TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T31186	Eukaryotic initiation factor 4E	B0P9AQ	4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-(2-dimethylamino-ethylcarbamoyl)-biphenyl-2-carboxylic acid	Investigative	71534653	C27H23Cl2N3O3S	540.5	CN(C)CCNC(=O)C1=CC=C(C=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=CC(=C(C=C4)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B16BIE	4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-(4-methyl-piperazine-1-carbonyl)-biphenyl-2-carboxylic acid	Investigative	71534657	C28H23Cl2N3O3S	552.5	CN1CCN(CC1)C(=O)C2=CC=C(C=C2)C3=C(C=C(C=C3)C4=NC(=CS4)C5=CC(=C(C=C5)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B19WYL	Sodium;2-amino-7-(cyclodecapentaenylmethyl)-9-[(2R,3R,4R,5R)-5-(phosphooxymethyl)-3,4-di(propan-2-yloxy)oxolan-2-yl]purin-9-ium-6-olate	Investigative	73348296	C27H34N5NaO7P+	594.6	CC(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OC(C)C)[N+]2=CN(C3=C2N=C(N=C3[O-])N)CC4=CC=CC=CC=CC=C4)CO[P+](=O)[O-].[Na+]	IC50 = 70000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B26BZP	2'-Nitro-4-(4-pyridin-4-yl-thiazol-2-yl)-biphenyl-2-carboxylic acid	Investigative	71535814	C21H13N3O4S	403.4	C1=CC=C(C(=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=CC=NC=C4)C(=O)O)[N+](=O)[O-]	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B2TX7O	2'-Nitro-4-(4-pyridin-3-yl-thiazol-2-yl)-biphenyl-2-carboxylic acid	Investigative	71535810	C21H13N3O4S	403.4	C1=CC=C(C(=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=CN=CC=C4)C(=O)O)[N+](=O)[O-]	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B2XE9F	Disodium;[(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;bromide	Investigative	137169163	C11H15BrN5Na2O8P	502.12	CN1C=[N+](C2=C1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])[O-])O)O.[Na+].[Na+].[Br-]	IC50 = 50000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B34YSA	[(2R,3S,4R,5R)-5-[2-Amino-7-[(2-chlorophenyl)methyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Investigative	136138690	C17H19ClN5O8P	487.8	C1=CC=C(C(=C1)CN2C=[N+](C3=C2C(=O)NC(=N3)N)[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)[O-])O)O)Cl	IC50 = 54500 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B3T5PQ	Sodium;[(2R,3R,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-oxido-oxophosphanium	Investigative	137169131	C17H27N5NaO7P+2	467.4	CC(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OC(C)C)[N+]2=CN(C3=C2N=C(NC3=O)N)C)CO[P+](=O)[O-].[Na+]	IC50 = 55000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B3WI8N	4'-Chloro-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-2'-fluoro-biphenyl-2-carboxylic acid	Investigative	86679874	C22H11Cl3FNO2S	478.7	C1=CC(=C(C=C1C2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)C4=C(C=C(C=C4)Cl)F	IC50 = 55000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B5P2CN	4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-(2-morpholin-4-yl-ethylcarbamoyl)-biphenyl-2-carboxylic acid	Investigative	71538049	C29H25Cl2N3O4S	582.5	C1COCCN1CCNC(=O)C2=CC=C(C=C2)C3=C(C=C(C=C3)C4=NC(=CS4)C5=CC(=C(C=C5)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B7PY8M	2',3',5'-Trichloro-4-[4-(3,4-dichloro-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid	Investigative	86679886	C22H10Cl5NO2S	529.6	C1=CC(=C(C=C1C2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)C4=C(C(=CC(=C4)Cl)Cl)Cl	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	B8Y7TV	4-[4-(2,6-Difluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid	Investigative	71538603	C22H12F2N2O4S	438.4	C1=CC=C(C(=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=C(C=CC=C4F)F)C(=O)O)[N+](=O)[O-]	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BA5JZ3	4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-(1-methyl-piperidin-4-ylcarbamoyl)-biphenyl-2-carboxylic acid	Investigative	86679845	C29H25Cl2N3O3S	566.5	CN1CCC(CC1)NC(=O)C2=CC=C(C=C2)C3=C(C=C(C=C3)C4=NC(=CS4)C5=CC(=C(C=C5)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BBJ7W5	4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-(3-morpholin-4-yl-propylcarbamoyl)-biphenyl-2-carboxylic acid	Investigative	71537776	C30H27Cl2N3O4S	596.5	C1COCCN1CCCNC(=O)C2=CC=C(C=C2)C3=C(C=C(C=C3)C4=NC(=CS4)C5=CC(=C(C=C5)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BC65HA	4-[4-(4-Methanesulfonyl-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid	Investigative	71536906	C23H16N2O6S2	480.5	CS(=O)(=O)C1=CC=C(C=C1)C2=CSC(=N2)C3=CC(=C(C=C3)C4=CC=CC=C4[N+](=O)[O-])C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BE9SZ5	[(2R,3S,4R,5R)-5-[2-Amino-7-[2-(4-chloroanilino)-2-oxoethyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Investigative	136138707	C18H20ClN6O9P	530.8	C1=CC(=CC=C1NC(=O)CN2C=[N+](C3=C2C(=O)NC(=N3)N)[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)[O-])O)O)Cl	IC50 = 85400 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BERA93	[(2R,3R,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9-yl)-3,4-di(propan-2-yloxy)oxolan-2-yl]methoxy-hydroxy-oxophosphanium;N,N-diethylethanamine	Investigative	137169167	C22H40N6O7P+	531.6	CCN(CC)CC.CC(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OC(C)C)N2C=NC3=C2N=C(NC3=O)N)CO[P+](=O)O	IC50 = 180000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BFE2W1	5-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-[3-[ethyl(methyl)amino]propylcarbamoyl]phenyl]benzoic acid	Investigative	89461213	C29H27Cl2N3O3S	568.5	CCN(C)CCCNC(=O)C1=CC=C(C=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=CC(=C(C=C4)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BH34WM	Sodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxido-oxophosphanium	Investigative	137007091	C10H12N5NaO7P+	368.2	C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P+](=O)[O-])O)O)N=C(NC2=O)N.[Na+]	IC50 = 130000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BHQ7Y1	[(2R,3S,4R,5R)-5-[2-Amino-7-[(3-chlorophenyl)methyl]-6-oxo-1H-purin-9-ium-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate	Investigative	136138689	C17H19ClN5O8P	487.8	C1=CC(=CC(=C1)Cl)CN2C=[N+](C3=C2C(=O)NC(=N3)N)[C@H]4[C@@H]([C@@H]([C@H](O4)COP(=O)(O)[O-])O)O	IC50 = 56800 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BL4J2B	4-[4-(3,4-Dichloro-phenyl)-thiazol-2-yl]-4'-(3-diethylamino-propylcarbamoyl)-biphenyl-2-carboxylic acid	Investigative	71534654	C30H29Cl2N3O3S	582.5	CCN(CC)CCCNC(=O)C1=CC=C(C=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=CC(=C(C=C4)Cl)Cl)C(=O)O	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BN6EI5	Disodium;[(2R,3S,4R,5R)-5-(2-amino-7-ethyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;bromide	Investigative	137169164	C12H17BrN5Na2O8P	516.15	CCN1C=[N+](C2=C1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])[O-])O)O.[Na+].[Na+].[Br-]	IC50 = 100000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BR3J5P	2'-Nitro-4-(4-pyridin-2-yl-thiazol-2-yl)-biphenyl-2-carboxylic acid	Investigative	71535811	C21H13N3O4S	403.4	C1=CC=C(C(=C1)C2=C(C=C(C=C2)C3=NC(=CS3)C4=CC=CC=N4)C(=O)O)[N+](=O)[O-]	IC50 ~ 80000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BR94NY	Sodium;[(2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxido-oxophosphanium;bromide	Investigative	137007090	C17H19BrN5NaO7P+	539.2	C1=CC=C(C=C1)CN2C=[N+](C3=C2C(=O)NC(=N3)N)[C@H]4[C@@H]([C@@H]([C@H](O4)CO[P+](=O)[O-])O)O.[Na+].[Br-]	IC50 = 200000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BRQ97Z	(2Z)-2-[(7,8-Dimethoxy-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acid	Investigative	90644219	C21H18N4O7S	470.5	COC1=C(C=C2C(=C1)C3=C(CO2)SC(=N3)N/N=C(/CC4=CC=CC=C4[N+](=O)[O-])\\C(=O)O)OC	IC50 = 51500 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BTLI84	Sodium;2-amino-7-benzyl-9-[(2R,3R,4R,5R)-5-(phosphooxymethyl)-3,4-di(propan-2-yloxy)oxolan-2-yl]purin-9-ium-6-olate	Investigative	73345264	C23H30N5NaO7P+	542.5	CC(C)O[C@@H]1[C@H](O[C@H]([C@@H]1OC(C)C)[N+]2=CN(C3=C2N=C(N=C3[O-])N)CC4=CC=CC=C4)CO[P+](=O)[O-].[Na+]	IC50 = 85000 nM	Poor binder
T31186	Eukaryotic initiation factor 4E	BTPC40	(2Z)-2-[(6,7-Dimethoxy-4H-chromeno[4,3-d][1,3]thiazol-2-yl)hydrazinylidene]-3-(2-nitrophenyl)propanoic acid	Investigative	90644220	C21H18N4O7S	470.5	COC1=C(C2=C(C=C1)C3=C(CO2)SC(=N3)N/N=C(/CC4=CC=CC=C4[N+](=O)[O-])\\C(=O)O)OC	IC50 = 55500 nM	Poor binder