TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T20709	Muscarinic acetylcholine receptor M4	D0U7BW	Carbachol	Approved	2551	C6H15N2O2+	147.2	C[N+](C)(C)CCOC(=O)N	EC50 = 60000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	D07EFM	Arecoline	Phase 1	2230	C8H13NO2	155.19	CN1CCC=C(C1)C(=O)OC	Ki = 60000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B01URL	N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853778	C15H27N3O2	281.39	CCC(=O)N1CCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B0UJY6	N-[2-(Dimethylamino)ethyl]-N-methyl-1-(3-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274432	C21H23N3O	333.4	CN(C)CCN(C)C(=O)C1=C/C(=C\\C2=CN=CC=C2)/C3=CC=CC=C31	Ki = 54954.09 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B12LNH	Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44422698	C9H20INO2	301.17	C[C@@H]1COC[C@@H](O1)C[N+](C)(C)C.[I-]	Ki = 69183.1 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B1ELB7	Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2R)-	Investigative	24894515	C9H13NO	151.21	CN1CCC[C@@H]1C2=CC=CO2	Ki = 79432.82 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B1Z0TB	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium	Investigative	73349591	C7H15N2O2+	159.21	C[N+](C)(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B27QAO	6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579457	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B2DOR6	6,7,8,9-Tetrahydro-[1,2,5]thiadiazolo[3,4-h]isoquinoline	Investigative	14660293	C9H9N3S	191.26	C1CNCC2=C1C=CC3=NSN=C23	IC50 = 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B2TJ5E	4-[2-[(4-Hydroxy-4,4-diphenylbutyl)-methylamino]ethyl-methylamino]-1,1-diphenylbutan-1-ol;dihydrochloride	Investigative	49797390	C36H46Cl2N2O2	609.7	CN(CCCC(C1=CC=CC=C1)(C2=CC=CC=C2)O)CCN(C)CCCC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Cl.Cl	Ki = 162181.01 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B2V7EP	2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44578978	C25H29N5O	415.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B3K8HA	Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2S)-	Investigative	24894514	C9H13NO	151.21	CN1CCC[C@H]1C2=CC=CO2	Ki = 56234.13 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B40KXW	Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706052	C9H20INO2	301.17	C[C@@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B40WHA	(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545091	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B4BM5X	N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853777	C14H27N3O2	269.38	CCC(CC)NC(=O)CN1CCN(CC1)C(=O)CC	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B4SWH0	6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578928	C25H28ClF3N4O	493	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B50PAD	3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one	Investigative	44579417	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B57EKA	7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579418	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C(=CC=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B57PVF	7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579419	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C(=CC=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5DZS8	1-[3-(4-Butylpiperidino)propyl]-3,4-dihydroquinoline-2(1H)-one	Investigative	10236758	C21H32N2O	328.5	CCCCC1CCN(CC1)CCCN2C(=O)CCC3=CC=CC=C32	IC50 = 120226.44 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5ER0C	(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	58653718	C7H14N2O2	158.2	CN1C[C@@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5EZF0	(2S)-2-(Furan-2-yl)pyrrolidine	Investigative	7022778	C8H11NO	137.18	C1C[C@H](NC1)C2=CC=CO2	Ki = 102329.3 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5HRN9	Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide	Investigative	44422691	C9H20INO2	301.17	CC1COCC(O1)C[N+](C)(C)C.[I-]	Ki = 87096.36 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5J4WP	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium	Investigative	73349592	C7H15N2O2+	159.21	C[N+](C)(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5MGK3	6-Methoxy-1-(1-methyl-4-nitro-1H-pyrrol-2-yl)-4,9-dihydro-3H-pyrido[3,4-b]indole	Investigative	44439389	C17H16N4O3	324.33	CN1C=C(C=C1C2=NCCC3=C2NC4=C3C=C(C=C4)OC)[N+](=O)[O-]	Ki = 70000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5OK2T	(2R)-1-Methyl-2-(5-methylfuran-2-yl)pyrrolidine	Investigative	24894633	C10H15NO	165.23	CC1=CC=C(O1)[C@H]2CCCN2C	Ki = 58884.37 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B5ONL2	Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545329	C8H17N2O2+	173.23	CN1C[C@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B68VPY	3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10251795	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B6IUM0	3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578976	C24H29N5O3	435.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B6LW3I	2-(3,4-Dimethoxyphenyl)ethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575552	C23H27NO4	381.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B75HGX	1-[3-[4-[9-[[4-(1-Methyl-1,2,5,6-tetrahydropyridine-3-yl)-1,2,5-thiadiazole-3-yl]oxy]nonyl]piperidino]propyl]-3,4-dihydro-2(1H)-quinolinone	Investigative	101882890	C34H51N5O2S	593.9	CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCCC3CCN(CC3)CCCN4C(=O)CCC5=CC=CC=C54	EC50 = 66069.34 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B81BVZ	(2R)-2-(Furan-2-yl)pyrrolidine	Investigative	7047822	C8H11NO	137.18	C1C[C@@H](NC1)C2=CC=CO2	Ki = 89125.09 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B8ACZ5	(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	72545094	C7H14N2O2	158.2	CN1C[C@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B8CRU7	(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44571572	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B8FM1A	Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706050	C9H20INO2	301.17	C[C@]1(COCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B8GY1Q	[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227416	C10H22INO2	315.19	C[C@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B97EOI	(E)-Tert-butyl 6-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methyleneamino)indoline-1-carboxylate	Investigative	44439397	C25H31N3O4	437.5	CC(C)(C)OC(=O)N1CCC2=C1C=C(C=C2)N=CN3CCC4=CC(=C(C=C4C3)OC)OC	Ki = 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	B9M3LY	6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579375	C25H31ClN4O	439	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BB0F5D	1-(2-(Methylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	Investigative	44439393	C19H20N2S	308.4	CSC1=CC=CC=C1CC2C3=C(CCN2)C4=CC=CC=C4N3	Ki = 95000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BB30RM	Esaprazole	Investigative	68835	C12H23N3O	225.33	C1CCC(CC1)NC(=O)CN2CCNCC2	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BB4IT7	2-(3,4-Dimethoxyphenyl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574174	C23H26FNO4	399.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)F	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BB9YX3	N-Isopropyl-1-piperazineacetamide	Investigative	100826	C9H19N3O	185.27	CC(C)NC(=O)CN1CCNCC1	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BC5Y0W	(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	73351145	C6H12N2O2	144.17	CN(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BCAJ53	1,1-Diphenyl-4-(4-phenylpiperazin-1-yl)butan-1-ol;hydrochloride	Investigative	49797392	C26H31ClN2O	423	C1CN(CCN1CCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O)C4=CC=CC=C4.Cl	Ki = 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BCJ98E	Trimethyl-[[(2R,5R)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227554	C9H20INO2	301.17	C[C@@H]1CO[C@@H](CO1)C[N+](C)(C)C.[I-]	Ki = 93325.43 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BCYU05	2-Furan-2-yl-1-methylpyrrolidine	Investigative	24894631	C9H13NO	151.21	CN1CCCC1C2=CC=CO2	Ki = 69183.1 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BDJ9H1	1-(4-(Methylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	Investigative	44439394	C19H20N2S	308.4	CSC1=CC=C(C=C1)CC2C3=C(CCN2)C4=CC=CC=C4N3	Ki = 68000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BDPT63	[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate	Investigative	72545089	C7H14N2O2	158.2	CN1CCC[C@H]1COC(=O)N	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BE2OY8	5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579458	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=CC(=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BG3P0I	2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44579416	C25H28ClN5O	450	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BG5E7Y	1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine	Investigative	10354348	C10H15N3S2	241.4	CC1=C(CN(CC1)C)C2=NSN=C2SC	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BGM1F0	2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853883	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@@H]3C2	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BH1W6I	1-(2-(Propylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	Investigative	44439392	C21H24N2S	336.5	CCCSC1=CC=CC=C1CC2C3=C(CCN2)C4=CC=CC=C4N3	Ki = 94000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BH7I2B	N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide	Investigative	11110049	C20H23N3O	321.4	CN(C)CCNC(=O)C1=C(C2=CC=CC=C2C1)CC3=CC=NC=C3	Ki = 87096.36 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BHX4W2	5-(1-Ethyl-4-phenyl-3,6-dihydro-2H-pyridin-3-yl)-3-pentyl-1,2,4-oxadiazole;oxalic acid	Investigative	44346446	C22H29N3O5	415.5	CCCCCC1=NOC(=N1)C2CN(CC=C2C3=CC=CC=C3)CC.C(=O)(C(=O)O)O	IC50 = 63337.5 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BI6DN8	5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110765	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=CC(=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BI85JF	[(2R,6R)-6-Ethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	57326141	C10H22INO2	315.19	CC[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BIO5L9	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide	Investigative	49853987	C19H35N3O	321.5	CC(C)(C(=O)NC1CCCCC1)N2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BJ7T6P	2-(5-Methylfuran-2-yl)pyrrolidine	Investigative	4715419	C9H13NO	151.21	CC1=CC=C(O1)C2CCCN2	Ki = 51286.14 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BJEV61	Trimethyl-[[(2R)-5,5,6,6-tetramethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227486	C12H26INO2	343.24	CC1(C(O[C@@H](CO1)C[N+](C)(C)C)(C)C)C.[I-]	Ki = 53703.18 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BK56OP	1,7-Di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]heptane	Investigative	11017197	C23H34N6O2S2	490.7	CN1CCC=C(C1)C2=NSN=C2OCCCCCCCOC3=NSN=C3C4=CCCN(C4)C	EC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BKR16E	Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44446840	C9H20INO2	301.17	C[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki = 87096.36 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BL86PX	[(2R,5R,6S)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227454	C10H22INO2	315.19	C[C@@H]1[C@@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BM5FV4	2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide	Investigative	49853885	C17H33N3O	295.5	CC(C)NC(=O)C(C)(C)N1CCN(CC1)C2CCCCC2	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BNL89F	Trimethyl-[[(2R,6R)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227480	C11H24INO2	329.22	C[C@@H]1C(OC[C@H](O1)C[N+](C)(C)C)(C)C.[I-]	Ki = 87096.36 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BO3YC0	6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578975	C24H28Cl2N4O	459.4	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BO61QD	Trimethyl-[[(2R,5S)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227410	C9H20INO2	301.17	C[C@H]1CO[C@@H](CO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BR8NT5	2-Naphthalen-1-ylethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575553	C25H25NO2	371.5	CN1CCC(=C(C1)C(=O)OCCC2=CC=CC3=CC=CC=C32)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BS9AF4	Trimethyl-[[(2R,6S)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227460	C11H24INO2	329.22	C[C@H]1C(OC[C@H](O1)C[N+](C)(C)C)(C)C.[I-]	Ki = 57543.99 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BT0EO7	2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853884	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@H]3C2	IC50 = 73000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BTF8M9	(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44419370	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BTH09U	Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118723724	C9H20INO2	301.17	C[C@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BTHE57	Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545096	C8H17N2O2+	173.23	CN1C[C@@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BTZ9Y2	6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110764	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BU0N1E	1,8-Di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]octane	Investigative	11135606	C24H36N6O2S2	504.7	CN1CCC=C(C1)C2=NSN=C2OCCCCCCCCOC3=NSN=C3C4=CCCN(C4)C	EC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BU4J8L	Tbpb	Investigative	10092649	C25H32N4O	404.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BUN92J	1,6-Di[4-(1-methyl-1,2,3,6-tetrahydro-5-pyridinyl)-1,2,5-thiadiazol-3-yloxy]hexane	Investigative	10907744	C22H32N6O2S2	476.7	CN1CCC=C(C1)C2=NSN=C2OCCCCCCOC3=NSN=C3C4=CCCN(C4)C	EC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BVE0O6	6-Methoxy-1-(3-methoxyphenyl)-4,9-dihydro-3H-pyrido[3,4-b]indole	Investigative	44439388	C19H18N2O2	306.4	COC1=CC2=C(C=C1)NC3=C2CCN=C3C4=CC(=CC=C4)OC	Ki = 78000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BWB3G2	(4-Methylpiperazin-1-yl)-[(3E)-3-(pyridin-4-ylmethylidene)inden-1-yl]methanone	Investigative	44274477	C21H21N3O	331.4	CN1CCN(CC1)C(=O)C2=C/C(=C\\C3=CC=NC=C3)/C4=CC=CC=C42	Ki = 89125.09 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BWBH45	[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate	Investigative	72545098	C8H17N2O2+	173.23	C[N+]1(CCC[C@H]1COC(=O)N)C	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BWF9Y6	[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227458	C10H22INO2	315.19	CC1(CO[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BX9L7C	2-(Furan-2-yl)pyrrolidine	Investigative	3675988	C8H11NO	137.18	C1CC(NC1)C2=CC=CO2	Ki = 87096.36 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BYC1I9	3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10027177	C25H29F3N4O	458.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BYTO08	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide	Investigative	49853881	C17H31N3O	293.4	C1CCC(CC1)NC(=O)CN2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BYX70W	N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide	Investigative	49855131	C14H27N3O	253.38	CN1CCCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BYXU78	(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	57558000	C6H12N2O2	144.17	CN(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BZ3UC8	6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578977	C24H28ClN5O3	470	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BZ4I0N	(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545326	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T20709	Muscarinic acetylcholine receptor M4	BZP0V3	[(2R,5R,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227414	C10H22INO2	315.19	C[C@@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder