TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T40276	Protein kinase C beta	D01XYJ	Zidovudine	Approved	35370	C10H13N5O4	267.24	CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	D0R9YR	BETULINIC ACID	Phase 1	64971	C30H48O3	456.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	D0WS1V	L-751250	Preclinical	448991	C20H25ClN6O3	432.9	CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=C(C=C3)C(=O)O)Cl	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	B0AT4I	(1R)-2-[2,6-Dihydroxy-4-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]cyclohexane-1-carboxylic acid	Investigative	44322741	C28H32N2O9	540.6	C1CCC([C@@H](C1)C(=O)O)C(=O)C2=C(C=C(C=C2O)C(=O)O[C@@H]3CCCNCC3NC(=O)C4=CC=C(C=C4)O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B13BDT	3-Hydroxy-2-[4-[2-[(4-hydroxybenzoyl)amino]cyclopentyl]oxycarbonyl-2,6-dimethylbenzoyl]benzoic acid	Investigative	44322720	C29H27NO8	517.5	CC1=CC(=CC(=C1C(=O)C2=C(C=CC=C2O)C(=O)O)C)C(=O)OC3CCCC3NC(=O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B2T0RU	CID 46179972	Investigative	46179972	C28H31N6O3	499.6	CC1(CC(CC(N1[O])(C)C)NC(=O)C2=CC=CC(=C2)C3=NN4C(=CC=NC4=C3)NC5=CC(=CC=C5)O)C	IC50 ~ 60000 nM	Poor binder
T40276	Protein kinase C beta	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B4F1NE	2-[2,6-Dihydroxy-4-[[(3R,4S)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]-methylcarbamoyl]benzoyl]-3-hydroxybenzoic acid	Investigative	71718528	C29H29N3O9	563.6	CN([C@H]1CCCNC[C@H]1NC(=O)C2=CC=C(C=C2)O)C(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C=CC=C4O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B4R5FA	(R)-2-[(R)-2-(2-{(R)-2-[(R)-2-(2-Amino-5-guanidino-pentanoylamino)-5-guanidino-pentanoylamino]-5-guanidino-pentanoylamino}-5-guanidino-pentanoylamino)-5-guanidino-pentanoylamino]-5-guanidino-pentanoic acid	Investigative	9854502	C36H74N24O7	955.1	C(C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)O)N)CN=C(N)N	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	B4TLB5	(R)-2-{(R)-2-[2-((R)-2-{(R)-2-[2-(6-Acetylamino-hexanoylamino)-5-guanidino-pentanoylamino]-5-guanidino-pentanoylamino}-5-guanidino-pentanoylamino)-5-guanidino-pentanoylamino]-5-guanidino-pentanoylamino}-5-guanidino-pentanoic acid	Investigative	44282232	C44H87N25O9	1110.3	CC(=O)NCCCCCC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	B4U6PG	Platanic acid	Investigative	64980	C29H46O4	458.7	CC(=O)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	B5J3GY	5-Vinyl-3-pyridinecarbonitrile, 19	Investigative	44160269	C24H28N6	400.5	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/CCN4CCC[C@H](C4)N)C#N	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	B5XGJ1	Betulinic acid 28-O-carboxymethylmethylate	Investigative	10482065	C33H52O5	528.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)OCC(=O)OC	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	B5YNV2	6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile	Investigative	53357328	C27H27N3O2	425.5	CC1(C2=C(C=CC(=C2)C3CCN(CC3)C4COC4)C(=O)C5=C1NC6=C5C=CC(=C6)C#N)C	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B60CAW	(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide	Investigative	46232555	C20H15Cl2FN2O2	405.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)N	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B7AYK6	Betulinic acid 3-O-sulfonate potassium salt	Investigative	44575685	C30H47KO6S	574.9	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OS(=O)(=O)[O-])C)C(=O)O.[K+]	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	B7ZDB8	(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline	Investigative	46232443	C17H12Cl2FNO	336.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B8YTQ3	CID 49806721	Investigative	49806721	C28H30N4O2	454.6	CCC1=CC2=C(C=C1N3CCN(CC3)C4COC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	B93PBH	(1S)-2-[2,6-Dihydroxy-4-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonylbenzoyl]cyclohexane-1-carboxylic acid	Investigative	44322686	C28H32N2O9	540.6	C1CCC([C@H](C1)C(=O)O)C(=O)C2=C(C=C(C=C2O)C(=O)O[C@@H]3CCCNCC3NC(=O)C4=CC=C(C=C4)O)O	IC50 = 124000 nM	Poor binder
T40276	Protein kinase C beta	B9OES1	1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea	Investigative	11755812	C26H20F3N7O	503.5	C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(F)(F)F)C3=CN4C=CN=C4C(=N3)NCC5=CC=NC=C5	IC50 = 50000 nM	Poor binder
T40276	Protein kinase C beta	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	BA6CV3	[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 3,5-dihydroxy-4-(8-hydroxy-4-oxo-3H-phthalazin-1-yl)benzoate	Investigative	136026545	C27H23N3O8	517.5	C1CC(C(C1)OC(=O)C2=CC(=C(C(=C2)O)C3=NNC(=O)C4=C3C(=CC=C4)O)O)NC(=O)C5=CC=C(C=C5)O	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BCKU64	4-[[1-(2,6-Difluoro-3-methylbenzoyl)-5-methyl-1,2,4-triazol-3-yl]amino]benzenesulfonamide	Investigative	44398371	C17H15F2N5O3S	407.4	CC1=C(C(=C(C=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)C)F	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	BE3V4Z	[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 3,5-dihydroxy-4-(1-hydroxynaphthalene-2-carbonyl)benzoate	Investigative	44322982	C31H28N2O8	556.6	C1C[C@H](C(CNC1)NC(=O)C2=CC=C(C=C2)O)OC(=O)C3=CC(=C(C(=C3)O)C(=O)C4=C(C5=CC=CC=C5C=C4)O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BEI4R1	[2-[(4-Hydroxybenzoyl)amino]cyclopentyl] 3,5-dihydroxy-4-[2-hydroxy-6-[(2,2,2-trifluoroacetyl)amino]benzoyl]benzoate	Investigative	44322815	C28H23F3N2O9	588.5	C1CC(C(C1)OC(=O)C2=CC(=C(C(=C2)O)C(=O)C3=C(C=CC=C3O)NC(=O)C(F)(F)F)O)NC(=O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BJ7M1X	5-(3,4-Dimethoxyphenyl)-4-(1H-indol-5-ylamino)pyridine-3-carbonitrile	Investigative	24770517	C22H18N4O2	370.4	COC1=C(C=C(C=C1)C2=C(C(=CN=C2)C#N)NC3=CC4=C(C=C3)NC=C4)OC	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BK1FQ8	2-[[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]amino]benzoic acid	Investigative	44322684	C26H23N3O9	521.5	C1C(C(CN1)OC(=O)C2=CC(=C(C(=C2)O)C(=O)NC3=CC=CC=C3C(=O)O)O)NC(=O)C4=CC=C(C=C4)O	IC50 = 117000 nM	Poor binder
T40276	Protein kinase C beta	BL4KG2	4-[[5-Amino-1-(3-methylthiophene-2-carbonyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide	Investigative	5330804	C14H14N6O3S2	378.4	CC1=C(SC=C1)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	BM7JY6	Betulinic acid 3-O-succinate	Investigative	10415328	C34H52O6	556.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)CCC(=O)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BMJE80	Betulinic acid 3-O-crotonate	Investigative	11756581	C34H52O4	524.8	C/C=C/C(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@@H]4[C@H]5[C@@H](CC[C@@]5(CC[C@]4([C@@]3(CC[C@H]2C1(C)C)C)C)C(=O)O)C(=C)C)C	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BN17KD	4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid (1R,2R)-1-(4-hydroxy-benzoylamino)-indan-2-yl ester	Investigative	10460643	C31H23NO10	569.5	C1[C@H]([C@@H](C2=CC=CC=C21)NC(=O)C3=CC=C(C=C3)O)OC(=O)C4=CC(=C(C(=C4)O)C(=O)C5=C(C=CC=C5O)C(=O)O)O	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BOBD84	8-Hydroxy-6-[(4R)-3-[(4-hydroxybenzoyl)amino]azepan-4-yl]oxycarbonyl-9-oxoxanthene-1-carboxylic acid	Investigative	44322714	C28H24N2O9	532.5	C1C[C@H](C(CNC1)NC(=O)C2=CC=C(C=C2)O)OC(=O)C3=CC(=C4C(=C3)OC5=CC=CC(=C5C4=O)C(=O)O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BPV4H6	2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide	Investigative	46232556	C21H17Cl2FN2O2	419.3	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)C4CC4C(=O)N	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BRL5J7	[(4R)-3-[(4-Hydroxybenzoyl)amino]azepan-4-yl] 4-(2,6-dihydroxybenzoyl)-3,5-dimethoxybenzoate	Investigative	44322762	C29H30N2O9	550.6	COC1=CC(=CC(=C1C(=O)C2=C(C=CC=C2O)O)OC)C(=O)O[C@@H]3CCCNCC3NC(=O)C4=CC=C(C=C4)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BU6GL4	(1S,3As,5aR,5bR,9S,11aR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-propan-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid	Investigative	44337790	C30H50O3	458.7	CC(C)[C@@H]1CC[C@]2(C1C3CCC4[C@]5(CC[C@@H](C(C5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BYH31M	2-(N-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylbenzoyl]anilino)acetic acid	Investigative	44322889	C27H25N3O9	535.5	C1C(C(CN1)OC(=O)C2=CC(=C(C(=C2)O)C(=O)N(CC(=O)O)C3=CC=CC=C3)O)NC(=O)C4=CC=C(C=C4)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BYI18Q	Betulinic acid 3-O-benzoate	Investigative	10099352	C37H52O4	560.8	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)C6=CC=CC=C6)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	BZ3J6Q	2-[2,6-Dihydroxy-4-[4-[(4-hydroxybenzoyl)amino]pyrrolidin-3-yl]oxycarbonylphenyl]benzoic acid	Investigative	44322954	C25H22N2O8	478.4	C1C(C(CN1)OC(=O)C2=CC(=C(C(=C2)O)C3=CC=CC=C3C(=O)O)O)NC(=O)C4=CC=C(C=C4)O	IC50 ~ 50000 nM	Poor binder
T40276	Protein kinase C beta	BZ70IQ	3beta-Acetoxybetulinic acid	Investigative	10300534	C32H50O4	498.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)OC(=O)C)C)C(=O)O	IC50 ~ 150000 nM	Poor binder
T40276	Protein kinase C beta	D02XHC	aloisine A	Investigative	448912	C16H17N3O	267.33	CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)O	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	D04NGS	JNJ-7706621	Investigative	5330790	C15H12F2N6O3S	394.4	C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F	IC50 ~ 100000 nM	Poor binder
T40276	Protein kinase C beta	D05KJY	BETULIN	Investigative	72326	C30H50O2	442.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO	IC50 ~ 150000 nM	Poor binder