TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T49898	Cyclin-dependent kinase 1	D08IBS	Adenine	Approved	190	C5H5N5	135.13	C1=NC2=NC=NC(=C2N1)N	IC50 = 200000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	D08MXP	LEE011	Phase 3	44631912	C23H30N8O	434.5	CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5	IC50 = 113000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	D0A5MC	MLN8054	Phase 1	11712649	C25H15ClF2N4O2	476.9	C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B0CVG2	2,6,9-Trisubstituted purine deriv. 8	Investigative	6538913	C15H22N6O	302.37	CC(C)N1C=NC2=C1N=C(N=C2N3CCC=CC3)NCCO	IC50 = 110000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B0MA2U	Ethyl 8-ethyl-9-oxo-[1,3]thiazolo[5,4-f]quinazoline-2-carboximidate	Investigative	44563897	C14H14N4O2S	302.35	CCN1C=NC2=C(C1=O)C3=C(C=C2)N=C(S3)C(=N)OCC	IC50 = 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B0O5KF	7-(5-(2-Morpholinoethoxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	16666861	C22H23N3O3	377.4	C1COCCN1CCOC2=CC3=C(C=C2)NC(=C3)C4=CC=CC5=C4C(=O)NC5	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B1M8JT	2,6,9-Trisubstituted purine deriv. 25	Investigative	6538930	C24H26N6O	414.5	C1C[C@@H](N(C1)C2=NC(=C3C(=N2)N(C=N3)CC4=CC=CC=C4)NCC5=CC=CC=C5)CO	IC50 = 200000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B27PRM	(E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acid	Investigative	24960018	C23H15BrFNO5S	516.299	C1=CC(=CC=C1CS/C(=C/C2=CC(=C(C=C2)F)[N+](=O)[O-])/C(=O)C3=CC=C(C=C3)C(=O)O)Br	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B2ENW0	2-(8-Amino-6-benzylamino-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol	Investigative	9864131	C19H27N7O	369.5	CCC(CO)NC1=NC(=C2C(=N1)N(C(=N2)N)C(C)C)NCC3=CC=CC=C3	IC50 = 70000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B2PO0Z	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carbohydrazide	Investigative	44562420	C18H17ClN6O2	384.8	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)NN)N)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B2YA8S	Tert-butyl N-[4-[4-(3-chloroanilino)-2H-pyrazolo[3,4-d]pyrimidin-3-yl]phenyl]carbamate	Investigative	5327845	C22H21ClN6O2	436.9	CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=C3C(=NN2)N=CN=C3NC4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B3J8CL	(S)-N-(1-(3-Fluorobenzyl)-1H-indazol-5-yl)-5-((morpholin-2-ylmethoxy)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine	Investigative	10217590	C26H26FN7O2	487.5	C1CO[C@@H](CN1)COCC2=C3C(=NC=NN3C=C2)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B3RAE6	3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)urea	Investigative	11417488	C17H19ClN6O2	374.8	CC(CN(C)C)OC1=C(C=C(C=C1)Cl)NC(=O)NC2=NC=C(N=C2)C#N	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B43WPI	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325478	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B4JU8K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide	Investigative	25271513	C21H22ClN5O3	427.9	COCCNC(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B4WX0K	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide	Investigative	25271517	C24H20ClN5O2	445.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)NC4=CC=CC=C4)N)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B54BZL	Benzamide, 4-[[4-amino-6-(cyclohexylmethoxy)-2-pyrimidinyl]amino]-	Investigative	5329598	C18H23N5O2	341.4	C1CCC(CC1)COC2=NC(=NC(=C2)N)NC3=CC=C(C=C3)C(=O)N	IC50 = 63000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B54IZK	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-(piperidin-1-yl)ethyl)pyrimidine-5-carboxamide	Investigative	25271514	C25H29ClN6O2	481	C1CCN(CC1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B58TMC	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753787	C21H22ClN3O6S	479.9	CC1=C(C(=O)OC2=CC(=C(C=C12)Cl)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B5GE3I	Tert-butyl 9-bromo-6-oxo-5,7-dihydroindolo[3,2-d][1]benzazepine-12-carboxylate	Investigative	5331123	C21H19BrN2O3	427.3	CC(C)(C)OC(=O)N1C2=C(C=C(C=C2)Br)C3=C1C4=CC=CC=C4NC(=O)C3	IC50 = 70000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B5TS3F	2-Hydroxy-5-[2-(1-hydroxymethyl-2-methyl-propylamino)-9-isopropyl-9H-purin-6-ylamino]-benzoic acid	Investigative	12084813	C20H26N6O4	414.5	CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC(=C(C=C3)O)C(=O)O	IC50 = 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B5W4OJ	5-(3-Chlorophenyl)-7-phenyl-4-aminopyrrolo[2,3-d]pyrimidine	Investigative	44385080	C18H13ClN4	320.8	C1=CC=C(C=C1)N2C=C(C3=C(N=CN=C32)N)C4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B60CAW	(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide	Investigative	46232555	C20H15Cl2FN2O2	405.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)N	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B6EMU7	2-[1-(9-Isopropyl-6-phenylamino-9H-purin-2-yl)-piperidin-2-yl]-ethanol	Investigative	44315928	C21H28N6O	380.5	CC(C)N1C=NC2=C(N=C(N=C21)N3CCCCC3CCO)NC4=CC=CC=C4	IC50 = 130000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B6HO2T	2-[6-Benzylamino-8-(3-hydroxy-propylamino)-9-isopropyl-9H-purin-2-ylamino]-butan-1-ol	Investigative	44332685	C22H33N7O2	427.5	CCC(CO)NC1=NC(=C2C(=N1)N(C(=N2)NCCCO)C(C)C)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B6SOJ3	(5,6-Diphenyl-furo[2,3-D]pyrimidin-4-ylamino)-acetic	Investigative	4369432	C21H19N3O2	345.4	CN(CCO)C1=C2C(=C(OC2=NC=N1)C3=CC=CC=C3)C4=CC=CC=C4	IC50 = 111400 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B74BAN	7-(5-(3-(4-Hydroxypiperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	44579918	C24H27N3O3	405.5	C1CN(CCC1O)CCCOC2=CC3=C(C=C2)NC(=C3)C4=CC=CC5=C4C(=O)NC5	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7EIV2	2,6,9-Trisubstituted purine deriv. 7	Investigative	6538912	C14H22N6O	290.36	CC(C)N1C=NC2=C1N=C(N=C2N(C)CC=C)NCCO	IC50 = 150000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7GV9Y	7-(5-(Benzyloxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	16666806	C23H18N2O2	354.4	C1C2=C(C(=CC=C2)C3=CC4=C(N3)C=CC(=C4)OCC5=CC=CC=C5)C(=O)N1	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7KX8L	N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine	Investigative	25063262	C25H26ClN7O3	508	C1COCCN1CCC2=NN=C(O2)C3=C(N=CN=C3NC4=CC(=C(C=C4)OCC5=CC=CC=C5)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7N1WR	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325479	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7Y3DX	6-Chloro-2-iodo-9-isopropyl-9H-purine	Investigative	6538904	C8H8ClIN4	322.53	CC(C)N1C=NC2=C1N=C(N=C2Cl)I	IC50 = 150000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7YIK2	6-Benzylamino-2-(1-hydroxymethyl-propylamino)-9-isopropyl-9H-purin-8-ol	Investigative	9864175	C19H26N6O2	370.4	CCC(CO)NC1=NC(=C2C(=N1)N(C(=O)N2)C(C)C)NCC3=CC=CC=C3	IC50 = 65000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B7ZDB8	(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline	Investigative	46232443	C17H12Cl2FNO	336.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B81JIH	2-[(6-Amino-7H-purin-2-yl)amino]ethanol	Investigative	3960961	C7H10N6O	194.19	C1=NC2=NC(=NC(=C2N1)N)NCCO	IC50 = 200000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B8B7DK	6-Benzylaminopurine	Investigative	62389	C12H11N5	225.25	C1=CC=C(C=C1)CNC2=NC=NC3=C2NC=N3	IC50 = 200000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B8Q9PY	7-(5-(3-(4-Ethylpiperazin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	16666911	C25H30N4O2	418.5	CCN1CCN(CC1)CCCOC2=CC3=C(C=C2)NC(=C3)C4=CC=CC5=C4C(=O)NC5	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	B9AFH8	2-(6-Benzylamino-9-isopropyl-8-propoxy-9H-purin-2-ylamino)-butan-1-ol	Investigative	44332387	C22H32N6O2	412.5	CCCOC1=NC2=C(N=C(N=C2N1C(C)C)NC(CC)CO)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BAJD06	Tert-butyl 2-(2-methyl-3-oxoisoindolin-4-yl)-1H-pyrrole-1-carboxylate	Investigative	16666757	C18H20N2O3	312.4	CC(C)(C)OC(=O)N1C=CC=C1C2=CC=CC3=C2C(=O)N(C3)C	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BAL94P	4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol	Investigative	24825971	C27H32N6O	456.6	CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BAX6F9	3-{5-Chloro-2-[(3-methyloxetan-3-yl)methoxy]phenyl}-1-(5-cyanopyrazin-2-yl)urea	Investigative	11406175	C17H16ClN5O3	373.8	CC1(COC1)COC2=C(C=C(C=C2)Cl)NC(=O)NC3=NC=C(N=C3)C#N	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BBSW25	2-[6-(4-Chloro-phenylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol	Investigative	44316153	C19H25ClN6O	388.9	CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NC3=CC=C(C=C3)Cl	IC50 = 80000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BC5F4Q	1-[[2-(9-Bromoindolo[3,2-b]quinoxalin-6-yl)acetyl]amino]-3-cyclohexyl-thiourea	Investigative	3001650	C23H23BrN6OS	511.4	C1CCC(CC1)NC(=S)NNC(=O)CN2C3=C(C=C(C=C3)Br)C4=NC5=CC=CC=C5N=C42	IC50 = 70000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BC6P0W	7-(5-(3-Hydroxypropoxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	16666908	C19H18N2O3	322.4	C1C2=C(C(=CC=C2)C3=CC4=C(N3)C=CC(=C4)OCCCO)C(=O)N1	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BC8U1N	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide	Investigative	25271518	C25H22ClN5O3	475.9	COC1=CC=C(C=C1)NC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BCO6L0	2-(6-Benzylamino-8-bromo-9-isopropyl-9H-purin-2-ylamino)-butan-1-ol	Investigative	9910699	C19H25BrN6O	433.3	CCC(CO)NC1=NC(=C2C(=N1)N(C(=N2)Br)C(C)C)NCC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BCSL05	2-(6-Amino-9-methyl-9H-purin-2-ylamino)-ethanol	Investigative	10512545	C8H12N6O	208.22	CN1C=NC2=C(N=C(N=C21)NCCO)N	IC50 = 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BCY2T5	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-morpholinoethyl)pyrimidine-5-carboxamide	Investigative	25271515	C24H27ClN6O3	483	C1COCCN1CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BD0J7P	2,6-Diaminopurine	Investigative	30976	C5H6N6	150.14	C1=NC2=NC(=NC(=C2N1)N)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BD26EW	3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate	Investigative	25271180	C25H20ClFN4O3	478.9	C1=CC=C(C=C1)COC2=C(C=C(C=C2)NC3=NC=NC(=C3C(=O)OCC4=CC(=CC=C4)F)N)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BD73CK	(5R)-5-[(2E,7E,9E)-13-(3-Furanyl)-2,6,10-trimethyl-2,7,9-tridecatrienyl]-4-hydroxy-3-methyl-2(5H)-furanone	Investigative	54726684	C25H34O4	398.5	CC1=C([C@H](OC1=O)C/C(=C/CCC(C)/C=C/C=C(\\C)/CCCC2=COC=C2)/C)O	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BD7RK1	2-Chloro-9-methyl-9H-purin-6-amine	Investigative	145989	C6H6ClN5	183.6	CN1C=NC2=C(N=C(N=C21)Cl)N	IC50 = 70000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BE45ZP	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N''-(3-morpholinopropanoyl)pyrimidine-5-carbohydrazide	Investigative	44562431	C25H28ClN7O4	526	C1COCCN1CCC(=O)NNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BEJ7N0	Tert-butyl N-[4-[[4-(3-chloroanilino)-2H-pyrazolo[3,4-d]pyrimidin-3-yl]amino]phenyl]carbamate	Investigative	5327832	C22H22ClN7O2	451.9	CC(C)(C)OC(=O)NC1=CC=C(C=C1)NC2=C3C(=NN2)N=CN=C3NC4=CC(=CC=C4)Cl	IC50 = 57000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BFB4P3	2-(4-(4-Amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanol	Investigative	44384965	C21H21N5O	359.4	C1=CC=C(C=C1)C2=CN(C3=NC=NC(=C23)N)C4=CC=C(C=C4)CNCCO	IC50 = 82500 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BG5LM7	4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide	Investigative	25271181	C22H24ClN5O2	425.9	CCN(CC)C(=O)C1=C(N=CN=C1NC2=CC(=C(C=C2)OCC3=CC=CC=C3)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BG9A5Y	N,9-Dibenzyl-2-iodopurin-6-amine	Investigative	6538910	C19H16IN5	441.3	C1=CC=C(C=C1)CNC2=C3C(=NC(=N2)I)N(C=N3)CC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BGB5Y2	2-[1-(6-Benzylamino-9-isopropyl-9H-purin-2-yl)-piperidin-2-yl]-ethanol	Investigative	44315927	C22H30N6O	394.5	CC(C)N1C=NC2=C(N=C(N=C21)N3CCCCC3CCO)NCC4=CC=CC=C4	IC50 = 160000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BH4L2U	2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-4-methyl-pentan-1-ol	Investigative	12084810	C22H32N6O2	412.5	CC(C)C[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)OC	IC50 = 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BI2VA4	3-[4-(4-Hydroxyphenyl)phenyl]-N-(pyridin-4-ylmethyl)-1,4-dihydroindeno[1,2-c]pyrazole-6-carboxamide	Investigative	136060555	C29H22N4O2	458.5	C1C2=C(C=CC(=C2)C(=O)NCC3=CC=NC=C3)C4=C1C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BIR3H1	3-(4'-Hydroxybiphenyl-4-Yl)-N-(4-Hydroxycyclohexyl)-1,4-Dihydroindeno[1,2-C]pyrazole-6-Carboxamide	Investigative	135589980	C29H27N3O3	465.5	C1CC(CCC1NC(=O)C2=CC3=C(C=C2)C4=C(C3)C(=NN4)C5=CC=C(C=C5)C6=CC=C(C=C6)O)O	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BIUQ69	2-Amino-6-benzylamino-9H-purine	Investigative	16409607	C12H12N6	240.26	C1=CC=C(C=C1)CNC2=NC(=NC3=C2NC=N3)N	IC50 = 90000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BK3B8V	(2-Chloro-9-methyl-9H-purin-6-yl)-cyclohexyl-methyl-amine	Investigative	44353766	C13H18ClN5	279.77	CN1C=NC2=C1N=C(N=C2N(C)C3CCCCC3)Cl	IC50 = 130000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BKTU64	2-[6-(3-Iodo-benzylamino)-9-isopropyl-9H-purin-2-ylamino]-3-methyl-butan-1-ol	Investigative	44315926	C20H27IN6O	494.4	CC(C)[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC(=CC=C3)I	IC50 = 170000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BN9GH1	2,6,9-Trisubstituted purine deriv. 5d	Investigative	6538908	C17H18IN5	419.26	C1CCC(C1)N2C=NC3=C(N=C(N=C32)I)NCC4=CC=CC=C4	IC50 = 75000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BOB6L2	2,6,9-Trisubstituted purine deriv. 5e	Investigative	6538909	C18H20IN5	433.3	C1CCC(CC1)N2C=NC3=C(N=C(N=C32)I)NCC4=CC=CC=C4	IC50 = 90000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BON75J	4-(3-Chloro-phenylamino)-3-(3-nitro-phenyl)-1H-pyrazolo[3,4-d]pyrimidine	Investigative	5327843	C17H11ClN6O2	366.8	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C3C(=NN2)N=CN=C3NC4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BP7VQ9	7-(1H-Indol-2-yl)isoindolin-1-one	Investigative	16666862	C16H12N2O	248.28	C1C2=C(C(=CC=C2)C3=CC4=CC=CC=C4N3)C(=O)N1	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BPV4H6	2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide	Investigative	46232556	C21H17Cl2FN2O2	419.3	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)C4CC4C(=O)N	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BQ9Y5W	2-[9-(4-Amino-3-methoxyphenyl)-6-oxo-5,11-dihydrobenzo[b][1,4]benzodiazepin-3-yl]-N-(4-morpholin-4-ylphenyl)acetamide	Investigative	44427518	C32H31N5O4	549.6	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)C(=O)NC4=C(N3)C=CC(=C4)CC(=O)NC5=CC=C(C=C5)N6CCOCC6)N	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BQTO97	N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide	Investigative	25271516	C27H26ClN5O3	504	COC1=CC=C(C=C1)CCNC(=O)C2=C(N=CN=C2NC3=CC(=C(C=C3)OCC4=CC=CC=C4)Cl)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BR3CS5	N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine	Investigative	4705	C16H14BrN3O2	360.2	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC	IC50 = 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BRC06P	7-(5-(3-(Piperidin-1-yl)propoxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	16666860	C24H27N3O2	389.5	C1CCN(CC1)CCCOC2=CC3=C(C=C2)NC(=C3)C4=CC=CC5=C4C(=O)NC5	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BS1RQ2	9-Bromo-12-prop-2-enyl-5,7-dihydroindolo[3,2-d][1]benzazepin-6-one	Investigative	5331124	C19H15BrN2O	367.2	C=CCN1C2=C(C=C(C=C2)Br)C3=C1C4=CC=CC=C4NC(=O)C3	IC50 = 60000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BT03EA	7-(5-Methoxy-1H-indol-2-yl)isoindolin-1-one	Investigative	16666910	C17H14N2O2	278.3	COC1=CC2=C(C=C1)NC(=C2)C3=CC=CC4=C3C(=O)NC4	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BT5JQ2	7-Phenyl-5-o-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine	Investigative	44385739	C19H16N4	300.4	CC1=CC=CC=C1C2=CN(C3=NC=NC(=C23)N)C4=CC=CC=C4	IC50 = 90000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BT5N2Y	Ditert-butyl 9-bromo-6-oxo-7,12-dihydroindolo[3,2-d][1]benzazepine-5,7-dicarboxylate	Investigative	5331127	C26H27BrN2O5	527.4	CC(C)(C)OC(=O)C1C2=C(C3=CC=CC=C3N(C1=O)C(=O)OC(C)(C)C)NC4=C2C=C(C=C4)Br	IC50 = 80000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BTM0I6	N-(3-Chlorophenyl)-3-(4-methoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	5327841	C18H14ClN5O	351.8	COC1=CC=C(C=C1)C2=C3C(=NN2)N=CN=C3NC4=CC(=CC=C4)Cl	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BU7GC4	2-[[9-Methyl-6-(3-methylbut-2-enylamino)purin-2-yl]amino]ethanol	Investigative	10802411	C13H20N6O	276.34	CC(=CCNC1=C2C(=NC(=N1)NCCO)N(C=N2)C)C	IC50 = 65000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BUF0W8	7-(5-(2-(Piperidin-1-yl)ethoxy)-1H-indol-2-yl)isoindolin-1-one	Investigative	16666859	C23H25N3O2	375.5	C1CCN(CC1)CCOC2=CC3=C(C=C2)NC(=C3)C4=CC=CC5=C4C(=O)NC5	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BV5KY8	2-[9-Isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-butan-1-ol	Investigative	12084809	C20H28N6O2	384.5	CC[C@H](CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)OC	IC50 = 130000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BV5S3F	6-(Cyclohexylmethoxy)-9-methyl-9h-purin-2-amine	Investigative	398149	C13H19N5O	261.32	CN1C=NC2=C1N=C(N=C2OCC3CCCCC3)N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BVRM73	Methyl 6-((5-cyanopyrazin-2-yl)amino)-4-((piperidin-4-ylmethyl)amino)nicotinate	Investigative	42610232	C18H21N7O2	367.4	COC(=O)C1=CN=C(C=C1NCC2CCNCC2)NC3=NC=C(N=C3)C#N	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BW8AH4	6-(Adamantylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine	Investigative	10524103	C21H32N6O	384.5	CC(C)N1C=NC2=C(N=C(N=C21)NCCCO)NC34CC5CC(C3)CC(C5)C4	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BW94GV	(3Z)-3-[(2,4,6-Trimethoxyphenyl)methylidene]-1H-indol-2-one	Investigative	5353678	C18H17NO4	311.3	COC1=CC(=C(C(=C1)OC)/C=C\\2/C3=CC=CC=C3NC2=O)OC	IC50 ~ 100000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	BX1KB0	Tritert-butyl 9-bromo-6-oxo-7H-indolo[3,2-d][1]benzazepine-5,7,12-tricarboxylate	Investigative	5331130	C31H35BrN2O7	627.5	CC(C)(C)OC(=O)C1C2=C(C3=CC=CC=C3N(C1=O)C(=O)OC(C)(C)C)N(C4=C2C=C(C=C4)Br)C(=O)OC(C)(C)C	IC50 = 150000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	D0BU6T	CGP-62464	Investigative	354471	C18H14N4	286.3	C1=CC=C(C=C1)C2=CN(C3=NC=NC(=C23)N)C4=CC=CC=C4	IC50 = 54000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	D0D6DH	A-432411	Investigative	10125830	C20H16N2O3	332.4	COC1=C(C=CC(=C1)C2=CC3=C(C=C2)/C(=C/C4=CC=CN4)/C(=O)N3)O	IC50 ~ 50000 nM	Poor binder
T49898	Cyclin-dependent kinase 1	D0YZ7H	JNJ-10198409	Investigative	9797370	C18H16FN3O2	325.3	COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC	IC50 ~ 100000 nM	Poor binder