TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T25005	Tyrosine-protein kinase BTK	D02TUL	PF-06651600	Phase 2	118115473	C15H19N5O	285.34	C[C@H]1CC[C@H](CN1C(=O)C=C)NC2=NC=NC3=C2C=CN3	Ki = 62300 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	B31IHO	6-Tert-butyl-8-fluoro-2-[[2-fluoro-5-(hydroxymethyl)-4-(2-oxo-1H-pyridin-4-yl)phenyl]methyl]phthalazin-1-one	Investigative	76073534	C25H23F2N3O3	451.5	CC(C)(C)C1=CC2=C(C(=C1)F)C(=O)N(N=C2)CC3=CC(=C(C=C3F)C4=CC(=O)NC=C4)CO	IC50 = 52269.88 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	B3RF6Q	4-Amino-8-(4-Methylpyridin-3-Yl)cinnoline-3-Carboxamide	Investigative	91809511	C15H13N5O	279.3	CC1=C(C=NC=C1)C2=CC=CC3=C(C(=NN=C32)C(=O)N)N	IC50 = 100000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	B8I9YL	4-Amino-8-(1-methyl-1H-pyrazole-4-yl)cinnoline-3-carboxamide	Investigative	122180346	C13H12N6O	268.27	CN1C=C(C=N1)C2=CC=CC3=C(C(=NN=C32)C(=O)N)N	EC50 ~ 50000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	B8M6WR	6-Tert-butyl-8-fluoro-2-[[3-(hydroxymethyl)-4-(2-oxo-1H-pyridin-4-yl)phenyl]methyl]phthalazin-1-one	Investigative	76073533	C25H24FN3O3	433.5	CC(C)(C)C1=CC2=C(C(=C1)F)C(=O)N(N=C2)CC3=CC(=C(C=C3)C4=CC(=O)NC=C4)CO	IC50 ~ 100000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	BCZA06	3-(9H-Purin-6-ylamino)-cyclohexanecarboxylic acid 3-chloro-benzylamide	Investigative	78324036	C19H21ClN6O	384.9	C1CC(CC(C1)NC2=NC=NC3=C2NC=N3)C(=O)NCC4=CC(=CC=C4)Cl	IC50 = 100000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	BHZ8C9	N-(3-(2-((4-Morpholinophenyl)amino)-5-(phenylamino)pyrimidin-4-yl)phenyl)acrylamide	Investigative	71469142	C29H28N6O2	492.6	C=CC(=O)NC1=CC=CC(=C1)C2=NC(=NC=C2NC3=CC=CC=C3)NC4=CC=C(C=C4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	BN0JE5	4-Tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-9-(3-phenylpropyl)purin-2-yl]phenyl]benzamide	Investigative	90656061	C43H45N7O3	707.9	CC1=C(C=CC=C1NC(=O)C2=CC=C(C=C2)C(C)(C)C)C3=NC(=C4C(=N3)N(C=N4)CCCC5=CC=CC=C5)NC6=CC=C(C=C6)C(=O)N7CCOCC7	IC50 ~ 50000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	BPO57U	4-Tert-butyl-N-[3-[4-[4-(morpholine-4-carbonyl)anilino]pyrimidin-2-yl]phenyl]benzamide	Investigative	90656045	C32H33N5O3	535.6	CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)C3=NC=CC(=N3)NC4=CC=C(C=C4)C(=O)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T25005	Tyrosine-protein kinase BTK	BV2SO0	4-Tert-butyl-N-[3-[4-[4-(morpholine-4-carbonyl)anilino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]phenyl]benzamide	Investigative	90656046	C34H34N6O3	574.7	CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)C3=NN4C=CC=C4C(=N3)NC5=CC=C(C=C5)C(=O)N6CCOCC6	IC50 ~ 50000 nM	Poor binder