TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T23673	Proto-oncogene c-RAF	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	B5YNV2	6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile	Investigative	53357328	C27H27N3O2	425.5	CC1(C2=C(C=CC(=C2)C3CCN(CC3)C4COC4)C(=O)C5=C1NC6=C5C=CC(=C6)C#N)C	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	B6AUM4	5-(5-Methoxy-3-pyridin-4-yl-1H-pyrrolo[3,2-b]pyridin-2-yl)benzene-1,3-diol	Investigative	90666130	C19H15N3O3	333.3	COC1=NC2=C(C=C1)NC(=C2C3=CC=NC=C3)C4=CC(=CC(=C4)O)O	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	B8OC2B	4-Methyl-3-[3-(methylsulfamoylamino)anilino]-7-pyrimidin-2-yloxychromen-2-one	Investigative	59139472	C21H19N5O5S	453.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)NC4=CC(=CC=C4)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	B8YTQ3	CID 49806721	Investigative	49806721	C28H30N4O2	454.6	CCC1=CC2=C(C=C1N3CCN(CC3)C4COC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BG89ZC	(2S,3S)-2-((R)-4-(4-(2-Hydroxyethoxy)phenyl)-2,5-dioxoimidazolidin-1-yl)-3-phenyl-N-(4-propionylthiazol-2-yl)butanamide.	Investigative	11526671	C27H28N4O6S	536.6	CCC(=O)C1=CSC(=N1)NC(=O)[C@H]([C@@H](C)C2=CC=CC=C2)N3C(=O)[C@H](NC3=O)C4=CC=C(C=C4)OCCO	Ki ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BJ32VY	3-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenyl]-N-(1-phenylethyl)benzamide	Investigative	90655989	C29H23ClF3N3O2	538	CC(C1=CC=CC=C1)NC(=O)C2=CC=CC(=C2)C3=CC=C(C=C3)NC(=O)NC4=CC(=C(C=C4)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BJF28A	5-Bromo-3-(3-phenoxy-benzylidene)-1,3-dihydro-pyrrolo[2,3-b]pyridin-2-one	Investigative	44385063	C20H13BrN2O2	393.2	C1=CC=C(C=C1)OC2=CC=CC(=C2)/C=C\\3/C4=C(NC3=O)N=CC(=C4)Br	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BK6XI7	Meridianin E	Investigative	9995236	C12H9BrN4O	305.13	C1=CC(=C2C(=C1O)C(=CN2)C3=NC(=NC=C3)N)Br	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BNA26F	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71720141	C18H19N3O	293.4	CN1C[C@@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BNC32F	[4-Methyl-3-[[5-(methylsulfamoylamino)pyridin-3-yl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	90655795	C20H22N4O6S	446.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC(=O)N(C)C)CC3=CC(=CN=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BNQ1U5	Tert-butyl N-[(2R)-3-methyl-1-oxo-1-[[4-[3-(trifluoromethyl)anilino]quinazolin-6-yl]amino]butan-2-yl]carbamate	Investigative	137652990	C25H28F3N5O3	503.5	CC(C)[C@H](C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=CC(=C3)C(F)(F)F)NC(=O)OC(C)(C)C	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BO3E6D	1-Phenyl-3-(4-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}phenyl)urea	Investigative	24879141	C26H25N5O4	471.5	COC1=CC(=CC(=C1OC)OC)NC2=NC(=CN=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BQ5LG8	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71718330	C18H19N3O	293.4	CN1C[C@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	BRY85I	6-(5-Methoxy-3-pyridin-4-yl-1H-pyrrolo[3,2-b]pyridin-2-yl)naphthalen-2-ol	Investigative	136609931	C23H17N3O2	367.4	COC1=NC2=C(C=C1)NC(=C2C3=CC=NC=C3)C4=CC5=C(C=C4)C=C(C=C5)O	IC50 ~ 50000 nM	Poor binder
T23673	Proto-oncogene c-RAF	D02XHC	aloisine A	Investigative	448912	C16H17N3O	267.33	CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	D03MUZ	8-chloro-quinoline-3-carbonitrile	Investigative	17759555	C20H13Cl2FN6	427.3	C1=CC(=C(C=C1NC2=C3C=C(C=C(C3=NC=C2C#N)Cl)NCC4=CN=CN4)Cl)F	IC50 ~ 100000 nM	Poor binder
T23673	Proto-oncogene c-RAF	D08LYB	SB 239063	Investigative	5166	C20H21FN4O2	368.4	COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F	IC50 = 50000 nM	Poor binder