TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T33492 Tyrosyl-DNA phosphodiesterase 1 D09YDM Camptothecin Phase 3 24360 C20H16N2O4 348.4 CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B03DVB 4-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-4-oxobutanoic acid;hydrochloride Investigative 71546832 C23H22ClN3O5 455.9 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)NC(=O)CCC(=O)O)C(=O)N3CCCN.Cl IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B04SBV 6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,7]naphthyridine-5,11-dione Investigative 127044408 C18H14N2O4 322.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=NC=C4)C(=O)N3C[C@@H](CO)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B06OXJ 16-Methoxy-15-(3-morpholin-4-ylpropoxy)-20-(3-morpholin-4-ylpropyl)-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 86765193 C32H37N3O8 591.7 COC1=C(C=C2C(=C1)C(=O)N(C3=C2C(=O)C4=CC5=C(C=C43)OCO5)CCCN6CCOCC6)OCCCN7CCOCC7 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B0L3KX 6-[3-(Dimethylamino)propyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione Investigative 127044412 C20H19N3O2 333.4 CN(C)CCCN1C2=C(C3=C(C1=O)N=CC=C3)C(=O)C4=CC=CC=C42 IC50 = 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B0NFL3 4-Bromo-N-[4-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]benzenesulfonamide Investigative 57521692 C26H21BrN2O4S 537.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B0OHU9 10-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 118735587 C23H21N3O6 435.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=C(C=C4)[N+](=O)[O-])C(=O)C5=C3C=CC=C5O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B0Y7BN N-[4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]benzenesulfonamide Investigative 57522964 C26H22N2O4S 458.5 C1=CC=C(C=C1)S(=O)(=O)NCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B12AYW 20-[3-(Dimethylamino)propyl]-11,19-dioxo-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13(18),14,16-heptaene-16-carbonitrile Investigative 71544868 C23H19N3O4 401.4 CN(C)CCCN1C2=C(C3=C(C1=O)C=C(C=C3)C#N)C(=O)C4=CC5=C(C=C42)OCO5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B14DJA 6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione Investigative 127044405 C18H14N2O4 322.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CC=N4)C(=O)N3C[C@@H](CO)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B19KNQ 10-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735588 C22H17BrN4O5 497.3 C1=CC2=C(C(=C1)O)C(=O)C3=C2N(C(=O)C4=C3C=CC(=C4)[N+](=O)[O-])CCCN5C=CN=C5.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B1NB7Q 8-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735577 C23H22BrN3O6 516.299 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=C(C=C4)[N+](=O)[O-])C(=O)C5=C3C=C(C=C5)O.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B1V6PB 9-Hydroxy-2,3,8-trimethoxy-6-(3-morpholin-4-ylpropyl)indeno[1,2-c]isoquinoline-5,11-dione Investigative 71453649 C26H28N2O7 480.5 COC1=C(C=C2C(=C1)C3=C(C2=O)C4=CC(=C(C=C4C(=O)N3CCCN5CCOCC5)OC)OC)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B1WRQ2 6-[(2R)-2,3-Dihydroxypropyl]-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 76318269 C19H14N2O6 366.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3C[C@H](CO)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B1X2FI 6-(3-Hydroxypropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 60166112 C19H14N2O5 350.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B21UGO 5-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-5-oxopentanoic acid;hydrochloride Investigative 71546978 C24H24ClN3O5 469.9 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)NC(=O)CCCC(=O)O)C(=O)N3CCCN.Cl IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B2B4FH 6-(3-Azidopropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 71547129 C20H15N5O5 405.4 COC1=CC2=C(C=C1)C(=O)C3=C2N(C(=O)C4=C3C=CC(=C4)[N+](=O)[O-])CCCN=[N+]=[N-] IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B2PB1Y N-[4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]methanesulfonamide Investigative 57522821 C21H20N2O4S 396.5 CS(=O)(=O)NCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B2Y1XK N-[12-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]benzenesulfonamide Investigative 57521377 C34H38N2O4S 570.7 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3B5YD 6-[(2S)-2,3-Dihydroxypropyl]indeno[2,1-f][1,7]naphthyridine-5,11-dione Investigative 127044413 C18H14N2O4 322.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C(=O)N3C[C@@H](CO)O)N=CC=C4 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3CM0G N-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide Investigative 57522963 C25H20N2O4S 444.5 C1=CC=C(C=C1)S(=O)(=O)NCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3F4XL CID 57521911 Investigative 57521911 C29H26N2O8S 562.6 COC1=C(C=C2C(=C1)C3=C(C4=C(C3=O)C=C(C=C4)C(=O)OC)N(C2=O)CCCNS(=O)(=O)C5=CC=CC=C5)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3HDE5 N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]benzenesulfonamide Investigative 57523099 C28H26N2O4S 486.6 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3I2JE N-[2-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]benzenesulfonamide Investigative 57522962 C24H18N2O4S 430.5 C1=CC=C(C=C1)S(=O)(=O)NCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3NSQ6 6-(3-Morpholin-4-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione Investigative 127044239 C22H21N3O3 375.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)N=CC=C4)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B3PX8J 6-[[4-(Dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Investigative 91667394 C30H33N3O11S 643.7 CC1(C(N2C(S1)C(C2=O)NC(=O)C3=C(C4(C(CC5C(=C(C6=C(C5(C)O)C=CC=C6O)O)C4=O)C(C3=O)N(C)C)O)O)C(=O)O)C IC50 = 141000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B42WJY CID 57521693 Investigative 57521693 C27H23BrN2O4S 551.5 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B48EZU 6-(3-Imidazol-1-ylpropyl)-5,11-dioxoindeno[1,2-c]isoquinoline-3-carbonitrile Investigative 71544701 C23H16N4O2 380.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)C#N)C(=O)N3CCCN5C=CN=C5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B4IT5D 4-Bromo-N-[10-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]benzenesulfonamide Investigative 57521805 C32H33BrN2O4S 621.6 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B4U9WN 9-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrochloride Investigative 118735584 C22H17ClN4O5 452.8 C1=CC2=C(C=C1[N+](=O)[O-])C(=O)N(C3=C2C(=O)C4=C3C=CC(=C4)O)CCCN5C=CN=C5.Cl IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B4XIA7 6-(3-Hydroxypropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione Investigative 10494779 C19H15NO3 305.3 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B51AWI CID 57521489 Investigative 57521489 C31H32N2O4S 528.7 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B53QMD Methyl 2-[[16-methoxy-20-(3-morpholin-4-ylpropyl)-11,19-dioxo-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaen-15-yl]oxy]acetate Investigative 86765208 C28H28N2O9 536.5 COC1=C(C=C2C(=C1)C(=O)N(C3=C2C(=O)C4=CC5=C(C=C43)OCO5)CCCN6CCOCC6)OCC(=O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B54WQS 4-(Dimethylamino)-1,6,10,11,12a-pentahydroxy-N-(2-hydroxyethyl)-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Investigative 91667393 C24H28N2O9 488.5 CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCCO)N(C)C)O IC50 = 122000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B5E3FJ Methyl 4-{[4-(3-cyclopropyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxyphenoxy]methyl}benzoate Investigative 42915055 C27H26N2O5 458.5 COC1=C(C=CC(=C1)C2NC3=CC=CC=C3C(=O)N2C4CC4)OCC5=CC=C(C=C5)C(=O)OC IC50 = 89130 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B5ECZ0 20-(2,3-Dihydroxypropyl)-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76329155 C22H19NO8 425.4 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)CC(CO)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B5HQU9 3-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-3-oxopropanoic acid;hydrochloride Investigative 71546830 C22H20ClN3O5 441.9 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)NC(=O)CC(=O)O)C(=O)N3CCCN.Cl IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B5JCG3 N-[8-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)octyl]methanesulfonamide Investigative 57522825 C25H28N2O4S 452.6 CS(=O)(=O)NCCCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B5K8LQ 2-[(6-Methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]-2-oxoacetic acid Investigative 71546347 C19H12N2O5 348.3 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)C(=O)O)C(=O)C4=CC=CC=C42 IC50 = 61000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B5QW9P Schembl21803651 Investigative 137635992 C23H23FN4O3 422.5 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCNCC5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B64YVH Schembl21803662 Investigative 137661166 C23H22ClN3O4 439.9 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5CCOCC5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B67NCY CID 71546826 Investigative 71546826 C29H31N3O7 533.6 CC(C)(C)OC(=O)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CCCC(=O)O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B68ORQ Schembl21803683 Investigative 137646143 C22H22FN3O3 395.4 CC(C)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)F)C(=O)C4=C2N=CC(=C4)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B6CGX4 8-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735579 C22H17BrN4O5 497.3 C1=CC2=C(C=C1[N+](=O)[O-])C(=O)N(C3=C2C(=O)C4=C3C=C(C=C4)O)CCCN5C=CN=C5.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B6HG4C Ethyl 2-[7-fluoro-1-(4-methylphenyl)-3,9-dioxo-3,9-dihydrochromeno[2,3-c]pyrrol-2(1H)-yl]-4-methyl-1,3-thiazole-5-carboxylate Investigative 16434867 C25H19FN2O5S 478.5 CCOC(=O)C1=C(N=C(S1)N2C(C3=C(C2=O)OC4=C(C3=O)C=C(C=C4)F)C5=CC=C(C=C5)C)C IC50 = 50120 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B6J7PL (2E)-6-Acetyl-2-[1-[2-(dimethylamino)ethylamino]ethylidene]-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione Investigative 137658040 C22H26N2O6 414.5 CC1=C(C(=C2C(=C1O)C3(C(=CC(=O)/C(=C(/C)\\NCCN(C)C)/C3=O)O2)C)C(=O)C)O IC50 ~ 100000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B6ORM5 Chembl4160427 Investigative 145956398 C26H28N2O5 448.5 CCN(CC)CCOC1=NC2=C(C=CC3=CC4=C(C=C32)OCO4)C5=CC(=C(C=C51)OC)OC IC50 = 58000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B71KCJ 2-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-2-oxoacetic acid;hydrochloride Investigative 71546828 C21H18ClN3O5 427.8 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)NC(=O)C(=O)O)C(=O)N3CCCN.Cl IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B72XWH 2-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]benzoic acid Investigative 71453459 C11H7NO3S2 265.3 C1=CC=C(C(=C1)/C=C\\2/C(=S)NC(=O)S2)C(=O)O IC50 = 138000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B74JWL 4-Bromo-N-[3-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]benzenesulfonamide Investigative 57521691 C25H19BrN2O4S 523.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B74MAR n,n'-Dibenzoylcystine Investigative 91286 C20H20N2O6S2 448.5 C1=CC=C(C=C1)C(=O)NC(CSSCC(C(=O)O)NC(=O)C2=CC=CC=C2)C(=O)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B78IGC 6-(7-Hydroxyheptyl)indeno[1,2-c]isoquinoline-5,11-dione Investigative 57522600 C23H23NO3 361.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B7C6KZ (5Z)-1-Benzyl-5-[(4-fluorophenyl)methylidene]-2-sulfanylideneimidazolidin-4-one Investigative 71458832 C17H13FN2OS 312.4 C1=CC=C(C=C1)CN2/C(=C\\C3=CC=C(C=C3)F)/C(=O)NC2=S IC50 = 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B7GC3D 15,16-Dimethoxy-20-[(2R,3R,4R)-2,3,4,5-tetrahydroxypentyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76311079 C24H23NO10 485.4 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@H]([C@H]([C@@H](CO)O)O)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B7H1CY (5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione Investigative 2243892 C10H7NO4S 237.23 C1=CC(=C(C=C1/C=C\\2/C(=O)NC(=O)S2)O)O IC50 = 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B81RSP 6-[[6-(3-Aminopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]amino]-6-oxohexanoic acid;hydrochloride Investigative 71546980 C25H26ClN3O5 483.9 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)NC(=O)CCCCC(=O)O)C(=O)N3CCCN.Cl IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B86AMZ 20-[(2R)-2,3-Dihydroxypropyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76332814 C22H19NO8 425.4 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@H](CO)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B89XED 6-(3-Morpholin-4-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione Investigative 127044402 C22H21N3O3 375.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=CC=N4)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8AMJ7 (5Z)-5-[(2,4-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-one Investigative 136236294 C10H7NO3S2 253.3 C1=CC(=C(C=C1O)O)/C=C\\2/C(=S)NC(=O)S2 IC50 = 76000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8BP2U 6-[(2S)-2,3-Dihydroxypropyl]-3-iodoindeno[1,2-c]isoquinoline-5,11-dione Investigative 122179149 C19H14INO4 447.2 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)I)C(=O)N3C[C@@H](CO)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8BZR7 N-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]methanesulfonamide Investigative 57522717 C20H18N2O4S 382.4 CS(=O)(=O)NCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8DJL9 15,16-Dimethoxy-20-[(2R,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76311080 C25H25NO11 515.5 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8DT7O N-[10-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]-4-methylbenzenesulfonamide Investigative 57521586 C33H36N2O4S 556.7 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8FJX6 6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione Investigative 122179164 C21H16N4O2 356.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=NC=C4)C(=O)N3CCCN5C=CN=C5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8MZT0 N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]-3-methylbenzenesulfonamide Investigative 70690590 C29H28N2O4S 500.6 CC1=CC(=CC=C1)S(=O)(=O)NCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8QI2O 4-Bromo-N-[9-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]benzenesulfonamide Investigative 57521804 C31H31BrN2O4S 607.6 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8RVA9 {Imidazo[1,2-a]pyridin-2-yl}methyl 1H,2H,3H-cyclopenta[b]quinoline-9-carboxylate Investigative 9139208 C21H17N3O2 343.4 C1CC2=C(C3=CC=CC=C3N=C2C1)C(=O)OCC4=CN5C=CC=CC5=N4 IC50 = 50120 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8WA2P 6-[3-(Dimethylamino)propyl]indeno[1,2-h][1,6]naphthyridine-5,11-dione Investigative 127044404 C20H19N3O2 333.4 CN(C)CCCN1C2=C(C3=C(C1=O)C=CC=N3)C(=O)C4=CC=CC=C42 IC50 = 90000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8WZ6H 6-(6-Hydroxyhexyl)indeno[1,2-c]isoquinoline-5,11-dione Investigative 57522599 C22H21NO3 347.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B8XQB0 N-[6-(3-Aminopropyl)-11-hydroxy-5-oxo-11H-indeno[1,2-c]isoquinolin-3-yl]acetamide Investigative 60165957 C21H21N3O3 363.4 CC(=O)NC1=CC2=C(C=C1)C3=C(C4=CC=CC=C4C3O)N(C2=O)CCCN IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B98YJE 4-Bromo-N-[2-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]benzenesulfonamide Investigative 57521589 C24H17BrN2O4S 509.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B9JB0O 6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione Investigative 127044560 C21H16N4O2 356.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CN=C4)C(=O)N3CCCN5C=CN=C5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B9KVP1 CID 71546177 Investigative 71546177 C22H18N2O5 390.4 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CCC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B9O1WU (5Z)-5-[(3,4-Dihydroxyphenyl)methylidene]-3-phenyl-2-sulfanylideneimidazolidin-4-one Investigative 71451624 C16H12N2O3S 312.3 C1=CC=C(C=C1)N2C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/NC2=S IC50 = 74000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B9WZ7A CID 57521588 Investigative 57521588 C35H40N2O4S 584.8 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 B9X1YC Schembl21803696 Investigative 137652438 C22H17FN4O3 404.4 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5C=CN=C5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BA2KC5 6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,6]naphthyridine-5,11-dione Investigative 127044559 C22H21N3O3 375.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=CN=C4)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BAGL94 n,n'-Bis(phenylacetyl)cystine Investigative 220436 C22H24N2O6S2 476.6 C1=CC=C(C=C1)CC(=O)NC(CSSCC(C(=O)O)NC(=O)CC2=CC=CC=C2)C(=O)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BB3CH0 (2E)-6-Acetyl-7,9-dihydroxy-8,9b-dimethyl-2-[1-(3-morpholin-4-ylpropylamino)ethylidene]dibenzofuran-1,3-dione Investigative 137641552 C25H30N2O7 470.5 CC1=C(C(=C2C(=C1O)C3(C(=CC(=O)/C(=C(/C)\\NCCCN4CCOCC4)/C3=O)O2)C)C(=O)C)O IC50 ~ 100000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BB8Z2X Schembl21803682 Investigative 137643195 C25H27N5O6 493.5 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CCCN5CCN(CC5)CCO)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BB91DV 9-Hydroxy-6-(3-imidazol-1-ylpropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735564 C23H19BrN4O6 527.3 COC1=C(C=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CCCN5C=CN=C5)O.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BBN1R3 4-Sulfanyl-5-[(E)-[6-(tetrazol-5-ylidene)cyclohexa-2,4-dien-1-ylidene]methyl]-3H-1,3-thiazol-2-one Investigative 136236299 C11H7N5OS2 289.3 C1=C/C(=C\\C2=C(NC(=O)S2)S)/C(=C3N=NN=N3)C=C1 IC50 = 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BBSU72 (5E)-5-(1H-Indol-5-ylmethylene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one Investigative 135875770 C18H13N3OS 319.4 C1=CC=C(C=C1)N2C(=C(NC2=S)/C=C/3\\C=CC4=NC=CC4=C3)O IC50 = 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BBY74O N-[4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl]-4-methylbenzenesulfonamide Investigative 57521485 C27H24N2O4S 472.6 CC1=CC=C(C=C1)S(=O)(=O)NCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BC26SX CID 71544698 Investigative 71544698 C24H23N3O6 449.5 COC1=CC2=C(C=C1)C(=O)C3=C2N(C(=O)C4=C3C=CC(=C4)[N+](=O)[O-])CCCN5CCOCC5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BCJ4H7 Schembl21803687 Investigative 137653301 C23H22FN3O3 407.4 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCCC5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BCR4P5 N-[10-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]benzenesulfonamide Investigative 57521375 C32H34N2O4S 542.7 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BD5Z0O 3-Benzyl-5-hydroxy-4-[(E)-indol-5-ylidenemethyl]-1H-imidazole-2-thione Investigative 136236298 C19H15N3OS 333.4 C1=CC=C(C=C1)CN2C(=C(NC2=S)O)/C=C/3\\C=CC4=NC=CC4=C3 IC50 = 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BD67PE 7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl 4-methylbenzenesulfonate Investigative 57522712 C30H29NO5S 515.6 CC1=CC=C(C=C1)S(=O)(=O)OCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BEU84I 6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl 4-methylbenzenesulfonate Investigative 57522711 C29H27NO5S 501.6 CC1=CC=C(C=C1)S(=O)(=O)OCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BEVO64 5-Fluoro-14-methoxy-9-(3-morpholin-4-ylpropyl)-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione Investigative 137638718 C23H22FN3O4 423.4 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCOCC5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BF0QY6 6-(Furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dione Investigative 56837840 C13H9NO4 243.21 C1C2=C(C=CC(=C2)C3=CC=CO3)C(=O)N(C1=O)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BF35US 3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl 4-methylbenzenesulfonate Investigative 70696734 C26H21NO5S 459.5 CC1=CC=C(C=C1)S(=O)(=O)OCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BF6Q4R N-[7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]methanesulfonamide Investigative 57522824 C24H26N2O4S 438.5 CS(=O)(=O)NCCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BF83WM 6-(5-Hydroxypentyl)indeno[1,2-c]isoquinoline-5,11-dione Investigative 10640393 C21H19NO3 333.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BF98KQ 9-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735583 C23H22BrN3O6 516.299 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=C(C=C4)[N+](=O)[O-])C(=O)C5=C3C=CC(=C5)O.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BFJH30 5,6-Dihydro-6-(4-hydroxy-1-butyl)-5,11-diketo-11H-indeno[1,2-c]isoquinoline Investigative 10663416 C20H17NO3 319.4 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BFQ4C3 3-[(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino]-3-oxopropanoic Acid Investigative 71546348 C20H14N2O5 362.3 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CC(=O)O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BFXB62 N-[6-(3-Azidopropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamide Investigative 60165963 C21H17N5O3 387.4 CC(=O)NC1=CC2=C(C=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCN=[N+]=[N-] IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BG9EB5 2-((6-(3-((Tert-Butoxycarbonyl)amino)propyl)-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino)acetic Acid Investigative 71547124 C26H27N3O6 477.5 CC(C)(C)OC(=O)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)NCC(=O)O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BGB15O [4-[(Z)-(2-Oxo-4-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenyl]phosphonic acid Investigative 71451623 C10H8NO4PS2 301.3 C1=CC(=CC=C1/C=C\\2/C(=S)NC(=O)S2)P(=O)(O)O IC50 = 69000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BGC5O7 (Z)-4-((2,4-Dioxothiazolidin-5-ylidene)methyl)benzoic acid Investigative 6245483 C11H7NO4S 249.24 C1=CC(=CC=C1/C=C\\2/C(=O)NC(=O)S2)C(=O)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BGT83V 4-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)butyl 4-methylbenzenesulfonate Investigative 57522601 C27H23NO5S 473.5 CC1=CC=C(C=C1)S(=O)(=O)OCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BH02CK 3-Nitro-6-[(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]indeno[1,2-c]isoquinoline-5,11-dione Investigative 76321974 C21H18N2O8 426.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3C[C@@H]([C@@H]([C@@H](CO)O)O)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BH37VU 6-(2-Hydroxyethyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione Investigative 334474 C18H13NO3 291.3 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BH96EJ 2-[[4-(Dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carbonyl]amino]-3-hydroxybutanoic acid Investigative 91667392 C26H30N2O11 546.5 CC(C(C(=O)O)NC(=O)C1=C(C2(C(CC3C(=C(C4=C(C3(C)O)C=CC=C4O)O)C2=O)C(C1=O)N(C)C)O)O)O IC50 = 106000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BHL6I0 5,11-Dioxo-6-(2-amino-1-ethyl)-11H-indeno[1,2-c] isoquinoline hydrochloride Investigative 11370830 C18H15ClN2O2 326.8 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCN.Cl IC50 = 55300 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BHRN64 Schembl21803655 Investigative 137656446 C22H17ClN4O3 420.8 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)Cl)C(=O)N3CCCN5C=CN=C5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BIKL83 CID 57521807 Investigative 57521807 C34H37BrN2O4S 649.6 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BISA08 20-[(2S)-2,3-Dihydroxypropyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 73334714 C22H19NO8 425.4 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@@H](CO)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJ52OH (5Z)-5-[(2,5-Dihydroxyphenyl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-one Investigative 136236293 C10H7NO3S2 253.3 C1=CC(=C(C=C1O)/C=C\\2/C(=S)NC(=O)S2)O IC50 = 76000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJ52XV 4-Bromo-N-[7-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]benzenesulfonamide Investigative 57521695 C29H27BrN2O4S 579.5 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJ6YZ7 Schembl21803677 Investigative 137635101 C22H19FN4O3S 438.5 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCNC5=NCCS5)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJFU31 2-[3-(Dimethylamino)propyl]-3,4-(1,2-phenylenecarbonyl)-1,2-dihydro-2,6-naphthyridine-1-one Investigative 127044083 C20H19N3O2 333.4 CN(C)CCCN1C2=C(C3=C(C1=O)C=CN=C3)C(=O)C4=CC=CC=C42 IC50 = 63000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJM53Q 16-Methoxy-15-[3-(4-methylpiperazin-1-yl)propoxy]-20-(3-morpholin-4-ylpropyl)-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 90643551 C33H40N4O7 604.7 CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)C4=C(C5=CC6=C(C=C5C4=O)OCO6)N(C3=O)CCCN7CCOCC7)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJRS38 3-Nitro-6-[(2S,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexyl]indeno[1,2-c]isoquinoline-5,11-dione Investigative 76314699 C22H20N2O9 456.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3C[C@@H]([C@H]([C@H]([C@@H](CO)O)O)O)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJU9D7 N-[9-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]benzenesulfonamide Investigative 57523102 C31H32N2O4S 528.7 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BJX30T N-[2-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]methanesulfonamide Investigative 57522716 C19H16N2O4S 368.4 CS(=O)(=O)NCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BK39DV CID 57521803 Investigative 57521803 C30H29BrN2O4S 593.5 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BK87TF N-[3-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)propyl]-4-methylbenzenesulfonamide Investigative 57521379 C26H22N2O4S 458.5 CC1=CC=C(C=C1)S(=O)(=O)NCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BKD3A8 15,16-Dimethoxy-20-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76318268 C25H25NO11 515.5 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BKL7W0 Methyl 3-[(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino]-3-oxopropanoate Investigative 71546176 C21H16N2O5 376.4 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BL4TG3 N-[11-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]benzenesulfonamide Investigative 57521376 C33H36N2O4S 556.7 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BL6TY2 N-[11-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)undecyl]methanesulfonamide Investigative 57522960 C28H34N2O4S 494.6 CS(=O)(=O)NCCCCCCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BLQA14 (Z)-5-((1H-Indol-5-yl)methylene)thiazolidine-2,4-dione Investigative 135541470 C12H8N2O2S 244.27 C\\1=CC2=NC=CC2=C/C1=C/C3=C(NC(=O)S3)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BLX0K3 7-Hydroxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 118735573 C23H21N3O6 435.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=C(C=C4)[N+](=O)[O-])C(=O)C5=C3C(=CC=C5)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BM9E7Q CID 57522032 Investigative 57522032 C27H24N2O6S 504.6 COC1=C(C=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCNS(=O)(=O)C5=CC=CC=C5)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BMC96Y 2-[(6-Methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]acetic acid Investigative 71546986 C19H14N2O4 334.3 CN1C2=C(C3=C(C1=O)C=C(C=C3)NCC(=O)O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BMK4I7 CID 57521912 Investigative 57521912 C25H19N3O6S 489.5 C1=CC=C(C=C1)S(=O)(=O)NCCCN2C3=C(C4=C(C2=O)C=C(C=C4)[N+](=O)[O-])C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BMP9O3 N-[7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]benzenesulfonamide Investigative 57523100 C29H28N2O4S 500.6 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BN20KF Methyl 2-[(6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)amino]-2-oxoacetate Investigative 71546175 C20H14N2O5 362.3 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)C(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BN2H3A 15,16-Dimethoxy-20-[(2S,3R,4R)-2,3,4,5-tetrahydroxypentyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76321973 C24H23NO10 485.4 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@@H]([C@H]([C@@H](CO)O)O)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BN3B9Y CID 57522034 Investigative 57522034 C43H38N2O4 646.8 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCCCN5C6=C(C7=CC=CC=C7C5=O)C(=O)C8=CC=CC=C86 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BO47VL 6-(3-Bromopropyl)-8-methoxy-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 71547128 C20H15BrN2O5 443.2 COC1=CC2=C(C=C1)C(=O)C3=C2N(C(=O)C4=C3C=CC(=C4)[N+](=O)[O-])CCCBr IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BO64IH 16-Methoxy-20-(3-morpholin-4-ylpropyl)-15-prop-2-enoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 90643552 C28H28N2O7 504.5 COC1=C(C=C2C(=C1)C(=O)N(C3=C2C(=O)C4=CC5=C(C=C43)OCO5)CCCN6CCOCC6)OCC=C IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BO7KR6 (5Z)-5-(Pyridin-4-ylmethylidene)-4-sulfanylidene-1,3-thiazolidin-2-one Investigative 71455170 C9H6N2OS2 222.3 C1=CN=CC=C1/C=C\\2/C(=S)NC(=O)S2 IC50 = 75000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BO83QI N-[5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]benzenesulfonamide Investigative 57523098 C27H24N2O4S 472.6 C1=CC=C(C=C1)S(=O)(=O)NCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BO8U5J 7-Hydroxy-6-(3-imidazol-1-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 118735574 C22H16N4O5 416.4 C1=CC2=C(C(=C1)O)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CCCN5C=CN=C5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BO96HT N-[7-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)heptyl]-4-methylbenzenesulfonamide Investigative 57521488 C30H30N2O4S 514.6 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BOA4B8 8-Hydroxy-6-(3-imidazol-1-ylpropyl)-2,3,9-trimethoxyindeno[1,2-c]isoquinoline-5,11-dione Investigative 71457146 C25H23N3O6 461.5 COC1=C(C=C2C(=C1)C(=O)C3=C2N(C(=O)C4=CC(=C(C=C43)OC)OC)CCCN5C=CN=C5)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BOD15A 6-(3-Imidazol-1-ylpropyl)indeno[2,1-f][1,7]naphthyridine-5,11-dione Investigative 127044411 C21H16N4O2 356.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C(=O)N3CCCN5C=CN=C5)N=CC=C4 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BPC67N CID 71458831 Investigative 71458831 C12H9NO3S2 279.3 COC(=O)C1=CC=CC(=C1)/C=C\\2/C(=S)NC(=O)S2 IC50 = 51000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BPR73K CID 71546179 Investigative 71546179 C24H22N2O5 418.4 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CCCCC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BPSY83 6-(2,3-Dihydroxypropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione Investigative 76029213 C19H14N2O6 366.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CC(CO)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQ14OX 1,2,3,4-Tetrahydro-6-(2-furanyl)isoquinoline-1,3-dione Investigative 122483604 C13H9NO3 227.21 C1C2=C(C=CC(=C2)C3=CC=CO3)C(=O)NC1=O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQ3DH7 9-Hydroxy-6-(3-imidazol-1-ylpropyl)-2,3,8-trimethoxyindeno[1,2-c]isoquinoline-5,11-dione Investigative 71460811 C25H23N3O6 461.5 COC1=C(C=C2C(=C1)C3=C(C2=O)C4=CC(=C(C=C4C(=O)N3CCCN5C=CN=C5)OC)OC)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQ4A8Z Ethyl 2-[(6-methyl-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl)amino]acetate Investigative 71546982 C21H18N2O4 362.4 CCOC(=O)CNC1=CC2=C(C=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)C IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQ5HJ0 N-[8-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)octyl]benzenesulfonamide Investigative 57523101 C30H30N2O4S 514.6 C1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQ71XL (6-Methyl-5,11-dioxo-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-3-yl)-carbamic Acid Investigative 86706712 C18H12N2O4 320.3 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)O)C(=O)C4=CC=CC=C42 IC50 = 61000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQS1B6 5-Fluoro-14-methoxy-9-[3-(4-methylpiperazin-1-yl)propyl]-9,12-diazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2(7),3,5,11(16),12,14-heptaene-8,17-dione Investigative 137633472 C24H25FN4O3 436.5 CN1CCN(CC1)CCCN2C3=C(C4=C(C2=O)C=C(C=C4)F)C(=O)C5=C3N=CC(=C5)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQS3R7 CID 71546178 Investigative 71546178 C23H20N2O5 404.4 CN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CCCC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQV82R N-[6-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]methanesulfonamide Investigative 57522823 C23H24N2O4S 424.5 CS(=O)(=O)NCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BQYR60 Schembl22364348 Investigative 127044414 C18H17Cl2N3O2 378.2 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C(=O)N3CCCN)N=CC=C4.Cl.Cl IC50 ~ 60000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BR4PH6 2-[3-(Dimethylamino)propyl]-3,4-(1,2-phenylenecarbonyl)-1,2-dihydro-2,7-naphthyridine-1-one Investigative 122179163 C20H19N3O2 333.4 CN(C)CCCN1C2=C(C3=C(C1=O)C=NC=C3)C(=O)C4=CC=CC=C42 IC50 = 63000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BRD1Y7 N-[3-(11,20-Dioxo-5,7-dioxa-12-azapentacyclo[11.7.0.02,10.04,8.014,19]icosa-1(13),2,4(8),9,14,16,18-heptaen-12-yl)propyl]benzenesulfonamide Investigative 57521910 C26H20N2O6S 488.5 C1OC2=C(O1)C=C3C(=C2)C4=C(C5=CC=CC=C5C4=O)N(C3=O)CCCNS(=O)(=O)C6=CC=CC=C6 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BRE25C 4-Bromo-N-[6-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)hexyl]benzenesulfonamide Investigative 57521694 C28H25BrN2O4S 565.5 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BRM52V CID 57522035 Investigative 57522035 C44H40N2O4 660.8 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCCCCN5C6=C(C7=CC=CC=C7C5=O)C(=O)C8=CC=CC=C86 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BRO65D N-[10-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)decyl]methanesulfonamide Investigative 57522959 C27H32N2O4S 480.6 CS(=O)(=O)NCCCCCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BRT28Y N-[6-(3-Hydroxypropyl)-5,11-dioxoindeno[1,2-c]isoquinolin-3-yl]acetamide Investigative 60165960 C21H18N2O4 362.4 CC(=O)NC1=CC2=C(C=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCO IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BS0KB8 CID 57521909 Investigative 57521909 C31H23N3O6S 565.6 C1=CC=C(C=C1)C2=CC3=C(C=C2)C4=C(C3=O)C5=C(C=C(C=C5)[N+](=O)[O-])C(=O)N4CCCNS(=O)(=O)C6=CC=CC=C6 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BS30XD CID 71546514 Investigative 71546514 C30H33N3O7 547.6 CC(C)(C)OC(=O)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CCCC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BSV47G Schembl21803652 Investigative 137639878 C20H18FN3O3 367.4 CNCCCN1C2=C(C3=C(C1=O)C=C(C=C3)F)C(=O)C4=C2N=CC(=C4)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BSYZ76 Schembl21803664 Investigative 137652086 C21H20FN3O3 381.4 CCNCCCN1C2=C(C3=C(C1=O)C=C(C=C3)F)C(=O)C4=C2N=CC(=C4)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BT53FA 8-Hydroxy-9-methoxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735567 C24H24BrN3O7 546.4 COC1=C(C=C2C(=C1)C(=O)C3=C2N(C(=O)C4=C3C=CC(=C4)[N+](=O)[O-])CCCN5CCOCC5)O.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BT5DA1 N-[5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]-4-methylbenzenesulfonamide Investigative 57521486 C28H26N2O4S 486.6 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BT91PB CID 71546350 Investigative 71546350 C28H29N3O7 519.5 CC(C)(C)OC(=O)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BUF9S3 N-[5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl]methanesulfonamide Investigative 57522822 C22H22N2O4S 410.5 CS(=O)(=O)NCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BUN5C6 Schembl21803665 Investigative 137660083 C24H24FN3O4 437.5 COC1=CC2=C(C3=C(C2=O)C4=C(C=C(C=C4)F)C(=O)N3CCCN5CCC(CC5)O)N=C1 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BV28JG 9-Hydroxy-8-methoxy-6-(3-morpholin-4-ylpropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione;hydrobromide Investigative 118735562 C24H24BrN3O7 546.4 COC1=C(C=C2C(=C1)C3=C(C2=O)C4=C(C=C(C=C4)[N+](=O)[O-])C(=O)N3CCCN5CCOCC5)O.Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BV7TP8 N-[2-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)ethyl]-4-methylbenzenesulfonamide Investigative 57521378 C25H20N2O4S 444.5 CC1=CC=C(C=C1)S(=O)(=O)NCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BVOB04 2-[[11-Hydroxy-16-methoxy-20-(3-morpholin-4-ylpropyl)-19-oxo-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaen-15-yl]oxy]acetohydrazide Investigative 90643550 C27H30N4O8 538.5 COC1=C(C=C2C(=C1)C(=O)N(C3=C2C(C4=CC5=C(C=C43)OCO5)O)CCCN6CCOCC6)OCC(=O)NN IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BVPE14 CID 71546351 Investigative 71546351 C29H31N3O7 533.6 CC(C)(C)OC(=O)NCCCN1C2=C(C3=C(C1=O)C=C(C=C3)NC(=O)CCC(=O)OC)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BVR70X 6-[(2S)-2,3-Dihydroxypropyl]indeno[1,2-c][2,6]naphthyridine-5,11-dione Investigative 127043728 C18H14N2O4 322.3 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CN=C4)C(=O)N3C[C@@H](CO)O IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BW4K1R 5-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)pentyl 4-methylbenzenesulfonate Investigative 57522602 C28H25NO5S 487.6 CC1=CC=C(C=C1)S(=O)(=O)OCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BW4S1T N-[9-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]-4-methylbenzenesulfonamide Investigative 57521585 C32H34N2O4S 542.7 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BW5JI7 (-)-Usnic acid Investigative 442614 C18H16O7 344.3 CC1=C(C(=C2C(=C1O)[C@]3(C(=CC(=C(C3=O)C(=O)C)O)O2)C)C(=O)C)O IC50 ~ 100000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BW9A4G 6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dione Investigative 122179162 C22H21N3O3 375.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=NC=C4)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BWCN31 CID 57521806 Investigative 57521806 C33H35BrN2O4S 635.6 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCCCNS(=O)(=O)C5=CC=C(C=C5)Br IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BWE06B 6-(3-Imidazol-1-ylpropyl)indeno[1,2-h][1,6]naphthyridine-5,11-dione Investigative 127044403 C21H16N4O2 356.4 C1=CC=C2C(=C1)C3=C(C2=O)C4=C(C=CC=N4)C(=O)N3CCCN5C=CN=C5 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BX16MF N-[12-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)dodecyl]methanesulfonamide Investigative 57522961 C29H36N2O4S 508.7 CS(=O)(=O)NCCCCCCCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BX30FG CID 57522033 Investigative 57522033 C42H36N2O4 632.7 C1=CC=C2C(=C1)C3=C(C4=CC=CC=C4C3=O)N(C2=O)CCCCCCCCCCN5C6=C(C7=CC=CC=C7C5=O)C(=O)C8=CC=CC=C86 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BXF3M0 (2-Oxo-1-phenyl-2-piperidin-1-ylethyl) (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate Investigative 18230892 C23H25NO5 395.4 COC1=C(C=CC(=C1)/C=C/C(=O)OC(C2=CC=CC=C2)C(=O)N3CCCCC3)O IC50 = 70790 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BY0R4T CID 57521587 Investigative 57521587 C34H38N2O4S 570.7 CC1=CC=C(C=C1)S(=O)(=O)NCCCCCCCCCCCN2C3=C(C4=CC=CC=C4C2=O)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BY2J1C 15,16-Dimethoxy-20-[(2R,3S,4R)-2,3,4,5-tetrahydroxypentyl]-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione Investigative 76311078 C24H23NO10 485.4 COC1=C(C=C2C(=C1)C3=C(C4=CC5=C(C=C4C3=O)OCO5)N(C2=O)C[C@H]([C@@H]([C@@H](CO)O)O)O)OC IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BY67CG (4Z)-4-[[4-[Bis(2-cyanoethyl)amino]phenyl]methylidene]-5-oxo-1-(4-sulfophenyl)pyrazole-3-carboxylic acid Investigative 5478021 C23H19N5O6S 493.5 C1=CC(=CC=C1/C=C\\2/C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)O)C(=O)O)N(CCC#N)CCC#N IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BY8MA9 CID 71544702 Investigative 71544702 C24H21N3O3 399.4 C1COCCN1CCCN2C3=C(C4=C(C2=O)C=C(C=C4)C#N)C(=O)C5=CC=CC=C53 IC50 ~ 111000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BZ0K4L (4S,4As,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-N-(pyrrolidin-1-ylmethyl)-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Investigative 54687414 C27H33N3O8 527.6 CC1(C2CC3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCN5CCCC5)N(C)C)O IC50 = 84000 nM Poor binder T33492 Tyrosyl-DNA phosphodiesterase 1 BZX25E N-[9-(5,11-Dioxoindeno[1,2-c]isoquinolin-6-yl)nonyl]methanesulfonamide Investigative 57522826 C26H30N2O4S 466.6 CS(=O)(=O)NCCCCCCCCCN1C2=C(C3=CC=CC=C3C1=O)C(=O)C4=CC=CC=C42 IC50 ~ 111000 nM Poor binder