TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T21307	MAPK-activated protein kinase 2	D0E6XR	Dasatinib	Approved	3062316	C22H26ClN7O2S	488	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	D0LF0O	BMS-695735	Preclinical	135441202	C26H31ClFN7O	512	.	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B0KJG5	5-Hydroxyisoquinoline	Investigative	30386	C9H7NO	145.16	C1=CC2=C(C=CN=C2)C(=C1)O	IC50 = 85000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B0ZT5D	N-((3-Amino-6-chloropyrazin-2-yl)methylcarbamothioyl)benzamide	Investigative	54584340	C13H12ClN5OS	321.79	C1=CC=C(C=C1)C(=O)NC(=S)NCC2=NC(=CN=C2N)Cl	IC50 = 91000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B1L4PB	25-Hydroxy-13(24),15,17-cheilanthatrien-19,25-olide	Investigative	11632412	C25H36O3	384.6	C[C@]12CCCC([C@@H]1CC[C@@]3([C@@H]2CCC(=C)[C@H]3/C=C/C4=CC(=O)OC4O)C)(C)C	IC50 = 90000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B1T7IX	1-((3-Amino-6-phenylpyrazin-2-yl)methyl)-3-phenylthiourea	Investigative	54582407	C18H17N5S	335.4	C1=CC=C(C=C1)C2=CN=C(C(=N2)CNC(=S)NC3=CC=CC=C3)N	IC50 = 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B2DHC0	7-N-(3-Chloro-4-fluorophenyl)-5-N-[4-(diethylamino)cyclohexyl]pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60199934	C22H28ClFN6	430.9	CCN(CC)C1CCC(CC1)NC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B2GU7D	6-Methoxy-1-(2H-tetrazol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole	Investigative	44441134	C13H14N6O	270.29	COC1=CC2=C(C=C1)NC3=C2CCNC3C4=NNN=N4	IC50 = 130000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B2T0RU	CID 46179972	Investigative	46179972	C28H31N6O3	499.6	CC1(CC(CC(N1[O])(C)C)NC(=O)C2=CC=CC(=C2)C3=NN4C(=CC=NC4=C3)NC5=CC(=CC=C5)O)C	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B3AX7F	8-Bromo-4-(3-chloro-4-fluoroanilino)-6-[(1-methylimidazol-4-yl)methylamino]quinoline-3-carbonitrile	Investigative	17758574	C21H15BrClFN6	485.7	CN1C=C(N=C1)CNC2=CC3=C(C(=CN=C3C(=C2)Br)C#N)NC4=CC(=C(C=C4)F)Cl	IC50 = 87100 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B3P6WU	Phaeochromycin C	Investigative	54697518	C18H16O5	312.3	CCCC1=CC(=O)C2=C(C=CC=C2O1)CC3=CC(=CC(=O)O3)O	IC50 = 130000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B3ZVA7	N-(4-Chloro-2-fluorophenyl)-6-(4-chlorophenyl)quinolin-4-amine	Investigative	49862051	C21H13Cl2FN2	383.2	C1=CC(=CC=C1C2=CC3=C(C=CN=C3C=C2)NC4=C(C=C(C=C4)Cl)F)Cl	IC50 = 121000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B4DC5V	1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-phenethylthiourea	Investigative	54583388	C14H16ClN5S	321.8	C1=CC=C(C=C1)CCNC(=S)NCC2=NC(=CN=C2N)Cl	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B4RAP7	25-Hydroxy-13(24),17-cheilanthadien-16,19-olide	Investigative	21590533	C25H38O3	386.6	C[C@]12CCCC([C@@H]1CC[C@@]3([C@@H]2CCC(=C)[C@H]3CC4C(=CC(=O)O4)CO)C)(C)C	IC50 = 90000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B4WOQ1	2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	145879	C12H12N2O2	216.24	C1CNC(C2=C1C3=CC=CC=C3N2)C(=O)O	IC50 = 87000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B4XFN0	8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(4-propyl-1H-imidazol-5-yl)methyl]amino}quinoline-3-carbonitrile	Investigative	17758239	C23H19Cl2FN6	469.3	CCCC1=C(NC=N1)CNC2=CC3=C(C(=CN=C3C(=C2)Cl)C#N)NC4=CC(=C(C=C4)F)Cl	IC50 = 62700 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B5KD4L	(2S)-1-(1H-Indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine	Investigative	6914611	C25H22N4O	394.5	C1=CC=C2C(=C1)C(=CN2)C[C@@H](COC3=CN=CC(=C3)C4=CC5=C(C=C4)C=NC=C5)N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B5NSE7	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375865	C28H28N6O2S	512.6	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C)C#N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B79DJR	7-N-(3-Chloro-4-fluorophenyl)-5-N-(piperidin-4-ylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60200099	C18H20ClFN6	374.8	C1CNCCC1CNC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B7AB4N	1,3-Diamino-6,8-dihydroxy-9H-xanthene-2-carbonitrile	Investigative	122197376	C14H11N3O3	269.25	C1C2=C(C=C(C=C2OC3=C1C(=C(C(=C3)N)C#N)N)O)O	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B7FU4N	2-Isopropyl-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441127	C16H20N2O3	288.34	CC(C)N1CCC2=C(C1C(=O)O)NC3=C2C=C(C=C3)OC	IC50 = 170000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B7KD3M	3-[(2-Chloropyridin-4-yl)amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	Investigative	25207353	C17H14ClN3O2	327.8	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)Cl	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B7PCB1	2-[[7-(4-Ethoxyanilino)-6-methylpyrazolo[1,5-a]pyrimidin-5-yl]amino]ethanol	Investigative	60200255	C17H21N5O2	327.4	CCOC1=CC=C(C=C1)NC2=C(C(=NC3=CC=NN32)NCCO)C	IC50 = 83000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B7VHX4	1-((3-Amino-6-(trifluoromethyl)pyrazin-2-yl)methyl)-3-phenylthiourea	Investigative	54586261	C13H12F3N5S	327.33	C1=CC=C(C=C1)NC(=S)NCC2=NC(=CN=C2N)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B8DZ6F	1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-cyclopentylthiourea	Investigative	54586258	C11H16ClN5S	285.8	C1CCC(C1)NC(=S)NCC2=NC(=CN=C2N)Cl	IC50 = 53000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B8MZQ2	N-[4-[[7-(3-Chloro-4-fluoroanilino)pyrazolo[1,5-a]pyrimidin-5-yl]amino]cyclohexyl]acetamide	Investigative	60199938	C20H22ClFN6O	416.9	CC(=O)NC1CCC(CC1)NC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B8OGN1	Unii-O5YT36mst0	Investigative	9885748	C19H15F2NO	311.3	C\\1NC/C(=C\\C2=CC=CC=C2F)/C(=O)/C1=C/C3=CC=CC=C3F	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B92LZO	13,16-Epoxy-25-hydroxy-17-cheilanthen-19,25-olide	Investigative	10621161	C25H38O4	402.6	C[C@]12CCCC([C@@H]1CC[C@@]3([C@@H]2CC[C@]4([C@H]3C[C@@H](O4)C5=CC(=O)OC5O)C)C)(C)C	IC50 = 90000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B95TYS	((R)-7-Methyl-9-oxo-6,7,8,9-tetrahydro-5H-10-thia-5,8-diaza-benzo[a]azulen-3-yloxy)-acetic acid methyl ester	Investigative	45267641	C15H16N2O4S	320.4	C[C@@H]1CNC2=C(C(=O)N1)SC3=C2C=C(C=C3)OCC(=O)OC	IC50 = 78000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B9GY5N	1,3,7-Triamino-9H-xanthene-2-carbonitrile	Investigative	122197373	C14H12N4O	252.27	C1C2=C(C=CC(=C2)N)OC3=C1C(=C(C(=C3)N)C#N)N	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B9JZ6L	Cot inhibitor-2	Investigative	44143370	C26H25Cl2FN8	539.4	CCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl	IC50 = 63000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B9NI3B	8,10-Diamino-3,11-dihydro-2H-[1,4]dioxino[2,3-b]xanthene-9-carbonitrile	Investigative	122197372	C16H13N3O3	295.29	C1COC2=C(O1)C=C3CC4=C(C=C(C(=C4N)C#N)N)OC3=C2	IC50 = 55700 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B9RJ8I	2-Benzyl-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441128	C20H20N2O3	336.4	COC1=CC2=C(C=C1)NC3=C2CCN(C3C(=O)O)CC4=CC=CC=C4	IC50 = 130000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B9RYW6	6-Acetoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441117	C14H14N2O4	274.27	CC(=O)OC1=CC2=C(C=C1)NC3=C2CCNC3C(=O)O	IC50 = 170000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	B9T3GS	3-Ethyl-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441141	C15H18N2O3	274.31	CCC1CC2=C(C(N1)C(=O)O)NC3=C2C=C(C=C3)OC	IC50 = 64000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BA27UE	1,3-Diamino-9H-xanthene-2-carbonitrile	Investigative	122197374	C14H11N3O	237.26	C1C2=CC=CC=C2OC3=C1C(=C(C(=C3)N)C#N)N	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BAR0L6	7-Hydroxy-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylic acid	Investigative	44441114	C13H14N2O4	262.26	COC1=C(C=C2C(=C1)C3=C(N2)C(NCC3)C(=O)O)O	IC50 = 53000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BBA86V	2-(4-(1H-Pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenylamino)-N-(2,4-difluorophenyl)nicotinamide	Investigative	16223008	C25H16F3N5O2	475.4	C1=CC(=C(N=C1)NC2=CC(=C(C=C2)OC3=C4C=CNC4=NC=C3)F)C(=O)NC5=C(C=C(C=C5)F)F	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BBF0P2	1-((3-Amino-6-chloro-5-ethoxypyrazin-2-yl)methyl)-3-phenylthiourea	Investigative	54583392	C14H16ClN5OS	337.8	CCOC1=NC(=C(N=C1Cl)CNC(=S)NC2=CC=CC=C2)N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BD14WF	5-N-(4-Aminophenyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60200098	C18H14ClFN6	368.8	C1=CC(=CC=C1N)NC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BDL57V	4-({3-Chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl}-amino)-7-[(1E)-4-(4-ethylpiperazin-1-yl)but-1-enyl]quinoline-3-carbonitrile	Investigative	25211064	C30H32ClN7S	558.1	CCN1CCN(CC1)CC/C=C/C2=CC3=NC=C(C(=C3C=C2)NC4=CC(=C(C=C4)SC5=NC=CN5C)Cl)C#N	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BE5R1Z	7-Amino-4-(3-phenylphenyl)thieno[2,3-c]pyridine-2-carboxamide	Investigative	25218756	C20H15N3OS	345.4	C1=CC=C(C=C1)C2=CC(=CC=C2)C3=CN=C(C4=C3C=C(S4)C(=O)N)N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BF61ZO	1-((3-Amino-6-chloro-5-(dimethylamino)pyrazin-2-yl)methyl)-3-phenylthiourea	Investigative	54582408	C14H17ClN6S	336.8	CN(C)C1=NC(=C(N=C1Cl)CNC(=S)NC2=CC=CC=C2)N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BFH82E	5-N-(3-Aminocyclohexyl)-7-N-(3-chloro-4-fluorophenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60199940	C18H20ClFN6	374.8	C1CC(CC(C1)NC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl)N	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BFQ37Y	8-Chloro-4-(3-chloro-4-fluorophenylamino)-6-((1-(1-cyclobutylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl)methylamino)quinoline-3-carbonitrile	Investigative	44143373	C28H27Cl2FN8	565.5	C1CC(C1)N2CCC(CC2)N3C=C(N=N3)CNC4=CC5=C(C(=CN=C5C(=C4)Cl)C#N)NC6=CC(=C(C=C6)F)Cl	IC50 = 131000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BH23CX	N-Hydroxy-6-methoxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxamide	Investigative	44441133	C13H15N3O3	261.279	COC1=CC2=C(C=C1)NC3=C2CCNC3C(=O)NO	IC50 = 88000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BH27GI	3-[Methyl(pyridin-4-yl)amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	Investigative	25207516	C18H17N3O2	307.3	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)N(C)C3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BIA7J9	3-[2-[(1R,4Ar,4bS,8aS,10aS)-4b,8,8,10a-tetramethyl-2-methylidene-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-1-yl]-1-hydroxyethyl]-2-hydroxy-2H-furan-5-one	Investigative	21590534	C25H38O4	402.6	C[C@]12CCCC([C@@H]1CC[C@@]3([C@@H]2CCC(=C)[C@H]3CC(C4=CC(=O)OC4O)O)C)(C)C	IC50 = 90000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BINH24	3-[[(1R)-1-Phenylethyl]amino]-4-(pyrimidin-4-ylamino)cyclobut-3-ene-1,2-dione	Investigative	25207350	C16H14N4O2	294.31	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=NC=NC=C3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BIR3H1	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	Investigative	135589980	C29H27N3O3	465.5	C1CC(CCC1NC(=O)C2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O)O	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BJ4E7P	(3S)-3-[[7-(4-Ethoxyanilino)-6-methylpyrazolo[1,5-a]pyrimidin-5-yl]amino]piperidin-2-one	Investigative	71462244	C20H24N6O2	380.4	CCOC1=CC=C(C=C1)NC2=C(C(=NC3=CC=NN32)N[C@H]4CCCNC4=O)C	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BK2L7N	3-(Benzylamino)-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	Investigative	25205757	C16H13N3O2	279.29	C1=CC=C(C=C1)CNC2=C(C(=O)C2=O)NC3=CC=NC=C3	IC50 = 88000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BK34FN	3-{[(1R)-1-Phenylethyl]amino}-4-(1H-pyrazol-3-ylamino)cyclobut-3-ene-1,2-dione	Investigative	25207352	C15H14N4O2	282.3	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC=NN3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BL86IV	N-(4-Morpholinophenyl)-6-phenylquinolin-4-amine	Investigative	49862778	C25H23N3O	381.5	C1COCCN1C2=CC=C(C=C2)NC3=C4C=C(C=CC4=NC=C3)C5=CC=CC=C5	IC50 = 120000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BN3Y0E	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	Investigative	11235063	C21H21N7O2	403.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC=N3)NC4CCCC4)C#N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BNA26F	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71720141	C18H19N3O	293.4	CN1C[C@@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BPI93B	2-({2-[(3-Hydroxyphenyl)amino]pyrimidin-4-YL}amino)benzamide	Investigative	16058637	C17H15N5O2	321.33	C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BQ5LG8	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71718330	C18H19N3O	293.4	CN1C[C@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BQX9A6	N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide	Investigative	11632737	C19H17F2N5OS	401.4	C1CC1NC(=O)C2=CC(=C(C=C2F)F)NCC3=CN=C(S3)NC4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BSI02Y	3-[[(1R)-1-Cyclohexylethyl]amino]-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	Investigative	25207355	C17H21N3O2	299.37	C[C@H](C1CCCCC1)NC2=C(C(=O)C2=O)NC3=CC=NC=C3	IC50 = 65000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BSQ69C	7-(7-(Benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5-(cyclopenta-2,4-dienyl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine	Investigative	46226031	C26H18N6S	446.5	C1=CC=C2C(=C1)C=C(S2)C3=CC(=CC4=C3NN=C4)C5=CN(C6=CN=C(N=C65)N)C7C=CC=C7	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BT96YI	1-((3-Amino-6-chloro-5-(methylthio)pyrazin-2-yl)methyl)-3-phenylthiourea	Investigative	54585310	C13H14ClN5S2	339.9	CSC1=NC(=C(N=C1Cl)CNC(=S)NC2=CC=CC=C2)N	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BU9HK6	(R)-3-(1-Phenylethylamino)-4-(pyridin-3-ylamino)cyclobut-3-ene-1,2-dione	Investigative	44575025	C17H15N3O2	293.32	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BUO06B	2,4-Diamino-10-methyl-5,10-dihydro-benzo[b][1,8]naphthyridine-3-carbonitrile	Investigative	10106198	C14H13N5	251.29	CN1C2=CC=CC=C2CC3=C(C(=C(N=C31)N)C#N)N	IC50 = 70000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BV5HC2	1,3-Diamino-6,7-dimethoxy-9H-xanthene-2-carbonitrile	Investigative	122197369	C16H15N3O3	297.31	COC1=C(C=C2C(=C1)CC3=C(O2)C=C(C(=C3N)C#N)N)OC	IC50 = 64800 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BV9OQ5	(3Z)-6-(4-Hydroxy-3-methoxyphenyl)-3-{1H-pyrrolo[2,3-b]pyridin-3-ylmethylidene}-2,3-dihydro-1H-indol-2-one	Investigative	10215912	C23H17N3O3	383.4	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)/C(=C/C4=CNC5=C4C=CC=N5)/C(=O)N3)O	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BW63OY	1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-(3-(diethylamino)propyl)thiourea	Investigative	54585308	C13H23ClN6S	330.88	CCN(CC)CCCNC(=S)NCC1=NC(=CN=C1N)Cl	IC50 ~ 50000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BWC98E	4-[[7-(4-Ethoxyanilino)-6-methylpyrazolo[1,5-a]pyrimidin-5-yl]amino]cyclohexan-1-ol	Investigative	60200105	C21H27N5O2	381.5	CCOC1=CC=C(C=C1)NC2=C(C(=NC3=CC=NN32)NC4CCC(CC4)O)C	IC50 = 89000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BWF9O4	1-Naphthol	Investigative	7005	C10H8O	144.17	C1=CC=C2C(=C1)C=CC=C2O	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BYTJ71	3-(Pyridin-4-ylamino)-4-{[1-(1,3-thiazol-2-yl)ethyl]-amino}cyclobut-3-ene-1,2-dione	Investigative	44574928	C14H12N4O2S	300.34	CC(C1=NC=CS1)NC2=C(C(=O)C2=O)NC3=CC=NC=C3	IC50 = 81000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BYX2O0	3-{Methyl[(1R)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione	Investigative	25206065	C18H17N3O2	307.3	C[C@H](C1=CC=CC=C1)N(C)C2=C(C(=O)C2=O)NC3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BZW62K	7-N-(3-Chloro-4-fluorophenyl)-5-N-cyclohexylpyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60199775	C18H19ClFN5	359.8	C1CCC(CC1)NC2=NC3=CC=NN3C(=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	BZY9H6	3-{[(1S)-1-Phenylethyl]amino}-4-(pyridin-4-ylamino)-cyclobut-3-ene-1,2-dione	Investigative	44574873	C17H15N3O2	293.32	C[C@@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC=NC=C3	IC50 ~ 100000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	D06KSF	Tpl2 kinase inhibitor	Investigative	9549300	C21H14ClFN6	404.8	C1=CC(=CN=C1)CNC2=NC=C3C(=C2)C(=C(C=N3)C#N)NC4=CC(=C(C=C4)F)Cl	IC50 = 110000 nM	Poor binder
T21307	MAPK-activated protein kinase 2	D0D6DH	A-432411	Investigative	10125830	C20H16N2O3	332.4	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)/C(=C/C4=CC=CN4)/C(=O)N3)O	IC50 ~ 50000 nM	Poor binder