TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T25307	Nuclear receptor ROR-gamma	B0CE6F	5-[(2-Chlorophenoxy)methyl]-N-(4-sulfamoylphenyl)furan-2-carboxamide	Investigative	5057409	C18H15ClN2O5S	406.8	C1=CC=C(C(=C1)OCC2=CC=C(O2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)N)Cl	IC50 = 81690 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B12KZI	N-[2-(4-Acetylpiperazin-1-yl)-2-oxoethyl]-4-methyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide	Investigative	127046061	C22H24F3N3O4S	483.5	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)N2CCN(CC2)C(=O)C)C3=CC=CC(=C3)C(F)(F)F	IC50 = 175300 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B30CTV	N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide	Investigative	127048039	C25H19F9N2O4S	614.5	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NC2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O)C3=CC=CC(=C3)C(F)(F)F	IC50 = 112250 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B3HJE7	2-[N-(4-Methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]-N-(4-phenylmethoxyphenyl)acetamide	Investigative	51344334	C29H25F3N2O4S	554.6	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NC2=CC=C(C=C2)OCC3=CC=CC=C3)C4=CC=CC(=C4)C(F)(F)F	IC50 = 93850 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B3JH9B	Methyl 4-[[[2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetyl]amino]methyl]benzoate	Investigative	127047774	C25H23F3N2O5S	520.5	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NCC2=CC=C(C=C2)C(=O)OC)C3=CC=CC(=C3)C(F)(F)F	IC50 = 67050 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B4FQ5E	N-(1-Acetyl-2,3-dihydroindol-5-yl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide	Investigative	90654877	C23H21N3O4S	435.5	CCN1C2=C3C(=C(C=C2)S(=O)(=O)NC4=CC5=C(C=C4)N(CC5)C(=O)C)C=CC=C3C1=O	IC50 = 52260 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B64NEO	Chembl4176087	Investigative	145973599	C11H12ClNO2	225.67	CC(=O)NC1=CC(=C(C=C1)OC2CC2)Cl	IC50 = 69000 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B7PDU9	N-(4-Carbamoylphenyl)-3-[(4-chlorophenoxy)methyl]benzamide	Investigative	3595981	C21H17ClN2O3	380.8	C1=CC(=CC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)N)COC3=CC=C(C=C3)Cl	IC50 = 168270 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	B7VOU4	N-(4-Acetylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide	Investigative	86288875	C21H18N2O4S	394.4	CCN1C2=C3C(=C(C=C2)S(=O)(=O)NC4=CC=C(C=C4)C(=O)C)C=CC=C3C1=O	IC50 = 70140 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BBQ8X0	3-(1,3-Benzodioxol-5-yl)-N,N-diethyl-3-(2-hydroxy-4,6-dimethoxyphenyl)propanamide	Investigative	16746480	C22H27NO6	401.5	CCN(CC)C(=O)CC(C1=CC2=C(C=C1)OCO2)C3=C(C=C(C=C3OC)OC)O	IC50 ~ 50000 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BCR1D2	N-(2-Benzoylphenyl)-1-ethyl-2-oxobenzo[cd]indole-6-sulfonamide	Investigative	90654878	C26H20N2O4S	456.5	CCN1C2=C3C(=C(C=C2)S(=O)(=O)NC4=CC=CC=C4C(=O)C5=CC=CC=C5)C=CC=C3C1=O	IC50 = 156300 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BD0PY2	N-[(4-Methylphenyl)sulfonyl]-N-[3-(trifluoromethyl)phenyl]glycine	Investigative	1286153	C16H14F3NO4S	373.3	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)O)C2=CC=CC(=C2)C(F)(F)F	IC50 = 93290 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BDV4T7	Chembl4211299	Investigative	145964574	C20H11ClF5NO2	427.7	C1=CC(=C(C(=C1)F)C(=O)NC2=CC=C(C=C2)C3=C(C=CC(=C3)OC(F)(F)F)Cl)F	IC50 ~ 50000 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BJ87IA	2-(4-Cyano-N-(4-methylphenyl)sulfonylanilino)-N-(4-cyanophenyl)acetamide	Investigative	127048041	C23H18N4O3S	430.5	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NC2=CC=C(C=C2)C#N)C3=CC=C(C=C3)C#N	IC50 = 65320 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BQOI94	N-(4-(1-Ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)phenyl)acetamide	Investigative	1523409	C21H19N3O4S	409.5	CCN1C2=C3C(=C(C=C2)S(=O)(=O)NC4=CC=C(C=C4)NC(=O)C)C=CC=C3C1=O	IC50 = 89760 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BRN7T3	2-({4-Allyl-5-[(4-chlorophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N'-(3-hydroxybenzylidene)acetohydrazide	Investigative	9617733	C21H20ClN5O3S	457.9	C=CCN1C(=NN=C1SCC(=O)N/N=C/C2=CC(=CC=C2)O)COC3=CC=C(C=C3)Cl	IC50 = 56640 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BSQ24X	2-({5-[3-(1,3-Dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propyl]-4-(prop-2-en-1-yl)-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-sulfamoylphenyl)acetamide	Investigative	4096741	C28H26N6O5S2	590.7	C=CCN1C(=NN=C1SCC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)CCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O	IC50 = 142210 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BUQF36	N-(2,4-Difluorophenyl)-2-[N-(4-methylphenyl)sulfonyl-3-(trifluoromethyl)anilino]acetamide	Investigative	1302006	C22H17F5N2O3S	484.4	CC1=CC=C(C=C1)S(=O)(=O)N(CC(=O)NC2=C(C=C(C=C2)F)F)C3=CC=CC(=C3)C(F)(F)F	IC50 = 62580 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BV2J4E	1-Ethyl-N-[(4-methoxyphenyl)methyl]-2-oxobenzo[cd]indole-6-sulfonamide	Investigative	90654880	C21H20N2O4S	396.5	CCN1C2=C3C(=C(C=C2)S(=O)(=O)NCC4=CC=C(C=C4)OC)C=CC=C3C1=O	IC50 = 174400 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BV8RX5	3-(1,3-Benzodioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-N-(4-methylphenyl)propanamide	Investigative	46943341	C25H25NO6	435.5	CC1=CC=C(C=C1)NC(=O)CC(C2=CC3=C(C=C2)OCO3)C4=C(C=C(C=C4OC)OC)O	IC50 ~ 50000 nM	Poor binder
T25307	Nuclear receptor ROR-gamma	BZC18T	3-(1,3-Benzodioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-pyrrolidin-1-ylpropan-1-one	Investigative	16746343	C22H25NO6	399.4	COC1=CC(=C(C(=C1)OC)C(CC(=O)N2CCCC2)C3=CC4=C(C=C3)OCO4)O	IC50 ~ 50000 nM	Poor binder