TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T26463	DNA polymerase alpha catalytic p180	B1CT5Z	N-(4-Chlorobenzyl)-2-[(2-hydroxyethoxy)methyl]-8-(morpholin-4-ylmethyl)-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide	Investigative	10185854	C27H28ClN3O5	510	C1COCCN1CC2=CC3=C4C(=C2)C(=O)C(=CN4C(=C3)COCCO)C(=O)NCC5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B2MS6B	N-(4-Chlorobenzothiazole-2-yl)-3-hydroxy-7-methoxynaphthalene-2-carboxamide	Investigative	481504	C19H13ClN2O3S	384.8	COC1=CC2=CC(=C(C=C2C=C1)O)C(=O)NC3=NC4=C(S3)C=CC=C4Cl	IC50 = 93000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B3VS7Q	[[(2R,3R,5R)-5-(7-Aminotriazolo[4,5-d]pyrimidin-3-yl)-3-hydroxyoxolan-2-yl]methoxy-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate	Investigative	10918740	C21H33N6O10P	560.5	CC(C)(C)C(=O)OCOP(=O)(OC[C@@H]1[C@@H](C[C@@H](O1)N2C3=NC=NC(=C3N=N2)N)O)OCOC(=O)C(C)(C)C	Ki = 156000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B4CWS0	6H-Purin-6-one, 2-((3,4-dichlorophenyl)amino)-1,9-dihydro-	Investigative	135435051	C11H7Cl2N5O	296.11	C1=CC(=C(C=C1NC2=NC3=C(C(=O)N2)NC=N3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B4LWN1	N-(4-Chlorobenzyl)-2-(2-hydroxyethyl)-8-(4-morpholinylmethyl)-6-oxo-6H-pyrrolo[3,2,1-ij]quinoline-5-carboxamide	Investigative	491953	C26H26ClN3O4	480	C1COCCN1CC2=CC3=C4C(=C2)C(=O)C(=CN4C(=C3)CCO)C(=O)NCC5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B4Z6KB	N~2~-(3,4-Dichlorophenyl)-9H-purine-2,6-diamine	Investigative	496192	C11H8Cl2N6	295.12	C1=CC(=C(C=C1NC2=NC(=C3C(=N2)N=CN3)N)Cl)Cl	IC50 = 85000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B59WAG	{[({2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy}methyl)(hydroxy)phosphoryl]oxy}phosphonic acid	Investigative	53320320	C11H18N6O7P2	408.24	C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)CCOCP(=O)(O)OP(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B6R8GS	Dihydroxyphosphoryl (((2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl)methoxy-hydroxy-phosphoryl) hydrogen phosphate	Investigative	23725128	C10H16FN2O14P3	500.16	C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B8OM9T	[({[2-(2-Amino-6-oxo-6,9-dihydro-3H-purin-9-yl)ethoxy]methyl}(hydroxy)phosphoryl)oxy]phosphonic acid	Investigative	136030640	C8H13N5O8P2	369.17	C1=NC2=C(N1CCOCP(=O)(O)OP(=O)(O)O)N=C(NC2=O)N	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B8QYC6	Plakevulin A	Investigative	10385259	C23H42O4	382.6	CCCCCCCCCCCCCCCC[C@@]1(C=C[C@@H]([C@H]1C(=O)OC)O)O	IC50 = 66000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	B9GH5I	1-[(2-Amino-4-chloro-5-methylphenyl)sulfonyl]-L-proline	Investigative	6914644	C12H15ClN2O4S	318.78	CC1=CC(=C(C=C1Cl)N)S(=O)(=O)N2CCC[C@H]2C(=O)O	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BB7PG9	N-Acetyl-[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy]phosphonamidic acid	Investigative	90654419	C11H15F2N4O7P	384.23	CC(=O)NP(=O)(O)OC[C@@H]1[C@H](C([C@@H](O1)N2C=CC(=NC2=O)N)(F)F)O	EC50 = 70000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BBZ61D	5-Methyluridine triphosphate	Investigative	451388	C10H17N2O15P3	498.17	CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BCNQ08	(3As,4S,7R,7aR)-1,6-diethyl-2,7-bis(methoxycarbonyl)-3-oxo-3a,4,7,7a-tetrahydro-3H-indene-4-carboxylic acid	Investigative	10893485	C18H22O7	350.4	CCC1=C[C@@H]([C@@H]2[C@H]([C@H]1C(=O)OC)C(=C(C2=O)C(=O)OC)CC)C(=O)O	IC50 ~ 50000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BE8B7D	[[(2R,3R,4R,5S)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	Investigative	25000921	C12H19N4O13P3	520.22	C[C@]1([C@@H]([C@H](O[C@H]1C2=CC=C3N2N=CN=C3N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BFSP54	[[(2S,3R,5S)-5-(4-Amino-2-oxopyrimidin-1-yl)-3-fluorooxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	Investigative	497310	C9H15FN3O12P3	469.15	C1[C@H]([C@@H](O[C@@H]1N2C=CC(=NC2=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)F	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BJ08ML	[({[({2-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]ethoxy}methyl)(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl)oxy]phosphonic acid	Investigative	53324652	C11H19N6O10P3	488.22	C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)CCOCP(=O)(O)OP(=O)(O)OP(=O)(O)O	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BJ57BK	2-[[2-Chloro-6-methoxy-5-(trifluoromethyl)naphthalene-1-carbonyl]-methoxycarbonylamino]acetic acid	Investigative	3012981	C17H13ClF3NO6	419.7	COC1=C(C2=C(C=C1)C(=C(C=C2)Cl)C(=O)N(CC(=O)O)C(=O)OC)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BLJ08A	3,5-Dihydroxy-naphthalene-2-carboxylic acid 4-chloro-benzylamide	Investigative	481498	C18H14ClNO3	327.8	C1=CC2=CC(=C(C=C2C(=C1)O)O)C(=O)NCC3=CC=C(C=C3)Cl	IC50 = 63000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BMV8N7	[[(2S,3R,5S)-5-(2,4-Dioxopyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate	Investigative	497308	C9H14FN2O13P3	470.13	C1[C@H]([C@@H](O[C@@H]1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)F	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BQI6X0	3-Hydroxy-7-methoxy-N-[(4-nitrophenyl)methyl]naphthalene-2-carboxamide	Investigative	481501	C19H16N2O5	352.3	COC1=CC2=CC(=C(C=C2C=C1)O)C(=O)NCC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BQZ4F9	1-(2-Cyclopropylethyl)-3-(1,1-Dioxido-2h-1,2,4-Benzothiadiazin-3-Yl)-6-Fluoro-4-Hydroxyquinolin-2(1h)-One	Investigative	135435181	C21H18FN3O4S	427.5	C1CC1CCN2C3=C(C=C(C=C3)F)C(=C(C2=O)C4=NS(=O)(=O)C5=CC=CC=C5N4)O	IC50 ~ 50000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BR30ZB	3,5-Dihydroxy-N-[(4-nitrophenyl)methyl]naphthalene-2-carboxamide	Investigative	481497	C18H14N2O5	338.3	C1=CC2=CC(=C(C=C2C(=C1)O)O)C(=O)NCC3=CC=C(C=C3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T26463	DNA polymerase alpha catalytic p180	BZYQ83	N-[[(2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]pyridine-3-carboxamide	Investigative	86302310	C15H16F2N5O6PS	463.4	C1=CC(=CN=C1)C(=O)NP(=S)(O)OC[C@@H]2[C@H](C([C@@H](O2)N3C=CC(=NC3=O)N)(F)F)O	EC50 = 80000 nM	Poor binder