TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T40488 Matrix metalloproteinase-10 B6O4DQ (E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide Investigative 53374826 C10H8F3NO2 231.17 C1=CC(=CC=C1/C=C/C(=O)NO)C(F)(F)F IC50 ~ 100000 nM Poor binder T40488 Matrix metalloproteinase-10 BBGK09 2-(2,5-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one Investigative 11778852 C14H12N2O3S 288.32 COC1=CC(=C(C=C1)OC)N2C(=O)C3=C(S2)N=CC=C3 IC50 = 53000 nM Poor binder T40488 Matrix metalloproteinase-10 BE5TD1 2-(2,4-Dimethoxy-phenyl)-isothiazolo[5,4-b]pyridin-3-one Investigative 10016964 C14H12N2O3S 288.32 COC1=CC(=C(C=C1)N2C(=O)C3=C(S2)N=CC=C3)OC IC50 = 62000 nM Poor binder T40488 Matrix metalloproteinase-10 BTE1R5 N-Phenyl-4-[(4h-1,2,4-Triazol-3-Ylsulfanyl)methyl]-1,3-Thiazol-2-Amine Investigative 2366268 C12H11N5S2 289.4 C1=CC=C(C=C1)NC2=NC(=CS2)CSC3=NC=NN3 IC50 = 83000 nM Poor binder