TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T50594	Serine/threonine-protein kinase pim-1	D0G5CS	PINOCEMBRIN	Phase 2	68071	C15H12O4	256.25	C1[C@H](OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3	IC50 = 107000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B06POE	N-(3-Methoxyphenyl)-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030426	C25H25N5O	411.5	COC1=CC=CC(=C1)NC2=C3C(=CN=C2)N=C(C=N3)C4=CC=C(C=C4)N5CCCCC5	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B1A4EI	(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one	Investigative	9547398	C27H42O3	414.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3C[C@@H]([C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C)O	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B1TV6D	3-Phenyl-N-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-7-amine	Investigative	127031368	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=CC(=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B1VO9R	Calicoferol E	Investigative	5283685	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCCC(C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B2CME9	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127033165	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=C3C(=C2)N=C(C=N3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B2NRQ3	1-[7-(3,4-Dimethoxyphenyl)-1,5-naphthyridin-2-yl]-3-ethylurea	Investigative	53239374	C19H20N4O3	352.4	CCNC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B42PVG	N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031386	C23H21N5O	383.4	C1COCCN1C2=CC=C(C=C2)NC3=NC=CC4=NC(=CN=C43)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B4NZ6S	3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide	Investigative	46934144	C24H20ClN3O3	433.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=C(C=C4)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B4YXC8	7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol	Investigative	76335685	C24H33NO3	383.5	C[C@H]1CC[C@@]2([C@H]([C@]1(C)CC3=C4C(=CC(=C3O)OC)N=C(O4)C)CCC=C2C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B50YSK	(5E)-1-Benzyl-5-[(4-methoxyphenyl)methylidene]imidazolidine-2,4-dione;hydrochloride	Investigative	44581101	C18H17ClN2O3	344.8	COC1=CC=C(C=C1)/C=C/2\\C(=O)NC(=O)N2CC3=CC=CC=C3.Cl	IC50 = 75000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B54GSK	Benzofuran-2-carboxylic acid	Investigative	10331	C9H6O3	162.14	C1=CC=C2C(=C1)C=C(O2)C(=O)O	IC50 = 119000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B5BHU3	4-(1H-Indol-3-yl)-1H-imidazo[4,5-c]pyridin-2-amine	Investigative	46224842	C14H11N5	249.27	C1=CC=C2C(=C1)C(=CN2)C3=NC=CC4=C3N=C(N4)N	IC50 = 50000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B6TCU4	N-(4-Morpholin-4-ylphenyl)-2-phenylpyrido[3,4-b]pyrazin-7-amine	Investigative	127031677	C23H21N5O	383.4	C1COCCN1C2=CC=C(C=C2)NC3=NC=C4C(=C3)N=C(C=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B76FRE	1-Tert-butyl-3-[7-(3,4-dimethoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	53239375	C21H24N4O3	380.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)OC)OC	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B7P4NU	N-(3-Ethynylphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031076	C21H14N4	322.4	C#CC1=CC(=CC=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B87HIO	(5E)-1-Benzyl-5-[(4-chlorophenyl)methylidene]imidazolidine-2,4-dione	Investigative	25185172	C17H13ClN2O2	312.7	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)Cl)/C(=O)NC2=O	IC50 = 69000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B9L7RP	(5E)-1-Benzyl-5-[(4-bromophenyl)methylidene]imidazolidine-2,4-dione	Investigative	25185174	C17H13BrN2O2	357.2	C1=CC=C(C=C1)CN2/C(=C/C3=CC=C(C=C3)Br)/C(=O)NC2=O	IC50 = 58000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	B9S0YQ	1-Ethyl-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127031075	C16H15N5O	293.32	CCNC(=O)NC1=NC=CC2=NC(=CN=C21)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BA18UB	1,4,5,8,9,10-Anthracenehexol	Investigative	95731	C14H10O6	274.22	C1=CC(=C2C(=C1O)C(=C3C(=CC=C(C3=C2O)O)O)O)O	IC50 = 57100 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BB4I1G	1-(3-Methoxyphenyl)-3-(2-phenylpyrido[3,4-b]pyrazin-5-yl)urea	Investigative	127030427	C21H17N5O2	371.4	COC1=CC=CC(=C1)NC(=O)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BBFY93	1-(3-Phenylpyrido[3,4-b]pyrazin-8-yl)-3-prop-2-enylurea	Investigative	127032542	C17H15N5O	305.33	C=CCNC(=O)NC1=C2C(=CN=C1)N=C(C=N2)C3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BD6YR7	N-Phenyl-3-(4-piperidin-1-ylphenyl)pyrido[3,4-b]pyrazin-8-amine	Investigative	127030425	C24H23N5	381.5	C1CCN(CC1)C2=CC=C(C=C2)C3=NC4=CN=CC(=C4N=C3)NC5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BDK9R0	Calicoferol C	Investigative	10024683	C28H44O2	412.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BF32AR	Calicoferol B	Investigative	10047545	C27H44O3	416.6	CC1=C(C=C(C=C1)O)CC[C@@H]2[C@@H](CC[C@]3([C@H]2C[C@@H]([C@@H]3[C@H](C)CCCC(C)C)O)C)O	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BG37WO	Astrogorgiadiol B	Investigative	5283727	C27H44O2	400.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@H]2O)C)[C@H](C)CCCC(C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BGVU25	N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide	Investigative	16723801	C23H20ClN3O	389.9	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)CCC(=O)NC4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BH2NY3	(5E)-1-Benzyl-5-[(2-methoxyphenyl)methylidene]imidazolidine-2,4-dione	Investigative	25185175	C18H16N2O3	308.3	COC1=CC=CC=C1/C=C/2\\C(=O)NC(=O)N2CC3=CC=CC=C3	IC50 = 78000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BH9N3O	N-(3-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127033758	C20H16N4O	328.4	COC1=CC=CC(=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BK5HQ8	N-(2-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031383	C20H16N4O	328.4	COC1=CC=CC=C1NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BMZL97	(5E)-1-Benzyl-5-[(4-ethoxyphenyl)methylidene]imidazolidine-2,4-dione	Investigative	25185173	C19H18N2O3	322.4	CCOC1=CC=C(C=C1)/C=C/2\\C(=O)NC(=O)N2CC3=CC=CC=C3	IC50 = 73000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BOKJ71	N-(3-Chloro-4-fluorophenyl)-3-phenylpyrido[3,4-b]pyrazin-8-amine	Investigative	127030124	C19H12ClFN4	350.8	C1=CC=C(C=C1)C2=NC3=CN=CC(=C3N=C2)NC4=CC(=C(C=C4)F)Cl	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BP04FA	5-(1-(4-Fluorobenzyl)-1H-1,2,3-triazol-4-yl)-1H-indazole	Investigative	25166058	C16H12FN5	293.3	C1=CC(=CC=C1CN2C=C(N=N2)C3=CC4=C(C=C3)NN=C4)F	Ki = 165230 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BP39OV	3-(2-Fluorobenzyl)-1,3-thiazolidine-2,4-dione	Investigative	3157072	C10H8FNO2S	225.24	C1C(=O)N(C(=O)S1)CC2=CC=CC=C2F	IC50 = 63000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BQS51E	Calicoferol A	Investigative	9547698	C27H40O2	396.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BT3H1C	N-(4-Methoxyphenyl)-2-phenylpyrido[3,4-b]pyrazin-5-amine	Investigative	127031384	C20H16N4O	328.4	COC1=CC=C(C=C1)NC2=NC=CC3=NC(=CN=C32)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BTOA20	1-Tert-butyl-3-[7-(1-methylpyrazol-4-yl)-1,5-naphthyridin-2-yl]urea	Investigative	53236670	C17H20N6O	324.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CN(N=C3)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BUI1J6	N-[4-[[3-[3-(Dimethylamino)phenyl]pyrazolo[1,5-a]pyrimidin-5-yl]amino]phenyl]-4-methylbenzenesulfonamide	Investigative	59380314	C27H26N6O2S	498.6	CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)NC3=NC4=C(C=NN4C=C3)C5=CC(=CC=C5)N(C)C	IC50 = 52000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BVI90B	Chembl4276946	Investigative	134611886	C12H11Cl2N3O	284.14	CC1=NN(C(=C1C2=CC(=C(C=C2)Cl)Cl)N)C(=O)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BWAL85	2-(4-Methoxyphenyl)-N-(4-morpholin-4-ylphenyl)pyrido[3,4-b]pyrazin-5-amine	Investigative	127031675	C24H23N5O2	413.5	COC1=CC=C(C=C1)C2=CN=C3C(=N2)C=CN=C3NC4=CC=C(C=C4)N5CCOCC5	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BX0D7J	Rel-Astrogorgol F	Investigative	54764923	C27H42O2	398.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CC[C@@H]2O)C)[C@H](C)/C=C/CC(C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BXW85K	(5E)-1-Benzyl-5-[[4-(dimethylamino)phenyl]methylidene]imidazolidine-2,4-dione	Investigative	25185444	C19H19N3O2	321.4	CN(C)C1=CC=C(C=C1)/C=C/2\\C(=O)NC(=O)N2CC3=CC=CC=C3	IC50 = 78000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BYA5E9	1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]urea	Investigative	136065882	C20H22N4O3	366.4	CC(C)(C)NC(=O)NC1=NC2=C(C=C1)N=CC(=C2)C3=CC(=C(C=C3)O)OC	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	BYB0C2	24-Exomethylenecalicoferol E	Investigative	10047202	C28H42O2	410.6	CC1=C(C=C(C=C1)O)CC[C@H]2[C@@H]3CC[C@@H]([C@]3(CCC2=O)C)[C@H](C)CCC(=C)C(C)C	IC50 ~ 100000 nM	Poor binder
T50594	Serine/threonine-protein kinase pim-1	D0W7TU	NSC-73306	Investigative	947057	C16H14N4O2S	326.4	.	IC50 ~ 50000 nM	Poor binder