TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T33584	Glutamate receptor AMPA 1	D00ENY	L-Glutamic Acid	Approved	33032	C5H9NO4	147.13	C(CC(=O)O)[C@@H](C(=O)O)N	EC50 = 71000 nM	Poor binder
T33584	Glutamate receptor AMPA 1	B2WLD9	(3S,4Ar,6S,8aR)-6-[(4-carboxyimidazol-1-yl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;dihydrochloride	Investigative	45262167	C15H23Cl2N3O4	380.3	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CN3C=C(N=C3)C(=O)O)C(=O)O.Cl.Cl	Ki = 134000 nM	Poor binder
T33584	Glutamate receptor AMPA 1	B3YHK1	6-((1S)-1-(1-(5-(2-Hydroxyethoxy)-2-pyridinyl)-1H-pyrazol-3-yl)ethyl)-2(3H)-benzothiazolone	Investigative	74223604	C19H18N4O3S	382.4	C[C@@H](C1=CC2=C(C=C1)NC(=O)S2)C3=NN(C=C3)C4=NC=C(C=C4)OCCO	IC50 = 68500 nM	Poor binder
T33584	Glutamate receptor AMPA 1	B5ZSG4	(S)-2-Amino-4-(1-ethyl-propylidene)-pentanedioic acid	Investigative	10398361	C10H17NO4	215.25	CCC(=C(C[C@@H](C(=O)O)N)C(=O)O)CC	Ki ~ 100000 nM	Poor binder
T33584	Glutamate receptor AMPA 1	B7FBR0	Kainic acid	Investigative	10255	C10H15NO4	213.23	CC(=C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O	EC50 = 60000 nM	Poor binder
T33584	Glutamate receptor AMPA 1	B8Z4TB	N-(1H-Indazol-5-yl)-N-[(1-methylpyrazol-3-yl)methyl]-4-pyridin-2-yl-1,3-thiazol-2-amine	Investigative	127048931	C20H17N7S	387.5	CN1C=CC(=N1)CN(C2=CC3=C(C=C2)NN=C3)C4=NC(=CS4)C5=CC=CC=N5	IC50 = 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BCY52J	N-Methyl-N-(1-pyridin-2-ylpyrazol-3-yl)-1H-indazol-5-amine	Investigative	127052039	C16H14N6	290.32	CN(C1=CC2=C(C=C1)NN=C2)C3=NN(C=C3)C4=CC=CC=N4	IC50 ~ 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BD41BU	4-Chloro-2-(naphthalen-2-ylcarbamoylamino)benzoic Acid	Investigative	10132082	C18H13ClN2O3	340.8	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=C(C=CC(=C3)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BF5W4T	6-[(1S)-1-(1-Pyridin-2-ylpyrazol-3-yl)ethyl]-3H-1,3-benzothiazol-2-one	Investigative	127048930	C17H14N4OS	322.4	C[C@@H](C1=CC2=C(C=C1)NC(=O)S2)C3=NN(C=C3)C4=CC=CC=N4	IC50 = 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BG43YK	6-[(1S)-1-[1-(5-Fluoropyridin-2-yl)pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	Investigative	127050488	C17H13FN4OS	340.4	C[C@@H](C1=CC2=C(C=C1)NC(=O)S2)C3=NN(C=C3)C4=NC=C(C=C4)F	IC50 = 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BJ4Z1S	6-[(1R)-1-(1-Pyridin-2-ylpyrazol-3-yl)ethyl]-3H-1,3-benzothiazol-2-one	Investigative	127048574	C17H14N4OS	322.4	C[C@H](C1=CC2=C(C=C1)NC(=O)S2)C3=NN(C=C3)C4=CC=CC=N4	IC50 = 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BOQ7Z1	(2S,4Z)-2-Amino-4-(2-methylpropylidene)pentanedioic Acid	Investigative	11820131	C9H15NO4	201.22	CC(C)/C=C(/C[C@@H](C(=O)O)N)\\C(=O)O	Ki = 113400 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BOZ4N3	6-[Methyl-(4-pyridin-2-yl-1,3-thiazol-2-yl)amino]-3H-1,3-benzothiazol-2-one	Investigative	127049895	C16H12N4OS2	340.4	CN(C1=CC2=C(C=C1)NC(=O)S2)C3=NC(=CS3)C4=CC=CC=N4	IC50 ~ 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BQZ2E7	4-[Methyl[4-(2-pyridinyl)thiazole-2-yl]amino]phenol	Investigative	973101	C15H13N3OS	283.4	CN(C1=CC=C(C=C1)O)C2=NC(=CS2)C3=CC=CC=N3	IC50 ~ 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BWKO90	N-(1H-Indazol-5-yl)-N-methyl-4-pyridin-2-yl-1,3-thiazol-2-amine	Investigative	127052038	C16H13N5S	307.4	CN(C1=CC2=C(C=C1)NN=C2)C3=NC(=CS3)C4=CC=CC=N4	IC50 ~ 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BWV9J2	6-[1-(1-Pyridin-2-ylpyrazol-3-yl)ethyl]-3H-1,3-benzothiazol-2-one	Investigative	127052040	C17H14N4OS	322.4	CC(C1=CC2=C(C=C1)NC(=O)S2)C3=NN(C=C3)C4=CC=CC=N4	IC50 = 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BXJ68T	6-[(1S)-1-[1-[5-(2-Hydroxyethyl)pyridin-2-yl]pyrazol-3-yl]ethyl]-3H-1,3-benzothiazol-2-one	Investigative	118536551	C19H18N4O2S	366.4	C[C@@H](C1=CC2=C(C=C1)NC(=O)S2)C3=NN(C=C3)C4=NC=C(C=C4)CCO	IC50 = 83300 nM	Poor binder
T33584	Glutamate receptor AMPA 1	BZ0LV2	N-[1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-butyramide	Investigative	14608128	C23H41N5O3	435.6	CCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NCCCNCCCCNCCCN	Ki = 170000 nM	Poor binder
T33584	Glutamate receptor AMPA 1	D0N1CL	2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid	Investigative	9799478	C14H10BrClN2O3	369.6	C1=CC(=CC(=C1)Br)NC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder