TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T53764	Prolyl endopeptidase FAP	D0L3DK	Vildagliptin	Approved	6918537	C17H25N3O2	303.4	C1C[C@H](N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C#N	IC50 = 73000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	D0NJ5H	Alogliptin	Approved	11450633	C18H21N5O2	339.4	CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[C@H](C3)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	D0T8XB	Anagliptin	Approved	44513473	C19H25N7O2	383.4	CC1=NN2C=C(C=NC2=C1)C(=O)NCC(C)(C)NCC(=O)N3CCC[C@H]3C#N	IC50 = 72700 nM	Poor binder
T53764	Prolyl endopeptidase FAP	D0U2JP	Sitagliptin	Approved	4369359	C16H15F6N5O	407.31	C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[C@@H](CC3=CC(=C(C=C3F)F)F)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	D0M3XR	MK-3102	Phase 3	46209133	C17H20F2N4O3S	398.4	CS(=O)(=O)N1C=C2CN(CC2=N1)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 67000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B12BGJ	(2R,3S,5R)-2-(2-Chloro-5-fluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73349220	C16H18ClFN4O	336.79	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)Cl)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B18IJR	(2R,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72188903	C16H18F2N4O	320.34	C1[C@@H](CO[C@@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 = 51000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B2LX9S	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethyl)-4,6-dihydro-1H-pyrrolo[3,4-d]imidazol-5-yl]oxan-3-amine	Investigative	73355286	C17H17F5N4O	388.33	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)N=C(N4)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B2Y9VJ	1-Benzyl-7-but-2-ynyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione	Investigative	22029894	C21H24N6O2	392.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B3B5YH	(2S)-1-(2-Benzyl-3-oxo-1H-isoindole-4-carbonyl)pyrrolidine-2-carbonitrile	Investigative	60195087	C21H19N3O2	345.4	C1C[C@H](N(C1)C(=O)C2=CC=CC3=C2C(=O)N(C3)CC4=CC=CC=C4)C#N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B45EFX	(1S,2R,5R)-5-(11-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	127051639	C21H22F3N5	401.4	CC1=NC2=C3CN(CC3=NN2C=C1)[C@@H]4CC[C@@H]([C@H](C4)N)C5=CC(=C(C=C5F)F)F	IC50 = 57000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B4G7MW	(2R,3S,5R)-2-(2,4-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73350799	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=C(C=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B4NG8J	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127049204	C20H21F2N5O	385.4	CC1=NC2=C3CN(CC3=NN2C=C1)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B4QZL7	(2R,3S,5R)-5-(2-Cyclopropyl-5,5-dimethyl-7H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	73352283	C22H26F2N4O	400.5	CC1(C2=CN=C(N=C2CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N)C5CC5)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B5L6RD	2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole	Investigative	10383508	C20H26N4O2	354.4	CC(C)(CC(=O)N1CC2=CC=CC=C2C1)NCC(=O)N3CCC[C@H]3C#N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B6L7QG	CID 44123747	Investigative	44123747	C22H25FN6O2	424.5	C[C@]1(CCCN(C1)C2=CC3=C(N2CC4=C(C=CC(=C4)F)C#N)C(=O)N(C(=O)N3C)C)N	IC50 ~ 50000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B70SUP	7-But-2-ynyl-3-methyl-1-[(5-methyl-2-phenyltriazol-4-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189870	C24H27N9O2	473.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=NN(N=C4C)C5=CC=CC=C5)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B72UBN	US9051329, Example 2	Investigative	71203783	C21H22N8O2	418.5	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=CC=CC=C5C#N	IC50 = 53600 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B75EWK	7-But-2-ynyl-3-methyl-8-piperazin-1-yl-1-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]purine-2,6-dione	Investigative	122189871	C23H25N9O2	459.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)N5C=NC=N5)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B7O6VW	7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione	Investigative	122189865	C22H22N6O3	418.4	CCOC1=NC2=C(N1CC#CC)C(=O)N(C(=O)N2C)CC3=NC4=CC=CC=C4C(=N3)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B91XGN	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189875	C14H16N6O3	316.32	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B9JP6T	2-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-3H-isoindol-1-one	Investigative	73347698	C19H18F2N2O2	344.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CC=CC=C4C3=O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	B9OZE8	3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	47370344	C11H14N6O3	278.27	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)NC2=O)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BA84EQ	(2R,3S,5S)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine	Investigative	127048876	C20H20F3N5O	403.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 91000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BB2SI7	CID 68845950	Investigative	68845950	C16H18F2N4O	320.34	C1[C@@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BB7XV5	(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one	Investigative	46916387	C18H21N3O3S	359.4	C1CSCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 50000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BB9AT8	7-But-2-ynyl-1-[[2-(hydroxymethyl)-1,3-thiazol-4-yl]methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione	Investigative	122189864	C19H23N7O3S	429.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CSC(=N4)CO)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BBL8H4	(2R,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72188904	C16H18F2N4O	320.34	C1[C@H](CO[C@@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BBQ08T	(1S,2R,5S)-5-(3-(Trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	44431316	C19H20F6N4	418.4	C1CC([C@H](C[C@H]1N2CCN3C(=NC=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 = 60000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BC3O6M	2-[4-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]phenyl]benzonitrile	Investigative	122189869	C28H27N7O2	493.6	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)C5=CC=CC=C5C#N)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BCJM04	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]oxan-3-amine	Investigative	73353756	C17H18F5N5O	403.35	C1CN2C(=NN=C2C(F)(F)F)CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BCU2D7	(2R,3S,5R)-5-(2-Cyclopropyl-7,7-dimethyl-5H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	73353757	C22H26F2N4O	400.5	CC1(C2=NC(=NC=C2CN1[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N)C5CC5)C	IC50 = 75000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BD70UI	(2R,3S,5R)-2-(2-Chlorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73353758	C16H19ClN4O	318.8	C1[C@H](CO[C@@H]([C@H]1N)C2=CC=CC=C2Cl)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BEF9T1	Allo-Ile-Isoindoline	Investigative	24784416	C14H20N2O	232.32	CC[C@@H](C)[C@@H](C(=O)N1CC2=CC=CC=C2C1)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BEO4P7	(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938499	C24H32N4O4	440.5	CC(C)(C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BF0D1S	US9051329, Example 1	Investigative	71203752	C21H21F4N7O2	479.4	CN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BF1PL7	(2R,3S,5R)-5-(3H-1,2-Benzoxazol-2-yl)-2-(2,5-difluorophenyl)oxan-3-amine	Investigative	73350798	C18H18F2N2O2	332.3	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=CC=CC=C4O3	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BF5C8N	8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-propan-2-ylpurine-2,6-dione	Investigative	122189874	C18H26N6O2	358.4	CC#CCN1C2=C(N=C1N3CCC[C@H](C3)N)N(C(=O)N(C2=O)C(C)C)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BF5N2S	(2R)-2-[4-[[[(2S)-1-(2-Amino-2-cyclohexylacetyl)pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid	Investigative	49796938	C27H38F3N3O7	573.6	CC(C)[C@H](C(=O)O)OC1=CC=C(C=C1)CNC(=O)[C@@H]2CCCN2C(=O)C(C3CCCCC3)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BFI0Y3	(2r,3s,5r)-2-(2,5-Difluorophenyl)-5-(7h-Pyrrolo[3',4':3,4]pyrazolo[1,5-A]pyrimidin-8(9h)-Yl)oxan-3-Amine	Investigative	24951732	C19H19F2N5O	371.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C5N=CC=CN5N=C4C3	IC50 = 62000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BGU6X1	2-[4-[[[(4R)-3-[3-Amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetic acid;2,2,2-trifluoroacetic acid	Investigative	49796940	C25H27F4N3O6S	573.6	C1[C@H](N(CS1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCC3=CC=C(C=C3)CC(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BH0S9T	(2S,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193503	C16H18F2N4O	320.34	C1[C@H](CO[C@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BH2YG8	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796945	C25H26F7N3O4	565.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCC3=CC=C(C=C3)C(F)(F)F.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BHW27S	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione	Investigative	122189872	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CN=CC=C4)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BJ1ZB7	(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide	Investigative	46938602	C20H24N4O4	384.4	C1C[C@H](N(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3)C(=O)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BJF84U	(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Investigative	49796942	C22H29F4N7O4	531.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC=CC=C2F)N)C(=O)NCCCCC3=NNN=N3.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BKB15R	(1S,2R,5R)-5-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	44431317	C18H19F6N5	419.4	C1CC([C@H](C[C@@H]1N2CCN3C(=NN=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BKTP80	(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one	Investigative	46938802	C19H23N3O3	341.4	C1CCN(C1)C(=O)[C@@H]2C[C@H](C(=O)N2)CC(=O)N3CC4=CC=CC=C4C3	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BL82NA	1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189876	C21H22N8O4	450.5	CN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BMX32J	3-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]benzonitrile	Investigative	22029457	C22H23N7O2	417.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC(=CC=C4)C#N)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BN9WM6	2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide	Investigative	122189867	C22H22N8O3	446.5	CC#CCN1C2=C(N=C1NCC(=O)N)N(C(=O)N(C2=O)CC3=NC4=CC=CC=C4C(=N3)C)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BNH8A6	[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acid	Investigative	71655395	C15H22BN3O4	319.17	B([C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)C2=CN=CC=C2)(O)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BNV4S9	US9051329, Example 8	Investigative	71203746	C22H23F4N7O2	493.5	CCN1C(=O)CN2C1=NC3=C(C2=O)N(C(=N3)N4CCC[C@H](C4)N)CC5=C(C=CC(=C5)F)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BO34KM	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]oxazol-5-yl)oxan-3-amine	Investigative	73355285	C17H19F2N3O2	335.35	CC1=NC2=C(O1)CN(C2)[C@@H]3C[C@@H]([C@H](OC3)C4=C(C=CC(=C4)F)F)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BO7R2A	4-[(3R,5S,6R)-5-Amino-6-(2,4,5-trifluorophenyl)oxan-3-yl]-11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),10-trien-9-one	Investigative	127049507	C20H20F3N5O2	419.4	CC1=CC(=O)N2C(=N1)C3=C(N2)CN(C3)[C@@H]4C[C@@H]([C@H](OC4)C5=CC(=C(C=C5F)F)F)N	IC50 = 55000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BR1O8U	(1S,2R,5R)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine	Investigative	127048875	C21H22F3N5	401.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@@H]4CC[C@@H]([C@H](C4)N)C5=CC(=C(C=C5F)F)F	IC50 = 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BSAY01	(2R,3S,5R)-2-(4-Chloro-2,5-difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	73346173	C16H17ClF2N4O	354.78	C1[C@H](CO[C@@H]([C@H]1N)C2=CC(=C(C=C2F)Cl)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BSPH26	(S)-3-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethylamino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide	Investigative	11596219	C20H28N4O4	388.5	CC(C)(CC(=O)NC1=CC(=C(C=C1)OC)OC)NCC(=O)N2CCC[C@H]2C#N	IC50 ~ 50000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BT04CA	1-[4-(1H-Pyrazole-1-yl)benzyl]-3-methyl-7-(2-butynyl)-8-piperazinoxanthine	Investigative	101887275	C24H26N8O2	458.5	CC#CCN1C2=C(N=C1N3CCNCC3)N(C(=O)N(C2=O)CC4=CC=C(C=C4)N5C=CC=N5)C	IC50 ~ 50000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BT1C8X	(2S)-1-[(2S)-2-Amino-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-4-oxobutanoyl]pyrrolidine-2-carbonitrile	Investigative	23646026	C26H29F2N5O2	481.5	C1C[C@H](N(C1)C(=O)[C@H](CC(=O)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)N)C#N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BT82FY	2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one	Investigative	11232123	C16H24ClN3O	309.83	C1CCN(CC1)C(=O)[C@H](CCNCC2=CC=CC=C2Cl)N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BU8OS2	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,10,12-pentazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	24952089	C18H18F2N6O	372.4	C1[C@H](CO[C@@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C5N=CN=CN5N=C4C3	IC50 = 58000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BUQY47	(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine	Investigative	127050762	C20H21F2N5O	385.4	CC1=CC=NC2=C3CN(CC3=NN12)[C@@H]4C[C@@H]([C@H](OC4)C5=C(C=CC(=C5)F)F)N	IC50 = 77000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BUS09Q	(2S,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193502	C16H18F2N4O	320.34	C1[C@@H](CO[C@H]([C@@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BV3G9D	4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid	Investigative	49796939	C25H26F5N3O6	559.5	C1C[C@H](N(C1)C(=O)CC(CC2=CC(=C(C=C2)F)F)N)C(=O)NCC3=CC=C(C=C3)C(=O)O.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BV9FP3	N-Benzyl-2-[(2S)-2-cyanopyrrolidine-1-carbonyl]benzamide	Investigative	60195086	C20H19N3O2	333.4	C1C[C@H](N(C1)C(=O)C2=CC=CC=C2C(=O)NCC3=CC=CC=C3)C#N	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BV9NG7	(2S,3As,6aS)-1-[(3R)-3-amino-4-(2-methylphenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712779	C19H25N3O	311.4	CC1=CC=CC=C1C[C@H](CC(=O)N2[C@H]3CCC[C@H]3C[C@H]2C#N)N	IC50 = 109880 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BWZC31	7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione	Investigative	122189873	C20H21N7O3	407.4	CC#CCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=CC=NC=C4)C	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BX0H4O	(2S,3As,6aS)-1-[(3R)-3-amino-4-(4-fluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile	Investigative	118712781	C18H22FN3O	315.4	C1C[C@H]2C[C@H](N([C@H]2C1)C(=O)C[C@@H](CC3=CC=C(C=C3)F)N)C#N	IC50 = 153700 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BX4WD0	1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione	Investigative	122189878	C26H30N8O4	518.6	CC(=CCCN1C2=C(N=C1N3CCNC(=O)C3)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)OC)C)C	IC50 ~ 50000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BX5EA9	(1S,2R,5S)-5-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-A]pyrazin-7(8H)-YL]-2-(2,4,5-trifluorophenyl)cyclohexanamine	Investigative	11538992	C18H19F6N5	419.4	C1C[C@@H]([C@H](C[C@H]1N2CCN3C(=NN=C3C(F)(F)F)C2)N)C4=CC(=C(C=C4F)F)F	IC50 = 60000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BXT1B4	(2S,3S,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine	Investigative	72193505	C16H18F2N4O	320.34	C1[C@@H](CO[C@H]([C@H]1N)C2=C(C=CC(=C2)F)F)N3CC4=C(C3)NN=C4	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BYCI63	(1S,2R,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)cyclohexan-1-amine	Investigative	127052290	C21H23F2N5	383.4	CC1=NN2C3=C(CN(C3)[C@@H]4CC[C@@H]([C@H](C4)N)C5=C(C=CC(=C5)F)F)C=NC2=C1	IC50 = 53000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BYT61V	Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid	Investigative	49796933	C26H29F4N3O6S	587.6	COC(=O)CC1=CC=C(C=C1)CNC(=O)[C@@H]2CSCN2C(=O)CC(CC3=CC=CC=C3F)N.C(=O)(C(F)(F)F)O	IC50 ~ 100000 nM	Poor binder
T53764	Prolyl endopeptidase FAP	BYX21O	2-Benzyl-7-(pyrrolidine-1-carbonyl)-3H-isoindol-1-one	Investigative	60195088	C20H20N2O2	320.4	C1CCN(C1)C(=O)C2=CC=CC3=C2C(=O)N(C3)CC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder