TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T30372	Trypanosoma Cruzipain	D01XBA	Raloxifene	Approved	5035	C28H27NO4S	473.6	C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D04AIT	B-Lactams	Approved	5280445	C15H10O6	286.24	C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O)O	IC50 = 155700 nM	Poor binder
T30372	Trypanosoma Cruzipain	D07XGR	Fenofibrate	Approved	3339	C20H21ClO4	360.8	CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl	IC50 = 61000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D08QIP	Pranlukast	Approved	4887	C27H23N5O4	481.5	C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5	IC50 = 68000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D09NYS	Methylene blue	Approved	6099	C16H18ClN3S	319.9	CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]	IC50 = 55000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0L3MP	VRX496	Approved	64143	C32H45N3O4S	567.8	CC1=C(C=CC=C1O)C(=O)N[C@@H](CSC2=CC=CC=C2)[C@@H](CN3C[C@H]4CCCC[C@H]4C[C@H]3C(=O)NC(C)(C)C)O	IC50 = 144000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0Q3YO	Cinnarizine	Approved	1547484	C26H28N2	368.5	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 124000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0ED3R	Clopidogrel	Phase 2	60606	C16H16ClNO2S	321.8	COC(=O)[C@H](C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3	IC50 = 123000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0L4FS	Genistein	Phase 2	5280961	C15H10O5	270.24	C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O	IC50 = 82700 nM	Poor binder
T30372	Trypanosoma Cruzipain	D01RYO	Gefitinib	Patented	123631	C22H24ClFN4O3	446.9	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4	IC50 = 88000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0KP0U	PMID26394986-Compound-22	Patented	2662	C17H14F3N3O2S	381.4	CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F	IC50 = 126000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B03SNH	2-Oxo-2-(5-phenyl-1,3,4-oxadiazol-2-ylamino)ethyl 3-phenoxybenzoate	Investigative	7700632	C23H17N3O5	415.4	C1=CC=C(C=C1)C2=NN=C(O2)NC(=O)COC(=O)C3=CC(=CC=C3)OC4=CC=CC=C4	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B1MJU0	5-(2-Aminophenyl)-N-(3-pyrrolidin-1-ylphenyl)-1,3,4-oxadiazole-2-carboxamide	Investigative	44234904	C19H19N5O2	349.4	C1CCN(C1)C2=CC=CC(=C2)NC(=O)C3=NN=C(O3)C4=CC=CC=C4N	IC50 = 99000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B1SLA0	[(3-Carbamoylthiophen-2-yl)carbamoyl]methyl 2-amino-5-bromobenzoate	Investigative	7149198	C14H12BrN3O4S	398.23	C1=CC(=C(C=C1Br)C(=O)OCC(=O)NC2=C(C=CS2)C(=O)N)N	IC50 = 90000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B21QHM	5-(2-Aminophenyl)-N-piperidin-4-yl-1,3,4-oxadiazole-2-carboxamide	Investigative	45267085	C14H17N5O2	287.32	C1CNCCC1NC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B2ESH9	(E)-3-(1,3-Benzodioxol-5-yl)-N-[(E)-(2-hydroxyphenyl)methylideneamino]prop-2-enamide	Investigative	136242670	C17H14N2O4	310.3	C1OC2=C(O1)C=C(C=C2)/C=C/C(=O)N/N=C/C3=CC=CC=C3O	IC50 = 74800 nM	Poor binder
T30372	Trypanosoma Cruzipain	B2SAE5	4-(Pyrrolidin-1-ylsulfonyl)-N-(4-(thiophen-2-yl)thiazol-2-yl)benzamide	Investigative	2327228	C18H17N3O3S3	419.5	C1CCN(C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=NC(=CS3)C4=CC=CS4	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B2T6CB	1-Benzyl-5-chloro-1H-indole-2,3-dione	Investigative	3704739	C15H10ClNO2	271.7	C1=CC=C(C=C1)CN2C3=C(C=C(C=C3)Cl)C(=O)C2=O	IC50 = 90000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B3CP8X	N-[2-[5-[(2,4-Dichlorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]ethyl]carbamic acid tert-butyl ester	Investigative	665449	C16H19Cl2N3O5S	436.3	CC(C)(C)OC(=O)NCCC1=NN=C(O1)S(=O)(=O)CC2=C(C=C(C=C2)Cl)Cl	IC50 = 95000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B3UTJ7	N4-Allyl benzofuroxan-5-carboxaldehydethiosemicarbazone	Investigative	135869166	C11H11N5O2S	277.3	C=CCNC(=S)N/N=C/C1=CC2=[N+](ON=C2C=C1)[O-]	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4BA2X	[(2,5-Dichlorophenyl)carbamoyl]methyl 2-aminobenzoate	Investigative	4403597	C15H12Cl2N2O3	339.2	C1=CC=C(C(=C1)C(=O)OCC(=O)NC2=C(C=CC(=C2)Cl)Cl)N	IC50 = 58000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4BTZ1	5-(2-Aminophenyl)-N-(5-thiophen-2-yl-1H-pyrazol-3-yl)-1,3,4-oxadiazole-2-carboxamide	Investigative	44235161	C16H12N6O2S	352.4	C1=CC=C(C(=C1)C2=NN=C(O2)C(=O)NC3=NNC(=C3)C4=CC=CS4)N	IC50 = 102000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4DN9E	Methyl 4-[3-(5-bromo-2-furyl)-1,2,4-oxadiazol-5-yl]benzoate	Investigative	717866	C14H9BrN2O4	349.14	COC(=O)C1=CC=C(C=C1)C2=NC(=NO2)C3=CC=C(O3)Br	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4GEA6	2-(2-(4-Methyl-4H-1,2,4-triazol-3-ylthio)acetamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide	Investigative	2514971	C13H15N5O2S2	337.4	CN1C=NN=C1SCC(=O)NC2=C(C3=C(S2)CCC3)C(=O)N	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4LD3E	[(5-Methyl-2-oxoindol-3-yl)amino]thiourea	Investigative	766854	C10H10N4OS	234.28	CC1=CC2=C(C=C1)NC(=C2N=NC(=S)N)O	IC50 = 50000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4OML9	2-[(7-Chloroquinolin-4-yl)amino]ethanol	Investigative	4650466	C11H11ClN2O	222.67	C1=CC2=C(C=CN=C2C=C1Cl)NCCO	IC50 = 62000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4R8TL	2-Nitro-N-[[4-[(1,2,3,4-tetrahydronaphthalen-2-ylmethylamino)methyl]cyclohexyl]methyl]benzenesulfonamide	Investigative	9982218	C25H33N3O4S	471.6	C1CC(CCC1CNCC2CCC3=CC=CC=C3C2)CNS(=O)(=O)C4=CC=CC=C4[N+](=O)[O-]	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B4VM9E	Ethyl [(4E)-4-[[4-(dimethylamino)phenyl]methylidene]-5-oxo-1,3-thiazol-2-yl]sulfanylformate	Investigative	2191015	C15H16N2O3S2	336.4	CCOC(=O)SC1=N/C(=C/C2=CC=C(C=C2)N(C)C)/C(=O)S1	IC50 = 73000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B52RHL	5(E)-[2-(Phenylsulfonyl)vinyl]benzo[1,2-c]1,2,5-oxadiazole N1-oxide	Investigative	23730473	C14H10N2O4S	302.31	C1=CC=C(C=C1)S(=O)(=O)/C=C/C2=CC3=NO[N+](=C3C=C2)[O-]	IC50 ~ 50000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B52TMO	[(4-Methyl-2-oxo-2H-chromen-7-yl)oxy]acetonitrile	Investigative	1633306	C12H9NO3	215.2	CC1=CC(=O)OC2=C1C=CC(=C2)OCC#N	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B5AM8H	Ethyl (2Z)-2-[(3-ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]-4-methyl-3-prop-2-enyl-1,3-thiazole-5-carboxylate	Investigative	127045466	C21H26N2O4S2	434.6	CCOC(=O)C1=C(SC2=C1CCCC2)/N=C\\3/N(C(=C(S3)C(=O)OCC)C)CC=C	IC50 = 85000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B5D6TV	5-(2-Aminophenyl)-N-(2-morpholin-4-ylethyl)-1,3,4-oxadiazole-2-carboxamide	Investigative	44235158	C15H19N5O3	317.34	C1COCCN1CCNC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B5ZU0M	4,6-Dichloro-3-hydroxy-3-[2-(2-hydroxyphenyl)-2-oxoethyl]-1,3-dihydro-2H-indol-2-one	Investigative	664316	C16H11Cl2NO4	352.2	C1=CC=C(C(=C1)C(=O)CC2(C3=C(C=C(C=C3Cl)Cl)NC2=O)O)O	IC50 = 73000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B67COD	Pyridin-3-yl 2-oxo-2H-chromene-3-carboxylate	Investigative	2235625	C15H9NO4	267.24	C1=CC=C2C(=C1)C=C(C(=O)O2)C(=O)OC3=CN=CC=C3	IC50 = 70000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B6GR7U	N4-Phenyl benzofuroxan-5-carboxaldehydethiosemicarbazone	Investigative	136099760	C14H11N5O2S	313.34	C1=CC=C(C=C1)NC(=S)N/N=C/C2=CC3=[N+](ON=C3C=C2)[O-]	IC50 = 78000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B6GZU9	2-[[4-(4-Fluorophenyl)-1,2-thiazol-2-ium-2-yl]sulfanyl]-N-(furan-2-ylmethylcarbamoyl)acetamide;chloride	Investigative	45485273	C17H15ClFN3O3S2	427.9	C1=COC(=C1)CNC(=O)NC(=O)CS[N+]2=CC(=CS2)C3=CC=C(C=C3)F.[Cl-]	IC50 = 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B74RPH	2-(4-Chlorobenzylthio)-1-(furan-2-yl)ethanone	Investigative	2382051	C13H11ClO2S	266.74	C1=COC(=C1)C(=O)CSCC2=CC=C(C=C2)Cl	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B7DY6P	(2E)-N'-[(E)-2-Hydroxybenzylidene]-3-phenylprop-2-enohydrazide	Investigative	136229843	C16H14N2O2	266.29	C1=CC=C(C=C1)/C=C/C(=O)N/N=C/C2=CC=CC=C2O	IC50 = 52200 nM	Poor binder
T30372	Trypanosoma Cruzipain	B7EA9Z	Vitamin E Nicotinate	Investigative	27990	C35H53NO3	535.8	CC1=C(C(=C(C2=C1O[C@](CC2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C)OC(=O)C3=CN=CC=C3)C	IC50 = 98000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B7M4TY	N-[2-(1H-Benzimidazol-2-yl)ethyl]-2-(2-cyanophenoxy)acetamide	Investigative	18143836	C18H16N4O2	320.3	C1=CC=C(C(=C1)C#N)OCC(=O)NCCC2=NC3=CC=CC=C3N2	IC50 = 65100 nM	Poor binder
T30372	Trypanosoma Cruzipain	B7QXA6	2-(2,5-Dichlorophenylamino)-2-oxoethyl 2-aminonicotinate	Investigative	2341222	C14H11Cl2N3O3	340.2	C1=CC(=C(N=C1)N)C(=O)OCC(=O)NC2=C(C=CC(=C2)Cl)Cl	IC50 = 77000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B7YGA3	2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-ylamino)-2-oxoethyl 2-aminonicotinate	Investigative	8893764	C16H15N3O5	329.31	C1COC2=C(O1)C=CC(=C2)NC(=O)COC(=O)C3=C(N=CC=C3)N	IC50 = 182000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B8DJ1P	2-(5-Methylisoxazol-3-ylamino)-2-oxoethyl 2-methyl-5-(N-m-tolylsulfamoyl)benzoate	Investigative	2117743	C21H21N3O6S	443.5	CC1=CC(=CC=C1)NS(=O)(=O)C2=CC(=C(C=C2)C)C(=O)OCC(=O)NC3=NOC(=C3)C	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B8LKB9	2-(1-(4-Bromophenyl)propylamino)-2-oxoethyl 2-aminonicotinate	Investigative	17421760	C17H18BrN3O3	392.2	CCC(C1=CC=C(C=C1)Br)NC(=O)COC(=O)C2=C(N=CC=C2)N	IC50 = 84000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B9L8UN	Chembl4161560	Investigative	46899194	C24H21N5O2S	443.5	C1=CC=C(C=C1)CN2C3=C(N=C2C4=CC=CC=C4)N(S(=O)(=O)N=C3N)CC5=CC=CC=C5	IC50 = 81000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B9R0NL	5-(2-Aminophenyl)-N-[(3S)-2-oxoazepan-3-yl]-1,3,4-oxadiazole-2-carboxamide	Investigative	45268824	C15H17N5O3	315.33	C1CCNC(=O)[C@H](C1)NC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B9U4GZ	5-Bromo-N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]-2-thiophenecarboxamide	Investigative	1246514	C9H8BrN3OS3	350.3	CCSC1=NN=C(S1)NC(=O)C2=CC=C(S2)Br	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B9WQZ5	(1S,2R,3R,4R,7S)-7-Methyl-3-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid	Investigative	44450298; 91930121	C22H18O7	394.4	C[C@H]1[C@H]2C=C[C@@H]1[C@H]([C@@H]2C3=C4C=CC(=O)C(=C4OC5=C3C=CC(=C5O)O)O)C(=O)O	IC50 = 95000 nM	Poor binder
T30372	Trypanosoma Cruzipain	B9ZHU8	1-Benzyl-5-iodoindoline-2,3-dione	Investigative	10642441	C15H10INO2	363.15	C1=CC=C(C=C1)CN2C3=C(C=C(C=C3)I)C(=O)C2=O	IC50 = 90000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BAWB56	S-2-(3-Chloro-4-methylphenylamino)-2-oxoethyl carbamothioate	Investigative	873495	C10H11ClN2O2S	258.73	CC1=C(C=C(C=C1)NC(=O)CSC(=O)N)Cl	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BB3CH2	1-Phenyl-4-{[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]acetyl}piperazine	Investigative	2155684	C20H20N4O2S	380.5	C1CN(CCN1C2=CC=CC=C2)C(=O)CSC3=NN=C(O3)C4=CC=CC=C4	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BB4VQ6	N-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-1,2-oxazole-5-carboxamide	Investigative	2999703	C14H11N3O2S	285.32	CC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=NO3	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BCIL81	(2S)-2-Amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid	Investigative	6604839	C16H16Cl2NO6P	420.2	C1=CC(=C(C=C1Cl)Cl)C2=CC(=C(C(=C2)CP(=O)(O)O)O)C[C@@H](C(=O)O)N	IC50 = 77000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BDJ1I0	S-2-(3-Chlorophenylamino)-2-oxoethyl carbamothioate	Investigative	873501	C9H9ClN2O2S	244.7	C1=CC(=CC(=C1)Cl)NC(=O)CSC(=O)N	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BDX7V2	2-[(Benzofuroxan-5-yl)methylene]-1-(5-bromo-2-hydroxybenzylidene)hydrazine	Investigative	91935569; 136099765	C14H9BrN4O3	361.15	C1=CC(=C(C=C1C=[N+]=N/C=C/2\\C=CC3=NON(C3=C2)[O-])Br)O	IC50 = 73000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BEP2W7	4-(Benzofuroxan-5-ylmethyloxy)benzaldehydesemicarbazone	Investigative	44560381	C15H13N5O4	327.29	C1=CC(=CC=C1/C=N/NC(=O)N)OCC2=CC3=[N+](ON=C3C=C2)[O-]	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BER7U1	Chembl4203721	Investigative	145968211	C27H33N3O4	463.6	CCN(CC)C(=O)/C=C/C1(CC1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	Ki = 199526.23 nM	Poor binder
T30372	Trypanosoma Cruzipain	BF3W2Y	Aurintricarboxylic acid	Investigative	2259	C22H14O9	422.3	C1=CC(=C(C=C1C(=C2C=CC(=O)C(=C2)C(=O)O)C3=CC(=C(C=C3)O)C(=O)O)C(=O)O)O	IC50 = 53000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BF4X1Y	Delavirdine mesylate	Investigative	441386	C23H32N6O6S2	552.7	CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C.CS(=O)(=O)O	IC50 = 122000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BF8YG3	1-(2,5-Dimethyl-benzyl)-5-methyl-1H-indole-2,3-dione	Investigative	44344692	C18H17NO2	279.3	CC1=CC(=C(C=C1)C)CN2C3=C(C=C(C=C3)C)C(=O)C2=O	IC50 = 80000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BGL6T7	2-[(Benzofuroxan-5-yl)methylene]-1-(2-hydroxybenzylidene)hydrazine	Investigative	91935567; 136099763	C14H10N4O3	282.25	C1=CC=C(C(=C1)C=[N+]=N/C=C/2\\C=CC3=NON(C3=C2)[O-])O	IC50 = 68000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BGZ7R1	2-[(2Z)-2-[(3-Ethoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]-4-oxo-3-prop-2-enyl-1,3-thiazolidin-5-yl]acetic acid	Investigative	21235665	C19H22N2O5S2	422.5	CCOC(=O)C1=C(SC2=C1CCCC2)/N=C\\3/N(C(=O)C(S3)CC(=O)O)CC=C	IC50 = 50000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BH3TR6	2,4-Dimethoxy-N-(1,3,4-thiadiazol-2-yl)benzamide	Investigative	821625	C11H11N3O3S	265.29	COC1=CC(=C(C=C1)C(=O)NC2=NN=CS2)OC	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BH93XE	5-(2-Aminophenyl)-N-(2-methylpyrazol-3-yl)-1,3,4-oxadiazole-2-carboxamide	Investigative	45267082	C13H12N6O2	284.27	CN1C(=CC=N1)NC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BI13JD	(E)-3-(3,4-Dimethoxy-5-nitrophenyl)-N-[(E)-(2-hydroxyphenyl)methylideneamino]prop-2-enamide	Investigative	136242673	C18H17N3O6	371.3	COC1=CC(=CC(=C1OC)[N+](=O)[O-])/C=C/C(=O)N/N=C/C2=CC=CC=C2O	IC50 = 83900 nM	Poor binder
T30372	Trypanosoma Cruzipain	BI7RQ0	1-(Benzyloxycarbonyl)-5-chloro-2,3-dihydro-1H-indole-2,3-dione	Investigative	44344950	C16H10ClNO4	315.71	C1=CC=C(C=C1)COC(=O)N2C3=C(C=C(C=C3)Cl)C(=O)C2=O	IC50 = 80000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BJ01GL	5-(2-Aminophenyl)-N-(4-morpholin-4-ylphenyl)-1,3,4-oxadiazole-2-carboxamide	Investigative	45267942	C19H19N5O3	365.4	C1COCCN1C2=CC=C(C=C2)NC(=O)C3=NN=C(O3)C4=CC=CC=C4N	IC50 = 62000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BJ8V4Q	5-(2-Aminophenyl)-N-(2-methyl-1H-indol-5-yl)-1,3,4-oxadiazole-2-carboxamide	Investigative	44235164	C18H15N5O2	333.3	CC1=CC2=C(N1)C=CC(=C2)NC(=O)C3=NN=C(O3)C4=CC=CC=C4N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BL0TX1	2-[3-(Phenylcarbonyl)-1H-indol-1-yl]-1-(pyrrolidin-1-yl)ethanone	Investigative	963166	C21H20N2O2	332.4	C1CCN(C1)C(=O)CN2C=C(C3=CC=CC=C32)C(=O)C4=CC=CC=C4	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BM9ED5	1-Benzoyl-1H-indole-2,3-dione	Investigative	34200	C15H9NO3	251.24	C1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3C(=O)C2=O	IC50 = 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BM9FP5	Tert-butyl N-[[5-[(2,4-dichlorophenyl)methylsulfonyl]-1,3,4-oxadiazol-2-yl]methyl]carbamate	Investigative	44450464	C15H17Cl2N3O5S	422.3	CC(C)(C)OC(=O)NCC1=NN=C(O1)S(=O)(=O)CC2=C(C=C(C=C2)Cl)Cl	IC50 = 95000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BMI7F2	2-(2-{[3-(Ethoxycarbonyl)(4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)]azamethylen e}-4-oxo-3-phenyl-1,3-thiazolidin-5-yl)acetic acid	Investigative	9651823	C22H22N2O5S2	458.6	CCOC(=O)C1=C(SC2=C1CCCC2)/N=C\\3/N(C(=O)C(S3)CC(=O)O)C4=CC=CC=C4	IC50 = 121000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BN46CT	2-[(2Z)-4-Oxo-2-[(3-propan-2-yloxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)imino]-3-prop-2-enyl-1,3-thiazolidin-5-yl]acetic acid	Investigative	127045313	C20H24N2O5S2	436.5	CC(C)OC(=O)C1=C(SC2=C1CCCC2)/N=C\\3/N(C(=O)C(S3)CC(=O)O)CC=C	IC50 = 111000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BOHA86	N-{4-[4-(1-Azepanylsulfonyl)phenyl]-1,3-thiazol-2-yl}-2-thiophenecarboxamide	Investigative	1161245	C20H21N3O3S3	447.6	C1CCCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CSC(=N3)NC(=O)C4=CC=CS4	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BOL6K0	Meclizine hydrochloride	Investigative	92303	C25H28Cl2N2	427.4	CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl	IC50 = 129000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BP29NQ	Chembl4213366	Investigative	145965335	C25H28N2O5	436.5	CCOC(=O)/C=C/C1(CC1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	Ki = 125892.54 nM	Poor binder
T30372	Trypanosoma Cruzipain	BP6VQ8	Chembl4176677	Investigative	46898369	C17H13ClFN5O2S	405.8	C1=CC=C(C(=C1)C2=NC3=C(N2)C(=NS(=O)(=O)N3CC4=CC=C(C=C4)Cl)N)F	IC50 = 86000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BP89LF	2-[(Benzofuroxan-5-yl)methylene]-1-(4-hydroxybenzylidene)hydrazine	Investigative	91935568; 136099764	C14H10N4O3	282.25	C1=CC(=CC=C1C=[N+]=N/C=C/2\\C=CC3=NON(C3=C2)[O-])O	IC50 = 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BPCO58	Benzotriazol-1-yl-(2-methylfuran-3-yl)methanone	Investigative	898637	C12H9N3O2	227.22	CC1=C(C=CO1)C(=O)N2C3=CC=CC=C3N=N2	IC50 = 106000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BPY52E	Benzofuroxan-5-carboxaldehyde thiosemicarbazone	Investigative	136099759	C8H7N5O2S	237.24	C1=CC2=NO[N+](=C2C=C1/C=N/NC(=S)N)[O-]	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BQ71VF	N-(5-Methyl-1,2-oxazol-3-yl)-2-thiophen-2-ylacetamide	Investigative	717599	C10H10N2O2S	222.27	CC1=CC(=NO1)NC(=O)CC2=CC=CS2	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BS4B1V	Chlorpromazine hydrochloride	Investigative	6240	C17H20Cl2N2S	355.3	CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl.Cl	IC50 = 189000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BS60GI	5-Isobutyl-N-(5-methylisoxazol-3-yl)isoxazole-3-carboxamide	Investigative	5308729	C12H15N3O3	249.27	CC1=CC(=NO1)NC(=O)C2=NOC(=C2)CC(C)C	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BSKH95	N-[2-(1H-Benzimidazol-2-yl)ethyl]-3-(2-bromophenyl)propanamide	Investigative	49853260	C18H18BrN3O	372.3	C1=CC=C(C(=C1)CCC(=O)NCCC2=NC3=CC=CC=C3N2)Br	IC50 = 77500 nM	Poor binder
T30372	Trypanosoma Cruzipain	BSKY32	5-(2-Amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid 2-amino-6-fluorobenzylamide	Investigative	45270500	C16H14FN5O2	327.31	C1=CC=C(C(=C1)C2=NN=C(O2)C(=O)NCC3=C(C=CC=C3F)N)N	IC50 = 52000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BSU45Y	3-(3-Chlorobenzo[b]thiophen-2-yl)-2-(1-methyl-1H-benzo[d]imidazol-2-yl)-3-oxopropanenitrile	Investigative	2998581	C19H12ClN3OS	365.8	CN1C2=CC=CC=C2N=C1C(C#N)C(=O)C3=C(C4=CC=CC=C4S3)Cl	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BT40YQ	5-(2-Aminophenyl)-N-(1-methylpyrazol-3-yl)-1,3,4-oxadiazole-2-carboxamide	Investigative	44235163	C13H12N6O2	284.27	CN1C=CC(=N1)NC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BT4X8R	5-(2-Aminophenyl)-N-[2-(2-oxoimidazolidin-1-yl)ethyl]-1,3,4-oxadiazole-2-carboxamide	Investigative	45268826	C14H16N6O3	316.32	C1CN(C(=O)N1)CCNC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BT72FK	2-(2-(Difluoromethoxy)phenylamino)-2-oxoethyl 2-aminonicotinate	Investigative	4828813	C15H13F2N3O4	337.28	C1=CC=C(C(=C1)NC(=O)COC(=O)C2=C(N=CC=C2)N)OC(F)F	IC50 = 126000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BTK9A5	8-Methoxy-3-[(3-methylpyrazolyl)carbonyl]chromen-2-one	Investigative	974754	C15H12N2O4	284.27	CC1=NN(C=C1)C(=O)C2=CC3=C(C(=CC=C3)OC)OC2=O	IC50 = 106000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BUL1A7	N'-[(E)-(2-Hydroxyphenyl)methylidene]-3-phenylpropanehydrazide	Investigative	135419539	C16H16N2O2	268.31	C1=CC=C(C=C1)CCC(=O)N/N=C/C2=CC=CC=C2O	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BUR04E	5(Z)-[2-(Phenylsulfonyl)vinyl]benzo[1,2-c]1,2,5-oxadiazole N1-oxide	Investigative	23730357	C14H10N2O4S	302.31	C1=CC=C(C=C1)S(=O)(=O)/C=C\\C2=CC3=NO[N+](=C3C=C2)[O-]	IC50 ~ 50000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BV31SU	5-(2-Amino-phenyl)-[1,3,4]oxadiazole-2-carboxylic acid 3,4,5-trimethoxybenzylamide	Investigative	45270502	C19H20N4O5	384.4	COC1=CC(=CC(=C1OC)OC)CNC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BVLD90	5-(2-Aminophenyl)-N-(((S)-1-ethylpyrrolidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide	Investigative	45273055	C16H21N5O2	315.37	CCN1CCC[C@H]1CNC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BW0FA4	5-(2-Aminophenyl)-N-[(2-morpholin-4-ylpyridin-4-yl)methyl]-1,3,4-oxadiazole-2-carboxamide	Investigative	45268823	C19H20N6O3	380.4	C1COCCN1C2=NC=CC(=C2)CNC(=O)C3=NN=C(O3)C4=CC=CC=C4N	IC50 = 83000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BW4F6V	5-(2-Aminophenyl)-N-[3-(2-oxopyrrolidin-1-yl)propyl]-1,3,4-oxadiazole-2-carboxamide	Investigative	44235159	C16H19N5O3	329.35	C1CC(=O)N(C1)CCCNC(=O)C2=NN=C(O2)C3=CC=CC=C3N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BWQ7K1	(1S,2S)-2-(4-Chlorobenzoyl)-N-((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)cyclohexanecarboxamide	Investigative	46882251	C31H32ClNO4S	550.1	C1CC[C@@H]([C@H](C1)C(=O)C2=CC=C(C=C2)Cl)C(=O)N[C@@H](CCC3=CC=CC=C3)/C=C/S(=O)(=O)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BWR12B	N-(3-Hydroxy-4,5-diphenylfuran-2-yl)-2-(2-oxobenzo[d]oxazol-3(2H)-yl)acetamide	Investigative	45485251	C25H18N2O5	426.4	C1=CC=C(C=C1)C2=C(OC(=C2O)NC(=O)CN3C4=CC=CC=C4OC3=O)C5=CC=CC=C5	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BWTR54	Candesartan cilexetil	Investigative	2540	C33H34N6O6	610.7	CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6	IC50 = 168000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BXU12P	5-(2-Aminophenyl)-N-(3-imidazol-1-ylpropyl)-1,3,4-oxadiazole-2-carboxamide	Investigative	45273074	C15H16N6O2	312.33	C1=CC=C(C(=C1)C2=NN=C(O2)C(=O)NCCCN3C=CN=C3)N	IC50 ~ 100000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BZ68UE	(2,3-Dimethoxyphenyl)(1-ethyl-1H-imidazol-2-yl)methanol	Investigative	2881154	C14H18N2O3	262.3	CCN1C=CN=C1C(C2=C(C(=CC=C2)OC)OC)O	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BZJ1X6	3-Amino-4''-methyl-5-(2-methylallylthio)biphenyl-2,6-dicarbonitrile	Investigative	45485239	C19H17N3S	319.4	CC1=CC=C(C=C1)C2=C(C(=CC(=C2C#N)SCC(=C)C)N)C#N	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	BZYV29	{[(2H-1,3-Benzodioxol-5-yl)methyl]carbamoyl}methyl 2-(furan-2-yl)quinoline-4-carboxylate	Investigative	2368254	C24H18N2O6	430.4	C1OC2=C(O1)C=C(C=C2)CNC(=O)COC(=O)C3=CC(=NC4=CC=CC=C43)C5=CC=CO5	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D02GOH	AM-404	Investigative	6604822	C26H37NO2	395.6	CCCCC/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCC(=O)NC1=CC=C(C=C1)O	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D03JDL	AZ10417808	Investigative	135665263	C18H13Cl2N5O4	434.2	.	IC50 ~ 60000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0A1CM	ELLAGIC ACID	Investigative	5281855	C14H6O8	302.19	C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O	IC50 = 64000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0GP7D	NSC-119911	Investigative	54686376	C16H10O7	314.25	C1=CC(=C(C2=C1C(=C3C=CC(=O)C(=C3O2)O)/C=C/C(=O)O)O)O	IC50 = 95000 nM	Poor binder
T30372	Trypanosoma Cruzipain	D0MF5Y	3,7,3',4'-TETRAHYDROXYFLAVONE	Investigative	5281614	C15H10O6	286.24	C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O	IC50 ~ 60000 nM	Poor binder