TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T47768	Opioid receptor mu	D07TQN	Asimadoline	Phase 3	179340	C27H30N2O2	414.5	CN([C@H](CN1CC[C@@H](C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4	EC50 = 60000 nM	Poor binder
T47768	Opioid receptor mu	D02DLG	PMID28870136-Compound-38	Patented	1329	C16H24N4O2	304.39	CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B0NT3B	N-(2-Methoxyethyl)-2-thiophen-3-yl-1,2,3,4-tetrahydronaphthalen-1-amine	Investigative	44590514	C17H21NOS	287.4	COCCNC1C(CCC2=CC=CC=C12)C3=CSC=C3	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	B0QUJ2	(2S)-2-[[(2R)-2-Acetamido-3-(6-chloro-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide	Investigative	118709355	C24H26ClN5O4	483.9	CC(=O)N[C@H](CC1=CNC2=C1C=CC(=C2)Cl)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B18GPB	Tyr-Gly-Pro-Phe-Leu-Nle-Arg-NH2	Investigative	11051174	C43H65N11O8	864	CCCC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@H](CC3=CC=C(C=C3)O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B1N0IA	3,6,6-Trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one	Investigative	1878753	C10H14N2O	178.23	CC1=C2C(=NN1)CC(CC2=O)(C)C	EC50 ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B26CVM	4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide	Investigative	743974	C16H19NO3S	305.4	CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C	EC50 ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B38OEG	3-Chloro-N-(2-methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]thiophene-2-carboxamide	Investigative	44590629	C28H30ClN3O2S	508.1	COCCN(C1C(C=CC2=CC=CC=C12)N3CCN(CC3)C4=CC=CC=C4)C(=O)C5=C(C=CS5)Cl	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	B3MA5Y	4-N-[2-(1H-Indol-3-yl)ethyl]-1-N,1-N-dimethyl-1-phenylcyclohexane-1,4-diamine;dihydrochloride	Investigative	69337698	C24H33Cl2N3	434.4	CN(C)C1(CCC(CC1)NCCC2=CNC3=CC=CC=C32)C4=CC=CC=C4.Cl.Cl	EC50 = 51000 nM	Poor binder
T47768	Opioid receptor mu	B5T7CE	(2S)-2-[[(2S)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide	Investigative	71457207	C24H27N5O4	449.5	CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N	Ki = 74000 nM	Poor binder
T47768	Opioid receptor mu	B67YHI	6-Chloro-3-(4-(3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)quinoline	Investigative	24894134	C22H17Cl2FN4O	443.3	C1CN(CCC1C2=NC(=NO2)C3=C(C=C(C=C3)F)Cl)C4=CN=C5C=CC(=CC5=C4)Cl	IC50 ~ 50000 nM	Poor binder
T47768	Opioid receptor mu	B6BW7V	(2S)-2-[[(2R)-2-Acetamido-3-(5-fluoro-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide	Investigative	118709352	C24H26FN5O4	467.5	CC(=O)N[C@H](CC1=CNC2=C1C=C(C=C2)F)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B7IL4O	3,4-Dichloro-N-(2-methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]benzamide	Investigative	44590554	C30H31Cl2N3O2	536.5	COCCN(C1C(C=CC2=CC=CC=C12)N3CCN(CC3)C4=CC=CC=C4)C(=O)C5=CC(=C(C=C5)Cl)Cl	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	B90WYC	Chembl4176316	Investigative	145974323	C18H27N3O2	317.4	C[C@@H](C1=CC=CC=C1)NC(C)(C)CN(C)C(=O)C2(CC2)C(=O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B95TAP	(2S)-2-[[(2R)-2-Acetamido-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanamide	Investigative	15923664	C22H24N4O3	392.5	CC(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	B9E5FS	2-(4-Chlorophenoxy)-N-[2-(dimethylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-(2-methoxyethyl)acetamide	Investigative	44590631	C25H33ClN2O5	477	CN(C)C1CCC2=CC(=C(C=C2C1N(CCOC)C(=O)COC3=CC=C(C=C3)Cl)OC)OC	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	B9OCU1	(7S,12Bs)-9-methoxy-7-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline	Investigative	124037302	C31H47NO9	577.7	CN1CC[C@]23C4C1CC5=C2C(=C(C=C5)OC)OC3[C@H](C=C4)OCCOCCOCCOCCOCCOCCOC	EC50 = 97381 nM	Poor binder
T47768	Opioid receptor mu	BAKL20	(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanamide;2,2,2-trifluoroacetic acid	Investigative	71455428	C19H22F3N5O5	457.4	CC(=O)N[C@H](CC1=CN=CN1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BBM9D3	2-(4-Chlorophenyl)-N-(2-methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]acetamide	Investigative	44590582	C31H34ClN3O2	516.1	COCCN(C1C(C=CC2=CC=CC=C12)N3CCN(CC3)C4=CC=CC=C4)C(=O)CC5=CC=C(C=C5)Cl	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	BBT7P3	N-(2-Methoxyethyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]furan-2-carboxamide	Investigative	44590553	C28H31N3O3	457.6	COCCN(C1C(C=CC2=CC=CC=C12)N3CCN(CC3)C4=CC=CC=C4)C(=O)C5=CC=CO5	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	BC04VF	2-(4-Ethoxyanilino)-N,N-diethyl-1-(3-methylbutyl)benzimidazole-5-carboxamide	Investigative	10224082	C25H34N4O2	422.6	CCN(CC)C(=O)C1=CC2=C(C=C1)N(C(=N2)NC3=CC=C(C=C3)OCC)CCC(C)C	Ki = 50118.72 nM	Poor binder
T47768	Opioid receptor mu	BCJ87O	1-(3-Chlorophenyl)-3,6,6-trimethyl-5,7-dihydroindazol-4-one	Investigative	22733016	C16H17ClN2O	288.77	CC1=NN(C2=C1C(=O)CC(C2)(C)C)C3=CC(=CC=C3)Cl	EC50 ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BD6OC8	(2R)-2-Acetamido-6-amino-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid	Investigative	71453703	C21H30F3N5O6	505.5	CC(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BD8B5V	(2R)-2-Acetamido-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid	Investigative	71453705	C21H30F3N7O6	533.5	CC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BE6H3S	8-(Diphenylmethyl)-1-phenyl-3-(prop-2-en-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one	Investigative	25190579	C29H31N3O	437.6	C=CCN1CN(C2(C1=O)CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CC=C5	Ki = 63020 nM	Poor binder
T47768	Opioid receptor mu	BE7LF0	3-Oxo-4-[1-(1-propylcyclooctyl)piperidin-4-yl]quinoxaline-2-carboxylic acid	Investigative	59451016	C25H35N3O3	425.6	CCCC1(CCCCCCC1)N2CCC(CC2)N3C4=CC=CC=C4N=C(C3=O)C(=O)O	Ki = 57791 nM	Poor binder
T47768	Opioid receptor mu	BE92FR	N-(2-Methoxyethyl)-2-phenylmethoxy-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]acetamide	Investigative	44590580	C32H37N3O3	511.7	COCCN(C1C(C=CC2=CC=CC=C12)N3CCN(CC3)C4=CC=CC=C4)C(=O)COCC5=CC=CC=C5	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	BEC0H7	3,6,6-Trimethyl-1-phenyl-6,7-dihydro-1H-indazol-4(5H)-one	Investigative	2912831	C16H18N2O	254.33	CC1=NN(C2=C1C(=O)CC(C2)(C)C)C3=CC=CC=C3	EC50 ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BF2V0J	(2R)-2-Acetamido-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)pentanamide;2,2,2-trifluoroacetic acid	Investigative	71450062	C19H27F3N6O5	476.5	CC(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BG32SN	3-[(7R)-7-(Cyclopropylmethylamino)-4-methyl-2-(3-phenylpropyl)-2-azabicyclo[3.3.1]nonan-5-yl]phenol	Investigative	90656090	C28H38N2O	418.6	CC1CN(C2C[C@@H](CC1(C2)C3=CC(=CC=C3)O)NCC4CC4)CCCC5=CC=CC=C5	EC50 = 130000 nM	Poor binder
T47768	Opioid receptor mu	BG7H8I	Zilmax	Investigative	25257237	C14H20ClN3O2	297.78	CC(C)N[C@H]1CCN2C3=C([C@@H]1O)C=CC=C3NC2=O.Cl	IC50 = 140000 nM	Poor binder
T47768	Opioid receptor mu	BJ9W2L	N-(2-Methoxyethyl)-2-(3-methoxyphenyl)-N-[2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl]acetamide	Investigative	44590581	C32H37N3O3	511.7	COCCN(C1C(C=CC2=CC=CC=C12)N3CCN(CC3)C4=CC=CC=C4)C(=O)CC5=CC(=CC=C5)OC	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	BMFG07	4-Chloro-N-[3-(2-pyrrolidin-1-ylethyl)imidazo[4,5-b]pyridin-2-yl]benzamide	Investigative	118725857	C19H20ClN5O	369.8	C1CCN(C1)CCN2C3=C(C=CC=N3)N=C2NC(=O)C4=CC=C(C=C4)Cl	EC50 = 52500 nM	Poor binder
T47768	Opioid receptor mu	BN0HI2	(2S)-2-[[(2R)-2-Acetamido-3-(7-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide	Investigative	118709351	C25H29N5O4	463.5	CC1=C2C(=CC=C1)C(=CN2)C[C@H](C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N)NC(=O)C	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BN98IW	(2S)-2-[[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide;2,2,2-trifluoroacetic acid	Investigative	71459066	C21H25F3N6O6	514.5	CC(=O)N[C@H](CC1=CN=CN1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NCC(=O)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BNUX51	Zilpaterol hydrochloride	Investigative	11507658	C14H20ClN3O2	297.78	CC(C)N[C@@H]1CCN2C3=C([C@H]1O)C=CC=C3NC2=O.Cl	Ki = 130000 nM	Poor binder
T47768	Opioid receptor mu	BP0UO5	Methyl 2-(4-hydroxy-4-phenylpiperidin-1-yl)-2-phenylacetate	Investigative	44426818	C20H23NO3	325.4	COC(=O)C(C1=CC=CC=C1)N2CCC(CC2)(C3=CC=CC=C3)O	Ki = 59810 nM	Poor binder
T47768	Opioid receptor mu	BRF8H5	3,4-Dichloro-N-[2-(dimethylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-(2-methoxyethyl)benzamide	Investigative	44590632	C24H30Cl2N2O4	481.4	CN(C)C1CCC2=CC(=C(C=C2C1N(CCOC)C(=O)C3=CC(=C(C=C3)Cl)Cl)OC)OC	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	BTD5M6	Chembl4164452	Investigative	145958562	C33H34N6O7	626.7	C1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N4C(=O)[C@H](OC4=O)CNC(=O)[C@H](CC5=CC=C(C=C5)O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BTI67C	(2R)-2-Acetamido-6-amino-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide;2,2,2-trifluoroacetic acid	Investigative	71457208	C19H27F3N4O5	448.4	CC(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N.C(=O)(C(F)(F)F)O	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BTP5U2	(2S)-2-[[(2R)-2-Acetamido-3-(5-chloro-2-methyl-1H-indol-3-yl)propanoyl]amino]-N-(2-amino-2-oxoethyl)-3-phenylpropanamide	Investigative	118709359	C25H28ClN5O4	498	CC1=C(C2=C(N1)C=CC(=C2)Cl)C[C@H](C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)NCC(=O)N)NC(=O)C	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BVA37O	Chembl4172330	Investigative	145950961	C33H34N6O7	626.7	C1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)[C@@H](CC2=CNC3=CC=CC=C32)N4C(=O)[C@@H](OC4=O)CNC(=O)[C@H](CC5=CC=C(C=C5)O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BWM0A3	2-(4-Chlorophenyl)-N-[2-(dimethylamino)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalen-1-yl]-N-(2-methoxyethyl)acetamide	Investigative	44590677	C25H33ClN2O4	461	CN(C)C1CCC2=CC(=C(C=C2C1N(CCOC)C(=O)CC3=CC=C(C=C3)Cl)OC)OC	EC50 ~ 90000 nM	Poor binder
T47768	Opioid receptor mu	BX14NC	Chembl4172964	Investigative	72153748	C16H19ClFN5	335.81	C1CN(CCC1NC2=CC(=NC(=N2)N)Cl)CC3=CC=CC=C3F	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BXOC42	Chembl4159127	Investigative	145957352	C33H34N6O7	626.7	C1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N4C(=O)[C@@H](OC4=O)CNC(=O)[C@H](CC5=CC=C(C=C5)O)N	Ki ~ 100000 nM	Poor binder
T47768	Opioid receptor mu	BXQ75O	N-[1-(2-Pyrrolidin-1-ylethyl)benzimidazol-2-yl]-1,3-benzothiazole-2-carboxamide	Investigative	118725849	C21H21N5OS	391.5	C1CCN(C1)CCN2C3=CC=CC=C3N=C2NC(=O)C4=NC5=CC=CC=C5S4	EC50 = 100000 nM	Poor binder
T47768	Opioid receptor mu	BYX28E	5-Methyl-N-[1-(2-pyrrolidin-1-ylethyl)benzimidazol-2-yl]pyridine-2-carboxamide	Investigative	118725843	C20H23N5O	349.4	CC1=CN=C(C=C1)C(=O)NC2=NC3=CC=CC=C3N2CCN4CCCC4	EC50 = 100000 nM	Poor binder
T47768	Opioid receptor mu	BZQE17	[(2R,3R)-Tmt1]dpdpe	Investigative	44356081	C33H47N5O7S2	689.9	CC1=CC(=CC(=C1[C@@H](C)[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](C(=O)O)C(C)(C)S)C(C)(C)S)N)C)O	IC50 = 77000 nM	Poor binder