4=CC(=CC(=C4)C#N)OC(F)(F)F)C(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN2IC3	4-Tert-Butyl-N-[2-Methyl-3-(6-{[4-(Morpholin-4-Ylcarbonyl)phenyl]amino}-7h-Purin-2-Yl)phenyl]benzamide	Investigative	53356518	C34H35N7O3	589.7	CC1=C(C=CC=C1NC(=O)C2=CC=C(C=C2)C(C)(C)C)C3=NC4=C(C(=N3)NC5=CC=C(C=C5)C(=O)N6CCOCC6)NC=N4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN36CZ	(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide	Investigative	72947595	C24H32F3N5O4	511.5	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN46PD	N-{6-[(1S)-1-(4-Fluorophenyl)-2,2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfonamide	Investigative	11525190	C24H21FN4O2S	448.5	CS(=O)(=O)NC1=CC=CC(=N1)[C@H](C2=CC=C(C=C2)F)C(C3=CN=CC=C3)C4=CN=CC=C4	IC50 = 110000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN4PU0	1-Phenyl-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60143416	C21H27N3O4S	417.5	C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN4VB2	(2S,3S)-2-[4-[Acetyl(methyl)amino]cyclohexyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride	Investigative	49797361	C19H34ClFN4O3	420.9	CC(=O)N(C)C1CCC(CC1)[C@@H]([C@@H](C(=O)N2CC[C@@H](C2)F)N)C(=O)N(C)C.Cl	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN56OF	N-{4-[(S)-1-Amino-2-((R)-3-fluoro-pyrrolidin-1-yl)-2-oxo-ethyl]-cyclohexyl}-2,4-difluoro-benzenesulfonamide	Investigative	10342016	C18H24F3N3O3S	419.5	C1CN(C[C@@H]1F)C(=O)[C@H](C2CCC(CC2)NS(=O)(=O)C3=C(C=C(C=C3)F)F)N	Ki = 52000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN5B3X	6-(5-Chloropyridin-2-yl)-3-[6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridin-3-yl]pyrrolo[2,1-f][1,2,4]triazin-4-one	Investigative	45278576	C20H17ClN6O2	408.8	C1CN(C[C@@H]1O)C2=NC=C(C=C2)N3C=NN4C=C(C=C4C3=O)C5=NC=C(C=C5)Cl	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN5PU1	N-[1-[4-Hydroxy-4-(1,3-thiazol-5-yl)cyclohexyl]azetidin-3-yl]-2-[[3-(trifluoromethyl)-1,6-naphthyridin-5-yl]amino]acetamide	Investigative	68004016	C23H25F3N6O2S	506.5	C1CC(CCC1N2CC(C2)NC(=O)CNC3=NC=CC4=C3C=C(C=N4)C(F)(F)F)(C5=CN=CS5)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN6E4G	(S)-7-(3-(Aminomethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425432	C19H23N3O4	357.4	COC1=C(C=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)N4CC[C@H](C4)CN	Ki = 64000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN74LI	7-[[[1-[[(3R)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-2,3-dihydro-[1,4]dioxino[2,3-c]pyridine-8-carbonitrile	Investigative	118736670	C27H26FN5O5	519.5	C1CC2(CCC1(CO2)NCC3=NC=C4C(=C3C#N)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN7A9U	trans-4-{2-[(1r)-1-Hydroxyethyl]imidazo[4,5-D]pyrrolo[2,3-B]pyridin-1(6h)-Yl}cyclohexanecarbonitrile	Investigative	58394837	C17H19N5O	309.4	C[C@H](C1=NC2=CN=C3C(=C2N1C4CCC(CC4)C#N)C=CN3)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BN8D4L	1-[({2-[(1S)-1-Cyclohexyl-3,4-dihydroisoquinolin-2(1H)-yl]-2-oxoethyl}amino)methyl]cyclohexanol	Investigative	25067546	C24H36N2O2	384.6	C1CCC(CC1)[C@H]2C3=CC=CC=C3CCN2C(=O)CNCC4(CCCCC4)O	IC50 = 98000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BND0J1	6-[[[1-[2-[2-Oxo-7-[(3R)-oxolan-3-yl]oxy-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187102	C27H32N6O5	520.6	C1COC[C@@H]1OC2=CC3=C(C=CC(=O)N3CCN4CCC(CC4)NCC5=NC6=C(C=C5)OCC(=O)N6)N=C2	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BND75P	[(8R)-8-Ethyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-fluorophenyl)methanone	Investigative	86275209	C17H17FN6OS	372.4	CC[C@@H]1C2=NN=C(N2CCN1C(=O)C3=CC=C(C=C3)F)C4=NC(=NS4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNE4K6	7-Methoxy-2-[[(2R)-2-methyl-4-pyrimidin-2-ylpiperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-c]quinazolin-5-amine	Investigative	122182835	C20H23N9O	405.5	C[C@@H]1CN(CCN1CC2=NN3C(=N2)C4=C(C(=CC=C4)OC)N=C3N)C5=NC=CC=N5	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNP23C	3-Anilino-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide	Investigative	89471136	C16H17N5O2	311.34	C1COC[C@@H]([C@H]1C#N)N2C=C(C(=N2)NC3=CC=CC=C3)C(=O)N	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNPA34	N-Ethyl-6-[[4-(4-fluorophenyl)-1-methylpiperidin-4-yl]methoxymethyl]-4-(trifluoromethyl)pyridin-2-amine	Investigative	24799365	C22H27F4N3O	425.5	CCNC1=CC(=CC(=N1)COCC2(CCN(CC2)C)C3=CC=C(C=C3)F)C(F)(F)F	IC50 = 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNR15A	3-[4-[2-[3-(2-Methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]-4-phenylpiperidine-1-carbonyl]benzenesulfonamide	Investigative	54584057	C35H41N5O3S	611.8	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC(=CC=C6)S(=O)(=O)N)C7=CC=CC=C7	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNUF92	[(2R,3Ar,6aR)-2-(pentan-3-ylamino)-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71518405	C23H32F3N3O	423.5	CCC(CC)N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNX0M9	CID 68767124	Investigative	68767124	C27H43N3O4S	505.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)C(C)(C)C	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BNZ4X6	4-(5-Chloro-3-{1-[2-(2-oxo-imidazolidin-1-yl)-ethyl]-piperidin-4-yl}-indol-1-yl)-benzoic acid	Investigative	44297377	C25H27ClN4O3	467	C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)C(=O)O)CCN5CCNC5=O	IC50 = 74131.02 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO15SN	5-Amino-4-(isobutylamino)-6-morpholinopyrimidine-2-carbonitrile	Investigative	25256832	C13H20N6O	276.34	CC(C)CNC1=C(C(=NC(=N1)C#N)N2CCOCC2)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO1HL3	6-[[[1-[2-[2-Oxo-7-(pyridin-2-ylmethoxy)-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187104	C29H31N7O4	541.6	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=N5)OCC6=CC=CC=N6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO1YR5	(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-N-propan-2-yl-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide	Investigative	76314234	C27H38F3N5O4	553.6	CC(C)NC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO2NH7	2-Chloro-4-fluoro-5-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]benzenesulfonamide	Investigative	54582114	C35H38ClF2N5O3S	682.2	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC(=C(C=C6F)Cl)S(=O)(=O)N)C7=CC(=CC=C7)F	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO35FM	N-({1-[4-Hydroxy-4-(1-methyl-1H-pyrazol-3-yl)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide	Investigative	46240381	C23H28F3N5O3	479.5	CN1C=CC(=N1)C2(CCC(CC2)N3CC(C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO4A1Y	N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride	Investigative	49797359	C22H32ClF2N3O2	444	C[C@@H](C1CCC(CC1)N(C)C(=O)C2=CC(=CC=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.Cl	IC50 = 78000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BO59WG	1-(3-Methoxyphenyl)-3-[2-(4-propan-2-ylpiperazin-1-yl)ethyl]imidazolidin-2-one	Investigative	45272437	C19H30N4O2	346.5	CC(C)N1CCN(CC1)CCN2CCN(C2=O)C3=CC(=CC=C3)OC	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOA36V	2,2,2-Trifluoro-N-[3-oxo-4-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]piperidin-1-yl]ethyl]-1,4-benzoxazin-6-yl]acetamide	Investigative	56675817	C25H27F3N6O5	548.5	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)COC5=C4C=C(C=C5)NC(=O)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOA94N	Chembl4217332	Investigative	118613626	C28H36N4O4	492.6	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(C(=O)C4)C)OC)OCCCN5CCCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOB84S	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-ethylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	127035240	C18H22F2N4O3S	412.5	CCS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOF96B	2-[[(2R)-4-(1-Tert-butylpyrazol-4-yl)-2-methylpiperazin-1-yl]methyl]-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine	Investigative	122182882	C23H31N9O	449.6	C[C@@H]1CN(CCN1CC2=NN3C(=N2)C4=C(C(=CC=C4)OC)N=C3N)C5=CN(N=C5)C(C)(C)C	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOG1Z9	(1S,2R,5R,7R,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-15-[1-[(3-hydroxy-1,8-naphthyridin-4-yl)methyl]azetidin-3-yl]-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone	Investigative	45482740	C42H61N5O11	812	CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)N(C(=O)O2)C4CN(C4)CC5=C6C=CC=NC6=NC=C5O)C	IC50 = 140000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOKP62	[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-(1,3-thiazol-2-yl)-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	76321527	C26H32F3N5O3S	551.6	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C6=NC=CS6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BON3M1	[2-(5-Fluoropyridin-2-yl)-6,7-dihydro-4H-[1,3]oxazolo[4,5-c]pyridin-5-yl]-phenylmethanone	Investigative	74221949	C18H14FN3O2	323.3	C1CN(CC2=C1OC(=N2)C3=NC=C(C=C3)F)C(=O)C4=CC=CC=C4	IC50 = 64000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOQ2G5	N-(1-(3-Fluoro-4-((2-(pyrrolidin-1-yl)ethyl)carbamoyl)benzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide	Investigative	16739263	C29H32F2N4O4	538.6	C1CCN(C1)CCNC(=O)C2=C(C=C(C=C2)CN3CCC(CC3)NC(=O)C4=CC(=O)C5=C(O4)C=C(C=C5)F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOQK19	1-(2,5-Dichlorophenyl)-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145772	C20H23Cl2N3O4S	472.4	C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BOSA32	N-Hydroxy-3-[4-[4-(pyrrolidine-1-carbonyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide	Investigative	118179807	C27H33N3O6S	527.6	C1CCN(C1)C(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)S(=O)(=O)C4(CCC5(C4)CCNCC5)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP1VC3	N-[3-Chloro-4-[4-(3-methoxypyridine-2-carbonyl)piperazin-1-yl]phenyl]-2-methyl-2-phenylpropanamide;hydrochloride	Investigative	44249748	C27H30Cl2N4O3	529.5	CC(C)(C1=CC=CC=C1)C(=O)NC2=CC(=C(C=C2)N3CCN(CC3)C(=O)C4=C(C=CC=N4)OC)Cl.Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP29WC	Chembl4237919	Investigative	131985494	C27H34N6O2	474.6	CC1=NN=CN1C2=CC=CC(=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP2N6X	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(5-methylpyrazin-2-yl)propanamide	Investigative	57504312	C19H17ClN8O3	440.8	CC1=CN=C(C=N1)NC(=O)[C@H](COC)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 ~ 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP2RB3	6-[[[1-[2-(7-Methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-3-methylpyrazine-2-carbonitrile	Investigative	90644106	C23H27N7O2	433.5	CC1=NC=C(N=C1C#N)CNC2CCN(CC2)CCN3C(=O)C=CC4=C3C=C(C=N4)OC	IC50 = 69000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP54US	(2S)-2-[1-(2-Chloro-6-cyanophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide	Investigative	57504457	C22H17ClFN7O4	497.9	C1=CC(=C(C(=C1)Cl)N2C3=C(C=N2)C(=NC=N3)O[C@@H](COCCO)C(=O)NC4=NC=C(C=C4)F)C#N	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP5E0A	4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-	Investigative	42602260	C21H25ClN6O2	428.9	C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP5KB0	3-[[3-(Hydroxymethyl)morpholin-4-yl]methyl]-N-[(2R)-7-[(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalen-2-yl]-5-(trifluoromethyl)benzamide	Investigative	68513796	C32H33F3N4O5	610.6	C1CC2=C(C[C@@H]1NC(=O)C3=CC(=CC(=C3)CN4CCOCC4CO)C(F)(F)F)C=C(C=C2)OC5=C6CCC(=O)NC6=NC=C5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP7JC1	2-Acetamidoethyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72946775	C28H38F3N5O6	597.6	CC(=O)NCCOC(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP84CB	Chembl4170114	Investigative	118607432	C28H38N4O3	478.6	CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP87DV	US10087188, Example 30	Investigative	121454982	C28H27F3N6O3	552.5	CC1(CCC(CC1)(C)C(=O)O)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC(=C5)C(F)(F)F	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP89HN	CID 60201945	Investigative	60201945	C25H26FN5O3	463.5	C1CN(C[C@@H]([C@@H]1NCC2=CC3=C(C=N2)OCCO3)F)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 199000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BP8ZC2	US10087188, Example 80	Investigative	121455652	C27H25F3N6O3	538.5	C[C@]1(CC[C@](C1)(C)C(=O)O)C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=NC=CC(=C5)C(F)(F)F	IC50 = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BPG8K7	N-((3S,4S)-4-(4-(5-Fluoropyridin-3-yl)phenyl)tetrahydrofuran-3-yl)propane-2-sulfonamide	Investigative	52947618	C18H21FN2O3S	364.4	CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1C2=CC=C(C=C2)C3=CC(=CN=C3)F	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BPN29R	1-[(3S)-Spiro[cyclopentane-3,9'-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene]-1-yl]piperidine-4-carboxylic acid	Investigative	49836299	C25H29NO2	375.5	C1C[C@@]2(CC1N3CCC(CC3)C(=O)O)CC4=CC=CC=C4CC5=CC=CC=C25	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BPN72Y	(3R,4R)-1-([1,2,4]Triazolo[4,3-a]pyrimidin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid	Investigative	23661708	C18H16F6N6O2	462.3	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NC4=NN=CN4C=C3.C(=O)(C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BPQ06W	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-([1,3]thiazolo[4,5-b]pyridin-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	25129041	C22H26N6O2S	438.5	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)C=CC=N5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BPXV62	N-[5-(Trifluoromethyl)pyridine-3-yl]-2-(trifluoromethyl)benzenesulfonamide	Investigative	118917671	C13H8F6N2O2S	370.27	C1=CC=C(C(=C1)C(F)(F)F)S(=O)(=O)NC2=CN=CC(=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ05EB	Clozapine N-oxide	Investigative	135445691	C18H19ClN4O	342.8	C[N+]1(CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)[O-]	IC50 = 133299.95 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ06LI	6-Fluoro-N-(6-(4-methoxytetrahydro-2H-pyran-4-yl)pyridin-3-yl)-4-oxo-8-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4H-chromene-2-carboxamide	Investigative	45104767	C27H27FN4O5	506.5	CC1=C(C(=NN1C)C)C2=CC(=CC3=C2OC(=CC3=O)C(=O)NC4=CN=C(C=C4)C5(CCOCC5)OC)F	IC50 = 95000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ0J2V	N-Tert-butyl-2-[[2-(4-fluorophenyl)phenyl]methyl]-3-oxo-1H-isoindole-1-carboxamide	Investigative	68775928	C26H25FN2O2	416.5	CC(C)(C)NC(=O)C1C2=CC=CC=C2C(=O)N1CC3=CC=CC=C3C4=CC=C(C=C4)F	IC50 = 56000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ1G3Y	Chembl4282585	Investigative	145982242	C25H36N2O	380.6	CC1=C(C=C(N1C2CCCCC2)C3=CC=C(C=C3)C(C)C)CN4CCOCC4	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ1X8H	6-[(3R,9As)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-3,4-dihydroisochromen-1-one	Investigative	89633340	C24H25N7O4	475.5	C1COC(=O)C2=C1C=C(C=C2)[C@@H]3CN4CCN(C[C@H]4CO3)C(=O)CC5=CN=C(C=C5)N6C=NN=N6	IC50 = 75900 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ1YD9	1-[(2R)-4-Benzoyl-2-methylpiperazin-1-yl]-2-(1H-pyrrolo[3,2-b]pyridin-3-yl)ethane-1,2-dione	Investigative	507791	C21H20N4O3	376.4	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=C2N=CC=C3)C(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ2R5C	N-[(3S)-1-[(1S,2R,4R)-2-(Tert-butylsulfonylmethyl)-4-[methyl(propan-2-yl)amino]cyclohexyl]-2-oxopyrrolidin-3-yl]-3-(trifluoromethyl)benzamide	Investigative	68988296	C27H40F3N3O4S	559.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C(C)(C)C)N2CC[C@@H](C2=O)NC(=O)C3=CC(=CC=C3)C(F)(F)F	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ3E4I	7-Fluoro-4-oxo-N-(1-((2-oxo-2H-chromen-7-yl)methyl)piperidin-4-yl)-4H-chromene-2-carboxamide	Investigative	11583193	C25H21FN2O5	448.4	C1CN(CCC1NC(=O)C2=CC(=O)C3=C(O2)C=C(C=C3)F)CC4=CC5=C(C=C4)C=CC(=O)O5	IC50 = 51100 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ70DS	4-[[1-[(5-Chloro-1-methyl-1H-pyrazole-4-yl)carbonyl]-4-piperidinyl]amino]quinoline-2(1H)-one	Investigative	90644461	C19H20ClN5O2	385.8	CN1C(=C(C=N1)C(=O)N2CCC(CC2)NC3=CC(=O)NC4=CC=CC=C43)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQ71GI	N-Methyl-4-(spiro[chromene-2,4''-piperidine]-4-yl)benzamide	Investigative	44254859	C21H22N2O2	334.4	CNC(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC=C42	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQEZ40	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(4-ethyl-1,3-thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70686820	C21H29N5O2S	415.6	CCC1=CSC(=N1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQR47W	1-(2,5-Dichlorophenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60143588	C21H25Cl2N3O4S	486.4	C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQT05U	Chembl4212403	Investigative	42916879	C24H22N2O3	386.4	COC1=CC(=CC(=C1)NC(C2=CC=CC=C2)C(=O)C3=CNC4=CC=CC=C43)OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BQX9L2	2-Methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol	Investigative	25210756	C19H26N2O2	314.4	CC1=CC2=C(C=C1)NC(=C2)C(=O)N3CCC(CC3)CC(C)(C)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR02YQ	N-(3,4-Difluorophenyl)-6-(trifluoromethoxy)-1H-pyrazolo[4,3-b]pyridin-3-amine	Investigative	137637559	C13H7F5N4O	330.21	C1=CC(=C(C=C1NC2=NNC3=C2N=CC(=C3)OC(F)(F)F)F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR0D1Z	(1R,2R)-N-(1-Cyanocyclopropyl)-2-[4-(6,7-dihydro-4H-pyrano[4,3-d][1,3]thiazol-2-yl)piperazine-1-carbonyl]cyclohexane-1-carboxamide	Investigative	70280758	C22H29N5O3S	443.6	C1CC[C@H]([C@@H](C1)C(=O)NC2(CC2)C#N)C(=O)N3CCN(CC3)C4=NC5=C(S4)COCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR0F7J	1-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxymethyl]cyclopropane-1-carboxylic acid	Investigative	71181547	C30H32FN5O6	577.6	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CCC5=C6C(=NC=C5F)C=CC(=N6)OCC7(CC7)C(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR0U2L	(R)-Phenyl[(2R,5S)-5-(4-{[4-(pyridin-2-ylmethyl)piperazin-1-yl]carbonyl}benzyl)pyrrolidin-2-yl]methanol	Investigative	67972431	C29H34N4O2	470.6	C1C[C@@H](N[C@@H]1CC2=CC=C(C=C2)C(=O)N3CCN(CC3)CC4=CC=CC=N4)[C@@H](C5=CC=CC=C5)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR2YG7	[(3As,5S,6aR)-5-[(3-methoxyoxan-4-yl)-methylamino]-2,3,4,5,6,6a-hexahydrocyclopenta[b]furan-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	90656025	C24H32F3N3O4	483.5	CN([C@@H]1C[C@@H]2[C@](C1)(CCO2)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)C5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR46XN	4-Chloro-3-[4-(3-fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidine-1-carbonyl]benzenesulfonamide	Investigative	54581080	C35H39ClFN5O3S	664.2	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=C(C=CC(=C6)S(=O)(=O)N)Cl)C7=CC(=CC=C7)F	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR53FA	CID 49849007	Investigative	49849007	C32H29FN6O5	596.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=C(C=C(C=C6)C(=O)O)F	IC50 = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BR8HA0	2-Morpholin-4-yl-2-phenylethanol	Investigative	10899797	C12H17NO2	207.27	C1COCCN1C(CO)C2=CC=CC=C2	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BRFD05	6-(4-{(1S,2S)-2-Amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-YL]-3-oxopropyl}phenyl)-1H-[1,2,4]triazolo[1,5-A]pyridin-4-ium	Investigative	10320144	C22H25FN6O2	424.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CC[C@@H](C4)F)N	IC50 = 86000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BRL56D	5-Amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide	Investigative	49838879	C21H17FN6O3	420.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC(=O)C3=C(N(N=C3)C4=CC=CC=C4F)N	IC50 ~ 160000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BRN25W	[(2R,3Ar,6aR)-2-[[(3R,4R)-3-methoxyoxan-4-yl]amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71519381	C24H32F3N3O3	467.5	CO[C@H]1COCC[C@H]1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BRS1F5	3-[5-[2-Fluoro-5-(trifluoromethoxy)phenyl]-1-benzofuran-2-yl]propanoic acid	Investigative	134134229	C18H12F4O4	368.3	C1=CC2=C(C=C1C3=C(C=CC(=C3)OC(F)(F)F)F)C=C(O2)CCC(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BRT45S	7-((R)-3-((S)-1-(2-Cyanoethylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425436	C23H27FN4O3	426.5	CC1=C2C(=CC(=C1N3CC[C@H](C3)[C@H](C)NCCC#N)F)C(=O)C(=CN2C4CC4)C(=O)O	Ki = 72000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS0OT3	(4-Isopropylpiperazin-1-yl)(4-phenylpiperidin-1-yl)methanone	Investigative	44418498	C19H29N3O	315.5	CC(C)N1CCN(CC1)C(=O)N2CCC(CC2)C3=CC=CC=C3	IC50 = 52500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS0T5C	1-[4-[5-[[Deuterio-(3-nitrophenyl)methyl]amino]-7-(trifluoromethyl)quinolin-3-yl]piperazin-1-yl]ethanone	Investigative	90667609	C23H22F3N5O3	474.5	[2H]C(C1=CC(=CC=C1)[N+](=O)[O-])NC2=CC(=CC3=C2C=C(C=N3)N4CCN(CC4)C(=O)C)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS1YA4	[(8R)-3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-8-methyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-(4-fluorophenyl)methanone	Investigative	86274961	C17H17FN6O2	356.4	CCC1=NOC(=N1)C2=NN=C3N2CCN([C@@H]3C)C(=O)C4=CC=C(C=C4)F	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS4JI6	2-(Dimethylamino)-2-phenyl-1,1-di(pyridin-3-yl)ethanol	Investigative	11638319	C20H21N3O	319.4	CN(C)C(C1=CC=CC=C1)C(C2=CN=CC=C2)(C3=CN=CC=C3)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS53BW	4-Methoxy-2-fluorobenzylcyanide	Investigative	621620	C15H18O4	262.3	CC1C2C(CC3(C=CC(=O)C(=C3C2OC1=O)C)C)O	IC50 = 109647.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS5F6X	6-[[[1-[(9-Chloro-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl)methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728972	C26H25ClFN5O5	542	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CC5(CN6C(=O)C=C(C7=NC=C(C5=C76)F)Cl)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS6B3J	2-[8-[5-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]pyridin-2-yl]-1-oxa-8-azaspiro[4.5]decan-2-yl]acetic acid	Investigative	56603353	C23H23F3N4O3	460.4	C1CC2(CCN(CC2)C3=NC=C(C=C3)C4=NC5=C(N4)C=C(C=C5)C(F)(F)F)OC1CC(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS6WJ5	(S)-5-Oxo-5-(4-(pentyloxycarbonyl)piperazin-1-yl)-4-(6-phenyl-4-(4-(pyrrolidine-1-carbonyl)piperidin-1-yl)picolinamido)pentanoic acid	Investigative	46232900	C37H50N6O7	690.8	CCCCCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(=O)O)NC(=O)C2=CC(=CC(=N2)C3=CC=CC=C3)N4CCC(CC4)C(=O)N5CCCC5	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS8L1E	2-[[1-(2-Hydroxyethyl)-5-(trifluoromethyl)indazol-3-yl]amino]-N-[1-[4-(1,3-thiazol-2-yl)cyclohexyl]azetidin-3-yl]acetamide	Investigative	56659196	C24H29F3N6O2S	522.6	C1CC(CCC1C2=NC=CS2)N3CC(C3)NC(=O)CNC4=NN(C5=C4C=C(C=C5)C(F)(F)F)CCO	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS8OF3	Chembl4237498	Investigative	130454058	C27H35N3O4	465.6	C1CC2=C(NC1)N=C(C=C2)CC[C@@H]3CCN(C3)C[C@@H](CC(=O)O)C4=CC(=CC=C4)OC5COC5	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BS9EI1	Methyl [3-(Aminomethyl)-4-(2,4-Dichlorophenyl)-2-Methyl-7-Oxo-5,7-Dihydro-6h-Pyrrolo[3,4-B]pyridin-6-Yl]acetate	Investigative	15950538	C18H17Cl2N3O3	394.2	CC1=C(C(=C2CN(C(=O)C2=N1)CC(=O)OC)C3=C(C=C(C=C3)Cl)Cl)CN	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSA93H	4-Amino-N-(1-(4-chlorophenyl)-3-(dimethylamino)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	42602178	C23H30ClN7O	456	CN(C)CCC(C1=CC=C(C=C1)Cl)NC(=O)C2(CCN(CC2)C3=NC=NC4=C3C=CN4)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSB81O	4-Amino-5-cyano-6-ethoxy-N-[(4-methylsulfonylphenyl)methyl]pyridine-2-carboxamide	Investigative	11846124	C17H18N4O4S	374.4	CCOC1=C(C(=CC(=N1)C(=O)NCC2=CC=C(C=C2)S(=O)(=O)C)N)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSBD59	7-Methoxy-2-[[(2R)-2-methyl-4-(1-methylpyrazol-4-yl)piperazin-1-yl]methyl]-[1,2,4]triazolo[1,5-c]quinazolin-5-amine	Investigative	122182839	C20H25N9O	407.5	C[C@@H]1CN(CCN1CC2=NN3C(=N2)C4=C(C(=CC=C4)OC)N=C3N)C5=CN(N=C5)C	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSC75K	2-[(4-{2-[3-(2-Methyl-1H-benzimidazol-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]ethyl}-4-phenylpiperidin-1-yl)carbonyl]benzoic acid	Investigative	54585005	C36H40N4O3	576.7	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C6=CC=CC=C6C(=O)O)C7=CC=CC=C7	IC50 = 125892.54 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSE2H4	1-(4-Fluorophenyl)-3-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-ylpyrimidin-2-yl]phenyl]urea	Investigative	24804985	C23H24FN5O4S	485.5	CS(=O)(=O)CC1=CC(=NC(=N1)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)F)N4CCOCC4	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSE83Z	[(2R,3As,5R,6aS)-2-(dimethylamino)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517737	C26H37F3N4O3	510.6	CN(C)[C@@H]1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSEF80	Auglurant	Investigative	60168069	C16H12FN5O2	325.3	CC1=CC(=CC(=N1)C(=O)NC2=NC=C(C=C2)F)OC3=CN=CN=C3	IC50 = 73600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSKD90	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-4-methoxy-N-(5-methylpyridin-2-yl)butanamide	Investigative	57504325	C21H20ClN7O3	453.9	CC1=CN=C(C=C1)NC(=O)[C@H](CCOC)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSN6V9	7-(3-((2-Cyanoethylamino)methyl)-3-methylazetidin-1-yl)-1-cyclopropyl-6-fluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425441	C22H25FN4O3	412.5	CC1=C2C(=CC(=C1N3CC(C3)(C)CNCCC#N)F)C(=O)C(=CN2C4CC4)C(=O)O	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSR1P0	3-Ethyl-4-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-2-oxocyclopent-3-ene-1-carboxamide	Investigative	53321474	C25H35N3O5S	489.6	CCC1=C(CC(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C	IC50 = 74131.02 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSR43T	Schembl20719106	Investigative	49850345	C21H18N2O4	362.4	CC(C)C1(C(=O)NC(=O)O1)C2=CC=C(NC2=O)C3=CC4=CC=CC=C4C=C3	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSTK62	1-(((R)-3-Methyl-4-(4-((R)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclopropanecarboxamide	Investigative	44564565	C19H26F3N3O4S	449.5	C[C@@H]1CN(CCN1S(=O)(=O)C2=CC=C(C=C2)[C@](C)(C(F)(F)F)O)CC3(CC3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSU6G0	6-[[[(3S,4R)-3-Fluoro-1-[2-(2-oxo-7-pyridin-3-yloxy-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187108	C28H28FN7O4	545.6	C1CN(C[C@@H]([C@@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)F)CCN4C(=O)C=CC5=C4C=C(C=N5)OC6=CN=CC=C6	IC50 = 75000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSUH23	7-Ethyl-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118736659	C28H30FN5O5	535.6	CCC1=CC2=C(NC(=O)CO2)N=C1CNC34CCC(CC3)(OC4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSUR86	(2s,3s)-3-Amino-4-(3,3-Difluoropyrrolidin-1-Yl)-N,N-Dimethyl-4-Oxo-2-(trans-4-[1,2,4]triazolo[1,5-A]pyridin-6-Ylcyclohexyl)butanamide	Investigative	11554165	C22H30F2N6O2	448.5	CN(C)C(=O)[C@@H](C1CCC(CC1)C2=CN3C(=NC=N3)C=C2)[C@@H](C(=O)N4CCC(C4)(F)F)N	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSWP74	N-{4-[(S)-1-Amino-2-((R)-3-fluoro-pyrrolidin-1-yl)-2-oxo-ethyl]-cyclohexyl}-3,4-difluoro-benzamide	Investigative	44458573	C19H24F3N3O2	383.4	C1CN(C[C@@H]1F)C(=O)[C@H](C2CCC(CC2)NC(=O)C3=CC(=C(C=C3)F)F)N	Ki = 73000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BSZM83	CID 60199796	Investigative	60199796	C25H31N5O5	481.5	CO[C@H]1CN(CC[C@H]1NCC2=CC3=C(C=N2)OCCO3)CCN4C5=C(C=CC(=C5)OC)N=CC4=O	IC50 = 75000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT03WH	5-[[2-(4-Phenylphenyl)-2-adamantyl]methyl]-2H-tetrazole	Investigative	73213123	C24H26N4	370.5	C1C2CC3CC1CC(C2)C3(CC4=NNN=N4)C5=CC=C(C=C5)C6=CC=CC=C6	EC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT0O1I	6-[[[4-[(1R)-1-Amino-2-(7-fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118720932	C24H27FN6O3	466.5	C1CC(CCC1[C@H](CN2C(=O)C=CC3=C2C=C(C=N3)F)N)NCC4=NC5=C(C=C4)OCC(=O)N5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT13BX	6-[[[(3S,4R)-3-Methoxy-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	90644117	C25H30N6O5	494.5	CO[C@H]1CN(CC[C@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=N5)OC	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT1IK5	Bms-378806	Investigative	5495818	C22H22N4O4	406.4	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=NC=CC(=C23)OC)C(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT1Z6B	4-Amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	42602175	C22H27ClN6O2	442.9	C1CN(CCC1(C(=O)NC(CCCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4	IC50 = 57793 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT4IU6	4-((1R,3S)-3-Amino-2,2,3-trimethylcyclopentylamino)-6-(6-methoxypyridin-3-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide	Investigative	86707711	C22H28N6O2	408.5	C[C@@]1(CC[C@H](C1(C)C)NC2=C(C=NN3C2=CC(=C3)C4=CN=C(C=C4)OC)C(=O)N)N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT5BO8	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-[(2S)-1-hydroxypropan-2-yl]oxypropanamide	Investigative	57482815	C22H19ClN8O4	494.9	C[C@@H](CO)OC[C@@H](C(=O)NC1=NC=C(C=C1)C#N)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT5M9C	3-[1-(Oxan-4-yl)piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	16038385	C17H23N3O2	301.4	C1CN(CCC1N2C3=CC=CC=C3NC2=O)C4CCOCC4	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT8X3Y	9-Chloro-N-(2,4-difluorophenyl)-2,3,4,5-tetrahydro-3-methyl-3-ethyl-2,5-dioxo-1H-1,4-benzodiazepine-7-sulfonamide	Investigative	76322162	C18H16ClF2N3O4S	443.9	CCC1(C(=O)NC2=C(C=C(C=C2Cl)S(=O)(=O)NC3=C(C=C(C=C3)F)F)C(=O)N1)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT91NA	4-Amino-N-(1-(4-chlorophenyl)-3-(methylsulfonamido)propyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	57750312	C22H28ClN7O3S	506	CS(=O)(=O)NCCC(C1=CC=C(C=C1)Cl)NC(=O)C2(CCN(CC2)C3=NC=NC4=C3C=CN4)N	IC50 = 80124 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BT9E6B	4-[4-[1-(6-Methoxypyrimidin-4-yl)-8-[(3-methylpyridin-2-yl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-3-yl]phenyl]furan-2-carboxylic acid	Investigative	70688210	C30H28N6O6	568.6	CC1=C(N=CC=C1)CN2CCC3(CC2)C(=O)N(C(=O)N3C4=CC(=NC=N4)OC)C5=CC=C(C=C5)C6=COC(=C6)C(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTBC39	Chembl4279795	Investigative	145980764	C34H36N4O6S	628.7	C1CC1CN2CCN(CC2)CCCCOC3=CC=C(C=C3)N4C(=O)/C(=C/C5=CC=C(C=C5)OC6=CC=C(C=C6)[N+](=O)[O-])/SC4=O	IC50 = 55300 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTH0O4	(1R)-2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]-1-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethanol	Investigative	56643450	C24H28FN5O4	469.5	COC1=NC2=C(C(=CN=C2C=C1)F)[C@H](CN3CCC(CC3)NCC4=CC5=C(C=N4)OCCO5)O	IC50 = 79400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTI7F2	6-[[[(3R,4S)-3-Fluoro-1-[2-(7-fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	90644114	C23H24F2N6O3	470.5	C1CN(C[C@H]([C@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)F)CCN4C(=O)C=CC5=C4C=C(C=N5)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTK85P	CID 60202105	Investigative	60202105	C25H27N5O4	461.5	C1CN(C[C@H]([C@H]1NCC2=CC3=C(C=N2)OCCO3)O)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 156000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTM8F2	(1R)-1-[3-[4-(2,2,2-Trifluoroethylamino)cyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol	Investigative	67345882	C18H22F3N5O	381.4	C[C@H](C1=NC2=CN=C3C(=C2N1C4CCC(CC4)NCC(F)(F)F)C=CN3)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTS5B1	4-Amino-5-cyano-6-ethoxy-N-(pyridin-3-ylmethyl)pyridine-2-carboxamide	Investigative	11846126	C15H15N5O2	297.31	CCOC1=C(C(=CC(=N1)C(=O)NCC2=CN=CC=C2)N)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTV59H	2-Fluoro-4-[8-fluoro-3-(quinolin-6-ylmethyl)imidazo[1,2-a]pyridin-6-yl]-N-methylbenzamide	Investigative	122179442	C25H18F2N4O	428.4	CNC(=O)C1=C(C=C(C=C1)C2=CN3C(=CN=C3C(=C2)F)CC4=CC5=C(C=C4)N=CC=C5)F	IC50 = 93560 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTW2U7	1-Cyclohexyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60143412	C20H31N3O4S	409.5	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTX82S	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-cyanopyridin-2-yl)-3-(2-hydroxyethoxy)propanamide	Investigative	57504388	C21H17ClN8O4	480.9	C1=CC(=C(N=C1)N2C3=C(C=N2)C(=NC=N3)O[C@@H](COCCO)C(=O)NC4=NC=C(C=C4)C#N)Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTYI62	5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid	Investigative	49797115	C22H25F4N3O4	471.4	C[C@@H](C1=CC=C(C=C1)C2=CN(C(=O)C=C2)C)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTZ5U6	7-((R)-3-((S)-2-Cyano-1-(methylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	11166256	C22H25FN4O4	428.5	CN[C@@H](CC#N)[C@@H]1CCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BTZR53	N-{[1-(4-Hydroxy-4-[1,3,4]thiadiazol-2-yl-cyclohexyl)-azetidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide	Investigative	46241011	C21H24F3N5O3S	483.5	C1CC(CCC1N2CC(C2)NC(=O)CNC(=O)C3=CC(=CC=C3)C(F)(F)F)(C4=NN=CS4)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BU0S2K	N-[2-(Benzylamino)-2-oxoethyl]-4-(dimethylamino)-N-[6-(hydroxyamino)-6-oxohexyl]benzamide	Investigative	132585192	C24H32N4O4	440.5	CN(C)C1=CC=C(C=C1)C(=O)N(CCCCCC(=O)NO)CC(=O)NCC2=CC=CC=C2	IC50 = 50815.94 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BU6X8G	4-[1-(4-Hydroxyphenyl)-2-phenyl-1-butenyl]cinnamic acid	Investigative	9799518	C25H22O3	370.4	CC/C(=C(/C1=CC=C(C=C1)/C=C/C(=O)O)\\C2=CC=C(C=C2)O)/C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BU85LP	N-[(3S,4R)-4-(4-Thiophen-2-ylphenyl)oxolan-3-yl]propane-2-sulfonamide	Investigative	52946383	C17H21NO3S2	351.5	CC(C)S(=O)(=O)N[C@@H]1COC[C@@H]1C2=CC=C(C=C2)C3=CC=CS3	IC50 ~ 63000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BU90JW	6,7-Difluoro-4-[[1-[(5-chloro-1-methyl-1H-pyrazole-4-yl)carbonyl]-4-piperidinyl]amino]quinoline-2(1H)-one	Investigative	90644463	C19H18ClF2N5O2	421.8	CN1C(=C(C=N1)C(=O)N2CCC(CC2)NC3=CC(=O)NC4=CC(=C(C=C43)F)F)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUB17F	4-(2-Chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide	Investigative	24905400	C20H22ClN3O3	387.9	CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUCX89	3-[(2R)-2-Methylpiperidin-1-yl]-N-[[4-[[3-[(2R)-2-methylpiperidin-1-yl]propylamino]methyl]phenyl]methyl]propan-1-amine;hydrochloride	Investigative	71462364	C26H47ClN4	451.1	C[C@@H]1CCCCN1CCCNCC2=CC=C(C=C2)CNCCCN3CCCC[C@H]3C.Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUFJ68	Chembl4293085	Investigative	145988110	C17H11ClF4N4O4S2	510.9	C1=CC(=C(C=C1CNC(=O)C2=CC(=C(C=C2)S(=O)(=O)NC3=NC=NS3)F)Cl)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUJK89	(2S,3S)-1-(4-Methoxyphenyl)-3-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-4-oxoazetidine-2-carboxylic acid	Investigative	9983904	C30H28N2O6	512.6	CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=CC=C(C=C3)C[C@H]4[C@H](N(C4=O)C5=CC=C(C=C5)OC)C(=O)O	IC50 = 54000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUKO52	2-[[(2R)-2-Hydroxypropyl]amino]-1-[(1S)-8-methoxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-yl]ethanone	Investigative	25118805	C21H26N2O3	354.4	C[C@H](CNCC(=O)N1CCC2=C([C@@H]1C3=CC=CC=C3)C(=CC=C2)OC)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUQ5F8	6-[[[1-[[(3S)-5-Chloro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728975	C26H26ClN5O5	524	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)C[C@]5(CN6C(=O)C=CC7=NC=C(C5=C76)Cl)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUQY47	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127050762	C20H21F2N5O	385.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 97000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BURD31	cis-N-(3-Chlorobenzyl)-N-(-4-aminocyclohexyl)-1-methyl-1H-imidazole-4-carboxamide	Investigative	45272913	C18H23ClN4O	346.9	CN1C=C(N=C1)C(=O)N(CC2=CC(=CC=C2)Cl)C3CCC(CC3)N	IC50 = 65600 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUS6N3	(2s,3s)-1-(4-Methoxyphenyl)-3-(3-(2-(5-Methyl-2-Phenyloxazol-4-Yl)ethoxy)benzyl)-4-Oxoazetidine-2-Carboxylic Acid	Investigative	10391684	C30H28N2O6	512.6	CC1=C(N=C(O1)C2=CC=CC=C2)CCOC3=CC=CC(=C3)C[C@H]4[C@H](N(C4=O)C5=CC=C(C=C5)OC)C(=O)O	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUV24E	2-Cyclohexyl-6-[[(3S)-1-(2-methoxyethyl)piperidin-3-yl]methyl]-5-(2-methylpyridin-3-yl)pyrazolo[4,3-d]pyrimidin-7-one	Investigative	90666019	C26H36N6O2	464.6	CC1=C(C=CC=N1)C2=NC3=CN(N=C3C(=O)N2C[C@H]4CCCN(C4)CCOC)C5CCCCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BUV27B	(2S,3S)-2-Amino-4-cyclopropyl-3-[3-(2-fluoro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid	Investigative	11527019	C22H25F5N4O6S	568.5	CS(=O)(=O)C1=CC(=C(C=C1)C2=NOC(=N2)[C@@H](CC3CC3)[C@@H](C(=O)N4CC[C@@H](C4)F)N)F.C(=O)(C(F)(F)F)O	IC50 = 58500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV18AX	(1R)-1-[3-[(1S,3R)-3-(2,2,2-Trifluoroethylamino)cyclopentyl]-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl]ethanol	Investigative	71230234	C17H20F3N5O	367.4	C[C@H](C1=NC2=CN=C3C(=C2N1[C@H]4CC[C@H](C4)NCC(F)(F)F)C=CN3)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV18CO	2-Methyl-1-morpholino-1-phenylpropan-2-ol	Investigative	46885514	C14H21NO2	235.32	CC(C)(C(C1=CC=CC=C1)N2CCOCC2)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV20BS	6-[({1-[2-(6-Hydroxy-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl)amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	Investigative	15983810	C23H27N5O5	453.5	C1CN(CCC1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)COC5=C4C=C(C=C5)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV2L5J	(E)-3-(4-((7-Hydroxy-2-oxo-3-phenyl-2H-chromen-4-yl)methyl)phenyl)acrylic acid	Investigative	45275362	C25H18O5	398.4	C1=CC=C(C=C1)C2=C(C3=C(C=C(C=C3)O)OC2=O)CC4=CC=C(C=C4)/C=C/C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV3G9D	4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49796939	C25H26F5N3O6	559.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC(=C(C=C2)F)F)N)C(=O)NCC3=CC=C(C=C3)C(=O)O.C(=O)(C(F)(F)F)O	IC50 = 79000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV3OS6	Teixobactin	Investigative	86341926	C58H95N15O15	1242.5	CC[C@H](C)[C@H]1C(=O)O[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C[C@H]2CN=C(N2)N)C)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CC3=CC=CC=C3)NC)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV47MS	2-(2-Methoxypyrimidin-5-yl)-5-phenyl-N-(pyridin-2-ylmethyl)quinazolin-4-amine	Investigative	51030830	C25H20N6O	420.5	COC1=NC=C(C=N1)C2=NC3=CC=CC(=C3C(=N2)NCC4=CC=CC=N4)C5=CC=CC=C5	IC50 = 66000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV4JL2	4-[[1-(6-Cyanopyridazin-3-yl)piperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	Investigative	59291925	C18H18N8O	362.4	C1CN(CCC1NC2=C3C=CNC3=NC=C2C(=O)N)C4=NN=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV4TA0	4-[(2-(Pyrrolidin-1-yl)ethoxy)]benzenesulfonamide	Investigative	18971393	C12H18N2O3S	270.35	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV6GP9	[(2R,3Ar,6aR)-2-[(1,1-dioxothian-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71518571	C23H30F3N3O3S	485.6	C1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCS(=O)(=O)CC5	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV7H2F	3-Ethyl-5-[(1R,3R)-3-[5-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl]-1-(1-methylpyrazol-4-yl)-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]-1,3,4-oxadiazol-2-one	Investigative	122179475	C27H24FN9O2	525.5	CCN1C(=O)OC(=N1)[C@]2(C3=C(C[C@@H](N2)C4=NC=C(N4)C5=NC=C(C=C5)F)C6=CC=CC=C6N3)C7=CN(N=C7)C	IC50 = 51500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV7Q2F	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796955	C29H31F8N3O7	685.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C(=C(C(=C3F)F)F)F)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV87DY	[(2S,3As,5R,6aS)-2-methoxy-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517575	C25H34F3N3O4	497.5	CO[C@H]1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV8O0D	2-Amino-4-[3-(methylamino)azetidin-1-yl]pyrido[3,2-d]pyrimidine-7-carbonitrile	Investigative	71525587	C12H13N7	255.28	CNC1CN(C1)C2=NC(=NC3=C2N=CC(=C3)C#N)N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV91JA	N,N-Diethyl-6-(spiro[chromene-2,4''-piperidine]-4-yl)nicotinamide	Investigative	44254061	C23H27N3O2	377.5	CCN(CC)C(=O)C1=CN=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC=C42	IC50 = 71666 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BV9HF7	6-[[[4-[(1S)-1-Amino-2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]cyclohexyl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	46205018	C25H30N6O4	478.5	COC1=CC2=C(C=CC(=O)N2C[C@H](C3CCC(CC3)NCC4=NC5=C(C=C4)OCC(=O)N5)N)N=C1	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVF21L	Chembl4279819	Investigative	118911481	C16H18N6O	310.35	CN([C@H]1CN(CC12CC2)C(=O)CC#N)C3=NC=NC4=C3C=CN4	IC50 = 120000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVFI70	(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-methoxy-N-(5-methylpyridin-2-yl)propanamide	Investigative	57504248	C21H19ClN6O3	438.9	CC1=CN=C(C=C1)NC(=O)[C@H](COC)OC2=NC=NC3=C2C=NN3C4=CC=CC=C4Cl	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVG92D	(2R)-2-(5-Fluoropyridin-2-yl)-2-{[3-(5-isopropoxy-1H-pyrazol-3-yl)-3H-imidazo[4,5-b]pyridin-5-yl]amino}ethanol	Investigative	25116186	C19H20FN7O2	397.4	CC(C)OC1=NNC(=C1)N2C=NC3=C2N=C(C=C3)N[C@@H](CO)C4=NC=C(C=C4)F	IC50 = 52000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVGY31	2-(4-Methoxyphenyl)-6-methyl-4H-chromen-4-one	Investigative	688682	C17H14O3	266.29	CC1=CC2=C(C=C1)OC(=CC2=O)C3=CC=C(C=C3)OC	IC50 = 57900 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVJY26	7-((R)-3-((S)-1-(2-Cyanoethylamino)ethyl)pyrrolidin-1-yl)-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	44425434	C23H28N4O4	424.5	C[C@@H]([C@@H]1CCN(C1)C2=C(C3=C(C=C2)C(=O)C(=CN3C4CC4)C(=O)O)OC)NCCC#N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVUK96	N-[[4,4-Difluoro-1-(4-propylsulfonylpiperazin-1-yl)cyclohexyl]methyl]-2,6-difluorobenzamide	Investigative	71582799	C21H29F4N3O3S	479.5	CCCS(=O)(=O)N1CCN(CC1)C2(CCC(CC2)(F)F)CNC(=O)C3=C(C=CC=C3F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BVZ0O7	Chembl4207711	Investigative	145978628	C14H18N2OS	262.37	C[C@H]1C[C@H]2CSC(=N[C@]2(CO1)C3=CC=CC=C3)N	IC50 = 85700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW05BP	N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid	Investigative	49797347	C26H29F5N4O5	572.5	CN(C)C(=O)[C@@H](C1=CC=C(C=C1)N(C)C(=O)C2=CC=C(C=C2)F)[C@@H](C(=O)N3CC[C@@H](C3)F)N.C(=O)(C(F)(F)F)O	IC50 ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW08RB	4-[(5-Methyl-1,2,4-oxadiazol-3-yl)methoxy]-5-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-2-amine	Investigative	121401335	C16H15N7O2	337.34	CC1=NC(=NO1)COC2=NC(=NC3=C2N(C=C3)CC4=CC=CC=N4)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW1F2E	(2S)-2-[1-(2-Chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-3-(3-hydroxyazetidin-1-yl)-N-pyridin-2-ylpropanamide	Investigative	57504447	C22H20ClN7O3	465.9	C1C(CN1C[C@@H](C(=O)NC2=CC=CC=N2)OC3=NC=NC4=C3C=NN4C5=CC=CC=C5Cl)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW2GC4	N-(2,3-Difluorophenyl)-2-[4-[[6-[3-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]propoxy]phthalazin-1-yl]amino]pyrazol-1-yl]acetamide	Investigative	44447872	C27H29F2N7O3	537.6	C1C[C@@H](N(C1)CCCOC2=CC3=CN=NC(=C3C=C2)NC4=CN(N=C4)CC(=O)NC5=C(C(=CC=C5)F)F)CO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW43IY	4-[[1-(5-Cyanopyrazin-2-yl)piperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	Investigative	59292008	C18H18N8O	362.4	C1CN(CCC1NC2=C3C=CNC3=NC=C2C(=O)N)C4=NC=C(N=C4)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW76OD	7-Cyclopropyl-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrido[3,2-d]pyrimidin-2-amine	Investigative	71525680	C15H20N6	284.36	CN[C@@H]1CCN(C1)C2=NC(=NC3=C2N=CC(=C3)C4CC4)N	Ki ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW7ZE2	6-[[[(3S,4R)-3-Fluoro-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	90644115	C24H27FN6O4	482.5	COC1=CC2=C(C=CC(=O)N2CCN3CC[C@H]([C@H](C3)F)NCC4=NC5=C(C=C4)OCC(=O)N5)N=C1	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BW9U0Q	Plerixafor Octahydrochloride	Investigative	65014	C28H62Cl8N8	794.5	C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWC3D6	[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2-propan-2-yl-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	76325121	C26H37F3N4O3	510.6	CC(C)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWD10R	(2S)-2-[4-[[4-(4-Chlorophenoxy)piperidin-1-yl]methyl]piperidin-1-yl]-3-(4-fluorophenyl)propanoic acid	Investigative	71451390	C26H32ClFN2O3	475	C1CN(CCC1CN2CCC(CC2)OC3=CC=C(C=C3)Cl)[C@@H](CC4=CC=C(C=C4)F)C(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWEA15	5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-c]pyridin-6-yl)pyrazin-2-amine	Investigative	45482763	C20H25N7S	395.5	C1CCN(CC1)C2CCN(CC2)C3=NC4=CN=C(C=C4S3)C5=CN=C(C=N5)N	IC50 = 132857.14 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWG51C	1-[3-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-3,4-dihydro-1,6-naphthyridin-2-one	Investigative	62705173	C23H27N5O2	405.5	C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCN4C(=O)CCC5=C4C=CN=C5	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWIH49	4-{4-[1-(Methylsulfonyl)cyclopropyl]-6-morpholin-4-ylpyrimidin-2-yl}-1H-indole	Investigative	46244173	C20H22N4O3S	398.5	CS(=O)(=O)C1(CC1)C2=CC(=NC(=N2)C3=C4C=CNC4=CC=C3)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWN2Z7	(1R)-2-[2-(1-Hydroxycyclohexylmethylamino)acetyl]-1,2,3,4-tetrahydro-1-isopropyl-6-methoxyisoquinoline	Investigative	122182156	C22H34N2O3	374.5	CC(C)[C@@H]1C2=C(CCN1C(=O)CNCC3(CCCCC3)O)C=C(C=C2)OC	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWNC97	(E)-1-[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrol-2-yl]-4,4-dimethylpent-2-en-1-one	Investigative	72948004	C30H41F3N4O4	578.7	CC(C)(C)/C=C/C(=O)N1C[C@@H]2C[C@H](C[C@@]2(C1)C(=O)N3CCC4=C(C3)C=C(C=N4)C(F)(F)F)NC5CCOCC5OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWP29B	(4-Ethylsulfonylpiperidin-1-yl)-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]methanone	Investigative	127041559	C26H34N2O4S	470.6	CCS(=O)(=O)C1CCN(CC1)C(=O)C2=CC=C(C=C2)C[C@@H]3CC[C@@H](N3)[C@@H](C4=CC=CC=C4)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWP7H6	CID 72946008	Investigative	72946008	C30H42F3N5O6	625.7	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OCCN6CCOCC6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWQ5E3	Chembl4243367	Investigative	145983050	C28H35N5O2	473.6	CC1=CC=NN1C2=CC=CC(=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWQJ28	5-[(3R,9Ar)-8-[2-[6-(tetrazol-1-yl)pyridin-3-yl]acetyl]-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-3-yl]-4-methyl-3H-2-benzofuran-1-one	Investigative	71604125	C24H25N7O4	475.5	CC1=C(C=CC2=C1COC2=O)[C@@H]3CN4CCN(C[C@@H]4CO3)C(=O)CC5=CN=C(C=C5)N6C=NN=N6	IC50 = 59400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWTS25	1-(4-Acetylphenyl)-3-[4-(3-piperidin-1-ylpropoxy)phenyl]sulfonylurea	Investigative	60144089	C23H29N3O5S	459.6	CC(=O)C1=CC=C(C=C1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCN3CCCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWU09V	6-[[[1-[[(3R)-5-Fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-7-methyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118736658	C27H28FN5O5	521.5	CC1=CC2=C(NC(=O)CO2)N=C1CNC34CCC(CC3)(OC4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BWY59Q	(3R)-3-[[4-[(1,1-Dioxo-2,3-dihydro-[1,4]oxathiino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736674	C26H27FN4O6S	542.6	C1CC2(CCC1(CO2)NCC3=CC4=C(C=N3)OCCS4(=O)=O)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX0L3N	4-[[(3R,4S)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide	Investigative	59291951	C19H18FN7O	379.4	C1CN(C[C@H]([C@H]1NC2=C3C=CNC3=NC=C2C(=O)N)F)C4=NC=C(C=C4)C#N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX0PI7	(S)-2-Amino-2-cyclohexyl-1-((R)-3-fluoro-pyrrolidin-1-yl)-ethanone	Investigative	44458603	C12H21FN2O	228.31	C1CCC(CC1)[C@@H](C(=O)N2CC[C@H](C2)F)N	Ki ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX1K0I	6-[[[1-[[(3R)-3-Hydroxy-5-methoxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728976	C27H29N5O6	519.5	COC1=CN=C2C=CC(=O)N3C2=C1[C@@](C3)(CC45CCC(CC4)(CO5)NCC6=NC7=C(C=C6)OCC(=O)N7)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX2L3D	6-{[(1-{2-[6-(Methylsulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)amino]methyl}-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one	Investigative	15982149	C24H29N5O6S	515.6	CS(=O)(=O)C1=CC2=C(C=C1)OCC(=O)N2CCN3CCC(CC3)NCC4=NC5=C(C=C4)OCC(=O)N5	IC50 = 50700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX2S4R	Methyl 8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylate	Investigative	592280	C10H15NO2	181.23	CN1C2CCC1C(=CC2)C(=O)OC	IC50 = 169824.37 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX3Z9S	Piperazine, 4-benzoyl-1-(1,2-dioxo-2-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-2-methyl-, (2R)-	Investigative	5495793	C21H20N4O3	376.4	C[C@@H]1CN(CCN1C(=O)C(=O)C2=CNC3=C2C=CC=N3)C(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX4SG8	N-(1-(3-Acetamidobenzyl)piperidin-4-yl)-7-fluoro-4-oxo-4H-chromene-2-carboxamide	Investigative	44417938	C24H24FN3O4	437.5	CC(=O)NC1=CC=CC(=C1)CN2CCC(CC2)NC(=O)C3=CC(=O)C4=C(O3)C=C(C=C4)F	IC50 = 60700 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX4T2I	(3Ar,5R,6aR)-N-benzyl-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxamide	Investigative	72948000	C31H38F3N5O4	601.7	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)NCC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX52NI	6-[[[(3R,4S)-3-Fluoro-1-[2-(7-methoxy-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	90644116	C24H27FN6O4	482.5	COC1=CC2=C(C=CC(=O)N2CCN3CC[C@@H]([C@@H](C3)F)NCC4=NC5=C(C=C4)OCC(=O)N5)N=C1	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX5LT7	Mavelertinib	Investigative	91668194	C18H22FN9O2	415.4	CN1C=C(C(=N1)OC)NC2=C3C(=NC(=N2)N4C[C@H]([C@@H](C4)F)NC(=O)C=C)N(C=N3)C	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX67ZK	(E)-1-[4-[5-[(3-Nitrophenyl)methylamino]-7-(trifluoromethyl)quinolin-3-yl]piperazin-1-yl]-3-[(2S)-pyrrolidin-2-yl]prop-2-en-1-one	Investigative	90667423	C28H29F3N6O3	554.6	C1C[C@H](NC1)/C=C/C(=O)N2CCN(CC2)C3=CC4=C(C=C(C=C4NCC5=CC(=CC=C5)[N+](=O)[O-])C(F)(F)F)N=C3	IC50 = 86200 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX84UK	(3S)-3-[[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]methyl]-5-fluoro-3-hydroxy-1,9-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12),9-tetraen-11-one	Investigative	73356819	C24H26FN5O4	467.5	C1CN(CCC1NCC2=CC3=C(C=N2)OCCO3)C[C@@]4(CN5C(=O)C=NC6=C5C4=C(C=C6)F)O	IC50 = 101000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX8LI9	Chembl4215407	Investigative	130282633	C26H30N4O6S	526.6	CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)S(=O)(=O)N(C)C4(CN(C4)C(=O)C(C)C)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX8Y9T	8-[2-[4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)piperidin-1-yl]ethyl]-2-methoxypteridin-7-one	Investigative	25024304	C22H27N7O4	453.5	COC1=NC=C2C(=N1)N(C(=O)C=N2)CCN3CCC(CC3)NCC4=CC5=C(C=N4)OCCO5	IC50 = 81000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BX94GO	6-[[[1-[[(3R)-5-Fluoro-3-hydroxy-9-methyl-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118728970	C27H28FN5O5	521.5	CC1=CC(=O)N2C[C@](C3=C2C1=NC=C3F)(CC45CCC(CC4)(CO5)NCC6=NC7=C(C=C6)OCC(=O)N7)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXA35U	1-Cyclohexyl-3-[4-(4-pyrrolidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143757	C21H33N3O4S	423.6	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCCCN3CCCC3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXCB18	(3S)-N-Hydroxy-3-[4-[4-(methylcarbamoyl)phenoxy]phenyl]sulfonyl-8-azaspiro[4.5]decane-3-carboxamide	Investigative	118734985	C24H29N3O6S	487.6	CNC(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)[C@]3(CCC4(C3)CCNCC4)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXE5L8	(2S)-2-[1-(3-Chloropyridin-2-yl)pyrazolo[3,4-d]pyrimidin-4-yl]oxy-N-(5-fluoropyridin-2-yl)-3-propan-2-yloxypropanamide	Investigative	57504363	C21H19ClFN7O3	471.9	CC(C)OC[C@@H](C(=O)NC1=NC=C(C=C1)F)OC2=NC=NC3=C2C=NN3C4=C(C=CC=N4)Cl	IC50 = 79432.82 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXE64S	5-[[[(3S,4R)-3-Fluoro-1-[2-(7-fluoro-2-oxo-1,5-naphthyridin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-2-methylpyridine-3-carbonitrile	Investigative	90644110	C23H24F2N6O	438.5	CC1=C(C=C(C=N1)CN[C@@H]2CCN(C[C@@H]2F)CCN3C(=O)C=CC4=C3C=C(C=N4)F)C#N	IC50 = 133000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXI93V	(S)-2-Amino-2-cyclohexyl-1-(3,3-difluoro-pyrrolidin-1-yl)-ethanone	Investigative	44458617	C12H20F2N2O	246.3	C1CCC(CC1)[C@@H](C(=O)N2CCC(C2)(F)F)N	Ki ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXIB96	[(2R,3Ar,6aR)-2-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71518574	C24H32F3N3O3	467.5	COC1COCCC1N[C@@H]2C[C@H]3CCC[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXIU60	CID 57780007	Investigative	57780007	C35H48N4O3	572.8	CCC1=CC(=C2C(=C1)C=CC(=N2)CCC(=O)O)N3CCN(CC3)CCC4=CC=C(C=C4)OCCCN5CCCCCC5	IC50 = 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXJ3P2	N,N-Diethyl-4-(7-hydroxyspiro[chromene-2,4''-piperidine]-4-yl)benzamide	Investigative	25129780	C24H28N2O3	392.5	CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C=CC(=C4)O	IC50 = 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXQF25	CID 59472858	Investigative	59472858	C24H22F3N7O2	497.5	CC1=CN(C=N1)C2=C(C=C(C=C2)C3=CN(N=N3)C4CCC5=C(C=CC=N5)N(C4=O)CC(F)(F)F)OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXRO73	4-Cyclopropyl-N-(5-hydroxy-2-adamantyl)-2-morpholin-4-ylpyrimidine-5-carboxamide	Investigative	57916503	C22H30N4O3	398.5	C1CC1C2=NC(=NC=C2C(=O)NC3C4CC5CC3CC(C5)(C4)O)N6CCOCC6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXS9L4	1-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60145633	C20H22F3N3O4S	457.5	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXSB03	3-[4-(3-Fluorophenyl)-4-[2-[3-(2-methylbenzimidazol-1-yl)-8-azabicyclo[3.2.1]octan-8-yl]ethyl]piperidin-1-yl]-2,2-dimethyl-3-oxopropanoic acid	Investigative	54580083	C33H41FN4O3	560.7	CC1=NC2=CC=CC=C2N1C3CC4CCC(C3)N4CCC5(CCN(CC5)C(=O)C(C)(C)C(=O)O)C6=CC(=CC=C6)F	IC50 = 56234.13 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXT5C8	1-Spiro[6H-benzo[b][1]benzoxepine-5,3'-cyclopentane]-1'-ylazetidine-3-carboxylic acid	Investigative	25184832	C22H23NO3	349.4	C1CC2(CC1N3CC(C3)C(=O)O)CC4=CC=CC=C4OC5=CC=CC=C25	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXU49V	Methyl (3aR,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-3a-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carbonyl]-1,3,4,5,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate	Investigative	72945830	C25H33F3N4O5	526.5	COC1COCCC1N[C@@H]2C[C@H]3CN(C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)C(=O)OC	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BXZ92E	7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimido[1,2-b]pyridazin-2-one;2,2,2-trifluoroacetic acid	Investigative	23661716	C20H17F6N5O3	489.4	C1CN(C[C@@H]([C@H]1C2=CC(=C(C=C2F)F)F)N)C3=NN4C=CC(=O)N=C4C=C3.C(=O)(C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BY06HG	CID 15950542	Investigative	15950542	C17H17Cl2N3O2	366.2	CC1=C(C(=C2CN(C(=O)C2=N1)CCO)C3=C(C=C(C=C3)Cl)Cl)CN	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BY2A3O	CID 57750369	Investigative	57750369	C26H34ClN7O2	512	C1CN(CCC1(C(=O)NC(CCCN2CCOCC2)C3=CC=C(C=C3)Cl)N)C4=NC=NC5=C4C=CN5	IC50 = 74807 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BY34KE	4-[5-[5-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydroindol-1-yl]-4-oxobutanoic acid	Investigative	44547414	C22H15F6N3O4	499.4	C1CN(C2=C1C=C(C=C2)C3=NOC(=N3)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C(=O)CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BY3MN8	6-[[[(3S,4R)-3-Fluoro-1-[2-[7-(1,2-oxazol-3-yloxy)-2-oxo-1,5-naphthyridin-1-yl]ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	122187107	C26H26FN7O5	535.5	C1CN(C[C@@H]([C@@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)F)CCN4C(=O)C=CC5=C4C=C(C=N5)OC6=NOC=C6	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BY4AD3	Chembl4242263	Investigative	121245346	C33H44N6O3	572.7	CC1=CC(=NN1C2=CC(=CC(=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4)N6CCOCC6)C	IC50 ~ 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BY96JX	Chembl4249629	Investigative	121246727	C29H37N5O2	487.6	CC1=C(N=C(N1)C)C2=CC(=CC=C2)[C@H](CC(=O)O)CN3CC[C@H](C3)CCC4=NC5=C(CCCN5)C=C4	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYD5V1	5-(2-(1,4''-Bipiperidin-1''-yl)thiazolo[4,5-c]pyridin-6-yl)pyridin-2-ol	Investigative	45482728	C21H25N5OS	395.5	C1CCN(CC1)C2CCN(CC2)C3=NC4=CN=C(C=C4S3)C5=CNC(=O)C=C5	IC50 = 190000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYFV19	N-[6-(Trifluoromethyl)pyridine-3-yl]-2-(trifluoromethyl)benzenesulfonamide	Investigative	118917669	C13H8F6N2O2S	370.27	C1=CC=C(C(=C1)C(F)(F)F)S(=O)(=O)NC2=CN=C(C=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYH96F	Schembl21622451	Investigative	137628639	C23H21Cl2NO5	462.3	CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)/C=C/C4=C(C=CC=C4Cl)Cl)O)O	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYI3J5	1-[4-Chloro-3-(1-ethylpiperidin-4-yl)sulfonyl-2-hydroxyphenyl]-3-(2-chloro-3-fluorophenyl)urea	Investigative	127049048	C20H22Cl2FN3O4S	490.4	CCN1CCC(CC1)S(=O)(=O)C2=C(C=CC(=C2O)NC(=O)NC3=C(C(=CC=C3)F)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYI7G8	(3R)-5-Fluoro-3-hydroxy-3-[[4-(1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-6-ylmethylamino)-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736762	C26H29FN6O3	492.5	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)NCCN4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYJ1X3	4-Amino-N-[1-(3,4-dimethoxyphenyl)ethyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	71583051	C22H28N6O3	424.5	CC(C1=CC(=C(C=C1)OC)OC)NC(=O)C2(CCN(CC2)C3=NC=NC4=C3C=CN4)N	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYO9F4	3-[2-[5-(3-Chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]-3-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-5-yl]propanoic acid	Investigative	49848557	C21H24ClN5O3S	462	CC1=C2CN(CCC2=NN1C3=NN=C(S3)C4=CC(=C(C=C4)OC(C)C)Cl)CCC(=O)O	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYP9A1	4-[(5-Methyl-1,3-oxazol-2-yl)methoxy]-5-(pyridin-2-ylmethyl)pyrrolo[3,2-d]pyrimidin-2-amine	Investigative	121401340	C17H16N6O2	336.3	CC1=CN=C(O1)COC2=NC(=NC3=C2N(C=C3)CC4=CC=CC=N4)N	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYS87U	4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfinylimidazol-4-yl]pyridin-2-amine	Investigative	137652270	C16H15FN4OS	330.4	CN1C(=C(N=C1S(=O)C)C2=CC=C(C=C2)F)C3=CC(=NC=C3)N	IC50 = 83000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYX5V9	2-[4-[2-[(1S,2R)-2-[1-(5-Chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]phenyl]-N-cyclopropylacetamide	Investigative	89583782	C25H31ClN4O2	455	C1CC1NC(=O)CC2=CC=C(C=C2)OCC[C@@H]3C[C@@H]3C4CCN(CC4)C5=NC=C(C=N5)Cl	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BYZ8B1	N-Isopropyl-4-oxo-1-phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide	Investigative	44588591	C18H17N3O2	307.3	CC(C)NC(=O)C1=CN(C2=C(C1=O)C=CC=N2)C3=CC=CC=C3	IC50 = 71500 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ0CF3	1-[4-(3-Pyrrolidin-1-ylpropoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60143414	C21H24F3N3O4S	471.5	C1CCN(C1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ0I6V	4-(2-Cyclopropyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzenesulfonamide	Investigative	24985115	C18H19N3O3S	357.4	C1CC1C2=CC3=C(C=CN=C3N2)C4=CC=C(C=C4)S(=O)(=O)NCCO	IC50 ~ 50118.72 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ1EH6	[(3Ar,5R,6aR)-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	72947593	C23H31F3N4O3	468.5	COC1COCCC1N[C@@H]2C[C@H]3CNC[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ2W7D	1-[2-((3R,4R)-3-Methoxy-4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}piperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile	Investigative	25008941	C26H28N6O4	488.5	CO[C@@H]1CN(CC[C@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C(=O)C=CC5=C4C=C(C=C5)C#N	IC50 = 124000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ31OF	[(2S,3As,5R,6aS)-2-chloro-5-[(3-methoxyoxan-4-yl)amino]-2,3,4,5,6,6a-hexahydro-1H-pentalen-3a-yl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone	Investigative	71517242	C24H31ClF3N3O3	502	COC1COCCC1N[C@@H]2C[C@H]3C[C@@H](C[C@]3(C2)C(=O)N4CCC5=C(C4)C=C(C=N5)C(F)(F)F)Cl	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ83WK	N-((S)-1-((1S,2R,4R)-4-(Isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexyl)-2-oxopyrrolidin-3-yl)benzamide	Investigative	46886537	C28H37N3O4S	511.7	CC(C)N(C)[C@@H]1CC[C@@H]([C@@H](C1)CS(=O)(=O)C2=CC=CC=C2)N3CC[C@@H](C3=O)NC(=O)C4=CC=CC=C4	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ8M4D	(R)-(4-(1-Amino-2-(2,4,5-trifluorophenyl)ethyl)piperidin-1-yl)(2,5-dimethylpyrimidin-4-yl)methanone	Investigative	44591848	C20H23F3N4O	392.4	CC1=CN=C(N=C1C(=O)N2CCC(CC2)[C@@H](CC3=CC(=C(C=C3F)F)F)N)C	IC50 = 85000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZ9W7S	3-[4-(1-Azetidinylcarbonyl)phenoxy]-5-[(1S)-2-hydroxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-benzamide	Investigative	11604824	C24H26N4O5	450.5	C[C@@H](CO)OC1=CC(=CC(=C1)OC2=CC=C(C=C2)C(=O)N3CCC3)C(=O)NC4=NN(C=C4)C	IC50 = 70000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZA6N0	1-Phenyl-3-[4-(4-piperidin-1-ylbutoxy)phenyl]sulfonylurea	Investigative	60143761	C22H29N3O4S	431.6	C1CCN(CC1)CCCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZB1N8	1-[2-[(3S,4S)-4-(2,3-Dihydro-[1,4]dioxino[2,3-c]pyridin-7-ylmethylamino)-3-fluoropiperidin-1-yl]ethyl]-7-methoxyquinoxalin-2-one	Investigative	60201948	C24H28FN5O4	469.5	COC1=CC2=C(C=C1)N=CC(=O)N2CCN3CC[C@@H]([C@H](C3)F)NCC4=CC5=C(C=N4)OCCO5	IC50 = 75000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZD0E2	(R)-(4-(1-Amino-2-(2,4,5-trifluorophenyl)ethyl)piperidin-1-yl)(imidazo[1,2-a]pyrimidin-3-yl)methanone	Investigative	44591850	C20H20F3N5O	403.4	C1CN(CCC1[C@@H](CC2=CC(=C(C=C2F)F)F)N)C(=O)C3=CN=C4N3C=CC=N4	IC50 = 59000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZH4J7	N-(6-Chloropyridin-3-yl)-6-(trifluoromethyl)-1H-indazol-3-amine	Investigative	9883254	C13H8ClF3N4	312.68	C1=CC2=C(C=C1C(F)(F)F)NN=C2NC3=CN=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZJ57E	7-Chloro-6-[[[1-[[(3R)-5-fluoro-3-hydroxy-11-oxo-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-3-yl]methyl]-2-oxabicyclo[2.2.2]octan-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-one	Investigative	118736657	C26H25ClFN5O5	542	C1CC2(CCC1(CO2)NCC3=C(C=C4C(=N3)NC(=O)CO4)Cl)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 = 126000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZK1N0	Chembl4207042	Investigative	118868365	C20H19F5N4O4	474.4	CNC(=O)C1=CC(=C(N=C1)N)O[C@H]2CN(CC2(F)F)C(=O)CC3=CC=C(C=C3)OC(F)(F)F	IC50 = 79000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZK6N8	(S)-2-Amino-2-cyclohexyl-1-((S)-3-fluoro-pyrrolidin-1-yl)-ethanone	Investigative	44458594	C12H21FN2O	228.31	C1CCC(CC1)[C@@H](C(=O)N2CC[C@@H](C2)F)N	Ki ~ 90000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZKF02	3-(4-Methylpiperazin-1-yl)-N-(quinolin-7-ylmethyl)-7-(trifluoromethyl)quinolin-5-amine	Investigative	90667603	C25H24F3N5	451.5	CN1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC5=C(C=CC=N5)C=C4)C(F)(F)F)N=C2	IC50 = 75800 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZL13E	CID 60201425	Investigative	60201425	C25H30N6O5	494.5	CO[C@H]1CN(CC[C@H]1NCC2=NC3=C(C=C2)OCC(=O)N3)CCN4C5=C(C=CC(=C5)OC)N=CC4=O	IC50 = 88000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZP8D9	(3R)-3-[[4-[(8-Chloro-2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]methyl]-5-fluoro-3-hydroxy-1,7-diazatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraen-11-one	Investigative	118736671	C26H26ClFN4O5	529	C1CC2(CCC1(CO2)NCC3=NC=C4C(=C3Cl)OCCO4)C[C@@]5(CN6C(=O)C=CC7=NC=C(C5=C76)F)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZQJ02	4-[[7-Fluoro-8-[2-[4-[(3-oxo-4H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino]-2-oxabicyclo[2.2.2]octan-1-yl]ethyl]-1,5-naphthyridin-2-yl]oxy]butanoic acid	Investigative	71153003	C29H32FN5O6	565.6	C1CC2(CCC1(CO2)NCC3=NC4=C(C=C3)OCC(=O)N4)CCC5=C6C(=NC=C5F)C=CC(=N6)OCCCC(=O)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZR7M8	(3R,3'S)-N-Cyclopropyl-5,6-difluoro-N-(isoquinolin-1-ylmethyl)spiro[1H-2-benzofuran-3,4'-piperidine]-3'-carboxamide	Investigative	57396097	C26H25F2N3O2	449.5	C1CC1N(CC2=NC=CC3=CC=CC=C32)C(=O)[C@H]4CNCC[C@]45C6=CC(=C(C=C6CO5)F)F	Ki ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZS3J7	1-[(1R)-1-Cyclohexyl-3,4-dihydro-1H-isoquinolin-2-yl]-2-[(1-hydroxycyclohexyl)methylamino]ethanone	Investigative	59396594	C24H36N2O2	384.6	C1CCC(CC1)[C@@H]2C3=CC=CC=C3CCN2C(=O)CNCC4(CCCCC4)O	IC50 = 76000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZS61A	4-[3-[4-(2-Oxo-1H-imidazo[4,5-c]pyridin-3-yl)piperidin-1-yl]propyl]-1,4-benzoxazin-3-one	Investigative	62705331	C22H25N5O3	407.5	C1CN(CCC1N2C3=C(C=CN=C3)NC2=O)CCCN4C(=O)COC5=CC=CC=C54	IC50 ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZU37R	7-((R)-3-((S)-1-Aminoethyl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	Investigative	10000396	C20H24FN3O4	389.4	C[C@@H]([C@@H]1CCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F)N	Ki = 85000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	BZYP13	(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796953	C29H34F5N3O7	631.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)CC(CC3=C(C=CC(=C3)F)F)N.C(=O)(C(F)(F)F)O	IC50 = 76000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D00WKK	2-morpholino-2-phenyl-1,1-di(pyridin-3-yl)ethanol	Investigative	11710246	C22H23N3O2	361.4	C1COCCN1C(C2=CC=CC=C2)C(C3=CN=CC=C3)(C4=CN=CC=C4)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D02TSN	AZ20	Investigative	46244454	C21H24N4O3S	412.5	C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4	IC50 = 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D04QDB	ABT-341	Investigative	49797177	C21H18F9N5O3	559.4	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C3=CC[C@@H]([C@H](C3)N)C4=CC(=C(C(=C4)F)F)F.C(=O)(C(F)(F)F)O	Ki ~ 50000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D06BMZ	2-morpholino-1,1,2-triphenylethanol	Investigative	46885513	C24H25NO2	359.5	C1COCCN1C(C2=CC=CC=C2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O	IC50 ~ 65000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D06GGT	MCL-1-specific antisense oligonucleotide + nilotinib (AMN107)	Investigative	644241	C28H22F3N7O	529.5	CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5	IC50 = 63095.73 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D06HOI	BMS-269223	Investigative	44249821	C23H28N6O3	436.5	CC1=CC2=C(O1)C=CC(=C2)NC(=N[C@H]3CCCCN(C3=O)CC(=O)N4CCCC4)NC#N	IC50 ~ 80000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D08TBU	Diphenyl(piperidin-4-yl)methanol	Investigative	15723	C18H21NO	267.4	C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0D8JU	2-phenyl-1,1-di(pyridin-3-yl)ethanol	Investigative	46885546	C18H16N2O	276.3	C1=CC=C(C=C1)CC(C2=CN=CC=C2)(C3=CN=CC=C3)O	IC50 ~ 60000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0OR6O	CM-352	Investigative	91623362	C24H29N3O6S	487.6	CNC(=O)C1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)[C@@]3(CCC4(C3)CCNCC4)C(=O)NO	IC50 ~ 100000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0PC5N	Premafloxacin	Investigative	71455	C21H26FN3O4	403.4	C[C@@H]([C@@H]1CCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F)NC	Ki ~ 150000 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0W7WV	L-869298	Investigative	11039077	C23H18F8N2O4S	570.5	C1CC1OC2=C(C=CC(=C2)[C@H](CC3=C[N+](=CC=C3)[O-])C4=CN=C(S4)C(C(F)(F)F)(C(F)(F)F)O)OC(F)F	Ki = 61400 nM	Poor binder
T20251	Voltage-gated potassium channel Kv11.1	D0Y8AB	2-amino-2-phenyl-1,1-di(pyridin-3-yl)ethanol	Investigative	46885586	C18H17N3O	291.3	C1=CC=C(C=C1)C(C(C2=CN=CC=C2)(C3=CN=CC=C3)O)N	IC50 ~ 60000 nM	Poor binder