TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T52297	Oxysterols receptor LXR-alpha	D0S5LT	Deoxynojirimycin	Phase 3	29435	C6H13NO4	163.17	C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O	IC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	D0R9YR	BETULINIC ACID	Phase 1	64971	C30H48O3	456.7	CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)C(=O)O	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	B1V8RY	(1S,4As,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid allyl ester	Investigative	44403619	C20H26O3	314.4	C[C@]12CCC[C@]([C@@H]1CCC3=C2C=C(C=C3)O)(C)C(=O)OCC=C	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	B34ERS	N-[(4-Chlorophenyl)methyl]-N-[(5-nitrothiophen-2-yl)methyl]-1-phenylmethanamine	Investigative	50916706	C19H17ClN2O2S	372.9	C1=CC=C(C=C1)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	B6Q3IS	5-[[(4-Methoxyphenyl)methyl-(pyridin-3-ylmethyl)amino]methyl]thiophene-2-carbonitrile	Investigative	71682939	C20H19N3OS	349.5	COC1=CC=C(C=C1)CN(CC2=CN=CC=C2)CC3=CC=C(S3)C#N	IC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	B9GQ7I	2-(2-(Ethyl(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)amino)-2-phenylethoxy)acetic acid	Investigative	44416861	C21H21F6NO4	465.4	CCN(C1=CC=C(C=C1)C(C(F)(F)F)(C(F)(F)F)O)C(COCC(=O)O)C2=CC=CC=C2	IC50 = 61000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	B9IE7C	3-Benzyl-8-chloro-4-{3-[(2-chlorobenzyl)oxy]phenyl}cinnoline	Investigative	11854316	C28H20Cl2N2O	471.4	C1=CC=C(C=C1)CC2=NN=C3C(=C2C4=CC(=CC=C4)OCC5=CC=CC=C5Cl)C=CC=C3Cl	IC50 = 92000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BA3HE1	[3-(8-Chloro-3-phenylcinnolin-4-yl)phenyl][(1-methyl-1H-indol-7-yl)methyl]amine	Investigative	11855081	C30H23ClN4	475	CN1C=CC2=C1C(=CC=C2)CNC3=CC=CC(=C3)C4=C5C=CC=C(C5=NN=C4C6=CC=CC=C6)Cl	IC50 = 62000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BBV07Q	3-Benzyl-4-[3-(benzyloxy)phenyl]-8-chlorocinnoline	Investigative	11854573	C28H21ClN2O	436.9	C1=CC=C(C=C1)CC2=NN=C3C(=C2C4=CC(=CC=C4)OCC5=CC=CC=C5)C=CC=C3Cl	IC50 = 180000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BC5QP7	1-(4-Chlorophenyl)-N-(1H-imidazol-2-ylmethyl)-N-(pyridin-3-ylmethyl)methanamine	Investigative	71682936	C17H17ClN4	312.8	C1=CC(=CN=C1)CN(CC2=CC=C(C=C2)Cl)CC3=NC=CN3	IC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BCKD48	Ethyl 2,4,6-Trihydroxybenzoate	Investigative	54344821	C9H10O5	198.17	CCOC(=O)C1=C(C=C(C=C1O)O)O	EC50 = 80760 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BDKO32	[3-(8-Chloro-3-phenylcinnolin-4-yl)phenyl][2-chloro-3-(trifluoromethyl)benzyl]amine	Investigative	11855894	C28H18Cl2F3N3	524.4	C1=CC=C(C=C1)C2=NN=C3C(=C2C4=CC(=CC=C4)NCC5=C(C(=CC=C5)C(F)(F)F)Cl)C=CC=C3Cl	IC50 = 179000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BFE39Y	4-(N-(3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)-N-methylsulfamoyl)benzoic acid	Investigative	44573717	C18H16ClF3N2O6S	480.8	CC(C(=O)NC1=C(C=C(C=C1)N(C)S(=O)(=O)C2=CC=C(C=C2)C(=O)O)Cl)(C(F)(F)F)O	EC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BFE6Q0	(1R,4Ar,7S,8aS,10aS)-N-(1-adamantylmethyl)-7-ethenyl-1,4a,7-trimethyl-3,4,6,8,8a,9,10,10a-octahydro-2H-phenanthrene-1-carboxamide	Investigative	44559244	C31H47NO	449.7	C[C@@]12CCC[C@@]([C@H]1CC[C@@H]3C2=CC[C@](C3)(C)C=C)(C)C(=O)NCC45CC6CC(C4)CC(C6)C5	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BFG3A0	(1S,4As,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid but-3-enyl ester	Investigative	44403620	C21H28O3	328.4	C[C@]12CCC[C@]([C@@H]1CCC3=C2C=C(C=C3)O)(C)C(=O)OCCC=C	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BIN05R	Tetrahydro-carbazole, (+/-)13	Investigative	25218830	C22H20Cl3NO4S	500.8	C[C@]([C@@H]1CCC2=C(C1)NC3=C2C=C(C=C3)Cl)(C(=O)OC)S(=O)(=O)C4=CC(=C(C=C4)Cl)Cl	IC50 = 87900 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BJBC94	{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}(1H-Indol-7-ylmethyl)Amine	Investigative	45271480	C32H24F3N3	507.5	C1=CC=C(C=C1)CC2=CN=C3C(=C2C4=CC(=CC=C4)NCC5=CC=CC6=C5NC=C6)C=CC=C3C(F)(F)F	IC50 = 134000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BJR4A1	N-[4-[Benzyl-(2-chlorophenyl)sulfonylamino]-2-chlorophenyl]-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide	Investigative	44573634	C23H19Cl2F3N2O4S	547.4	CC(C(=O)NC1=C(C=C(C=C1)N(CC2=CC=CC=C2)S(=O)(=O)C3=CC=CC=C3Cl)Cl)(C(F)(F)F)O	EC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BK0O9S	Podocarpic acid	Investigative	93017	C17H22O3	274.35	C[C@]12CCC[C@]([C@@H]1CCC3=C2C=C(C=C3)O)(C)C(=O)O	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BK2W8Y	3-Benzyl-8-chloro-4-[3-[[2-chloro-5-(trifluoromethyl)phenyl]methoxy]phenyl]cinnoline	Investigative	11857210	C29H19Cl2F3N2O	539.4	C1=CC=C(C=C1)CC2=NN=C3C(=C2C4=CC(=CC=C4)OCC5=C(C=CC(=C5)C(F)(F)F)Cl)C=CC=C3Cl	IC50 = 147000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BOM56K	(1S,4As,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid pent-4-enyl ester	Investigative	44403625	C22H30O3	342.5	C[C@]12CCC[C@]([C@@H]1CCC3=C2C=C(C=C3)O)(C)C(=O)OCCCC=C	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BOT18U	N-[(4-Chloro-2-methylphenyl)methyl]-1-(4-chlorophenyl)-N-[(5-nitrothiophen-2-yl)methyl]methanamine	Investigative	71682479	C20H18Cl2N2O2S	421.3	CC1=C(C=CC(=C1)Cl)CN(CC2=CC=C(C=C2)Cl)CC3=CC=C(S3)[N+](=O)[O-]	IC50 = 63000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BQI50L	2-(4-(3-(3-Benzyl-8-(trifluoromethyl)quinolin-4-yl)benzylamino)-2,3-dimethylphenyl)acetic acid	Investigative	25226691	C34H29F3N2O2	554.6	CC1=C(C=CC(=C1C)NCC2=CC(=CC=C2)C3=C4C=CC=C(C4=NC=C3CC5=CC=CC=C5)C(F)(F)F)CC(=O)O	IC50 = 58000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BRC37D	1-(4-Chlorophenyl)-N-(pyridin-3-ylmethyl)-N-(1,3-thiazol-2-ylmethyl)methanamine	Investigative	71682791	C17H16ClN3S	329.8	C1=CC(=CN=C1)CN(CC2=CC=C(C=C2)Cl)CC3=NC=CS3	IC50 = 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BUHR84	Rosacea acid B	Investigative	44559230	C30H48O3	456.7	C[C@H](CC/C=C(\\C)/C(=O)O)[C@H]1CC[C@@]2([C@@]1(CC[C@@]3([C@H]2CC=C4[C@H]3CC[C@H](C4(C)C)O)C)C)C	EC50 ~ 50000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BUN7K8	3-Benzyl-8-chloro-4-(3-{[3-(trifluoromethyl)benzyl]oxy}phenyl)cinnoline	Investigative	11854315	C29H20ClF3N2O	504.9	C1=CC=C(C=C1)CC2=NN=C3C(=C2C4=CC(=CC=C4)OCC5=CC(=CC=C5)C(F)(F)F)C=CC=C3Cl	IC50 = 62000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BV2B1J	3-(4-(N-(3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-2-methylpropanamido)phenyl)-N-methylsulfamoyl)phenyl)propanoic acid	Investigative	44573719	C20H20ClF3N2O6S	508.9	CC(C(=O)NC1=C(C=C(C=C1)N(C)S(=O)(=O)C2=CC=C(C=C2)CCC(=O)O)Cl)(C(F)(F)F)O	EC50 ~ 100000 nM	Poor binder
T52297	Oxysterols receptor LXR-alpha	BYQO83	1-Adamantan-1-yl-3-((1S,4aS,10aR)-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-propane-1,3-dione	Investigative	44403589	C29H38O2	418.6	C[C@]12CCC[C@]([C@@H]1CCC3=CC=CC=C23)(C)C(=O)CC(=O)C45CC6CC(C4)CC(C6)C5	EC50 ~ 50000 nM	Poor binder