TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T60631	Proto-oncogene c-Ret	D0Y3DN	Flavonoid derivative 4	Patented	5280343	C15H10O7	302.23	C1=CC(=C(C=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O)O	IC50 = 78100 nM	Poor binder
T60631	Proto-oncogene c-Ret	B0B2DO	N-(3-Bromophenyl)-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)acetamide	Investigative	118712373	C21H16BrN3O	406.3	C1=CC(=CC(=C1)Br)NC(=O)CC2=CC=C(C=C2)C3=CN4C=CN=C4C=C3	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B0TS9Z	3-(6-Fluoro-1H-benzimidazol-2-yl)-5-pyridin-3-yl-2H-pyrazolo[3,4-b]pyridine	Investigative	135497831	C18H11FN6	330.3	C1=CC(=CN=C1)C2=CC3=C(NN=C3N=C2)C4=NC5=C(N4)C=C(C=C5)F	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B17HJV	2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid	Investigative	136118033	C23H14N6O2	406.4	C1=CC=C2C(=C1)C=NC=C2C3=CC4=C(NN=C4N=C3)C5=NC6=C(C=CC=C6N5)C(=O)O	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B1BGK6	N-Methyl(5-(3-(5-(trifluoromethoxy)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)methanamine	Investigative	135497834	C21H16F3N7O	439.4	CNCC1=CC(=CN=C1)C2=CC3=C(NN=C3N=C2)C4=NC5=C(N4)C=C(C=C5)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B26WGE	4-(3-(4-(Isopropoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline	Investigative	135497877	C26H22N6O	434.5	CC(C)OCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B2FR4J	N-[2-(Dimethylamino)ethyl]-2-(5-isoquinolin-4-yl-2H-pyrazolo[3,4-b]pyridin-3-yl)-N-methyl-3H-benzimidazole-5-carboxamide	Investigative	136086927	C28H26N8O	490.6	CN(C)CCN(C)C(=O)C1=CC2=C(C=C1)N=C(N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B46PUS	(E)-5-Amino-3-(5-bromo-furan-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	46233146	C13H9BrN2O2	305.13	C1=CC2=C(C=C1N)/C(=C\\C3=CC=C(O3)Br)/C(=O)N2	IC50 = 66000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B49VLE	3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one	Investigative	6450842	C17H16N2O	264.32	CN(C)C1=CC=C(C=C1)/C=C\\2/C3=CC=CC=C3NC2=O	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B4QPA8	(E)-5-Amino-3-(4-methoxybenzylidene)indolin-2-one	Investigative	46233143	C16H14N2O2	266.29	COC1=CC=C(C=C1)/C=C/2\\C3=C(C=CC(=C3)N)NC2=O	IC50 = 63000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B4WI8A	(E)-5-Nitro-3-(5-thiophen-3-yl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one	Investigative	46233110	C17H10N2O4S	338.3	C1=CC2=C(C=C1[N+](=O)[O-])/C(=C\\C3=CC=C(O3)C4=CSC=C4)/C(=O)N2	IC50 = 78000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B63CRF	3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridine	Investigative	136118034	C19H15N7O	357.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CN=C5	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B69YJX	(2-(5-(Isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methanol	Investigative	135497853	C23H16N6O	392.4	C1=CC=C2C(=C1)C=NC=C2C3=CC4=C(NN=C4N=C3)C5=NC6=C(C=CC=C6N5)CO	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B6T4LS	(3Z)-5-Methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one	Investigative	23647607	C14H12N2O	224.26	CC1=CC\\2=C(C=C1)NC(=O)/C2=C\\C3=CC=CN3	IC50 = 66000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B7GE1T	1-Phenyl-N-[3-[[[1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide	Investigative	76318365	C27H26N6O2S	498.6	C1=CC=C(C=C1)CCN2C3=NC=NC(=C3C=N2)NCC4=CC(=CC=C4)NS(=O)(=O)CC5=CC=CC=C5	IC50 = 58600 nM	Poor binder
T60631	Proto-oncogene c-Ret	B7OC2K	N-(2-Fluorophenyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Investigative	44416036	C17H12FN5	305.31	C1=CC=C(C(=C1)NC2=NC=CC(=N2)C3=CNC4=C3C=CC=N4)F	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B8AK4E	N-((2-(5-(Isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methyl)propan-2-amine	Investigative	135497865	C26H23N7	433.5	CC(C)NCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	B9WT5K	5-[(1E)-{[3-(Dimethylamino)propoxy]imino}methyl]-6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]pyrimidin-4-amine	Investigative	23646063	C19H23FN6O2	386.4	CC1=CC2=C(N1)C=CC(=C2F)OC3=NC=NC(=C3/C=N/OCCCN(C)C)N	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BC87JM	(Z)-4-Methyl-3-(4-morpholinobenzylidene)indolin-2-one	Investigative	10663503	C20H20N2O2	320.4	CC1=C\\2C(=CC=C1)NC(=O)/C2=C\\C3=CC=C(C=C3)N4CCOCC4	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BCX9K5	4-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline	Investigative	136118031	C25H20N6O	420.5	CN1C2=C(C=C(C=N2)C3=CN=CC4=CC=CC=C43)C(=N1)C5=NC6=C(C=CC=C6N5)COC	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BEA14W	(2,4-Dichlorophenyl)-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-pyrimidin-2-yl]-amine	Investigative	56659827	C17H11Cl2N5	356.2	C1=CC2=C(NC=C2C3=NC(=NC=C3)NC4=C(C=C(C=C4)Cl)Cl)N=C1	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BEO4K1	2-(4-Imidazo[1,2-a]pyridin-6-ylphenyl)-N-(3-methylphenyl)acetamide	Investigative	118712374	C22H19N3O	341.4	CC1=CC(=CC=C1)NC(=O)CC2=CC=C(C=C2)C3=CN4C=CN=C4C=C3	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BF9T6X	6-(4-Fluorophenyl)-4-(4-methylbenzyl)-3(2H)-pyridazinone	Investigative	2811823	C18H15FN2O	294.3	CC1=CC=C(C=C1)CC2=CC(=NNC2=O)C3=CC=C(C=C3)F	IC50 = 66200 nM	Poor binder
T60631	Proto-oncogene c-Ret	BFS3W8	3-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)quinoline	Investigative	135497878	C24H18N6O	406.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CC6=CC=CC=C6N=C5	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BIT6H3	Chembl4237913	Investigative	2810885	C21H27N3O3	369.5	C1CN(C(=O)N1)CCN(CC(C2=CC=CC=C2)O)CC(C3=CC=CC=C3)O	IC50 = 54000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BJ27GK	N-(3-Fluorophenyl)-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)acetamide	Investigative	118712375	C21H16FN3O	345.4	C1=CC(=CC(=C1)F)NC(=O)CC2=CC=C(C=C2)C3=CN4C=CN=C4C=C3	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BJ9NR3	N-(Cyclohexylmethyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Investigative	11645208	C18H21N5	307.4	C1CCC(CC1)CNC2=NC=CC(=N2)C3=CNC4=C3C=CC=N4	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BJKG84	7-Ethoxy-5-hydroxy-2-phenyl-4H-chromen-4-one	Investigative	5391486	C17H14O4	282.29	CCOC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=CC=C3)O	IC50 = 68400 nM	Poor binder
T60631	Proto-oncogene c-Ret	BJRS40	4-Methoxy-N-[3-[[[1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-yl]amino]methyl]phenyl]benzenesulfonamide	Investigative	76311164	C27H26N6O3S	514.6	COC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC(=C2)CNC3=C4C=NN(C4=NC=N3)CCC5=CC=CC=C5	IC50 = 57200 nM	Poor binder
T60631	Proto-oncogene c-Ret	BM5AO3	2-(((2-Aminophenyl)thio)methyl)quinazolin-4(3H)-one	Investigative	135511450	C15H13N3OS	283.4	C1=CC=C2C(=C1)C(=O)NC(=N2)CSC3=CC=CC=C3N	IC50 = 63800 nM	Poor binder
T60631	Proto-oncogene c-Ret	BM5EJ3	N-[(1R,2R,4R)-2-Bicyclo[2.2.1]heptanyl]-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Investigative	56680305	C18H19N5	305.4	C1C[C@@H]2C[C@@H]1C[C@H]2NC3=NC=CC(=N3)C4=CNC5=C4C=CC=N5	IC50 = 55000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BN6CZ5	5-[(1E)-(Methoxyimino)methyl]-6-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-4-amine	Investigative	23646049	C15H15N5O2	297.31	CC1=CC2=C(N1)C=CC(=C2)OC3=NC=NC(=C3/C=N/OC)N	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BQ1W5F	5-[4-Amino-1-(2,2-dimethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	127045861	C16H17N7O3	355.35	COC(CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N)OC	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BRM6P9	N-(3-Chlorophenyl)-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)acetamide	Investigative	118712376	C21H16ClN3O	361.8	C1=CC(=CC(=C1)Cl)NC(=O)CC2=CC=C(C=C2)C3=CN4C=CN=C4C=C3	IC50 = 67800 nM	Poor binder
T60631	Proto-oncogene c-Ret	BT0V7B	5-[4-Amino-1-(1,3-dioxolan-2-ylmethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	127046862	C16H15N7O3	353.34	C1COC(O1)CN2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)OC(=N5)N)N	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BW1DA6	3,3-Dimethyl-5-oxo-5-[(3-phenyl-1H-pyrazol-5-yl)amino]pentanoic acid	Investigative	2814387	C16H19N3O3	301.34	CC(C)(CC(=O)NC1=NNC(=C1)C2=CC=CC=C2)CC(=O)O	IC50 = 82600 nM	Poor binder
T60631	Proto-oncogene c-Ret	BW6RT3	N-(4-Methoxycyclohexyl)-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Investigative	56670142	C18H21N5O	323.4	COC1CCC(CC1)NC2=NC=CC(=N2)C3=CNC4=C3C=CC=N4	IC50 = 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BX5E6T	2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester	Investigative	136118032	C24H16N6O2	420.4	COC(=O)C1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CN=CC6=CC=CC=C65	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BXB01F	5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	122163152	C18H21N7O3	383.4	CCOC(CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N)OCC	IC50 ~ 100000 nM	Poor binder
T60631	Proto-oncogene c-Ret	BY47PQ	3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine	Investigative	135497800	C20H16N6O	356.4	COCC1=C2C(=CC=C1)NC(=N2)C3=C4C=C(C=NC4=NN3)C5=CC=NC=C5	IC50 ~ 100000 nM	Poor binder