TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T55654	cAMP-dependent chloride channel	B16UVR	5,7-Dimethyl-2-[4-(pyridine-3-carbonyl)piperazin-1-yl]quinoline-3-carbonitrile	Investigative	56954960	C22H21N5O	371.4	CC1=CC(=C2C=C(C(=NC2=C1)N3CCN(CC3)C(=O)C4=CN=CC=C4)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B1LIA2	10-Chloro-5-propylbenzo[c]quinolizin-11-ium-6-ol;chloride	Investigative	11370263	C16H15Cl2NO	308.2	CCCC1=C(C2=C(C(=CC=C2)Cl)[N+]3=CC=CC=C13)O.[Cl-]	EC50 = 54200 nM	Poor binder
T55654	cAMP-dependent chloride channel	B2QCE3	5,7-Dimethyl-2-[4-(pyridine-2-carbonyl)piperazin-1-yl]quinoline-3-carbonitrile	Investigative	56954842	C22H21N5O	371.4	CC1=CC(=C2C=C(C(=NC2=C1)N3CCN(CC3)C(=O)C4=CC=CC=N4)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B30MRC	Chembl4243267	Investigative	145985497	C21H33NO2	331.5	CCCCCCCCC[C@@H]1C[C@@H]([C@H]2CN1O[C@@H]2C3=CC=CC=C3)O	IC50 = 58620 nM	Poor binder
T55654	cAMP-dependent chloride channel	B38YMI	1-(6-Benzyl-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)piperidine-4-carboxamide	Investigative	127040623	C25H28N6O	428.5	C1CN(CCC1C(=O)N)C2=NC(=NC3=C2CN(CC3)CC4=CC=CC=C4)C5=CN=CC=C5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B3HW5N	2-[4-(2-Methoxybenzoyl)piperazin-1-yl]-5,7-dimethylquinoline-3-carbonitrile	Investigative	46904956	C24H24N4O2	400.5	CC1=CC(=C2C=C(C(=NC2=C1)N3CCN(CC3)C(=O)C4=CC=CC=C4OC)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B4Q1LD	2-[4-(3-Methoxybenzoyl)piperazin-1-yl]-5,7-dimethylquinoline-3-carbonitrile	Investigative	46904957	C24H24N4O2	400.5	CC1=CC(=C2C=C(C(=NC2=C1)N3CCN(CC3)C(=O)C4=CC(=CC=C4)OC)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B4XT9A	Ethyl 10-fluoro-6-hydroxybenzo[c]quinolizin-11-ium-5-carboxylate;chloride	Investigative	10087442	C16H13ClFNO3	321.73	CCOC(=O)C1=C(C2=C(C(=CC=C2)F)[N+]3=CC=CC=C13)O.[Cl-]	EC50 = 70500 nM	Poor binder
T55654	cAMP-dependent chloride channel	B54CYE	2-[4-(6-Benzyl-2-pyridin-4-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)piperazin-1-yl]-N,N-dimethylethanamine	Investigative	127040948	C27H35N7	457.6	CN(C)CCN1CCN(CC1)C2=NC(=NC3=C2CN(CC3)CC4=CC=CC=C4)C5=CC=NC=C5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B71EIB	6-Benzyl-N-[3-(4-methylpiperazin-1-yl)propyl]-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-amine	Investigative	127040945	C27H35N7	457.6	CN1CCN(CC1)CCCNC2=NC(=NC3=C2CN(CC3)CC4=CC=CC=C4)C5=CN=CC=C5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B9P2AF	Disodium;4-[(Z)-[4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene]methyl]benzene-1,3-disulfonate	Investigative	44562178	C17H8F3NNa2O7S4	569.5	C1=CC(=CC(=C1)N2C(=O)/C(=C/C3=C(C=C(C=C3)S(=O)(=O)[O-])S(=O)(=O)[O-])/SC2=S)C(F)(F)F.[Na+].[Na+]	IC50 = 50000 nM	Poor binder
T55654	cAMP-dependent chloride channel	B9Y7EU	N-[3-[(3-Cyano-5,7-dimethylquinolin-2-yl)amino]propyl]-2-methoxybenzamide	Investigative	46904959	C23H24N4O2	388.5	CC1=CC(=C2C=C(C(=NC2=C1)NCCCNC(=O)C3=CC=CC=C3OC)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BA8U1Z	2-[4-(4-Methoxybenzoyl)piperazin-1-yl]-5,7-dimethylquinoline-3-carbonitrile	Investigative	46904958	C24H24N4O2	400.5	CC1=CC(=C2C=C(C(=NC2=C1)N3CCN(CC3)C(=O)C4=CC=C(C=C4)OC)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BAW7P1	2-[4-[6-(Benzenesulfonyl)-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-N,N-dimethylethanamine	Investigative	127042200	C26H33N7O2S	507.7	CN(C)CCN1CCN(CC1)C2=NC(=NC3=C2CN(CC3)S(=O)(=O)C4=CC=CC=C4)C5=CC=CC=N5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BAZK94	6-Benzyl-N-[3-(4-methylpiperazin-1-yl)propyl]-2-pyridin-4-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-amine	Investigative	127040947	C27H35N7	457.6	CN1CCN(CC1)CCCNC2=NC(=NC3=C2CN(CC3)CC4=CC=CC=C4)C5=CC=NC=C5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BC4X1S	[4-[4-[2-(Dimethylamino)ethyl]piperazin-1-yl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-phenylmethanone	Investigative	127042199	C27H33N7O	471.6	CN(C)CCN1CCN(CC1)C2=NC(=NC3=C2CN(CC3)C(=O)C4=CC=CC=C4)C5=CC=CC=N5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BE3CH5	2-[4-[6-[(4-Methoxyphenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-N,N-dimethylethanamine	Investigative	127041267	C28H37N7O	487.6	CN(C)CCN1CCN(CC1)C2=NC(=NC3=C2CN(CC3)CC4=CC=C(C=C4)OC)C5=CC=CC=N5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BE56AG	2-(1-Hydroxypentyl)-6-methyl-3-(2-phenylethyl)-1H-Indole-5-carboxylic acid	Investigative	11530695	C23H27NO3	365.5	CCCCC(C1=C(C2=C(N1)C=C(C(=C2)C(=O)O)C)CCC3=CC=CC=C3)O	IC50 = 160000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BEH57F	N-[2-[(3-Cyano-5,7-dimethylquinolin-2-yl)amino]ethyl]benzamide	Investigative	43815411	C21H20N4O	344.4	CC1=CC(=C2C=C(C(=NC2=C1)NCCNC(=O)C3=CC=CC=C3)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BFE47A	4-(1,3-Benzodioxol-5-yl)-N-(3-methylsulfanylphenyl)-1,3-thiazol-2-amine	Investigative	58910531	C17H14N2O2S2	342.4	CSC1=CC=CC(=C1)NC2=NC(=CS2)C3=CC4=C(C=C3)OCO4	EC50 = 71000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BH9A7X	N-[3-[(3-Cyano-5,7-dimethylquinolin-2-yl)amino]propyl]pyridine-2-carboxamide	Investigative	56954962	C21H21N5O	359.4	CC1=CC(=C2C=C(C(=NC2=C1)NCCCNC(=O)C3=CC=CC=N3)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BIG43C	Ethyl 5-[2-(3-methylsulfanylanilino)-1,3-thiazol-4-yl]-1,2-oxazole-3-carboxylate	Investigative	122183965	C16H15N3O3S2	361.4	CCOC(=O)C1=NOC(=C1)C2=CSC(=N2)NC3=CC(=CC=C3)SC	EC50 = 58000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BIL2G1	2-[4-[6-[(4-Fluorophenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-N,N-dimethylethanamine	Investigative	127041881	C27H34FN7	475.6	CN(C)CCN1CCN(CC1)C2=NC(=NC3=C2CN(CC3)CC4=CC=C(C=C4)F)C5=CC=CC=N5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BJUT61	10-Chloro-6-hydroxybenzo [c]quinolizinium chloride	Investigative	9795307	C13H9Cl2NO	266.12	C1=CC=[N+]2C(=C1)C=C(C3=C2C(=CC=C3)Cl)O.[Cl-]	EC50 = 141000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BK4LY5	6-(4-Hydroxy-2-methoxyphenyl)-7,9-dimethyl-11-phenyl-6,7-dihydropyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9H)-dione	Investigative	46265619	C28H24N4O4	480.5	CN1C2=C3C(NC4=CC=CC=C4N3C(=C2C(=O)N(C1=O)C)C5=CC=CC=C5)C6=C(C=C(C=C6)O)OC	IC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BM71UD	N-[2-[(3-Cyano-5,7-dimethylquinolin-2-yl)amino]ethyl]pyridine-2-carboxamide	Investigative	53382958	C20H19N5O	345.4	CC1=CC(=C2C=C(C(=NC2=C1)NCCNC(=O)C3=CC=CC=N3)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BQE9T8	2-(4-Carboxybutyl)-3-(hydroxymethyl)-5-methyl-1-phenethyl-1H-indole-6-carboxylic acid	Investigative	24882564	C24H27NO5	409.5	CC1=CC2=C(C=C1C(=O)O)N(C(=C2CO)CCCCC(=O)O)CCC3=CC=CC=C3	IC50 = 170000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BR5W3K	7-Chloro-6-hydroxypyrido[1,2-a]quinolinium chloride	Investigative	386896	C13H9Cl2NO	266.12	C1=CC=[N+]2C3=C(C(=CC=C3)Cl)C(=CC2=C1)O.[Cl-]	EC50 = 146000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BV62BG	N-[1-[6-[(4-Chlorophenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]pyrrolidin-3-yl]-N-ethylacetamide	Investigative	127042202	C27H31ClN6O	491	CCN(C1CCN(C1)C2=NC(=NC3=C2CN(CC3)CC4=CC=C(C=C4)Cl)C5=CC=CC=N5)C(=O)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BW5YM1	4-(3-Chlorophenyl)-N-(3-methylsulfanylphenyl)-1,3-thiazol-2-amine	Investigative	122183935	C16H13ClN2S2	332.9	CSC1=CC=CC(=C1)NC2=NC(=CS2)C3=CC(=CC=C3)Cl	EC50 = 53000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BWF3M4	2-[4-(6-Benzyl-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)piperazin-1-yl]acetamide	Investigative	127040944	C25H29N7O	443.5	C1CN(CC2=C1N=C(N=C2N3CCN(CC3)CC(=O)N)C4=CN=CC=C4)CC5=CC=CC=C5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BWG3I2	2-[4-(6-Benzyl-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl)piperazin-1-yl]-N,N-dimethylethanamine	Investigative	127040946	C27H35N7	457.6	CN(C)CCN1CCN(CC1)C2=NC(=NC3=C2CN(CC3)CC4=CC=CC=C4)C5=CN=CC=C5	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	BWP6A4	5,7-Dimethyl-2-[4-(pyridine-4-carbonyl)piperazin-1-yl]quinoline-3-carbonitrile	Investigative	56954961	C22H21N5O	371.4	CC1=CC(=C2C=C(C(=NC2=C1)N3CCN(CC3)C(=O)C4=CC=NC=C4)C#N)C	EC50 = 100000 nM	Poor binder
T55654	cAMP-dependent chloride channel	D00RIX	APIGENIN	Investigative	5280443	C15H10O5	270.24	C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O	Ki = 81000 nM	Poor binder