TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T60330 P2X purinoceptor 4 D04MSM Carbamazepine Approved 2554 C15H12N2O 236.27 C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 D08NLQ Licarbazepine Discontinued in Phase 3 114709 C15H14N2O2 254.28 C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B0SZG5 2-Methylbenzo[b][1]benzazepine-11-carboxamide Investigative 59586810 C16H14N2O 250.29 CC1=CC2=C(C=C1)C=CC3=CC=CC=C3N2C(=O)N IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B25UQB 2-Azatetracyclo[9.8.0.03,8.012,17]nonadeca-1(11),3,5,7,9,12,14,16,18-nonaene-2-carboxamide Investigative 76324697 C19H14N2O 286.3 C1=CC=C2C(=C1)C=CC3=C2C=CC4=CC=CC=C4N3C(=O)N IC50 = 51400 nM Poor binder T60330 P2X purinoceptor 4 B30VNW Benzo[b][1]benzazepin-11-yl-(4-hydroxypiperidin-1-yl)methanone Investigative 76321049 C20H20N2O2 320.4 C1CN(CCC1O)C(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B48DBY N,N-Dimethylbenzo[b][1]benzazepine-11-carboxamide Investigative 76331932 C17H16N2O 264.32 CN(C)C(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B4X5YP Benzo[b][1]benzazepin-11-yl(morpholin-4-yl)methanone Investigative 779112 C19H18N2O2 306.4 C1COCCN1C(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B5A0UJ N-Methylbenzo[b][1]benzazepine-11-carboxamide Investigative 738915 C16H14N2O 250.29 CNC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B5BK6E 5-Ethoxy-5,6-dihydrobenzo[b][1]benzazepine-11-carboxamide Investigative 2847675 C17H18N2O2 282.34 CCOC1CC2=CC=CC=C2N(C3=CC=CC=C13)C(=O)N IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B6SA2F 3-Hydroxycarbamazepine Investigative 135290 C15H12N2O2 252.27 C1=CC=C2C(=C1)C=CC3=C(N2C(=O)N)C=C(C=C3)O IC50 = 72800 nM Poor binder T60330 P2X purinoceptor 4 B76IRJ 5-Acetyl-5H-dibenz[b,f]azepine Investigative 606375 C16H13NO 235.28 CC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B78NFD N-[3-(Dimethylamino)propyl]-5H-dibenzo[b,f]azepine-5-carboxamide Investigative 3136467 C20H23N3O 321.4 CN(C)CCCNC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 = 100000 nM Poor binder T60330 P2X purinoceptor 4 B7CKL1 10,11-Dihydrocarbamazepine Investigative 19099 C15H14N2O 238.28 C1CC2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B7N9TC 2-Fluorocarbamazepine Investigative 67474845 C15H11FN2O 254.26 C1=CC=C2C(=C1)C=CC3=C(N2C(=O)N)C=CC(=C3)F IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 B8SJ6K 2-Methylpropyl benzo[b][1]benzazepine-11-carboxylate Investigative 76313803 C19H19NO2 293.4 CC(C)COC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 = 100000 nM Poor binder T60330 P2X purinoceptor 4 BB20FW 11-Benzylbenzo[b][1]benzazepine Investigative 12323384 C21H17N 283.4 C1=CC=C(C=C1)CN2C3=CC=CC=C3C=CC4=CC=CC=C42 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BD3Q4Z Methyl benzo[b][1]benzazepine-11-carboxylate Investigative 2893185 C16H13NO2 251.28 COC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 = 100000 nM Poor binder T60330 P2X purinoceptor 4 BE09PZ Methyl phenoxazine-10-carboxylate Investigative 71452007 C14H11NO3 241.24 COC(=O)N1C2=CC=CC=C2OC3=CC=CC=C31 IC50 = 52300 nM Poor binder T60330 P2X purinoceptor 4 BE2F9W NF 023 hydrate Investigative 6093160 C35H20N4Na6O21S6 1162.9 C1=CC(=CC(=C1)NC(=O)NC2=CC=CC(=C2)C(=O)NC3=C4C(=CC(=CC4=C(C=C3)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C(=O)NC5=C6C(=CC(=CC6=C(C=C5)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BEJ5H1 11-N,11-N-Diethyl-1-N,1-N-di(propan-2-yl)benzo[b][1]benzazepine-1,11-dicarboxamide Investigative 76313802 C26H33N3O2 419.6 CCN(CC)C(=O)N1C2=CC=CC=C2C=CC3=C1C(=CC=C3)C(=O)N(C(C)C)C(C)C IC50 = 52500 nM Poor binder T60330 P2X purinoceptor 4 BJWE75 N,N-Diethylpyrido[3,4-b][1]benzazepine-11-carboxamide Investigative 76331934 C18H19N3O 293.4 CCN(CC)C(=O)N1C2=CC=CC=C2C=CC3=C1C=NC=C3 IC50 = 100000 nM Poor binder T60330 P2X purinoceptor 4 BK1PR0 N,N-Bis(2-hydroxyethyl)benzo[b][1]benzazepine-11-carboxamide Investigative 76321048 C19H20N2O3 324.4 C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N(CCO)CCO IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BM0YW7 2-Methoxybenzo[b][1]benzazepine-11-carboxamide Investigative 70515212 C16H14N2O2 266.29 COC1=CC2=C(C=CC3=CC=CC=C3N2C(=O)N)C=C1 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BMI50L (S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate Investigative 5312126 C38H35N5O6S2 721.8 CN([C@@H](CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7 EC50 = 100000 nM Poor binder T60330 P2X purinoceptor 4 BQV9W2 10-Methoxycarbamazepine Investigative 120031 C16H14N2O2 266.29 COC1=CC2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BS2N4I N-[2-(Dimethylamino)ethyl]-N-methylbenzo[b][1]benzazepine-11-carboxamide Investigative 76310105 C20H23N3O 321.4 CN(C)CCN(C)C(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BSVJ39 N-Pyridin-4-ylbenzo[b][1]benzazepine-11-carboxamide Investigative 76331933 C20H15N3O 313.4 C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)NC4=CC=NC=C4 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BSX27C N-Butylbenzo[b][1]benzazepine-11-carboxamide Investigative 76321046 C19H20N2O 292.4 CCCCNC(=O)N1C2=CC=CC=C2C=CC3=CC=CC=C31 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BUH9G2 N-Benzylbenzo[b][1]benzazepine-11-carboxamide Investigative 76335512 C22H18N2O 326.4 C1=CC=C(C=C1)CNC(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42 IC50 = 78900 nM Poor binder T60330 P2X purinoceptor 4 BWEX87 N-(1-Methylpiperidin-4-yl)benzo[b][1]benzazepine-11-carboxamide Investigative 76321047 C21H23N3O 333.4 CN1CCC(CC1)NC(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42 IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BWJ3D0 2-Fluorobenzo[b][1]benzazepine-11-carboxamide Investigative 76328256 C15H11FN2O 254.26 C1=CC=C2C(=C1)C=CC3=C(N2C(=O)N)C=C(C=C3)F IC50 ~ 100000 nM Poor binder T60330 P2X purinoceptor 4 BWR6T7 2-Hydroxycarbamazepine Investigative 129274 C15H12N2O2 252.27 C1=CC=C2C(=C1)C=CC3=C(N2C(=O)N)C=CC(=C3)O IC50 = 146000 nM Poor binder T60330 P2X purinoceptor 4 BZG62P Dibenzo[b,f]azepin-5-yl-N-benzamide Investigative 4281839 C21H16N2O 312.4 C1=CC=C(C=C1)NC(=O)N2C3=CC=CC=C3C=CC4=CC=CC=C42 IC50 = 100000 nM Poor binder T60330 P2X purinoceptor 4 BZIF30 2-(Trifluoromethyl)benzo[b][1]benzazepine-11-carboxamide Investigative 76324696 C16H11F3N2O 304.27 C1=CC=C2C(=C1)C=CC3=C(N2C(=O)N)C=C(C=C3)C(F)(F)F IC50 = 54600 nM Poor binder T60330 P2X purinoceptor 4 D0B0ZQ RB 2 Investigative 9875920 C29H17ClN7Na3O11S3 840.1 C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3NC4=CC(=C(C=C4)NC5=NC(=NC(=N5)NC6=CC(=CC=C6)S(=O)(=O)[O-])Cl)S(=O)(=O)[O-])S(=O)(=O)[O-])N.[Na+].[Na+].[Na+] EC50 = 128000 nM Poor binder