TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T46185	Muscarinic acetylcholine receptor M2	D06HLY	Pilocarpine	Approved	5910	C11H16N2O2	208.26	CC[C@H]1[C@H](COC1=O)CC2=CN=CN2C	EC50 = 63000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	D0U7BW	Carbachol	Approved	2551	C6H15N2O2+	147.2	C[N+](C)(C)CCOC(=O)N	EC50 = 61000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	D0EY0A	AZD7687	Phase 1	42636350	C21H25N3O3	367.4	CC1=C(N=C(C(=N1)C)C(=O)N)C2=CC=C(C=C2)C3CCC(CC3)CC(=O)O	IC50 = 80500 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	D07MVE	PD-151832	Discontinued in Phase 1/2	5487543	C16H18N2O2	270.33	COC1=CC=CC(=C1)C#CCO/N=C/2\\CN3CCC2C3	IC50 = 52000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B01URL	N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853778	C15H27N3O2	281.39	CCC(=O)N1CCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B1Z0TB	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium	Investigative	73349591	C7H15N2O2+	159.21	C[N+](C)(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B27QAO	6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579457	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B2GD9K	N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-2-(1-methyl-3-indolyl)-2-oxoacetamide	Investigative	6604789	C18H21N3O2	311.4	CN1C=C(C2=CC=CC=C21)C(=O)C(=O)N[C@H]3CN4CCC3CC4	Ki = 50118.72 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B2V7EP	2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44578978	C25H29N5O	415.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B3C8NA	2-(2,3-Dihydro-1-benzofuran-5-yl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575122	C24H27NO3	377.5	CCN1CCC(=C(C1)C(=O)OCCC2=CC3=C(C=C2)OCC3)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B3UR9B	3-[(1-Methylpyrrolidin-3-yl)methoxymethyl]pyridine	Investigative	137644950	C12H18N2O	206.28	CN1CCC(C1)COCC2=CN=CC=C2	EC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B40KXW	Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706052	C9H20INO2	301.17	C[C@@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B40WHA	(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545091	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B4BM5X	N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853777	C14H27N3O2	269.38	CCC(CC)NC(=O)CN1CCN(CC1)C(=O)CC	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B4SWH0	6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578928	C25H28ClF3N4O	493	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B50PAD	3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one	Investigative	44579417	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B57EKA	7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579418	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C(=CC=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B57PVF	7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579419	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C(=CC=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B5ER0C	(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	58653718	C7H14N2O2	158.2	CN1C[C@@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B5EZF0	(2S)-2-(Furan-2-yl)pyrrolidine	Investigative	7022778	C8H11NO	137.18	C1C[C@H](NC1)C2=CC=CO2	Ki = 107151.93 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B5J4WP	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium	Investigative	73349592	C7H15N2O2+	159.21	C[N+](C)(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B5ONL2	Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545329	C8H17N2O2+	173.23	CN1C[C@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B68VPY	3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10251795	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B6IUM0	3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578976	C24H29N5O3	435.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B6LW3I	2-(3,4-Dimethoxyphenyl)ethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575552	C23H27NO4	381.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B7LR1C	(S)-3-Hydroxy-2-(2-tetradecanoylamino-acetylamino)-propionic acid benzyl ester	Investigative	10457079	C26H42N2O5	462.6	CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCC1=CC=CC=C1	Ki = 64565.42 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B81BVZ	(2R)-2-(Furan-2-yl)pyrrolidine	Investigative	7047822	C8H11NO	137.18	C1C[C@@H](NC1)C2=CC=CO2	Ki = 77624.71 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B8ACZ5	(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	72545094	C7H14N2O2	158.2	CN1C[C@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B8CRU7	(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44571572	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B8FM1A	Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706050	C9H20INO2	301.17	C[C@]1(COCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B8GY1Q	[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227416	C10H22INO2	315.19	C[C@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki = 89125.09 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B94YBT	(2-Methoxyphenyl)-N,N,N-trimethylmethanaminium iodide	Investigative	12586122	C11H18INO	307.17	C[N+](C)(C)CC1=CC=CC=C1OC.[I-]	Ki ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	B9M3LY	6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579375	C25H31ClN4O	439	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BA0RD2	3-(2-Ethyl-2H-1,2,3-triazole-5-yl)-1-methyl-1,2,5,6-tetrahydropyridine	Investigative	10012808	C10H16N4	192.26	CCN1N=CC(=N1)C2=CCCN(C2)C	EC50 ~ 51000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BA65LO	1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(2-methoxy-phenyl)-prop-2-ynyl]-oxime	Investigative	10707175	C16H18N2O2	270.33	COC1=CC=CC=C1C#CCO/N=C/2\\CN3CCC2C3	IC50 = 69300 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BAPC48	(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-1-methyl-alpha-oxo-3-indoleacetamide	Investigative	10337773	C18H21N3O2	311.4	CN1C=C(C2=CC=CC=C21)C(=O)C(=O)N[C@@H]3CN4CCC3CC4	Ki = 50118.72 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BB30RM	Esaprazole	Investigative	68835	C12H23N3O	225.33	C1CCC(CC1)NC(=O)CN2CCNCC2	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BB4IT7	2-(3,4-Dimethoxyphenyl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574174	C23H26FNO4	399.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)F	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BB9YX3	N-Isopropyl-1-piperazineacetamide	Investigative	100826	C9H19N3O	185.27	CC(C)NC(=O)CN1CCNCC1	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BC0H3X	[(2R,6R)-6-Benzhydryl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	57326238	C21H28INO2	453.4	C[N+](C)(C)C[C@@H]1COC[C@H](O1)C(C2=CC=CC=C2)C3=CC=CC=C3.[I-]	Ki = 79432.82 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BC5Y0W	(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	73351145	C6H12N2O2	144.17	CN(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BCR08U	(2R,3S,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide	Investigative	11515738	C10H20INO2S	345.24	C[C@@H]1O[C@@H](C[S@@]1=O)[C@@H]2CCC[N+]2(C)C.[I-]	Ki = 51286.14 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BDPT63	[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate	Investigative	72545089	C7H14N2O2	158.2	CN1CCC[C@H]1COC(=O)N	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BE2OY8	5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579458	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=CC(=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BF31WM	(2S,3S,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide	Investigative	11588240	C10H20INO2S	345.24	C[C@H]1O[C@H](C[S@@]1=O)[C@@H]2CCC[N+]2(C)C.[I-]	Ki = 77624.71 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BF86CS	(2S,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide	Investigative	45266385	C10H20NO2S+	218.34	C[C@H]1O[C@H](CS1=O)[C@@H]2CCC[N+]2(C)C	Ki = 77624.71 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BFX9B6	(2S,3S,5S)-2-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,3-oxathiolane 3-oxide	Investigative	11672895	C9H17NO2S	203.3	C[C@H]1O[C@H](C[S@@]1=O)[C@@H]2CCCN2C	Ki = 87096.36 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BG3P0I	2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44579416	C25H28ClN5O	450	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BG5E7Y	1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine	Investigative	10354348	C10H15N3S2	241.4	CC1=C(CN(CC1)C)C2=NSN=C2SC	IC50 = 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BGM1F0	2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853883	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@@H]3C2	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BH7I2B	N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide	Investigative	11110049	C20H23N3O	321.4	CN(C)CCNC(=O)C1=C(C2=CC=CC=C2C1)CC3=CC=NC=C3	Ki = 93325.43 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BHS92K	(2S,3R,5S)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide;iodide	Investigative	11530306	C10H20INO2S	345.24	C[C@H]1O[C@H](C[S@]1=O)[C@@H]2CCC[N+]2(C)C.[I-]	Ki = 81283.05 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BHSE03	1-Aza-bicyclo[2.2.1]heptan-3-one O-(4-methoxy-but-2-ynyl)-oxime	Investigative	15681303	C11H16N2O2	208.26	COCC#CCO/N=C/1\\CN2CCC1C2	IC50 = 59300 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BI6DN8	5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110765	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=CC(=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BIO5L9	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide	Investigative	49853987	C19H35N3O	321.5	CC(C)(C(=O)NC1CCCCC1)N2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BJ18HR	1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(4-methoxy-phenyl)-prop-2-ynyl]-oxime	Investigative	10778462	C16H18N2O2	270.33	COC1=CC=C(C=C1)C#CCO/N=C/2\\CN3CCC2C3	IC50 = 84400 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BJE41A	(2R,3S,5R)-2-Methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,3-oxathiolane 3-oxide	Investigative	11694119	C9H17NO2S	203.3	C[C@@H]1O[C@@H](C[S@@]1=O)[C@@H]2CCCN2C	Ki = 89125.09 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BK7YE3	3-[(1-Methylpiperidin-3-yl)oxymethyl]pyridine	Investigative	137639541	C12H18N2O	206.28	CN1CCCC(C1)OCC2=CN=CC=C2	EC50 = 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BKR16E	Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44446840	C9H20INO2	301.17	C[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki = 61659.5 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BM5FV4	2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide	Investigative	49853885	C17H33N3O	295.5	CC(C)NC(=O)C(C)(C)N1CCN(CC1)C2CCCCC2	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BN9XD5	3-(3-Methoxyphenyl)prop-2-ynyl-trimethylazanium;formate	Investigative	137653227	C14H19NO3	249.3	C[N+](C)(C)CC#CC1=CC(=CC=C1)OC.C(=O)[O-]	Ki = 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BNL89F	Trimethyl-[[(2R,6R)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227480	C11H24INO2	329.22	C[C@@H]1C(OC[C@H](O1)C[N+](C)(C)C)(C)C.[I-]	Ki = 72443.6 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BO3YC0	6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578975	C24H28Cl2N4O	459.4	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BO46KV	8-Hydroxy-2-(dimethylamino)-1,2,3,4-tetrahydronaphthalene	Investigative	15629515	C12H17NO	191.27	CN(C)C1CCC2=C(C1)C(=CC=C2)O	Ki ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BR8NT5	2-Naphthalen-1-ylethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575553	C25H25NO2	371.5	CN1CCC(=C(C1)C(=O)OCCC2=CC=CC3=CC=CC=C32)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BS7A1R	3-(3-Furyl)quinuclidin-3-ol	Investigative	15196231	C11H15NO2	193.24	C1CN2CCC1C(C2)(C3=COC=C3)O	Ki ~ 53000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BS9AF4	Trimethyl-[[(2R,6S)-5,5,6-trimethyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227460	C11H24INO2	329.22	C[C@H]1C(OC[C@H](O1)C[N+](C)(C)C)(C)C.[I-]	Ki = 60255.96 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BT0EO7	2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853884	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@H]3C2	IC50 = 93000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BTF8M9	(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44419370	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BTH09U	Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118723724	C9H20INO2	301.17	C[C@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BTHE57	Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545096	C8H17N2O2+	173.23	CN1C[C@@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BTZ9Y2	6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110764	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BU4J8L	Tbpb	Investigative	10092649	C25H32N4O	404.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BUO04X	Spiro[1-azabicyclo[2.2.2]octane-3,4'-[1,3]dioxolane]	Investigative	15749864	C9H15NO2	169.22	C1CN2CCC1C3(C2)COCO3	Ki = 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BWBH45	[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate	Investigative	72545098	C8H17N2O2+	173.23	C[N+]1(CCC[C@H]1COC(=O)N)C	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BWF9Y6	[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227458	C10H22INO2	315.19	CC1(CO[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki = 95499.26 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BYC1I9	3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10027177	C25H29F3N4O	458.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BYF2O7	(2R,5R)-5-[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]-2-methyl-1,3-oxathiolane 3-oxide	Investigative	45266386	C10H20NO2S+	218.34	C[C@@H]1O[C@@H](CS1=O)[C@@H]2CCC[N+]2(C)C	Ki = 81283.05 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BYTO08	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide	Investigative	49853881	C17H31N3O	293.4	C1CCC(CC1)NC(=O)CN2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BYX70W	N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide	Investigative	49855131	C14H27N3O	253.38	CN1CCCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BYXU78	(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	57558000	C6H12N2O2	144.17	CN(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BZ3UC8	6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578977	C24H28ClN5O3	470	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T46185	Muscarinic acetylcholine receptor M2	BZ4I0N	(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545326	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder