TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T40103	Cathepsin H	D0J2VB	Iboctadekin + rituximab	Phase 1	5478883	C34H63N5O9	685.9	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	D0U2SS	MDL-2170	Terminated	11199915	C22H26N2O4	382.5	CC(C)[C@@H](C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	B16GAX	Chembl4228921	Investigative	145988823	C23H21N5O5	447.4	C1CN(CCC1CNC(=O)C2=CC(=C3C=CC=NC3=C2O)[N+](=O)[O-])C4=NC5=CC=CC=C5O4	Ki = 108000 nM	Poor binder
T40103	Cathepsin H	B20ZUP	5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one	Investigative	44426056	C13H17NO3	235.28	CC1=C(C(=CC=C1)OCC2CN(C(=O)O2)C)C	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	B29TFB	2-Methyl-5-nitroquinoline-8-ol	Investigative	12737307	C10H8N2O3	204.18	CC1=NC2=C(C=CC(=C2C=C1)[N+](=O)[O-])O	Ki = 89000 nM	Poor binder
T40103	Cathepsin H	B2VAN9	(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	13186896	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@H]2O)C	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	B5B7YV	Trifluoroethylamine inhibitor, 2	Investigative	23648277	C16H17BrF3N3O3S	468.3	CS(=O)(=O)C[C@@H](C(=O)NC1(CC1)C#N)N[C@@H](C2=CC=C(C=C2)Br)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T40103	Cathepsin H	B5DBM8	3-Acetyl-5,8-dibromo-2-(4-bromophenylamino)quinolin-4(1H)-one	Investigative	44565900	C17H11Br3N2O2	515	CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)Br)Br)NC3=CC=C(C=C3)Br	IC50 = 91760 nM	Poor binder
T40103	Cathepsin H	B5I6RB	(2R)-2-Amino-N-[(1S,2S)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797572	C19H18F3N3O3S	425.4	C1[C@H]([C@@]1(C#N)NC(=O)[C@@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T40103	Cathepsin H	B7BSG8	7-(Cyanomethylaminomethyl)-5-nitro-8-quinolinol	Investigative	71520324	C12H10N4O3	258.23	C1=CC2=C(C=C(C(=C2N=C1)O)CNCC#N)[N+](=O)[O-]	Ki = 129000 nM	Poor binder
T40103	Cathepsin H	B9RI7L	(2S)-2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-thiophen-2-ylpropanamide;2,2,2-trifluoroacetic acid	Investigative	49797573	C19H18F3N3O3S	425.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T40103	Cathepsin H	BAVB51	(1S,2S)-2-Bromo-7-oxa-5-aza-bicyclo[3.2.1]octan-6-one	Investigative	24901102	C6H8BrNO2	206.04	C1CN2C[C@@H]([C@H]1Br)OC2=O	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BC1QT7	Z-FF-Fmk	Investigative	11705307	C27H27FN2O4	462.5	C1=CC=C(C=C1)C[C@@H](C(=O)CF)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BD8UG7	3-Acetyl-6-chloro-2-(2-chloro-4-methylphenylamino)-8-nitroquinolin-4(1H)-one	Investigative	44566195	C18H13Cl2N3O4	406.2	CC1=CC(=C(C=C1)NC2=C(C(=O)C3=C(N2)C(=CC(=C3)Cl)[N+](=O)[O-])C(=O)C)Cl	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BDEJ85	3-(1-Benzyloxycarbonyl-3-methyl-butylcarbamoyl)-1-(2-tert-butoxycarbonylamino-3-phenyl-propionyl)-aziridine-2-carboxylic acid ethyl ester	Investigative	10746284	C33H43N3O8	609.7	CCOC(=O)[C@H]1[C@@H](N1C(=O)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)OCC3=CC=CC=C3	Ki = 137000 nM	Poor binder
T40103	Cathepsin H	BEK87S	3-Acetyl-8-bromo-5-chloro-2-(4-chlorophenylamino)quinolin-4(1H)-one	Investigative	44565901	C17H11BrCl2N2O2	426.1	CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)Cl)Br)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BF9C4I	(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol	Investigative	6917747	C13H19NO2	221.29	CC1=C(C(=CC=C1)O[C@@H]2CCNC[C@@H]2O)C	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BKVT70	3-Acetyl-5,8-dichloro-2-(2,4-dichlorophenylamino)quinolin-4(1H)-one	Investigative	44219712	C17H10Cl4N2O2	416.1	CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)Cl)Cl)NC3=C(C=C(C=C3)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BM61WY	1-(2-Benzyloxycarbonylamino-propionyl)-aziridine-2,3-dicarboxylic acid diethyl ester	Investigative	10668225	C19H24N2O7	392.4	CCOC(=O)[C@@H]1[C@H](N1C(=O)[C@H](C)NC(=O)OCC2=CC=CC=C2)C(=O)OCC	Ki = 160000 nM	Poor binder
T40103	Cathepsin H	BNHQ54	cis-(S)-2-Amino-N-((1R,2R)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide	Investigative	24822701	C17H17N3OS	311.4	C1[C@@H]([C@]1(C#N)NC(=O)[C@H](CC2=CC=CS2)N)C3=CC=CC=C3	IC50 ~ 50000 nM	Poor binder
T40103	Cathepsin H	BSN5D6	3-Acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-methylquinolin-4(1H)-one	Investigative	44565925	C18H13Br2ClN2O2	484.6	CC1=C2C(=C(C=C1)Cl)NC(=C(C2=O)C(=O)C)NC3=C(C=C(C=C3)Br)Br	IC50 = 66520 nM	Poor binder
T40103	Cathepsin H	BU43OX	(1R,2S)-2-Phenoxy-7-oxa-5-aza-bicyclo[3.2.1]octane-6-thione	Investigative	44426055	C12H13NO2S	235.3	C1CN2C[C@H]([C@H]1OC3=CC=CC=C3)OC2=S	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BVKR62	3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-one	Investigative	44566188	C21H20ClN3O4	413.9	CC(=O)C1=C(NC2=C(C1=O)C=C(C=C2Cl)[N+](=O)[O-])NC3=CC=C(C=C3)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BW5U1T	2-Amino-N-[(1R,2R)-1-cyano-2-phenylcyclopropyl]-3-(3-fluorothiophen-2-yl)propanamide;2,2,2-trifluoroacetic acid	Investigative	49797571	C19H17F4N3O3S	443.4	C1[C@@H]([C@]1(C#N)NC(=O)C(CC2=C(C=CS2)F)N)C3=CC=CC=C3.C(=O)(C(F)(F)F)O	IC50 ~ 50000 nM	Poor binder
T40103	Cathepsin H	BX5GQ6	CID 9821383	Investigative	9821383	C18H29N3O6	383.4	CCCNC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2CCC[C@H]2C(=O)O	IC50 ~ 100000 nM	Poor binder
T40103	Cathepsin H	BXL1M8	Chembl346155	Investigative	10770036	C33H43N3O8	609.7	CCOC(=O)[C@@H]1[C@H](N1C(=O)[C@H](CC2=CC=CC=C2)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)OCC3=CC=CC=C3	Ki = 93000 nM	Poor binder