TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T31406	Hematopoietic cell kinase	D0M9QZ	ABT-869	Phase 3	11485656	C21H18FN5O	375.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	B1XR0L	1-Methyl-3-(quinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905204	C15H12N6	276.3	CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)N=CC=C4)N	IC50 = 100000 nM	Poor binder
T31406	Hematopoietic cell kinase	B29PCK	N-(4-(4-Amino-7-(3-(4-phenylpiperazin-1-yl)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	18451023	C37H36N6O2S	628.8	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5/C=C/CN6CCN(CC6)C7=CC=CC=C7)N)OC	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	B3I4WF	1-(4-Amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carboxamido)phenyl)thieno[3,2-c]pyridin-7-yl)-3-(2-(pyrrolidin-1-yl)ethyl)urea	Investigative	18451102	C31H33N7O3S	583.7	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5NC(=O)NCCN6CCCC6)N)OC	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	B5E8FS	1-Isopropyl-3-(isoquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905215	C17H16N6	304.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)C=NC=C4)N	IC50 = 100000 nM	Poor binder
T31406	Hematopoietic cell kinase	B7HC8A	Methyl 2-oxo-2-[[3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazol-5-yl]amino]acetate	Investigative	44440259	C26H19N3O4S	469.5	COC(=O)C(=O)NC1=CC=CC2=C1CC3=C2NN=C3C4=CSC(=C4)C#CCOC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BB2S4A	2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one	Investigative	24905149	C28H23N7O2	489.5	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C5=NC=NC(=C5C(=N4)C6=CC(=CC=C6)O)N	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BC23WJ	3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905246	C15H15N7	293.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NC=CN4C=C3)N	IC50 = 100000 nM	Poor binder
T31406	Hematopoietic cell kinase	BCH42U	cis-N-(4-(4-Amino-7-(3-(diethylamino)prop-1-enyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	44432309	C31H33N5O2S	539.7	CCN(CC)C/C=C\\C1=CN=C(C2=C1SC=C2C3=CC(=C(C=C3)NC(=O)C4=CC5=CC=CC=C5N4C)OC)N	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BD31QM	N-(4-(4-Amino-7-(1-methylpiperazine-4-carbonyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	44432304	C30H30N6O3S	554.7	CN1CCN(CC1)C(=O)C2=CN=C(C3=C2SC=C3C4=CC(=C(C=C4)NC(=O)C5=CC6=CC=CC=C6N5C)OC)N	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BDAR08	3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-(3-chlorophenyl)urea	Investigative	11429729	C21H17ClN4O3	408.8	COC1=C2C(=C(C=C1)C3=CC=C(C=C3)NC(=O)NC4=CC(=CC=C4)Cl)C(=NO2)N	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BDCI25	N-(4-(4,7-Diaminothieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	18450934	C24H21N5O2S	443.5	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5N)N)OC	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BF5M6P	2-(2-Methoxy-ethoxy)-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen-3-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-acetamide	Investigative	44440256	C28H25N3O4S	499.6	COCCOCC(=O)NC1=CC=CC2=C1CC3=C2NN=C3C4=CSC(=C4)C#CCOC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BKQ0H4	2-(4-Methyl-piperazin-1-yl)-N-{3-[5-(3-phenoxy-prop-1-ynyl)-thiophen-3-yl]-2,4-dihydro-indeno[1,2-c]pyrazol-5-yl}-acetamide	Investigative	16747696	C30H29N5O2S	523.6	CN1CCN(CC1)CC(=O)NC2=CC=CC3=C2CC4=C3NN=C4C5=CSC(=C5)C#CCOC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BS0W4I	7-((1H-1,2,4-Triazol-1-yl)methyl)-3-(5-(3-(2-methoxyethoxy)-prop-1-ynyl)thiophen-3-yl)-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	11590078	C23H21N5O2S	431.5	COCCOCC#CC1=CC(=CS1)C2=NNC3=C2CC4=C3C=C(C=C4)CN5C=NC=N5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BT2MA5	3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-[3-(trifluoromethyl)phenyl]urea	Investigative	11374110	C22H17F3N4O3	442.4	COC1=C2C(=C(C=C1)C3=CC=C(C=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F)C(=NO2)N	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BTCD52	3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzonitrile	Investigative	24905160	C15H14N6	278.31	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=CC(=C3)C#N)N	IC50 = 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BVAI69	N-(4-(4-Amino-7-(3-hydroxypropyl)thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide	Investigative	18451204	C27H26N4O3S	486.6	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5CCCO)N)OC	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BW08VY	3-[2-(3-Phenoxy-1-propynyl)-4-thienyl]-6-[(4-methyl-1-piperazinyl)methyl]-1,4-dihydroindeno[1,2-c]pyrazole	Investigative	16220354	C29H28N4OS	480.6	CN1CCN(CC1)CC2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CSC(=C5)C#CCOC6=CC=CC=C6	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BWX3M9	4-Amino-3-(3-methoxy-4-(1-methyl-1H-indole-2-carboxamido)phenyl)thieno[3,2-c]pyridine-7-carboxylic acid	Investigative	18450830	C25H20N4O4S	472.5	CN1C2=CC=CC=C2C=C1C(=O)NC3=C(C=C(C=C3)C4=CSC5=C4C(=NC=C5C(=O)O)N)OC	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BYHM49	Ethyl 3-oxo-3-[[3-[5-(3-phenoxyprop-1-ynyl)thiophen-3-yl]-1,4-dihydroindeno[1,2-c]pyrazol-5-yl]amino]propanoate	Investigative	44440261	C28H23N3O4S	497.6	CCOC(=O)CC(=O)NC1=CC=CC2=C1CC3=C2NN=C3C4=CSC(=C4)C#CCOC5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T31406	Hematopoietic cell kinase	BYJ2X1	3-[4-(3-Amino-7-methoxy-1,2-benzoxazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea	Investigative	11429654	C22H19FN4O3	406.4	CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=C(C=C3)OC)ON=C4N	IC50 ~ 50000 nM	Poor binder