TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T35940	ERK activator kinase 1	D0VF6E	PD173074	Phase 2	1401	C28H41N7O3	523.7	CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C	IC50 ~ 50000 nM	Poor binder
T35940	ERK activator kinase 1	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T35940	ERK activator kinase 1	B1A4EI	(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one	Investigative	9547398	C27H42O3	414.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3C[C@@H]([C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C)O	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	B1VO9R	Calicoferol E	Investigative	5283685	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	B4YXC8	7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol	Investigative	76335685	C24H33NO3	383.5	C[C@H]1CC[C@@]2([C@H]([C@]1(C)CC3=C4C(=CC(=C3O)OC)N=C(O4)C)CCC=C2C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	B7WB6T	N~3~-Cyclopropyl-N~4~'-(Cyclopropylmethyl)-6-Methylbiphenyl-3,4'-Dicarboxamide	Investigative	24856363	C22H24N2O2	348.4	CC1=C(C=C(C=C1)C(=O)NC2CC2)C3=CC=C(C=C3)C(=O)NCC4CC4	IC50 ~ 50000 nM	Poor binder
T35940	ERK activator kinase 1	B82GAY	Methyl 3-[[(1R,2S,4aR,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-4,5-dihydroxybenzoate	Investigative	10714343	C23H32O4	372.5	C[C@H]1CC[C@@]2([C@H]([C@]1(C)CC3=C(C(=CC(=C3)C(=O)OC)O)O)CCC=C2C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	B8OC2B	4-Methyl-3-[3-(methylsulfamoylamino)anilino]-7-pyrimidin-2-yloxychromen-2-one	Investigative	59139472	C21H19N5O5S	453.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)NC4=CC(=CC=C4)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T35940	ERK activator kinase 1	BBZ0D8	(4S,6E,12Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione	Investigative	53323592	C19H22O5	330.4	C[C@H]1C/C=C/C(=O)CCC/C=C\\C2=C(C(=CC(=C2)OC)O)C(=O)O1	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BCG3J8	2,3,6,8-Tetrahydroxy-1-methylxanthone	Investigative	10423452	C14H10O6	274.22	CC1=C(C(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O)O	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BDK9R0	Calicoferol C	Investigative	10024683	C28H44O2	412.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BF32AR	Calicoferol B	Investigative	10047545	C27H44O3	416.6	CC1=C(C=C(C=C1)O)CC[C@@H]2[C@@H](CC[C@]3([C@H]2C[C@@H]([C@@H]3[C@H](C)CCCC(C)C)O)C)O	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BK5H7E	7-Choro-6-[(3R)-pyrrolidin-3-ylmethoxy]isoquinolin-1(2H)-one	Investigative	73348939	C14H15ClN2O2	278.73	C1CNC[C@@H]1COC2=C(C=C3C(=C2)C=CNC3=O)Cl	IC50 = 157000 nM	Poor binder
T35940	ERK activator kinase 1	BNA26F	(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71720141	C18H19N3O	293.4	CN1C[C@@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BNC32F	[4-Methyl-3-[[5-(methylsulfamoylamino)pyridin-3-yl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	90655795	C20H22N4O6S	446.5	CC1=C(C(=O)OC2=C1C=CC(=C2)OC(=O)N(C)C)CC3=CC(=CN=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T35940	ERK activator kinase 1	BQ5LG8	(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one	Investigative	71718330	C18H19N3O	293.4	CN1C[C@H](C(=O)/C(=C/C2=CC=CC=N2)/C1)CC3=CC=CC=N3	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BQS51E	Calicoferol A	Investigative	9547698	C27H40O2	396.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BQX3F8	2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol	Investigative	137659496	C19H19N5O	333.4	CC1=CC=C(C=C1)CNC2=NC(=NC3=C2C4=C(N3)C=C(C(=C4)O)C)N	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BRC1U5	N-Cyclopropyl-4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)benzamide	Investigative	9864418	C23H25N3O2	375.5	CC1=C(C=C(C=C1)C(=O)NC2CC2)C3=CC4=C(C=C3)C(=NO4)C5CCNCC5	IC50 ~ 50000 nM	Poor binder
T35940	ERK activator kinase 1	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BX0D7J	Rel-Astrogorgol F	Investigative	54764923	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@@H]2O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BY6N0R	4-Methyl-5,6,7-trihydroxy-1,3-dihydroisobenzofuran-1-one	Investigative	76328313	C9H8O5	196.16	CC1=C2COC(=O)C2=C(C(=C1O)O)O	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BYB0C2	24-Exomethylenecalicoferol E	Investigative	10047202	C28H42O2	410.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T35940	ERK activator kinase 1	BZR76B	Norlichexanthone	Investigative	5281657	C14H10O5	258.23	CC1=CC(=CC2=C1C(=O)C3=C(C=C(C=C3O2)O)O)O	IC50 ~ 100000 nM	Poor binder