TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T51282	Rho-associated protein kinase 1	B08AYZ	3-{[2-(3-Thienyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione	Investigative	44575127	C21H17N3O2S	375.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CSC=C4	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B3IP4L	Nicotinamide, N-(4-pyridyl)-	Investigative	3049109	C11H9N3O	199.21	C1=CC(=CN=C1)C(=O)NC2=CC=NC=C2	IC50 = 75500 nM	Poor binder
T51282	Rho-associated protein kinase 1	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B46USG	3-(4-Methyl-1,4-diazepan-1-yl)-5-(3-methylpyridin-4-yl)pyrazin-2-amine	Investigative	11530100	C16H22N6	298.39	CC1=C(C=CN=C1)C2=CN=C(C(=N2)N3CCCN(CC3)C)N	IC50 = 120000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B4K5TJ	4-(3-((4-Hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide	Investigative	44541014	C26H21N3O5	455.5	CN1C=C(C2=C(C=CN=C21)C3=CC=C(C=C3)C(=O)NCCO)/C=C\\4/C(=O)C5=C(C=CC=C5O4)O	IC50 = 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B5J3GY	5-Vinyl-3-pyridinecarbonitrile, 19	Investigative	44160269	C24H28N6	400.5	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/CCN4CCC[C@H](C4)N)C#N	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B5NSE7	4-(4-Methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375865	C28H28N6O2S	512.6	CC1=C(C=CC2=C1C=CN2)NC3=C(C=NC=C3/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C)C#N	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	B98RFU	1-(1H-Indazol-5-yl)-3-phenylurea	Investigative	4421488	C14H12N4O	252.27	C1=CC=C(C=C1)NC(=O)NC2=CC3=C(C=C2)NN=C3	IC50 = 157100 nM	Poor binder
T51282	Rho-associated protein kinase 1	BA62QX	4-(4-Methyl-1H-indol-5-ylamino)-2-(3-oxo-3-(pyrrolidin-1-yl)prop-1-enyl)thieno[2,3-b]pyridine-5-carbonitrile	Investigative	24766030	C24H21N5OS	427.5	CC1=C(C=CC2=C1C=CN2)NC3=C4C=C(SC4=NC=C3C#N)/C=C/C(=O)N5CCCC5	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BDJQ37	1-[(1R)-1-(4-Methoxyphenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Investigative	89421294	C18H18N4O2S	354.4	C[C@H](C1=CC=C(C=C1)OC)NC(=O)NC2=NC(=CS2)C3=CC=NC=C3	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BDR7O9	4-Chloro-N-pyridin-4-ylpyridine-3-carboxamide	Investigative	70691888	C11H8ClN3O	233.65	C1=CN=CC=C1NC(=O)C2=C(C=CN=C2)Cl	IC50 = 72500 nM	Poor binder
T51282	Rho-associated protein kinase 1	BE04IQ	3-(1H-Indazol-5-yl)-1,1-dimethylurea	Investigative	70683491	C10H12N4O	204.23	CN(C)C(=O)NC1=CC2=C(C=C1)NN=C2	IC50 = 59100 nM	Poor binder
T51282	Rho-associated protein kinase 1	BET51Z	6-[(3S)-1-Methylsulfonylpiperidin-3-yl]oxyisoquinolin-1-amine	Investigative	53319060	C15H19N3O3S	321.4	CS(=O)(=O)N1CCC[C@@H](C1)OC2=CC3=C(C=C2)C(=NC=C3)N	IC50 ~ 100000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BFA4G7	4-(3-(4-Methyl-1,4-diazepan-1-yl)-5-(pyridin-4-yl)pyrazin-2-yl)morpholine	Investigative	11503627	C19H26N6O	354.4	CN1CCCN(CC1)C2=NC(=CN=C2N3CCOCC3)C4=CC=NC=C4	IC50 = 68000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BFE65Y	[4-(4-Oxo-3H-phthalazin-1-yl)phenyl] 3-phenylpyrrolidine-1-carboxylate	Investigative	90283800	C25H21N3O3	411.5	C1CN(CC1C2=CC=CC=C2)C(=O)OC3=CC=C(C=C3)C4=NNC(=O)C5=CC=CC=C54	IC50 = 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BH9CP0	5-Aminoindazole	Investigative	88012	C7H7N3	133.15	C1=CC2=C(C=C1N)C=NN2	IC50 = 181300 nM	Poor binder
T51282	Rho-associated protein kinase 1	BIKV80	3-[[2-(2-Fluorophenyl)pyridin-4-yl]amino]-4-[[(1R)-1-phenylethyl]amino]cyclobut-3-ene-1,2-dione	Investigative	44575073	C23H18FN3O2	387.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CC=CC=C4F	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BK1V8Q	3-{[2-(2-Furyl)pyridin-4-yl]amino}-4-{[(1R)-1-phenylethyl]amino}cyclobut-3-ene-1,2-dione	Investigative	44575126	C21H17N3O3	359.4	C[C@H](C1=CC=CC=C1)NC2=C(C(=O)C2=O)NC3=CC(=NC=C3)C4=CC=CO4	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BLI17W	3-(4-Methyl-1,4-diazepan-1-yl)-5-(2-methylpyridin-4-yl)pyrazin-2-amine	Investigative	46229922	C16H22N6	298.39	CC1=NC=CC(=C1)C2=CN=C(C(=N2)N3CCCN(CC3)C)N	IC50 ~ 100000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BMTS94	6-Methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile	Investigative	45375866	C29H30N6O2S	526.7	CC1=C(C=CC2=C1C=CN2)NC3=C(C(=NC=C3C#N)C)/C=C/C4=CC(=CC=C4)S(=O)(=O)N5CCN(CC5)C	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BOX1F9	1-[(1S)-1-(3-Chlorophenyl)ethyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Investigative	89421171	C17H15ClN4OS	358.8	C[C@@H](C1=CC(=CC=C1)Cl)NC(=O)NC2=NC(=CS2)C3=CC=NC=C3	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BTI7W2	4-(5-Chloro-3-methylbenzo[b]thiophen-2-yl)-N,N-dimethylpyrimidin-2-amine	Investigative	46889888	C15H14ClN3S	303.8	CC1=C(SC2=C1C=C(C=C2)Cl)C3=NC(=NC=C3)N(C)C	IC50 ~ 100000 nM	Poor binder
T51282	Rho-associated protein kinase 1	BWU63O	1-[(1S)-1-Phenylpropyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea	Investigative	87405909	C18H18N4OS	338.4	CC[C@@H](C1=CC=CC=C1)NC(=O)NC2=NC(=CS2)C3=CC=NC=C3	IC50 = 52170 nM	Poor binder
T51282	Rho-associated protein kinase 1	D0J7YE	N-(1H-indazol-5-yl)acetamide	Investigative	17164245	C9H9N3O	175.19	CC(=O)NC1=CC2=C(C=C1)NN=C2	IC50 = 65000 nM	Poor binder
T51282	Rho-associated protein kinase 1	D0W7TU	NSC-73306	Investigative	947057	C16H14N4O2S	326.4	.	IC50 ~ 50000 nM	Poor binder