TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T38584 Hepatocyte growth factor activator B3ZS9U 4-Benzamidophenylguanidine Investigative 12925854 C14H14N4O 254.29 C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)N=C(N)N IC50 ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator B4N8QM Methyl 6-[[4-(diaminomethylideneamino)phenyl]sulfonylamino]naphthalene-2-carboxylate Investigative 118729854 C19H18N4O4S 398.4 COC(=O)C1=CC2=C(C=C1)C=C(C=C2)NS(=O)(=O)C3=CC=C(C=C3)N=C(N)N IC50 ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator B76QTL 4-[(2S)-3-(3-Carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]-N-(2-phenylethyl)piperazine-1-carboxamide Investigative 118729860 C30H36N6O4S 576.7 CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC(=CC=C2)C(=N)N)C(=O)N3CCN(CC3)C(=O)NCCC4=CC=CC=C4 Ki ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BA6NY7 3-[[3-(1-Benzylpiperidin-4-yl)-5-methyl-2-oxo-1,3-diazinan-1-yl]methyl]benzenecarboximidamide Investigative 127033521 C25H33N5O 419.6 CC1CN(C(=O)N(C1)C2CCN(CC2)CC3=CC=CC=C3)CC4=CC(=CC=C4)C(=N)N Ki ~ 100000 nM Poor binder T38584 Hepatocyte growth factor activator BBJ50F Benzyl 4-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperazine-1-carboxylate Investigative 118729131 C29H33N5O5S 563.7 CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC(=CC=C2)C(=N)N)C(=O)N3CCN(CC3)C(=O)OCC4=CC=CC=C4 Ki ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BE87OC 4-[(2S)-3-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]-N-hexylpiperazine-1-carboxamide Investigative 118728084 C31H40N6O4S 592.8 CCCCCCNC(=O)N1CCN(CC1)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3 Ki ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BGO35E 3-[(2S)-3-[4-(1-Benzothiophene-3-carbonyl)piperazin-1-yl]-2-(naphthalen-2-ylsulfonylamino)-3-oxopropyl]benzenecarboximidamide Investigative 118729129 C33H31N5O4S2 625.8 C1CN(CCN1C(=O)C2=CSC3=CC=CC=C32)C(=O)[C@H](CC4=CC(=CC=C4)C(=N)N)NS(=O)(=O)C5=CC6=CC=CC=C6C=C5 Ki ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BLM40C Benzyl N-[(3R)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)propanoyl]piperidin-3-yl]carbamate Investigative 118729130 C33H35N5O5S 613.7 C1C[C@H](CN(C1)C(=O)[C@H](CC2=CC(=CC=C2)C(=N)N)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3)NC(=O)OCC5=CC=CC=C5 Ki ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BNAZ53 2-[4-[(4-Methylphenyl)sulfonylamino]phenyl]guanidine Investigative 12925858 C14H16N4O2S 304.37 CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N=C(N)N IC50 ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BPZ48V Benzyl N-[(3S)-1-[(2S)-3-(3-carbamimidoylphenyl)-2-[(4-methylphenyl)sulfonylamino]propanoyl]piperidin-3-yl]carbamate Investigative 118729857 C30H35N5O5S 577.7 CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CC2=CC(=CC=C2)C(=N)N)C(=O)N3CCC[C@@H](C3)NC(=O)OCC4=CC=CC=C4 Ki ~ 50000 nM Poor binder T38584 Hepatocyte growth factor activator BRI7J1 3-[3-(1-Benzyl-piperidin-4-yl)-ureido]-benzamidine Investigative 44324727 C20H25N5O 351.4 C1CN(CCC1NC(=O)NC2=CC=CC(=C2)C(=N)N)CC3=CC=CC=C3 Ki = 54600 nM Poor binder T38584 Hepatocyte growth factor activator BS80UH 4-(Diaminomethylideneamino)-N-phenylbenzamide Investigative 44457054 C14H14N4O 254.29 C1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)N=C(N)N IC50 ~ 50000 nM Poor binder