TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T28887	Histone deacetylase 8	D0L7LC	Romidepsin	Approved	5352062	C24H36N4O6S2	540.7	C/C=C\\1/C(=O)N[C@H](C(=O)O[C@H]\\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	D0Y3KG	Valproate	Approved	3121	C8H16O2	144.21	CCCC(CCC)C(=O)O	IC50 = 103000 nM	Poor binder
T28887	Histone deacetylase 8	D0B7CH	Phenylbutyrate	Phase 2	4775	C10H12O2	164.2	C1=CC=C(C=C1)CCCC(=O)O	IC50 = 93000 nM	Poor binder
T28887	Histone deacetylase 8	D0M8FD	SNDX-275	Phase 2	4261	C21H20N4O3	376.4	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3	IC50 = 63400 nM	Poor binder
T28887	Histone deacetylase 8	B03PZD	2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(6-phenylhexyl)acetamide	Investigative	136025984	C19H25N3O2S	359.5	CC1=CC(=O)NC(=N1)SCC(=O)NCCCCCCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B0GAH1	Pimelic Diphenylamide 106	Investigative	16070100	C20H25N3O2	339.4	CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B0IP6E	N-[(2S)-1-[[6-(2-Amino-4-fluoroanilino)-6-oxohexyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methoxybenzamide	Investigative	137657586	C31H34FN5O4	559.6	COC1=CC=C(C=C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NCCCCCC(=O)NC4=C(C=C(C=C4)F)N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B0LZ5N	Pyridin-3-ylmethyl N-[[4-[(3-aminophenyl)carbamoyl]phenyl]methyl]carbamate	Investigative	10785752	C21H20N4O3	376.4	C1=CC(=CC(=C1)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B0R4TM	2-{[2-(4-Tert-butylphenyl)-2-oxoethyl]sulfanyl}-6-methyl-3,4-dihydropyrimidin-4-one	Investigative	135497781	C17H20N2O2S	316.4	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B0VTQ6	N-(2-Aminophenyl)-7,7-di(1H-indol-3-yl)heptanamide	Investigative	45271073	C29H30N4O	450.6	C1=CC=C2C(=C1)C(=CN2)C(CCCCCC(=O)NC3=CC=CC=C3N)C4=CNC5=CC=CC=C54	IC50 = 74000 nM	Poor binder
T28887	Histone deacetylase 8	B1J8GQ	3-(Benzylamino)propionohydroxamic acid monohydrochloride	Investigative	211808	C10H14N2O2	194.23	C1=CC=C(C=C1)CNCCC(=O)NO	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B1SXO5	N-[4-[2-(4-Methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide	Investigative	56659403	C15H15N3O2S	301.4	CC1=NC(=NC=C1)SCC(=O)C2=CC=C(C=C2)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B2L5QJ	N-Phenyl-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide	Investigative	10832425	C21H19N3O3	361.4	C1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B2VLJ6	N-[4-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanylmethyl]phenyl]acetamide	Investigative	136025842	C14H15N3O2S	289.35	CC1=CC(=O)NC(=N1)SCC2=CC=C(C=C2)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B2WME0	N-(2-Aminophenyl)-4-[[[(4S)-4-(4-hydroxyphenyl)-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide	Investigative	137125267	C23H22N4O3	402.4	C1[C@@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)C4=CC=C(C=C4)O	IC50 = 83300 nM	Poor binder
T28887	Histone deacetylase 8	B3UK0O	Carbamic acid,N-[[4-[[(4-amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]-,methyl ester	Investigative	25032862	C22H21N3O3	375.4	COC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CC=C3)N	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	B40XIT	N-(2-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide	Investigative	137657892	C14H7ClF12N2O3	514.65	C1=CC=C(C(=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	B4JO8K	(R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(thiazole-5-carbonylamino)heptylboronic acid	Investigative	42637373	C23H26BN3O4S	451.4	B(CCCCC[C@H](C(=O)NC1=CC=CC(=C1)C2=CC=CC=C2)NC(=O)C3=CN=CS3)(O)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B4YZ2S	6-(Acetyl-hydroxy-amino)-hexanoic acid phenylamide	Investigative	44359800	C14H20N2O3	264.32	CC(=O)N(CCCCCC(=O)NC1=CC=CC=C1)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B5D4ZC	N-(3-Methyl-2-aminophenyl)-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide	Investigative	11794739	C22H22N4O3	390.4	CC1=C(C(=CC=C1)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B5HIZ3	N-[4-[2-[(4-Methyl-6-oxo-1H-pyridin-2-yl)oxy]acetyl]phenyl]acetamide	Investigative	56673261	C16H16N2O4	300.31	CC1=CC(=O)NC(=C1)OCC(=O)C2=CC=C(C=C2)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B5YA1D	2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(2-methylphenyl)octanediamide	Investigative	137647616	C15H10F12N2O3	494.23	CC1=CC=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	B68ULE	N-(2-Aminophenyl)-4-[[[4-[4-(trifluoromethyl)phenyl]-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide	Investigative	137125266	C24H21F3N4O2	454.4	C1C(NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)C4=CC=C(C=C4)C(F)(F)F	IC50 = 82100 nM	Poor binder
T28887	Histone deacetylase 8	B6H8VS	N-Hydroxy-2-pyrazin-2-yl-1,3-thiazole-4-carboxamide	Investigative	137226378	C8H6N4O2S	222.23	C1=CN=C(C=N1)C2=NC(=CS2)C(=O)NO	IC50 = 61420 nM	Poor binder
T28887	Histone deacetylase 8	B6K7LT	Benzyl (2S)-4-[5-[(2-amino-5-phenylphenyl)carbamoyl]pyridin-2-yl]-2-methylpiperazine-1-carboxylate	Investigative	16663079	C31H31N5O3	521.6	C[C@H]1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CC=C5)N	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	B76NHE	2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(4-phenylbutyl)acetamide	Investigative	136086923	C17H21N3O2S	331.4	CC1=CC(=O)NC(=N1)SCC(=O)NCCCCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B7EGQ0	N-(2-Aminophenyl)-4-(((S)-4-phenyl-2-oxazoline-2-yl)aminomethyl)benzamide	Investigative	137125263	C23H22N4O2	386.4	C1[C@@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)C4=CC=CC=C4	IC50 = 88000 nM	Poor binder
T28887	Histone deacetylase 8	B7JEZ8	1-((4-Hydroxy-6-methylpyrimidin-2-yl)thio)propan-2-one	Investigative	135462117	C8H10N2O2S	198.24	CC1=CC(=O)NC(=N1)SCC(=O)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B81YTQ	N-[4-[2-(3-Hydroxyphenyl)sulfanylacetyl]phenyl]acetamide	Investigative	56666337	C16H15NO3S	301.4	CC(=O)NC1=CC=C(C=C1)C(=O)CSC2=CC=CC(=C2)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	B8L3TH	N-[(2S)-1-(Hydroxyamino)-1-oxo-3-[4-(2-phenylethoxy)phenyl]propan-2-yl]-4-methylbenzamide	Investigative	71452975	C25H26N2O4	418.5	CC1=CC=C(C=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)OCCC3=CC=CC=C3)C(=O)NO	IC50 = 52500 nM	Poor binder
T28887	Histone deacetylase 8	B8LMT9	N-(2-Aminophenyl)-4-[[[(4S)-4-pyridin-3-yl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide	Investigative	137125269	C22H21N5O2	387.4	C1[C@@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)C4=CN=CC=C4	IC50 = 111000 nM	Poor binder
T28887	Histone deacetylase 8	B8YM4H	N-[4-(Dimethylamino)phenyl]-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide	Investigative	137631704	C16H13F12N3O3	523.27	CN(C)C1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	B93MKY	N-[4-[1-Hydroxy-2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]ethyl]phenyl]acetamide	Investigative	136025843	C15H17N3O3S	319.4	CC1=CC(=O)NC(=N1)SCC(C2=CC=C(C=C2)NC(=O)C)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BA2XF9	N-Hydroxy-3-[1-(3-naphthalen-2-ylpropyl)-5-oxo-2H-pyrrol-4-yl]propanamide	Investigative	11244651	C20H22N2O3	338.4	C1C=C(C(=O)N1CCCC2=CC3=CC=CC=C3C=C2)CCC(=O)NO	IC50 = 119700 nM	Poor binder
T28887	Histone deacetylase 8	BA60ZC	N-(2-Aminophenyl)-4-(((S)-4-benzyl-2-oxazoline-2-yl)thiomethyl)benzamide	Investigative	122186544	C24H23N3O2S	417.5	C1[C@@H](N=C(O1)SCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)CC4=CC=CC=C4	IC50 = 88000 nM	Poor binder
T28887	Histone deacetylase 8	BABT97	2-Azidoethyl 8-[4-[(3-azido-5-methoxyphenyl)methoxy]anilino]-8-oxooctanoate	Investigative	71449818	C24H29N7O5	495.5	COC1=CC(=CC(=C1)N=[N+]=[N-])COC2=CC=C(C=C2)NC(=O)CCCCCCC(=O)OCCN=[N+]=[N-]	IC50 = 67500 nM	Poor binder
T28887	Histone deacetylase 8	BAD74G	N-(3-Chlorophenyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N'-hydroxyoctanediamide	Investigative	137656303	C14H7ClF12N2O3	514.65	C1=CC(=CC(=C1)Cl)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BAI6T2	N-(2-Aminophenyl)-4-[[[(4S)-4-(1H-imidazol-5-ylmethyl)-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide	Investigative	137125258	C21H22N6O2	390.4	C1[C@@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)CC4=CN=CN4	IC50 = 179000 nM	Poor binder
T28887	Histone deacetylase 8	BART97	N-(2-Aminophenyl)-4-[[[(4S)-4-benzyl-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide	Investigative	137125259	C24H24N4O2	400.5	C1[C@@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)CC4=CC=CC=C4	IC50 = 63000 nM	Poor binder
T28887	Histone deacetylase 8	BB0U1G	N-(2-Aminophenyl)-4-((4,4-diphenyl-2-oxazoline-2-yl)aminomethyl)benzamide	Investigative	137125268	C29H26N4O2	462.5	C1C(NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)(C4=CC=CC=C4)C5=CC=CC=C5	IC50 = 53500 nM	Poor binder
T28887	Histone deacetylase 8	BC54SO	2-[2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one	Investigative	136086920	C15H14N2O4S	318.3	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC3=C(C=C2)OCCO3	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BD3HW6	Pyridin-3-ylmethyl N-[[4-[(4-aminophenyl)carbamoyl]phenyl]methyl]carbamate	Investigative	10643236	C21H20N4O3	376.4	C1=CC(=CN=C1)COC(=O)NCC2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BD8NR5	(R)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino)-7-oxoheptylboronic acid	Investigative	42637300	C26H29BN2O4	444.3	B(CCCCC[C@H](C(=O)NC1=CC=CC(=C1)C2=CC=CC=C2)NC(=O)C3=CC=CC=C3)(O)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BDCZ86	2-[(4-Methyl-6-oxo-1,6-dihydropyrimidin-2-yl)sulfanyl]-N-(2-phenylethyl)acetamide	Investigative	135441620	C15H17N3O2S	303.4	CC1=CC(=O)NC(=N1)SCC(=O)NCCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BDR0H9	8-(Acetyl-hydroxy-amino)-octanoic acid phenylamide	Investigative	44359673	C16H24N2O3	292.37	CC(=O)N(CCCCCCCC(=O)NC1=CC=CC=C1)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BFC08Z	2-[2-(4-Hydroxyphenyl)-2-oxoethyl]sulfanyl-4-methyl-1H-pyrimidin-6-one	Investigative	135928628	C13H12N2O3S	276.31	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BG09QH	N-{4-[2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetyl]-phenyl}-acetamide	Investigative	1108280	C16H17N3O2S	315.4	CC1=CC(=NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BH4RI7	N-[(2S)-1-[[6-(2-Amino-5-thiophen-2-ylanilino)-6-oxohexyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methoxybenzamide	Investigative	137633138	C35H37N5O4S	623.8	COC1=CC=C(C=C1)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)NCCCCCC(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BHD82W	Tert-butyl 8-[4-[(3,5-dimethylphenyl)methoxy]anilino]-8-oxooctanoate	Investigative	71458833	C27H37NO4	439.6	CC1=CC(=CC(=C1)COC2=CC=C(C=C2)NC(=O)CCCCCCC(=O)OC(C)(C)C)C	IC50 = 53200 nM	Poor binder
T28887	Histone deacetylase 8	BHGX52	6-Methyl-2-phenacylsulfanyl-1H-pyrimidin-4-one	Investigative	135412194	C13H12N2O2S	260.31	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BI45NK	N-(2-Aminophenyl)-4-[[(4S)-4-pyridin-3-yl-4,5-dihydro-1,3-oxazol-2-yl]sulfanylmethyl]benzamide	Investigative	122186543	C22H20N4O2S	404.5	C1[C@@H](N=C(O1)SCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)C4=CN=CC=C4	IC50 = 112000 nM	Poor binder
T28887	Histone deacetylase 8	BI6ZB1	N-Methyl-N-[4-[2-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]acetamide	Investigative	136025986	C16H17N3O3S	331.4	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)N(C)C(=O)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BJ1OD3	2-(Tert-butylcarbonylmethylthio)-4-hydroxy-6-methylpyrimidine	Investigative	135473106	C11H16N2O2S	240.32	CC1=CC(=O)NC(=N1)SCC(=O)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BJ2Y3N	2-(4-Chlorophenacylthio)-4-hydroxy-6-methylpyrimidine	Investigative	135437514	C13H11ClN2O2S	294.76	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BK4QE3	N-(2-Aminophenyl)-4-(((R)-5-phenyl-2-oxazoline-2-yl)aminomethyl)benzamide	Investigative	122186553	C23H22N4O2	386.4	C1[C@H](OC(=N1)NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)C4=CC=CC=C4	IC50 = 173000 nM	Poor binder
T28887	Histone deacetylase 8	BK57JA	N-Hydroxy-2-(4-methoxyphenyl)-1,3-oxazole-4-carboxamide	Investigative	127027174	C11H10N2O4	234.21	COC1=CC=C(C=C1)C2=NC(=CO2)C(=O)NO	IC50 = 50940 nM	Poor binder
T28887	Histone deacetylase 8	BL5N1X	Nampt-IN-3	Investigative	137634086	C29H25N7O2	503.6	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CN3C=C(N=N3)C4=CC=C(C=C4)C(=O)NCC5=CN=CC=C5	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BL9F0X	Hdac3-IN-T326	Investigative	71721558	C21H18N6O3S	434.5	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(S2)C3=CN(N=N3)CCC4=CC(=CC=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BLBA30	2-[(4-Hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(4-methoxyphenyl)ethanone	Investigative	135449197	C14H14N2O3S	290.34	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)OC	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BLBE28	(R)-7-(Biphenyl-3-ylamino)-7-oxo-6-(pyridine-3-carbonylamino)heptylboronic acid	Investigative	42638004	C25H28BN3O4	445.3	B(CCCCC[C@H](C(=O)NC1=CC=CC(=C1)C2=CC=CC=C2)NC(=O)C3=CN=CC=C3)(O)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BLV57O	(S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino)-7-oxoheptylboronic acid	Investigative	42637299	C26H29BN2O4	444.3	B(CCCCC[C@@H](C(=O)NC1=CC=CC(=C1)C2=CC=CC=C2)NC(=O)C3=CC=CC=C3)(O)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BM2BW1	N-(4-Methyl-2-aminophenyl)-4-[[(3-pyridylmethoxy)carbonylamino]methyl]benzamide	Investigative	10572471	C22H22N4O3	390.4	CC1=CC(=C(C=C1)NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3)N	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BMC98T	2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-(4-fluorophenyl)-N'-hydroxyoctanediamide	Investigative	137649646	C14H7F13N2O3	498.2	C1=CC(=CC=C1NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)F	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BMH13O	Ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate	Investigative	25155956	C21H21N3O3S	395.5	CCOC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BMZ5H3	2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(4-methoxyphenyl)octanediamide	Investigative	137652670	C15H10F12N2O4	510.23	COC1=CC=C(C=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BN59HZ	(2S)-2-(Methanesulfonamido)-3-[4-(2-phenylethoxy)phenyl]propanoic acid	Investigative	71452974	C18H21NO5S	363.4	CS(=O)(=O)N[C@@H](CC1=CC=C(C=C1)OCCC2=CC=CC=C2)C(=O)O	IC50 = 102300 nM	Poor binder
T28887	Histone deacetylase 8	BN7MF9	Methyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoyl)benzylcarbamate	Investigative	44447194	C20H19N3O3S	381.4	COC(=O)NCC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BNP3Y7	N-(2-Aminophenyl)-4-[1-[2-(3-thienyl)ethyl]-1H-1,2,3-triazol-4-yl]benzamide	Investigative	71721946	C21H19N5OS	389.5	C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)C3=CN(N=N3)CCC4=CSC=C4	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BNT36V	(2S)-N-Hydroxy-2-[(4-methylphenyl)sulfonylamino]-3-[4-(2-phenylethoxy)phenyl]propanamide	Investigative	71461883	C24H26N2O5S	454.5	CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC=C(C=C2)OCCC3=CC=CC=C3)C(=O)NO	IC50 = 82500 nM	Poor binder
T28887	Histone deacetylase 8	BO5I0U	N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)oxy]acetyl]phenyl]acetamide	Investigative	136086924	C15H15N3O4	301.3	CC1=CC(=O)NC(=N1)OCC(=O)C2=CC=C(C=C2)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BPRY15	Methyl 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio)acetate	Investigative	135412048	C8H10N2O3S	214.24	CC1=CC(=O)NC(=N1)SCC(=O)OC	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BQ7PW6	N-Benzoyl-O-benzyltyrosine	Investigative	13746652	C23H21NO4	375.4	C1=CC=C(C=C1)COC2=CC=C(C=C2)C[C@@H](C(=O)O)NC(=O)C3=CC=CC=C3	IC50 = 110500 nM	Poor binder
T28887	Histone deacetylase 8	BRGV98	1-(3,4-Dihydroxyphenyl)-2-[(4-hydroxy-6-methylpyrimidin-2-YL)thio]ethanone	Investigative	135444536	C13H12N2O4S	292.31	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC(=C(C=C2)O)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BS2B3C	3-(4-Formyl-1-methylpyrrol-2-yl)-N-hydroxypropanamide	Investigative	45269071	C9H12N2O3	196.2	CN1C=C(C=C1CCC(=O)NO)C=O	IC50 = 52560 nM	Poor binder
T28887	Histone deacetylase 8	BT8A9U	(2S)-2-Acetamido-3-[4-(2-phenylethoxy)phenyl]propanoic acid	Investigative	71460170	C19H21NO4	327.4	CC(=O)N[C@@H](CC1=CC=C(C=C1)OCCC2=CC=CC=C2)C(=O)O	IC50 = 120900 nM	Poor binder
T28887	Histone deacetylase 8	BU2T0V	Methyl 7-anilino-7-oxoheptyl(hydroxy)carbamate	Investigative	44359814	C15H22N2O4	294.35	COC(=O)N(CCCCCCC(=O)NC1=CC=CC=C1)O	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BULF09	N-(2-Amino-5-thiophen-2-ylphenyl)benzamide	Investigative	44454144	C17H14N2OS	294.4	C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BV3ON1	Chembl4173739	Investigative	145952088	C20H25Cl2N3O	394.3	C1=CC=C(C(=C1)N)NC(=O)CCCC2=CC=C(C=C2)N(CCCl)CCCl	IC50 = 75200 nM	Poor binder
T28887	Histone deacetylase 8	BVSP75	6-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1,3-dihydroindol-2-one	Investigative	136086921	C15H13N3O3S	315.3	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC3=C(CC(=O)N3)C=C2	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BW53QM	N-[4-[2-(4-Methoxy-6-methylpyrimidin-2-yl)sulfanylacetyl]phenyl]acetamide	Investigative	56673234	C16H17N3O3S	331.4	CC1=CC(=NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C)OC	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BW7C9A	2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-N-hydroxy-N'-(3-methylphenyl)octanediamide	Investigative	137658785	C15H10F12N2O3	494.23	CC1=CC(=CC=C1)NC(=O)C(C(C(C(C(C(C(=O)NO)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F	Ki ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BX18GK	Ethyl 4-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]-3-oxobutanoate	Investigative	136086922	C11H14N2O4S	270.31	CCOC(=O)CC(=O)CSC1=NC(=CC(=O)N1)C	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BX62ZD	6-Methyl-2-{[2-oxo-2-(thiophen-2-yl)ethyl]sulfanyl}-3,4-dihydropyrimidin-4-one	Investigative	135407493	C11H10N2O2S2	266.3	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=CS2	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BX8AF0	N-[4-[2-[(4-Methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]phenyl]benzamide	Investigative	136025837	C20H17N3O3S	379.4	CC1=CC(=O)NC(=N1)SCC(=O)C2=CC=C(C=C2)NC(=O)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BXK72U	Thailandepsin A	Investigative	56602459	C23H37N3O6S3	547.8	CC[C@H](C)[C@@H]1[C@H](CC(=O)O[C@H]\\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)CCSC)O	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	BYJ90D	N-(2-Aminophenyl)-4-((4-(3-fluorophenyl)-2-oxazoline-2-yl)aminomethyl)benzamide	Investigative	137125265	C23H21FN4O2	404.4	C1C(NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)C4=CC(=CC=C4)F	IC50 = 52200 nM	Poor binder
T28887	Histone deacetylase 8	BZ06MN	N-(2-Aminophenyl)-4-[[[(4R)-4-(1H-imidazol-5-ylmethyl)-1,3-oxazolidin-2-ylidene]amino]methyl]benzamide	Investigative	137125262	C21H22N6O2	390.4	C1[C@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)CC4=CN=CN4	IC50 = 113000 nM	Poor binder
T28887	Histone deacetylase 8	BZB04V	Pyridin-3-ylmethyl N-[[4-[(2-acetamidophenyl)carbamoyl]phenyl]methyl]carbamate	Investigative	10502119	C23H22N4O4	418.4	CC(=O)NC1=CC=CC=C1NC(=O)C2=CC=C(C=C2)CNC(=O)OCC3=CN=CC=C3	IC50 ~ 100000 nM	Poor binder
T28887	Histone deacetylase 8	BZC5G4	N-(2-Aminophenyl)-4-(((R)-4-phenyl-2-oxazoline-2-yl)aminomethyl)benzamide	Investigative	137125261	C23H22N4O2	386.4	C1[C@H](NC(=NCC2=CC=C(C=C2)C(=O)NC3=CC=CC=C3N)O1)C4=CC=CC=C4	IC50 = 80700 nM	Poor binder
T28887	Histone deacetylase 8	D03QOD	N-hydroxy-2,2-diphenylacetamide	Investigative	239512	C14H13NO2	227.26	C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NO	IC50 = 66000 nM	Poor binder
T28887	Histone deacetylase 8	D04UVL	N-(2-aminophenyl)nicotinamide	Investigative	1133083	C12H11N3O	213.23	C1=CC=C(C(=C1)N)NC(=O)C2=CN=CC=C2	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	D0E0TA	N-(4-hydroxybiphenyl-3-yl)benzamide	Investigative	44454650	C19H15NO2	289.3	C1=CC=C(C=C1)C2=CC(=C(C=C2)O)NC(=O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	D0M9LJ	N-(4-aminobiphenyl-3-yl)nicotinamide	Investigative	44454415	C18H15N3O	289.3	C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CN=CC=C3	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	D0MD7H	N-(4-aminobiphenyl-3-yl)benzamide	Investigative	44454143	C19H16N2O	288.3	C1=CC=C(C=C1)C2=CC(=C(C=C2)N)NC(=O)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	D0Q2GM	N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide	Investigative	44454416	C16H13N3OS	295.4	C1=CC(=CN=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N	IC50 ~ 50000 nM	Poor binder
T28887	Histone deacetylase 8	D0U8FC	N-(2-aminophenyl)benzamide	Investigative	759408	C13H12N2O	212.25	C1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N	IC50 ~ 50000 nM	Poor binder