TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61243	Metabotropic glutamate receptor 7	D0U5CS	LY354740	Discontinued in Phase 2	213056	C8H11NO4	185.18	C1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B0GOR1	(2S)-2-Amino-4-[hydroxy-[hydroxy-(5-nitrothiophen-2-yl)methyl]phosphoryl]butanoic acid	Investigative	57765633	C9H13N2O7PS	324.25	C1=C(SC(=C1)[N+](=O)[O-])C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B1H5PN	(2S)-2-Amino-4-[hydroxy-[(3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	58058372	C11H15N2O6P	302.22	C1=CC(=CC(=C1)[N+](=O)[O-])CP(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B1KEW7	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-propyl-cyclopropanecarboxylic acid	Investigative	44329024	C23H25NO5	395.4	CCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 = 67820 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B1QE3X	(2S)-2-Amino-4-[hydroxy-[hydroxy-[4-nitro-3-(trifluoromethyl)phenyl]methyl]phosphoryl]butanoic acid	Investigative	57765616	C12H14F3N2O7P	386.22	C1=CC(=C(C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)C(F)(F)F)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B1RS0P	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	46918015	C11H15N2O8P	334.22	C1=CC(=C(C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 = 69000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B1ST5P	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-methylsulfonylphenyl)methyl]phosphoryl]butanoic acid	Investigative	24780092	C12H18NO7PS	351.31	CS(=O)(=O)C1=CC=C(C=C1)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B20YKD	4-[[[(3S)-3-Amino-3-carboxypropyl]-hydroxyphosphoryl]-hydroxymethyl]benzoic acid	Investigative	24780088	C12H16NO7P	317.23	C1=CC(=CC=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)C(=O)O	EC50 = 169000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B3ESW7	(2S)-2-Amino-4-[2-carboxyethyl(hydroxy)phosphoryl]butanoic acid	Investigative	6348408	C7H14NO6P	239.16	C(CP(=O)(CCC(=O)O)O)[C@@H](C(=O)O)N	EC50 = 89000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B3G2CD	(2S)-2-Amino-4-[[(R)-(3-fluoro-4-hydroxy-5-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	137655963	C11H14FN2O8P	352.21	C1=C(C=C(C(=C1[N+](=O)[O-])O)F)[C@H](O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 53800 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B5Y9TE	(2S)-2-Amino-4-[[(3-fluoro-4-hydroxy-5-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	137650519	C11H14FN2O8P	352.21	C1=C(C=C(C(=C1[N+](=O)[O-])O)F)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 51200 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B6BH5N	4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Investigative	10198133	C7H9NO4S	203.22	C1[C@]([C@@H]2[C@H]([C@@H]2S1)C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B7ES3J	(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137639752	C11H15N2O8P	334.22	C1=CC(=C(C=C1[C@@H](O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 = 62000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B8ZU4A	(2S)-2-Amino-4-[[(4-fluoro-3-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	57765613	C11H14FN2O7P	336.21	C1=CC(=C(C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])F	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B9C6TH	(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(4-methoxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137634883	C12H17N2O8P	348.25	COC1=C(C=C(C=C1)[C@@H](O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	B9H5SN	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-morpholin-4-yl-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	57765549	C15H22N3O8P	403.32	C1COCCN1C2=C(C=C(C=C2)C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BC3QT8	(2S)-2-Amino-4-[[(3,4-dihydroxy-5-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	58058356	C11H15N2O9P	350.22	C1=C(C=C(C(=C1[N+](=O)[O-])O)O)C(O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BDW42P	(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137645989	C12H17N2O9P	364.24	COC1=CC(=CC(=C1O)[N+](=O)[O-])[C@@H](O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 63000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BED34S	(2S)-2-Amino-4-[hydroxy-[hydroxy-(2,3,4,5,6-pentafluorophenyl)methyl]phosphoryl]butanoic acid	Investigative	24780225	C11H11F5NO5P	363.17	C(CP(=O)(C(C1=C(C(=C(C(=C1F)F)F)F)F)O)O)[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BNS67U	(2S)-2-Amino-4-[hydroxy-[(4-hydroxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137646034	C11H15N2O7P	318.22	C1=CC(=C(C=C1CP(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BO13RY	(2S)-2-Amino-4-[hydroxy-[hydroxy-[3-nitro-4-(trifluoromethyl)phenyl]methyl]phosphoryl]butanoic acid	Investigative	57765622	C12H14F3N2O7P	386.22	C1=CC(=C(C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])C(F)(F)F	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BO20KN	(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137642874	C11H15N2O7P	318.22	C1=CC(=CC(=C1)[N+](=O)[O-])[C@H](O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BS84ZQ	(2S)-2-Amino-4-[hydroxy-[(S)-hydroxy-(3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137640190	C11H15N2O7P	318.22	C1=CC(=CC(=C1)[N+](=O)[O-])[C@@H](O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BTN09E	(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-methoxy-3-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	137647077	C12H17N2O8P	348.25	COC1=C(C=C(C=C1)[C@H](O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BUI5B6	(2S)-2-Amino-4-[hydroxy-[hydroxy-(4-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	57765536	C11H15N2O7P	318.22	C1=CC(=CC=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-]	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BWLA46	(2S)-2-Amino-4-[[(4-chloro-3-nitrophenyl)-hydroxymethyl]-hydroxyphosphoryl]butanoic acid	Investigative	57765535	C11H14ClN2O7P	352.66	C1=CC(=C(C=C1C(O)P(=O)(CC[C@@H](C(=O)O)N)O)[N+](=O)[O-])Cl	EC50 ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	BZ96PJ	(2S)-2-Amino-4-[hydroxy-[(R)-hydroxy-(4-hydroxy-3-methoxy-5-nitrophenyl)methyl]phosphoryl]butanoic acid	Investigative	124425164	C12H17N2O9P	364.24	COC1=CC(=CC(=C1O)[N+](=O)[O-])[C@H](O)P(=O)(CC[C@@H](C(=O)O)N)O	EC50 = 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D01EVA	CPCCOEt	Investigative	6278000	C13H13NO4	247.25	CCOC(=O)C12CC1/C(=N\\O)/C3=CC=CC=C3O2	Ki ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D06PAK	LY-389795	Investigative	10058694	C7H9NO4S	203.22	C1[C@](C2[C@H](C2S1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D07GRG	LY-379268	Investigative	10197984	C7H9NO5	187.15	C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D09AQK	(R,S)-4-phosphonophenylglycine	Investigative	4545574	C8H10NO5P	231.14	C1=CC(=CC=C1C(C(=O)O)N)P(=O)(O)O	Ki = 185000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D0IO8J	2-methyl-6-(phenylethynyl)pyridine	Investigative	3025961	C14H11N	193.24	CC1=NC(=CC=C1)C#CC2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T61243	Metabotropic glutamate receptor 7	D0Q6VH	SIB-1893	Investigative	5311432	C14H13N	195.26	CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder