TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T27812	Serotonin transporter	D02PPN	Methylphenidate	Approved	4158	C14H19NO2	233.31	COC(=O)C(C1CCCCN1)C2=CC=CC=C2	Ki = 65000 nM	Poor binder
T27812	Serotonin transporter	B09YKM	(2S,3S)-2-Biphenyl-4-yl-3,5,5-trimethylmorpholin-2-ol	Investigative	46837783	C19H23NO2	297.4	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=C(C=C2)C3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B0ON2P	Radafaxine	Investigative	9795056	C13H18ClNO2	255.74	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B0RNS4	(2S,3S)-2-(3-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837648	C13H18FNO2	239.29	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)F)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B1U9RG	(2S,3S)-2-(4-Fluorophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837653	C13H18FNO2	239.29	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=C(C=C2)F)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B26CVM	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	Investigative	743974	C16H19NO3S	305.4	CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B29NIY	3-(Benzhydrylsulfinylmethyl)-2-bromothiophene	Investigative	137643954	C18H15BrOS2	391.3	C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC3=C(SC=C3)Br	IC50 = 59600 nM	Poor binder
T27812	Serotonin transporter	B2F1KT	(cis)-2-(5-Bromopentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one	Investigative	25258806	C21H27BrN2O3	435.4	COC1=C(C=C(C=C1)C2=NN(C(=O)[C@H]3[C@@H]2CC=CC3)CCCCCBr)OC	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B2M0OR	6-Hydroxy-8-methyl-3-phenyl-8-aza-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester	Investigative	44322646	C16H19NO3	273.33	CN1C2C[C@@H](C1CC(=C2C(=O)OC)C3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B2PXF6	2-[[(4-Methylphenyl)-phenylmethyl]sulfinylmethyl]thiophene	Investigative	137637663	C19H18OS2	326.5	CC1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC3=CC=CS3	IC50 = 118400 nM	Poor binder
T27812	Serotonin transporter	B3B8DP	N-Ethyl-2-pyrrolidin-1-yl-N-{2-[2-(trifluoromethoxy)phenyl]-ethyl}ethanamine	Investigative	24878953	C17H25F3N2O	330.4	CCN(CCC1=CC=CC=C1OC(F)(F)F)CCN2CCCC2	Ki ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B3SAG0	(2S,3S)-2-(4-Methoxyphenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837782	C14H21NO3	251.32	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=C(C=C2)OC)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B4A3JO	(2R,3R)-2-(3-Chlorophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	9943908	C13H18ClNO2	255.74	C[C@@H]1[C@](OCC(N1)(C)C)(C2=CC(=CC=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B4ER7L	4-Hydroxy Duloxetine	Investigative	29981497	C18H19NO2S	313.4	CNCC[C@@H](C1=CC=CS1)OC2=CC=C(C3=CC=CC=C32)O	Ki = 63900 nM	Poor binder
T27812	Serotonin transporter	B4H0KZ	(2S,3S)-2-(3,5-Difluorophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837785	C13H17F2NO2	257.279	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC(=C2)F)F)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B4P9DQ	(2S,3S)-2-(3-Chlorophenyl)-3,4,5,5-tetramethylmorpholin-2-ol	Investigative	46837924	C14H20ClNO2	269.77	C[C@H]1[C@@](OCC(N1C)(C)C)(C2=CC(=CC=C2)Cl)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B5EOA1	2-[(1R)-3-Amino-1-(1,2-oxazol-5-yl)propoxy]-6-(trifluoromethyl)pyridine-3-carbonitrile;oxalic acid	Investigative	54580936	C15H13F3N4O6	402.28	C1=CC(=NC(=C1C#N)O[C@H](CCN)C2=CC=NO2)C(F)(F)F.C(=O)(C(=O)O)O	IC50 = 70000 nM	Poor binder
T27812	Serotonin transporter	B5VDA8	3-(4-Chloro-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester	Investigative	23449988	C15H15ClO3	278.73	COC(=O)C1=C(CC2CCC1O2)C3=CC=C(C=C3)Cl	IC50 ~ 60000 nM	Poor binder
T27812	Serotonin transporter	B5W6IL	Methyl 2-(3,4-dichlorophenyl)cyclohept-1-enecarboxylate	Investigative	44429218	C15H16Cl2O2	299.2	COC(=O)C1=C(CCCCC1)C2=CC(=C(C=C2)Cl)Cl	Ki = 149000 nM	Poor binder
T27812	Serotonin transporter	B60AOI	(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one	Investigative	11044358	C16H18N2O3	286.33	COC1=C(C=C(C=C1)C2=NNC(=O)[C@H]3[C@@H]2CC=CC3)OC	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B6B4DP	2-[2-[2-[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]ethoxy]ethoxy]ethanethiol	Investigative	9880323	C16H24N2O3S	324.4	C1=CC2=C(C=C1OCCOCCOCCS)C(=CN2)CCN	IC50 = 99000 nM	Poor binder
T27812	Serotonin transporter	B6BP1I	(2S,3S)-2-(3-Methoxyphenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837651	C14H21NO3	251.32	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)OC)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B6H7VW	(1R,2S,4R)-1-Aminocyclopentane-1,2,4-tricarboxylic acid	Investigative	44437018	C8H11NO6	217.18	C1[C@H](C[C@@]([C@H]1C(=O)O)(C(=O)O)N)C(=O)O	Ki ~ 50000 nM	Poor binder
T27812	Serotonin transporter	B6H8MO	N-Methyl-2-pyrrolidin-1-yl-N-{2-[2-(trifluoromethoxy)phenyl]-ethyl}ethanamine	Investigative	24879008	C16H23F3N2O	316.36	CN(CCC1=CC=CC=C1OC(F)(F)F)CCN2CCCC2	Ki ~ 100000 nM	Poor binder
T27812	Serotonin transporter	B6JBG3	3-[3-(4-Fluorophenyl)-1H-benzo[f][2]benzofuran-3-yl]-N,N-dimethylpropan-1-amine	Investigative	137636508	C23H24FNO	349.4	CN(C)CCCC1(C2=CC3=CC=CC=C3C=C2CO1)C4=CC=C(C=C4)F	EC50 = 95000 nM	Poor binder
T27812	Serotonin transporter	B6PY4Z	(1S,2R,4S)-1-Aminocyclopentane-1,2,4-tricarboxylic acid	Investigative	24809704	C8H11NO6	217.18	C1[C@@H](C[C@]([C@@H]1C(=O)O)(C(=O)O)N)C(=O)O	Ki ~ 50000 nM	Poor binder
T27812	Serotonin transporter	B9PKO5	2-(3,5-Dichlorophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	49799634	C13H17Cl2NO2	290.18	CC1C(OCC(N1)(C)C)(C2=CC(=CC(=C2)Cl)Cl)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BBJ87T	(1S,2S,4R)-1-Aminocyclopentane-1,2,4-tricarboxylic acid	Investigative	44437023	C8H11NO6	217.18	C1[C@H](C[C@]([C@H]1C(=O)O)(C(=O)O)N)C(=O)O	Ki ~ 50000 nM	Poor binder
T27812	Serotonin transporter	BD8I5B	(-)-O-Methylcubebin	Investigative	59800034	C21H22O6	370.4	COC1[C@H]([C@@H](CO1)CC2=CC3=C(C=C2)OCO3)CC4=CC5=C(C=C4)OCO5	IC50 = 90300 nM	Poor binder
T27812	Serotonin transporter	BDJ93A	(2S,3S)-2-(3-Nitrophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837652	C13H18N2O4	266.29	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)[N+](=O)[O-])O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BGH80W	3,5,5-Trimethyl-2-(pyridin-3-yl)morpholin-2-ol	Investigative	49799236	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CN=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BHEM18	Methyl 2-(biphenyl-4-yl)cycloheptanecarboxylate	Investigative	44429400	C21H24O2	308.4	COC(=O)[C@@H]1CCCCC[C@@H]1C2=CC=C(C=C2)C3=CC=CC=C3	Ki = 73000 nM	Poor binder
T27812	Serotonin transporter	BJ31AZ	2-[Bis(4-fluorophenyl)methylsulfinylmethyl]thiophene	Investigative	137632704	C18H14F2OS2	348.4	C1=CSC(=C1)CS(=O)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F	IC50 = 120500 nM	Poor binder
T27812	Serotonin transporter	BK3MR2	4-(3,4-Dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one	Investigative	22337182	C16H18N2O3	286.33	COC1=C(C=C(C=C1)C2=NNC(=O)C3C2CC=CC3)OC	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BKX0O6	2-(3,4-Dichlorophenyl)-N-(thiophen-2-ylmethyl)cyclopent-1-enecarboxamide	Investigative	44443890	C17H15Cl2NOS	352.3	C1CC(=C(C1)C(=O)NCC2=CC=CS2)C3=CC(=C(C=C3)Cl)Cl	Ki = 110000 nM	Poor binder
T27812	Serotonin transporter	BKYN16	1-[3-(Dimethylamino)propyl]-1-naphthalen-2-yl-3H-2-benzofuran-5-carbonitrile	Investigative	137639697	C24H24N2O	356.5	CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC4=CC=CC=C4C=C3	EC50 = 55000 nM	Poor binder
T27812	Serotonin transporter	BL34RV	(2S,3S)-2-(3,4-Difluorophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837784	C13H17F2NO2	257.279	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=C(C=C2)F)F)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BL8WP1	1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5-bromophthalane	Investigative	10150457	C19H21BrFNO	378.3	CN(C)CCCC1(C2=C(CO1)C=C(C=C2)Br)C3=CC=C(C=C3)F	IC50 = 120000 nM	Poor binder
T27812	Serotonin transporter	BNEF42	Dimethyl phthalate	Investigative	8554	C10H10O4	194.18	COC(=O)C1=CC=CC=C1C(=O)OC	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BP5IZ6	N-(4-Methoxyphenethyl)-N-methyl-2-(piperidin-1-yl)ethanamine	Investigative	9882069	C17H28N2O	276.4	CN(CCC1=CC=C(C=C1)OC)CCN2CCCCC2	Ki = 52647 nM	Poor binder
T27812	Serotonin transporter	BP6A5U	2-[(1R,2S,3S,5S)-3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octan-2-yl]-5,6-dimethyl-1H-benzimidazole	Investigative	49852019	C23H26ClN3	379.9	CC1=CC2=C(C=C1C)N=C(N2)[C@@H]3[C@H]4CC[C@H](N4C)C[C@@H]3C5=CC=C(C=C5)Cl	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BPVR73	(2S,3S)-3,5,5-Trimethyl-2-(4-methylphenyl)morpholin-2-ol	Investigative	46837781	C14H21NO2	235.32	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=C(C=C2)C)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BQ5J8X	2-(Benzhydrylsulfinylmethyl)-4-bromothiophene	Investigative	137649677	C18H15BrOS2	391.3	C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC3=CC(=CS3)Br	IC50 = 70900 nM	Poor binder
T27812	Serotonin transporter	BQ85RH	Methyl biphenyl-2-carboxylate	Investigative	9920766	C14H12O2	212.24	COC(=O)C1=CC=CC=C1C2=CC=CC=C2	IC50 ~ 70000 nM	Poor binder
T27812	Serotonin transporter	BQTE70	6-Hydroxy-8-methyl-3-phenyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester	Investigative	44322164	C16H21NO3	275.34	CN1C2C[C@@H](C1CC(C2C(=O)OC)C3=CC=CC=C3)O	IC50 = 88000 nM	Poor binder
T27812	Serotonin transporter	BR15OM	Methyl 2-(naphthalen-2-yl)cyclohex-1-enecarboxylate	Investigative	44429203	C18H18O2	266.3	COC(=O)C1=C(CCCC1)C2=CC3=CC=CC=C3C=C2	Ki = 109000 nM	Poor binder
T27812	Serotonin transporter	BR9X5E	2-Hydroxyethyl 2-(3,4-dichlorophenyl)cyclopent-1-enecarboxylate	Investigative	44443894	C14H14Cl2O3	301.2	C1CC(=C(C1)C(=O)OCCO)C2=CC(=C(C=C2)Cl)Cl	Ki = 50000 nM	Poor binder
T27812	Serotonin transporter	BRG56V	7-Hydroxy-8-methyl-3-phenyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester	Investigative	44322076	C16H21NO3	275.34	CN1C2C[C@H](C1C(C(C2)C3=CC=CC=C3)C(=O)OC)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BSTE79	2-N-Methylamino-1-(4-ethylthiophenyl)butane	Investigative	44613457	C13H21NS	223.38	CCC(CC1=CC=C(C=C1)SCC)NC	EC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BT4A9G	2-(5-Bromo-pentyl)-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one	Investigative	22337167	C21H27BrN2O3	435.4	COC1=C(C=C(C=C1)C2=NN(C(=O)C3C2CC=CC3)CCCCCBr)OC	Ki ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BU8PE0	N-Ethyl-2-piperidin-1-yl-N-{2-[2-(trifluoromethoxy)phenyl]-ethyl}ethanamine	Investigative	24879001	C18H27F3N2O	344.4	CCN(CCC1=CC=CC=C1OC(F)(F)F)CCN2CCCCC2	Ki ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BV2UL1	3,5,5-Trimethyl-2-(pyridin-2-yl)morpholin-2-ol	Investigative	49799237	C12H18N2O2	222.28	CC1C(OCC(N1)(C)C)(C2=CC=CC=N2)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BVE6T1	3-(4-Fluoro-phenyl)-8-oxa-bicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl ester	Investigative	23449989	C15H15FO3	262.28	COC(=O)C1=C(CC2CCC1O2)C3=CC=C(C=C3)F	IC50 ~ 50000 nM	Poor binder
T27812	Serotonin transporter	BW49RA	2-(Benzhydrylsulfinylmethyl)-5-chlorothiophene	Investigative	137656786	C18H15ClOS2	346.9	C1=CC=C(C=C1)C(C2=CC=CC=C2)S(=O)CC3=CC=C(S3)Cl	IC50 = 57200 nM	Poor binder
T27812	Serotonin transporter	BW4I1B	5-[(1S)-3-(Methylamino)-1-(thiophen-2-yl)propoxy]naphthalene-1,2-diol	Investigative	44344115	C18H19NO3S	329.4	CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=C2C=CC(=C3O)O	Ki = 120000 nM	Poor binder
T27812	Serotonin transporter	BWK3E4	Methyl 2-(4-(trifluoromethyl)phenyl)cyclohexanecarboxylate	Investigative	44429399	C15H17F3O2	286.29	COC(=O)[C@@H]1CCCC[C@@H]1C2=CC=C(C=C2)C(F)(F)F	Ki = 185000 nM	Poor binder
T27812	Serotonin transporter	BWQ23J	3-(4-Chlorophenyl)-5-[(1R,2S,3S,5S)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octan-2-yl]-1,2-oxazole	Investigative	11474847	C24H25ClN2O	392.9	CC1=CC=C(C=C1)[C@H]2C[C@@H]3CC[C@H]([C@H]2C4=CC(=NO4)C5=CC=C(C=C5)Cl)N3C	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BX2C5U	(2S,3S)-2-(3-Bromophenyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837649	C13H18BrNO2	300.19	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)Br)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	BX79MS	N-Methyl-2-piperidin-1-yl-N-{2-[2-(trifluoromethoxy)phenyl]-ethyl}ethanamine	Investigative	24879010	C17H25F3N2O	330.4	CN(CCC1=CC=CC=C1OC(F)(F)F)CCN2CCCCC2	Ki ~ 100000 nM	Poor binder
T27812	Serotonin transporter	D00QCP	(2S,3S)-2-Phenyl-3,5,5-trimethylmorpholin-2-ol	Investigative	46837647	C13H19NO2	221.29	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=CC=C2)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	D03YQY	(2S,3S)-2-(m-Tolyl)-3,5,5-trimethylmorpholin-2-ol	Investigative	46837650	C14H21NO2	235.32	C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC=CC(=C2)C)O	IC50 ~ 100000 nM	Poor binder
T27812	Serotonin transporter	D0X3CF	HINOKININ	Investigative	442879	C20H18O6	354.4	C1[C@@H]([C@H](C(=O)O1)CC2=CC3=C(C=C2)OCO3)CC4=CC5=C(C=C4)OCO5	IC50 = 175000 nM	Poor binder