TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T46360	Opioid receptor sigma 1	D0WE3O	Morphine	Approved	5288826	C17H19NO3	285.34	CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O	Ki ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	B01URL	N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853778	C15H27N3O2	281.39	CCC(=O)N1CCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	B2BX9N	Jervine	Investigative	10098	C27H39NO3	425.6	C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5C(=O)C4=C3C)C)O)C)NC1	Ki ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	B3XVJ0	N,N'-Dimethyl guanidine hydrogen bromide	Investigative	14122788	C3H10BrN3	168.04	CNC(=NC)N.Br	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	B4BM5X	N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853777	C14H27N3O2	269.38	CCC(CC)NC(=O)CN1CCN(CC1)C(=O)CC	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	B54CBM	N-Cyclopentyl-N-methyl-2-(piperazin-1-yl)acetamide	Investigative	43267406	C12H23N3O	225.33	CN(C1CCCC1)C(=O)CN2CCNCC2	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	B5IF1U	N-[(1S,2S,4R)-2-Bicyclo[2.2.1]heptanyl]-2-piperazin-1-ylacetamide	Investigative	73353481	C13H23N3O	237.34	C1C[C@H]2C[C@@H]1C[C@@H]2NC(=O)CN3CCNCC3	IC50 = 86800 nM	Poor binder
T46360	Opioid receptor sigma 1	B7FI1S	n,n-Diphenylguanidine	Investigative	14657	C13H13N3	211.26	C1=CC=C(C=C1)N(C2=CC=CC=C2)C(=N)N	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	BB9XG1	(3S,3'R,3'As,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',7'a,10,11b-pentamethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3,3a,4,5,6,7-hexahydrofuro[3,2-b]pyridine]-3-ol	Investigative	44398137	C28H43NO2	425.6	C[C@H]1C[C@@]2([C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1)C	Ki ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	BB9YX3	N-Isopropyl-1-piperazineacetamide	Investigative	100826	C9H19N3O	185.27	CC(C)NC(=O)CN1CCNCC1	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	BH42YB	N-(2-Methylbutyl)-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853580	C14H27N3O2	269.38	CCC(C)CNC(=O)CN1CCN(CC1)C(=O)CC	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	BV1AL0	N-Cyclopentyl-2-(4-propanoylpiperazin-1-yl)propanamide	Investigative	49853981	C15H27N3O2	281.39	CCC(=O)N1CCN(CC1)C(C)C(=O)NC2CCCC2	IC50 ~ 100000 nM	Poor binder
T46360	Opioid receptor sigma 1	D0RN5A	[3H]naloxone	Investigative	5284596	C19H21NO4	327.4	C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O	Ki ~ 100000 nM	Poor binder