TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T49031	Proteasome beta-5	D0T9TJ	Orlistat	Approved	3034010	C29H53NO5	495.7	CCCCCCCCCCC[C@@H](C[C@H]1[C@@H](C(=O)O1)CCCCCC)OC(=O)[C@H](CC(C)C)NC=O	IC50 ~ 100000 nM	Poor binder
T49031	Proteasome beta-5	B05DWI	N-[(S)-2-Azido-3-phenylpropanoyl]-L-Leu-L-Leu-[(1S,2E)-1-[4-(aminomethyl)benzyl]-3-(methylsulfonyl)allyl]NH2	Investigative	71562349	C33H47N7O5S	653.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)CN)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC2=CC=CC=C2)N=[N+]=[N-]	IC50 = 50000 nM	Poor binder
T49031	Proteasome beta-5	B2PCS7	(2S)-N-[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-3-(4-aminophenyl)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-4-methylpentanamide	Investigative	71561736	C36H46N8O5S	702.9	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)CN)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC2=CC=C(C=C2)N)NC(=O)[C@H](CC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	B36WOH	Chembl4127928	Investigative	145962168	C29H48FN7O6S	641.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CS(=O)(=O)F)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C	IC50 = 69000 nM	Poor binder
T49031	Proteasome beta-5	B3QX7V	Chembl4129702	Investigative	145962247	C31H46FN5O5S	619.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)CN)CS(=O)(=O)F)NC(=O)[C@H](CC2=CC=CC=C2)N	IC50 = 125000 nM	Poor binder
T49031	Proteasome beta-5	B5HO7E	Chembl4212401	Investigative	145966472	C89H150N36O12	1916.4	CCC(=C(C1=CC=C(C=C1)OCCN2CCCCCC2)C3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC(=CC=C5)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	B6K9SO	Ac-hPhe-Leu-(D)-Ala-LeuVSMe	Investigative	11613973	C29H46N4O6S	578.8	C[C@H](C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)C	IC50 = 56000 nM	Poor binder
T49031	Proteasome beta-5	B8FXZ4	(2S,3S)-N-[(2R)-1-(3,4-Dimethylanilino)-1-oxo-3-phenylpropan-2-yl]-3-methyl-2-[(3-nitrophenyl)carbamothioylamino]pentanamide	Investigative	137646135	C30H35N5O4S	561.7	CC[C@H](C)[C@@H](C(=O)N[C@H](CC1=CC=CC=C1)C(=O)NC2=CC(=C(C=C2)C)C)NC(=S)NC3=CC(=CC=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	B92BLZ	Chembl4128074	Investigative	145960456	C27H46FN7O5S	599.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CS(=O)(=O)F)NC(=O)[C@H](CC1=CC=CC=C1)N	IC50 = 140000 nM	Poor binder
T49031	Proteasome beta-5	BCKL30	Methyl N'-[(2S,3S)-1-[[(2R)-1-(3,4-dimethylanilino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]-N-(3-nitrophenyl)carbamimidothioate	Investigative	137639868	C31H37N5O4S	575.7	CC[C@H](C)[C@@H](C(=O)N[C@H](CC1=CC=CC=C1)C(=O)NC2=CC(=C(C=C2)C)C)N=C(NC3=CC(=CC=C3)[N+](=O)[O-])SC	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	BIB79Q	Chembl4130108	Investigative	145961391	C29H48FN5O6S	613.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)CS(=O)(=O)F)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C	IC50 ~ 100000 nM	Poor binder
T49031	Proteasome beta-5	BL6ES0	(2S)-2-[[(2S)-3-[4-(Aminomethyl)phenyl]-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]propanoyl]amino]-N-[(E,2S)-1-[4-(aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-4-methylpentanamide	Investigative	71561866	C37H48N8O5S	716.9	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)CN)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC2=CC=C(C=C2)CN)NC(=O)[C@H](CC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	BO2QI0	1,1'-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis[hexahydro-1H-azepine]	Investigative	24966906	C38H50N2O2	566.8	CCC(=C(C1=CC=C(C=C1)OCCN2CCCCCC2)C3=CC=C(C=C3)OCCN4CCCCCC4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T49031	Proteasome beta-5	BO45XH	Chembl4127967	Investigative	145963426	C27H46FN5O5S	571.8	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)CS(=O)(=O)F)NC(=O)[C@H](CC1=CC=CC=C1)N	IC50 ~ 100000 nM	Poor binder
T49031	Proteasome beta-5	BOWY37	Chembl4281070	Investigative	145980811	C39H47N5O10	745.8	C[C@@H](C(=O)N[C@@H](C[C@]1(C2=CC=CC=C2NC1=O)O)C(=O)NCCC(=O)OC)NC(=O)[C@H](CC3=CC=C(C=C3)OCC4=CC=CC=C4)NC(=O)OC(C)(C)C	IC50 = 64000 nM	Poor binder
T49031	Proteasome beta-5	BR60LA	(2S,3S)-2-[(4-Bromophenyl)carbamothioylamino]-N-[(2R)-1-(3-chloro-4-methylanilino)-1-oxo-3-phenylpropan-2-yl]-3-methylpentanamide	Investigative	137637883	C29H32BrClN4O2S	616	CC[C@H](C)[C@@H](C(=O)N[C@H](CC1=CC=CC=C1)C(=O)NC2=CC(=C(C=C2)C)Cl)NC(=S)NC3=CC=C(C=C3)Br	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	BU2YF4	Chembl4130258	Investigative	145963518	C27H44FN7O5S	597.7	CC(C)C[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)CS(=O)(=O)F)NC(=O)[C@H](CC1=CC=CC=C1)N=[N+]=[N-]	IC50 = 67000 nM	Poor binder
T49031	Proteasome beta-5	BVWK74	(2S)-N-[(E,2S)-1-[4-(Aminomethyl)phenyl]-4-methylsulfonylbut-3-en-2-yl]-2-[[(2S)-2-[[(2S)-2-azido-3-phenylpropanoyl]amino]-3-pyridin-4-ylpropanoyl]amino]-4-methylpentanamide	Investigative	71561735	C35H44N8O5S	688.8	CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)CN)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC2=CC=NC=C2)NC(=O)[C@H](CC3=CC=CC=C3)N=[N+]=[N-]	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	BXAF36	(2S,3S)-N-[(2R)-1-(3-Chloro-4-methylanilino)-1-oxo-3-phenylpropan-2-yl]-3-methyl-2-[(3-nitrophenyl)carbamothioylamino]pentanamide	Investigative	137656187	C29H32ClN5O4S	582.1	CC[C@H](C)[C@@H](C(=O)N[C@H](CC1=CC=CC=C1)C(=O)NC2=CC(=C(C=C2)C)Cl)NC(=S)NC3=CC(=CC=C3)[N+](=O)[O-]	IC50 ~ 50000 nM	Poor binder
T49031	Proteasome beta-5	D05MDE	Cbz-Ile-Pro-Ala-LeuVSMe	Investigative	11505372	C30H46N4O7S	606.8	CC[C@H](C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C)NC(=O)OCC2=CC=CC=C2	IC50 = 150000 nM	Poor binder