TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T27445 Bacterial Isoleucyl-tRNA synthetase B4XM8Q [(2R,3S,4R,5S)-5-[(6-Aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl (2S,3S)-2-amino-3-methylpentanoate Investigative 44385414 C17H26N6O5 394.4 CC[C@H](C)[C@@H](C(=O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)CN2C=NC3=C(N=CN=C32)N)O)O)N IC50 ~ 128000 nM Poor binder T27445 Bacterial Isoleucyl-tRNA synthetase BV1FL7 (2S,3S)-2-Amino-N-[[(2R,3S,4R,5S)-5-[(6-aminopurin-9-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methyl]-N-hydroxy-3-methylpentanamide Investigative 44386149 C17H27N7O5 409.4 CC[C@H](C)[C@@H](C(=O)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)CN2C=NC3=C(N=CN=C32)N)O)O)O)N IC50 ~ 128000 nM Poor binder