TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T42392	Glutamate receptor AMPA 2	D00ENY	L-Glutamic Acid	Approved	33032	C5H9NO4	147.13	C(CC(=O)O)[C@@H](C(=O)O)N	EC50 = 140000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D03CNS	Cyclothiazide	Approved	2910	C14H16ClN3O4S2	389.9	C1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl	EC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D04XMJ	LY525327	Terminated	11249042	C23H34N6O2	426.6	CCC(CC)COC(=O)[C@@H]1C[C@H]2C[C@H](CC[C@H]2CN1)NC3=CC=CC=C3C4=NNN=N4	Ki ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D0M7MW	GYKI-53655	Terminated	126758	C19H20N4O3	352.4	CC1CC2=CC3=C(C=C2C(=NN1C(=O)NC)C4=CC=C(C=C4)N)OCO3	EC50 = 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B01WPK	N-Cyclopentyl-2-{4-[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]phenyl}acetamide	Investigative	24825807	C21H24F3N3O	391.4	C1CCC(C1)NC(=O)CC2=CC=C(C=C2)N3C4=C(CCCC4)C(=N3)C(F)(F)F	EC50 = 63095.73 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B0IR4S	2-Methyl-N-[3-[2-(propan-2-ylsulfonylamino)-2,3-dihydro-1H-inden-5-yl]phenyl]propanamide	Investigative	11704038	C22H28N2O3S	400.5	CC(C)C(=O)NC1=CC=CC(=C1)C2=CC3=C(CC(C3)NS(=O)(=O)C(C)C)C=C2	EC50 ~ 50118.72 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B0Z6RL	CCN(Cc1cc(=O)n2c(CO)c(C)sc2n1)c1ccc(F)cc1	Investigative	118009526	C17H18FN3O2S	347.4	CCN(CC1=CC(=O)N2C(=C(SC2=N1)C)CO)C3=CC=C(C=C3)F	EC50 = 66300 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B1ATV2	(R)-2-Amino-3-(3'-Hydroxybiphenyl-3-Yl)propanoic Acid	Investigative	102515535	C15H15NO3	257.279	C1=CC(=CC(=C1)C2=CC(=CC=C2)O)C[C@H](C(=O)O)N	Ki = 84000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B1KM4T	6-(4-Amino-3-methylphenyl)-8-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methyl]-3,10-dihydro-2H-[1,4]dioxino[2,3-h][2,3]benzodiazepin-9-one	Investigative	137643689	C22H21BrN4O4	485.3	CC1=C(C=CC(=C1)C2=NN(C(=O)CC3=CC4=C(C=C32)OCCO4)CC5CC(=NO5)Br)N	Ki = 50000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B1V4JM	N-[5-(3-Acetylphenyl)-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonamide	Investigative	11689005	C20H23NO3S	357.5	CC(C)S(=O)(=O)NC1CC2=C(C1)C=C(C=C2)C3=CC(=CC=C3)C(=O)C	EC50 ~ 50118.72 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B2N7FX	(3S,4As,6S,8aR)-6-(2-carboxy-4-methoxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547290	C18H24ClNO6	385.8	COC1=CC(=C(C=C1)O[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O)C(=O)O.Cl	Ki = 87000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B2O1GJ	(3S,4As,6S,8aR)-6-(2-carboxy-5-chlorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	68588451	C17H21Cl2NO5	390.3	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C=CC(=C3)Cl)C(=O)O)C(=O)O.Cl	Ki = 151000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B2WLD9	(3S,4Ar,6S,8aR)-6-[(4-carboxyimidazol-1-yl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;dihydrochloride	Investigative	45262167	C15H23Cl2N3O4	380.3	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CN3C=C(N=C3)C(=O)O)C(=O)O.Cl.Cl	Ki = 117000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B31YIU	1-(3,5-Dimethyl-4-aminophenyl)-7,8-(ethylenedioxy)-3H-2,3-benzodiazepine-4(5H)-one	Investigative	44452462	C19H19N3O3	337.4	CC1=CC(=CC(=C1N)C)C2=NNC(=O)CC3=CC4=C(C=C32)OCCO4	Ki = 94000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B3J8QW	(3S,4As,6S,8aR)-6-(2-carboxy-3-fluorophenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547288	C17H21ClFNO5	373.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C(=CC=C3)F)C(=O)O)C(=O)O.Cl	Ki = 93000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B4XOQ9	N-[5-(3-Cyanophenyl)-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonamide	Investigative	11617056	C19H20N2O2S	340.4	CC(C)S(=O)(=O)NC1CC2=C(C1)C=C(C=C2)C3=CC=CC(=C3)C#N	EC50 ~ 50118.72 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B4ZL6H	1-[4-(1-Pyrrolidinylcarbonyl)phenyl]-3-(trifluoromethyl)-1,4,5,7-tetrahydropyrano[3,4-c]pyrazole	Investigative	24951942	C18H18F3N3O2	365.3	C1CCN(C1)C(=O)C2=CC=C(C=C2)N3C4=C(CCOC4)C(=N3)C(F)(F)F	EC50 = 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B6Q4GU	(3S,4As,6S,8aR)-6-[2-(1H-Tetrazol-5-yl)-phenoxy]-decahydro-isoquinoline-3-carboxylic acid isobutyl ester	Investigative	11154806	C21H29N5O3	399.5	CC(C)COC(=O)[C@@H]1C[C@H]2C[C@H](CC[C@H]2CN1)OC3=CC=CC=C3C4=NNN=N4	Ki ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	B9Q1AZ	Piperidin-1-yl-[4-[3-(trifluoromethyl)-4,5,6,7-tetrahydroindazol-1-yl]phenyl]methanone	Investigative	4862344	C20H22F3N3O	377.4	C1CCN(CC1)C(=O)C2=CC=C(C=C2)N3C4=C(CCCC4)C(=N3)C(F)(F)F	EC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BA7P6F	CCNC(=O)c1c(C)sc2nc(Cc3cccc(c3)C#N)cc(=O)n12	Investigative	118017736	C18H16N4O2S	352.4	CCNC(=O)C1=C(SC2=NC(=CC(=O)N12)CC3=CC(=CC=C3)C#N)C	EC50 = 53700 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BA8DU6	4-Ethyl-3,4-Dihydro-2h-Pyrido[3,2-E][1,2,4]thiadiazine 1,1-Dioxide	Investigative	10013456	C8H11N3O2S	213.26	CCN1CNS(=O)(=O)C2=C1C=CC=N2	EC50 = 50582.47 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BC3O2S	(3S,4As,6S,8aR)-6-(2-carboxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547031	C17H22ClNO5	355.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=CC=CC=C3C(=O)O)C(=O)O.Cl	Ki = 70000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BCZY82	2-Amino-3-(5-(2-ethyl-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid	Investigative	11288627	C9H12N6O4	268.23	CCN1N=C(N=N1)C2=C(C(=O)NO2)CC(C(=O)O)N	EC50 = 52000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BD41BU	4-Chloro-2-(naphthalen-2-ylcarbamoylamino)benzoic Acid	Investigative	10132082	C18H13ClN2O3	340.8	C1=CC=C2C=C(C=CC2=C1)NC(=O)NC3=C(C=CC(=C3)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BDI0U1	(3S,4As,6S,8aR)-6-(2-carboxy-4-phenylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547291	C23H26ClNO5	431.9	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C=C(C=C3)C4=CC=CC=C4)C(=O)O)C(=O)O.Cl	Ki = 172000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BE0L5A	CCN(Cc1cc(=O)n2c(N3CCOCC3)c(C)sc2n1)c1ccc(F)cc1	Investigative	118009524	C20H23FN4O2S	402.5	CCN(CC1=CC(=O)N2C(=C(SC2=N1)C)N3CCOCC3)C4=CC=C(C=C4)F	EC50 = 60200 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BFS4N1	CCN(Cc1cc(=O)n2c(C#N)c(C)sc2n1)c1ccc(F)cc1	Investigative	118010095	C17H15FN4OS	342.4	CCN(CC1=CC(=O)N2C(=C(SC2=N1)C)C#N)C3=CC=C(C=C3)F	EC50 = 66600 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BGA5X2	4-Methyl-2,3-dihydro-1lambda6,2,4-benzothiadiazine 1,1-dioxide	Investigative	16732327	C8H10N2O2S	198.24	CN1CNS(=O)(=O)C2=CC=CC=C21	EC50 = 176300 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BH32CY	N-[5-(5-Cyanopyridin-3-yl)-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonamide	Investigative	11522969	C18H19N3O2S	341.4	CC(C)S(=O)(=O)NC1CC2=C(C1)C=C(C=C2)C3=CN=CC(=C3)C#N	EC50 = 63095.73 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BJG1K0	CID 60023874	Investigative	60023874	C17H22N2O4	318.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1NC3=CC=CC=C3C(=O)O)C(=O)O	Ki = 77000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BK86GJ	(3S,4Ar,6S,8aR)-6-[3-methoxy-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72544188	C18H25ClN6O3	408.9	COC1=CC=CC(=C1C2=NNN=N2)N[C@H]3CC[C@H]4CN[C@@H](C[C@H]4C3)C(=O)O.Cl	Ki = 181000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BLI8U0	(3S,4As,6S,8aR)-6-(2-carboxy-5-methylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547534	C18H24ClNO5	369.8	CC1=CC(=C(C=C1)C(=O)O)O[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O.Cl	Ki = 89000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BP6ST5	(3S,4As,6S,8aR)-6-(2-carboxy-4-methylphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547289	C18H24ClNO5	369.8	CC1=CC(=C(C=C1)O[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O)C(=O)O.Cl	Ki = 107000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BQ4EF5	7-[[5-Chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide	Investigative	118017739	C15H13ClF3N5O2S	419.8	CCNC(=O)C1=C(SC2=NC(=CC(=O)N12)CN3C(=CC(=N3)C(F)(F)F)Cl)C	EC50 = 73000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BQ8V4J	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)pyrimidine-2,4-dione	Investigative	11544633	C13H13N3O6S	339.33	C1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BR76AK	(3S,4Ar,6S,8aR)-6-[3-methyl-2-(2H-tetrazol-5-yl)anilino]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid	Investigative	60023863	C18H24N6O2	356.4	CC1=C(C(=CC=C1)N[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O)C4=NNN=N4	Ki = 128000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BV45NR	(3S,4Ar,6S,8aR)-6-[(3-carboxyphenyl)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	73349560	C18H24ClNO4	353.8	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CC3=CC(=CC=C3)C(=O)O)C(=O)O.Cl	Ki = 149000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BV76KH	N-((3R,4R)-1-Methyl-4-(3''-(trifluoromethyl)biphenyl-4-yl)pyrrolidin-3-yl)propane-2-sulfonamide	Investigative	11647576	C21H25F3N2O2S	426.5	CC(C)S(=O)(=O)N[C@H]1CN(C[C@@H]1C2=CC=C(C=C2)C3=CC(=CC=C3)C(F)(F)F)C	EC50 = 79400 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BVH20R	(1r,2r)-2-(2-{[5-Chloro-3-(Trifluoromethyl)-1h-Pyrazol-1-Yl]methyl}-7-Methyl-4-Oxo-4h-Pyrido[1,2-A]pyrimidin-6-Yl)cyclopropane-1-Carbonitrile	Investigative	134157459	C18H13ClF3N5O	407.8	CC1=C(N2C(=NC(=CC2=O)CN3C(=CC(=N3)C(F)(F)F)Cl)C=C1)[C@@H]4C[C@H]4C#N	EC50 = 67000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BW8LB4	(3S,4As,6S,8aR)-6-(2-carboxy-5-methoxyphenoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid;hydrochloride	Investigative	72547535	C18H24ClNO6	385.8	COC1=CC(=C(C=C1)C(=O)O)O[C@H]2CC[C@H]3CN[C@@H](C[C@H]3C2)C(=O)O.Cl	Ki = 111000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	BWH79B	N-Ethyl-2-methyl-5-oxo-7-[[3-(trifluoromethyl)phenyl]methyl]-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide	Investigative	118017915	C18H16F3N3O2S	395.4	CCNC(=O)C1=C(SC2=NC(=CC(=O)N12)CC3=CC(=CC=C3)C(F)(F)F)C	EC50 = 66200 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D01BAG	ACET	Investigative	16125102	C20H19N3O6S	429.4	CC1=CN(C(=O)N(C1=O)CC2=C(SC(=C2)C3=CC=CC=C3)C(=O)O)C[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D0K5UI	UBP310	Investigative	6420160	C14H15N3O6S	353.35	CC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D0N1CL	2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid	Investigative	9799478	C14H10BrClN2O3	369.6	C1=CC(=CC(=C1)Br)NC(=O)NC2=C(C=CC(=C2)Cl)C(=O)O	IC50 ~ 100000 nM	Poor binder
T42392	Glutamate receptor AMPA 2	D0T1MK	LY382884	Investigative	656723	C18H23NO4	317.4	C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1CC3=CC=C(C=C3)C(=O)O)C(=O)O	Ki ~ 100000 nM	Poor binder