TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T23172	Janus kinase 3	D0HS5V	Brivanib	Phase 3	11234052	C19H19FN4O3	370.4	CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NN4C3=C(C(=C4)OC[C@@H](C)O)C	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B0NZT4	4-Chloro-N-(3-quinoxalin-2-ylphenyl)butanamide	Investigative	46917073	C18H16ClN3O	325.8	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CCCCl	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B0WV4G	p38 MAP Kinase Inhibitor IX	Investigative	16730109	C22H17N7O2	411.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C4C=NN(C4=NC=N3)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B18GAM	2-(Dimethylamino)-N-(3-quinoxalin-2-ylphenyl)acetamide	Investigative	46917070	C18H18N4O	306.4	CN(C)CC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B1E3KY	Disodium;2-[4-[4-(4-fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane	Investigative	76325323	C19H16FN6Na2O3P	472.3	CN1C(=C(N=C1C2=CN(N=N2)CCP(=O)([O-])[O-])C3=CC=C(C=C3)F)C4=CC=NC=C4.[Na+].[Na+]	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B1NM0O	3-Chloro-N-(3-quinoxalin-2-ylphenyl)propanamide	Investigative	46916410	C17H14ClN3O	311.8	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CCCl	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B24FDH	Sodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]acetate	Investigative	118707523	C21H14FN8NaO2S	484.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C4=CN(N=N4)CC(=O)[O-])C5=CC=C(C=C5)F.[Na+]	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B28CHV	N-[3-(2-Quinoxalinyl)phenyl]methanesulfonamide	Investigative	1485426	C15H13N3O2S	299.3	CS(=O)(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B2DO4T	4-[5-(4-Fluorophenyl)-3-methyl-2-(2H-triazol-4-yl)imidazol-4-yl]pyridine	Investigative	76325315	C17H13FN6	320.32	CN1C(=C(N=C1C2=NNN=C2)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B2X6MP	N-(3-Quinoxalin-2-ylphenyl)-2-(1,2,4-triazol-1-yl)acetamide	Investigative	46917074	C18H14N6O	330.3	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)CN4C=NC=N4	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B3H7WV	2-(4-Fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine	Investigative	9798589	C17H13FN6S	352.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)N)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B3K2IF	4-(6,7-Dimethoxy-quinoxalin-2-ylamino)-cyclohexanol	Investigative	9796455	C16H21N3O3	303.36	COC1=C(C=C2C(=C1)N=CC(=N2)NC3CCC(CC3)O)OC	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B4I1TG	N-Tert-butyl-3-[[5-cyano-2-[3-methyl-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]benzenesulfonamide	Investigative	134130282	C27H34N8O2S	534.7	CC1=C(C=CC(=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)S(=O)(=O)NC(C)(C)C)C#N)N4CCN(CC4)C	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B4K3YE	N-[3-(2-Quinoxalinyl)phenyl]-2-furamide	Investigative	1485419	C19H13N3O2	315.3	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NC(=O)C4=CC=CO4	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B64LHM	(2R,3R,4R,5S,6R)-3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]-6-(hydroxymethyl)oxane-2,4,5-triol	Investigative	118707521	C23H23FN6O5	482.5	CN1C(=C(N=C1C2=CN(N=N2)[C@@H]3[C@H]([C@@H]([C@H](O[C@H]3O)CO)O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B73IWP	2-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]ethanol	Investigative	76314414	C19H17FN6O	364.4	CN1C(=C(N=C1C2=CN(N=N2)CCO)C3=CC=C(C=C3)F)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B7LQ4K	2-(4-Methylpiperazin-1-yl)-N-(3-quinoxalin-2-ylphenyl)acetamide	Investigative	46916408	C21H23N5O	361.4	CN1CCN(CC1)CC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	B81JYI	Disodium;2-[4-[2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-yl]triazol-1-yl]ethyl-dioxido-oxo-lambda5-phosphane	Investigative	118707526	C21H16FN8Na2O3PS	556.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C4=CN(N=N4)CCP(=O)([O-])[O-])C5=CC=C(C=C5)F.[Na+].[Na+]	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	B82CPS	4-[4-(4-Fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-imidazol-2-yl]phenol	Investigative	136987005	C20H15FN4OS	378.4	CSC1=NC=CC(=N1)C2=C(N=C(N2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)F	IC50 = 78300 nM	Poor binder
T23172	Janus kinase 3	B8US7V	4-Amino-N-benzyl-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide	Investigative	56925358	C25H24N4O2S	444.6	C1COCCN1C2=CC=C(C=C2)C3=CC4=C(S3)C(=CN=C4N)C(=O)NCC5=CC=CC=C5	IC50 ~ 125000 nM	Poor binder
T23172	Janus kinase 3	B97OTQ	7-Ethynyl-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine	Investigative	118707522	C19H12FN5S	361.4	CSC1=NC=CC(=N1)C2=C(N=C3N2C=CC(=N3)C#C)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BAO69Z	JAK inhibitor 17b	Investigative	137321156	C23H25N3O3	391.5	COC1=C(C=C2C(=C1)C3=CN=C4C(=C3N(C2=O)CC5CCCCC5)C=CN4)OC	IC50 = 76900 nM	Poor binder
T23172	Janus kinase 3	BB5A6N	N-[4-(2-Quinoxalinyl)phenyl]cyclopropanecarboxamide	Investigative	45588498	C18H15N3O	289.3	C1CC1C(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BB7T4M	4-[2-(4-Ethynylphenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-methylsulfanylpyrimidine	Investigative	118707543	C22H15FN4S	386.4	CSC1=NC=CC(=N1)C2=C(N=C(N2)C3=CC=C(C=C3)C#C)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BC34WF	N-Methyl-N'-[3-(2-quinoxalinyl)phenyl]thiourea	Investigative	1485416	C16H14N4S	294.4	CNC(=S)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BCVE73	N-[3-(2-Quinoxalinyl)phenyl]-2-thiophenesulfonamide	Investigative	1485420	C18H13N3O2S2	367.4	C1=CC=C2C(=C1)N=CC(=N2)C3=CC(=CC=C3)NS(=O)(=O)C4=CC=CS4	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BD5O9Y	2-(4-Fluorophenyl)-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]imidazo[1,2-a]pyrimidin-7-amine	Investigative	44124695	C24H20FN7	425.5	C[C@@H](C1=CC=CC=C1)NC2=NC=CC(=N2)C3=C(N=C4N3C=CC(=N4)N)C5=CC=C(C=C5)F	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BDM21A	4-[5-(4-Fluorophenyl)-2-[1-[(3S,4S)-3-fluoropiperidin-4-yl]triazol-4-yl]-3-methylimidazol-4-yl]pyridine;hydrochloride	Investigative	76317978	C22H22ClF2N7	457.9	CN1C(=C(N=C1C2=CN(N=N2)[C@H]3CCNC[C@@H]3F)C4=CC=C(C=C4)F)C5=CC=NC=C5.Cl	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BGD0S5	3-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid	Investigative	76332540	C24H17FN6O2	440.4	CN1C(=C(N=C1C2=CN(N=N2)C3=CC=CC(=C3)C(=O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BGVU25	N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide	Investigative	16723801	C23H20ClN3O	389.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=NC=C4	IC50 = 52000 nM	Poor binder
T23172	Janus kinase 3	BGWA94	Chembl4283458	Investigative	138585156	C22H24N4O3	392.5	CN1CCC(CC1)N2C3=C4C=CNC4=NC=C3C5=CC(=C(C=C5C2=O)OC)OC	IC50 = 61570 nM	Poor binder
T23172	Janus kinase 3	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BKG16O	4-[2-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-5-(4-fluorophenyl)-3-methylimidazol-4-yl]pyridine	Investigative	76310785	C23H26FN6O3P	484.5	CCOP(=O)(CCN1C=C(N=N1)C2=NC(=C(N2C)C3=CC=NC=C3)C4=CC=C(C=C4)F)OCC	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BN34TA	6-(5-Methyl-1,3,4-oxadiazol-2-yl)-5-propan-2-yl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine	Investigative	44449577	C19H18N8O	374.4	CC1=NN=C(O1)C2=CN3C(=C2C(C)C)C(=NC=N3)NC4=CN=C5C(=C4)C=CN5	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BN3Y0E	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	Investigative	11235063	C21H21N7O2	403.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC=N3)NC4CCCC4)C#N	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BNK7H2	7-[1-(2-Diethoxyphosphorylethyl)triazol-4-yl]-2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyrimidine	Investigative	118707525	C25H26FN8O3PS	568.6	CCOP(=O)(CCN1C=C(N=N1)C2=NC3=NC(=C(N3C=C2)C4=NC(=NC=C4)SC)C5=CC=C(C=C5)F)OCC	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BQX9A6	N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide	Investigative	11632737	C19H17F2N5OS	401.4	C1CC1NC(=O)C2=CC(=C(C=C2F)F)NCC3=CN=C(S3)NC4=CC=CC=N4	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BSH4V3	N-(3-Quinoxalin-2-ylphenyl)propanamide	Investigative	952076	C17H15N3O	277.32	CCC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BWV26C	N-(4-Methoxyphenyl)-N'-[3-(2-quinoxalinyl)phenyl]urea	Investigative	1485415	C22H18N4O2	370.4	COC1=CC=C(C=C1)NC(=O)NC2=CC=CC(=C2)C3=NC4=CC=CC=C4N=C3	IC50 ~ 50000 nM	Poor binder
T23172	Janus kinase 3	BYZ38E	4-[4-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-ylimidazol-2-yl]triazol-1-yl]benzoic acid	Investigative	76310788	C24H17FN6O2	440.4	CN1C(=C(N=C1C2=CN(N=N2)C3=CC=C(C=C3)C(=O)O)C4=CC=C(C=C4)F)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	BZ03HB	2-Oxo-2-(3-(quinoxalin-2-yl)phenylamino)ethyl acetate	Investigative	46916459	C18H15N3O3	321.3	CC(=O)OCC(=O)NC1=CC=CC(=C1)C2=NC3=CC=CC=C3N=C2	IC50 = 150000 nM	Poor binder
T23172	Janus kinase 3	D0VC0I	Oxindole 94	Investigative	5169	C20H14FN3O	331.3	C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O	IC50 ~ 100000 nM	Poor binder
T23172	Janus kinase 3	D0Z7TM	BMS-645737	Investigative	22273644	C20H20N8O	388.4	CC1=CC2=CC(=CN=C2N1)NC3=NC=NN4C3=C(C(=C4)C5=NN=C(O5)C)C(C)C	IC50 ~ 50000 nM	Poor binder