TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T20761	Vascular endothelial growth factor A	D00ECX	US8598210, Table XV, 2	Patented	24891583	C15H13ClN2O4	320.73	COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC=C(C=C2)Cl)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	D00XHH	US8598210, Table XV, 5	Patented	24891042	C16H15NO4	285.29	CC1=CC=C(C=C1)C2=CC(=C(C=C2)C(=O)NCC(=O)O)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	B1MC4L	1-Benzyl-3-hydroxy-4-[(2-methylsulfanylethylamino)methyl]pyridin-2-one	Investigative	22339926	C16H20N2O2S	304.4	CSCCNCC1=C(C(=O)N(C=C1)CC2=CC=CC=C2)O	IC50 = 53000 nM	Poor binder
T20761	Vascular endothelial growth factor A	B2LCS6	Methyl 2-[[3-hydroxy-5-(4-isocyanophenyl)pyridine-2-carbonyl]amino]acetate	Investigative	59513087	C16H13N3O4	311.29	COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC=C(C=C2)[N+]#[C-])O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	B36MKO	1-Benzyl-3-hydroxy-4-[[(2R)-2-(2-hydroxyethyl)pyrrolidin-1-yl]methyl]pyridin-2-one	Investigative	58252391	C19H24N2O3	328.4	C1C[C@@H](N(C1)CC2=C(C(=O)N(C=C2)CC3=CC=CC=C3)O)CCO	IC50 = 53000 nM	Poor binder
T20761	Vascular endothelial growth factor A	B3BMV6	({3-Hydroxy-5-[3-(pyrrolidine-1-carbonyl)-phenyl]-pyridine-2-carbonyl}-amino)-acetic acid methyl ester	Investigative	24891635	C20H21N3O5	383.4	COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC(=CC=C2)C(=O)N3CCCC3)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	B3SBF8	US8722895, 21: {[5-(3-Carbamoyl-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester	Investigative	24891634	C16H15N3O5	329.31	COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC(=CC=C2)C(=O)N)O	EC50 = 50100 nM	Poor binder
T20761	Vascular endothelial growth factor A	B6M7IS	2-[[3-Hydroxy-5-(3-isocyanophenyl)pyridine-2-carbonyl]amino]acetic acid	Investigative	59513096	C15H11N3O4	297.26	[C-]#[N+]C1=CC=CC(=C1)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BB0P1Y	US8722895, 15: {[5-(4-Isopropoxyphenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid	Investigative	24890990	C17H18N2O5	330.33	CC(C)OC1=CC=C(C=C1)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BE8QT1	1-[(3-Chlorophenyl)methyl]-3-hydroxypyridin-2-one	Investigative	53235307	C12H10ClNO2	235.66	C1=CC(=CC(=C1)Cl)CN2C=CC=C(C2=O)O	IC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BF2MR9	1-Benzyl-3-hydroxy-4-[[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methyl]pyridin-2-one	Investigative	67155798	C19H24N2O3	328.4	COC[C@H]1CCCN1CC2=C(C(=O)N(C=C2)CC3=CC=CC=C3)O	IC50 = 53000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BF8V3A	3-[(1-Benzyl-3-hydroxy-2-oxopyridin-4-yl)methylamino]azepan-2-one	Investigative	10042946	C19H23N3O3	341.4	C1CCNC(=O)C(C1)NCC2=C(C(=O)N(C=C2)CC3=CC=CC=C3)O	IC50 = 62900 nM	Poor binder
T20761	Vascular endothelial growth factor A	BK1W4N	US8722895, 23: ({3-Hydroxy-5-[3-(pyrrolidine-1-carbonyl)phenyl]-pyridine-2-carbonyl}amino)-acetic acid	Investigative	24890988	C19H19N3O5	369.4	C1CCN(C1)C(=O)C2=CC=CC(=C2)C3=CC(=C(N=C3)C(=O)NCC(=O)O)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BM9C2I	US8722895, 24: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)phenyl]-pyridine-2-carbonyl}-amino)-acetic acid	Investigative	24890989	C15H12N6O4	340.29	C1=CC(=CC(=C1)C2=NNN=N2)C3=CC(=C(N=C3)C(=O)NCC(=O)O)O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BMQG50	US8722895, 14: {[5-(4-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}-acetic acid	Investigative	24891687	C14H11FN2O4	290.25	C1=CC(=CC=C1C2=CC(=C(N=C2)C(=O)NCC(=O)O)O)F	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BOV60B	1-Benzyl-4-[[4-(6-chloropyridazin-3-yl)piperazin-1-yl]methyl]-3-hydroxypyridin-2-one	Investigative	10386952	C21H22ClN5O2	411.9	C1CN(CCN1CC2=C(C(=O)N(C=C2)CC3=CC=CC=C3)O)C4=NN=C(C=C4)Cl	IC50 = 78000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BPK28R	Methyl 2-[[3-hydroxy-5-(3-isocyanophenyl)pyridine-2-carbonyl]amino]acetate	Investigative	59513091	C16H13N3O4	311.29	COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC(=CC=C2)[N+]#[C-])O	EC50 ~ 100000 nM	Poor binder
T20761	Vascular endothelial growth factor A	BVP3W9	US8722895, 19: ({3-Hydroxy-5-[3-(2H-tetrazol-5-yl)-phenyl]-pyridine-2-carbonyl}-amino)-acetic acid methyl ester	Investigative	24891638	C16H14N6O4	354.32	COC(=O)CNC(=O)C1=C(C=C(C=N1)C2=CC(=CC=C2)C3=NNN=N3)O	EC50 ~ 100000 nM	Poor binder