TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T22285 Glutamate receptor ionotropic NMDA 2A B02NKP 2-Methyl-5-[2-(4-benzylpiperidino)ethylthio]-1,3,4-thiadiazole Investigative 44366275 C17H23N3S2 333.5 CC1=NN=C(S1)SCCN2CCC(CC2)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B19NUD 4-[4-(4-Benzylpiperidino)-1-butynyl]phenol Investigative 10426105 C22H25NO 319.4 C1CN(CCC1CC2=CC=CC=C2)CCC#CC3=CC=C(C=C3)O IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B20MJK 5-[3-(4-Benzylpiperidino)propylthio]-1,3,4-thiadiazole-2-amine Investigative 12045495 C17H24N4S2 348.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NN=C(S3)N IC50 = 73000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B2GDF3 2-[3-(4-Benzylpiperidino)propylthio]-1H-imidazole Investigative 12045493 C18H25N3S 315.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NC=CN3 IC50 = 77000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B2KF3W 2-[3-(4-Benzylpiperidino)propylthio]-1H-benzimidazole Investigative 12045498 C22H27N3S 365.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NC4=CC=CC=C4N3 IC50 = 64000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B4AP0S 1-[3-(Phenylthio)propyl]-4-benzylpiperidine Investigative 12045491 C21H27NS 325.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=CC=CC=C3 IC50 = 85000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B4W5OZ 2-[2-(4-Benzylpiperidino)ethylthio]-1H-imidazole Investigative 9972103 C17H23N3S 301.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NC=CN3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B5SDC4 3-[3-(4-Benzylpiperidino)propylthio]-2H-1,2,4-triazole Investigative 44366153 C17H24N4S 316.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NC=NN3 IC50 = 51000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B6NF9K 2-[2-(4-Benzylpiperidino)ethylthio]-3H-imidazo[4,5-b]pyridine Investigative 44366045 C20H24N4S 352.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NC4=C(N3)C=CC=N4 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B6NWU9 5-[2-(4-Benzylpiperidino)ethylthio]-1H-1,2,4-triazole-3-amine Investigative 10425979 C16H23N5S 317.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NNC(=N3)N IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A B9K4ED 5-[2-(4-Benzylpiperidino)ethylthio]-1H-1,2,4-triazole Investigative 9972180 C16H22N4S 302.4 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NC=NN3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BARZ20 2-Methyl-5-[3-(4-benzylpiperidino)propylthio]-1,3,4-thiadiazole Investigative 12045496 C18H25N3S2 347.5 CC1=NN=C(S1)SCCCN2CCC(CC2)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BCD4N6 5-[2-(4-Benzylpiperidino)ethylthio]-1,3,4-thiadiazole-2-amine Investigative 34924882 C16H22N4S2 334.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NN=C(S3)N IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BCR25E 5-[3-(4-Benzylpiperidino)propylthio]-1H-1,2,4-triazole-3-amine Investigative 12045492 C17H25N5S 331.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NNC(=N3)N IC50 = 77000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BD36WG 1-[2-(Phenylthio)ethyl]-4-benzylpiperidine Investigative 12045832 C20H25NS 311.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BD7A3P 2-[3-(4-Benzylpiperidino)propylthio]-3H-imidazo[4,5-b]pyridine Investigative 44366090 C21H26N4S 366.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NC4=C(N3)C=CC=N4 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BL75SD 3-Methyl-5-[3-(4-benzylpiperidino)propylthio]-1H-1,2,4-triazole Investigative 12045494 C18H26N4S 330.5 CC1=NC(=NN1)SCCCN2CCC(CC2)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BQ8WE4 2-[2-(4-Benzylpiperidino)ethylthio]-1H-benzimidazole Investigative 44366039 C21H25N3S 351.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NC4=CC=CC=C4N3 IC50 = 75000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BR9Y1K 2-[3-(4-Benzylpiperidino)propylthio]-5-nitro-1H-benzimidazole Investigative 12045497 C22H26N4O2S 410.5 C1CN(CCC1CC2=CC=CC=C2)CCCSC3=NC4=C(N3)C=C(C=C4)[N+](=O)[O-] IC50 = 61000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BSL20F 3-Methyl-5-[2-(4-benzylpiperidino)ethylthio]-1H-1,2,4-triazole Investigative 44366109 C17H24N4S 316.5 CC1=NC(=NN1)SCCN2CCC(CC2)CC3=CC=CC=C3 IC50 ~ 100000 nM Poor binder T22285 Glutamate receptor ionotropic NMDA 2A BY1EH7 2-[2-(4-Benzylpiperidino)ethylthio]-5-nitro-1H-benzimidazole Investigative 44366056 C21H24N4O2S 396.5 C1CN(CCC1CC2=CC=CC=C2)CCSC3=NC4=C(N3)C=C(C=C4)[N+](=O)[O-] IC50 ~ 100000 nM Poor binder