TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T61744	Phosphodiesterase 4A	D01RCZ	B7673	Patented	2052828	C15H16N2OS2	304.4	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	D0SH7F	BC11-28	Patented	3257208	C25H19FN4	394.4	CC1=CC=CC=C1NC2=C3C(=CN(C3=NC=N2)C4=CC=C(C=C4)F)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	D0Z7YQ	AC1M1SP5	Patented	2155273	C16H18N2O2S2	334.5	CCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3OC)SCC2	IC50 = 60000 nM	Poor binder
T61744	Phosphodiesterase 4A	D0BK6B	CI-930	Discontinued in Phase 2	3021729	C14H14N4O	254.29	CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	Ki ~ 50000 nM	Poor binder
T61744	Phosphodiesterase 4A	D00YPW	ZAPRINAST	Terminated	135399235	C13H13N5O2	271.27	.	Ki ~ 50000 nM	Poor binder
T61744	Phosphodiesterase 4A	B0GAZ1	7-Amino-1-(2,5-dimethoxyphenyl)-3-propylpyrido[2,3-d]pyrimidine-2,4-dione	Investigative	21198161	C18H20N4O4	356.4	CCCN1C(=O)C2=C(N=C(C=C2)N)N(C1=O)C3=C(C=CC(=C3)OC)OC	IC50 = 70000 nM	Poor binder
T61744	Phosphodiesterase 4A	B14HRM	4-[2-[4-(2-Methylbenzoylaminosulfonyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide	Investigative	44282297	C29H24F4N2O6S	604.6	CC1=CC=CC=C1C(=O)NS(=O)(=O)C2=CC=C(C=C2)C(CC3=CC=[N+](C=C3)[O-])C4=CC(=C(C=C4)OC(F)F)OC(F)F	IC50 = 75000 nM	Poor binder
T61744	Phosphodiesterase 4A	B1H6WN	(Z)-2-(1-(3,3-Dimethylcyclohex-1-en-1-yl)ethylidene)hydrazinecarboximidamide acetate	Investigative	52997854	C13H24N4O2	268.36	C/C(=N/N=C(N)N)/C1=CC(CCC1)(C)C.CC(=O)O	Ki = 69000 nM	Poor binder
T61744	Phosphodiesterase 4A	B6N9PC	Chlortetracycline	Investigative	54675777	C22H23ClN2O8	478.9	C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)N)N(C)C)O	IC50 = 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	B6PU8G	(11S)-5-Anilino-8-methyl-11-(phenylmethoxymethyl)-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatricyclo[7.3.0.02,6]dodeca-2,5,9-trien-7-one	Investigative	127026294	C35H32N6O2	568.7	CN1C(=O)C2=C(N(N=C2N3C1=N[C@@H](C3)COCC4=CC=CC=C4)CC5=CC=C(C=C5)C6=CC=CC=C6)NC7=CC=CC=C7	Ki ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	B73INJ	4-[2-(4-Carboxyphenyl)-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide	Investigative	44282341	C22H17F4NO5	451.4	C1=CC(=CC=C1C(CC2=CC=[N+](C=C2)[O-])C3=CC(=C(C=C3)OC(F)F)OC(F)F)C(=O)O	IC50 = 77000 nM	Poor binder
T61744	Phosphodiesterase 4A	B8QG3N	3-Methoxy-2-[[4-(2-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline	Investigative	90668361	C26H22N4O2	422.5	CN1C(=C(C=N1)C2=CC=NC=C2)C3=CC=C(C=C3)OCC4=NC5=CC=CC=C5C=C4OC	IC50 = 199000 nM	Poor binder
T61744	Phosphodiesterase 4A	B9I0US	2-[4-[(3R)-3-Methyl-2-oxo-1,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]guanidine	Investigative	7447730	C13H13N5OS	287.34	C[C@@H]1C2=C(C=CC(=C2)C3=CSC(=N3)N=C(N)N)NC1=O	Ki = 115000 nM	Poor binder
T61744	Phosphodiesterase 4A	B9V3TH	N,N-Diethyl-3-methyl-1-(2-methylphenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide	Investigative	2409032	C23H24N4OS	404.5	CCN(CC)C(=O)C1=CC(=NC2=C1C(=NN2C3=CC=CC=C3C)C)C4=CC=CS4	IC50 = 70000 nM	Poor binder
T61744	Phosphodiesterase 4A	BCZ27F	4-[2-(4-Chlorophenyl)-2-[2-fluoro-3-(cyclopentyloxy)-4-methoxyphenyl]ethyl]pyridine	Investigative	44282270	C25H25ClFNO2	425.9	COC1=C(C(=C(C=C1)C(CC2=CC=NC=C2)C3=CC=C(C=C3)Cl)F)OC4CCCC4	IC50 = 98000 nM	Poor binder
T61744	Phosphodiesterase 4A	BJ21GO	4-Imino-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-3(4H)-amine	Investigative	5136241	C11H14N4S	234.32	CC1CCC2=C(C1)SC3=C2C(=N)N(C=N3)N	Ki = 66000 nM	Poor binder
T61744	Phosphodiesterase 4A	BJ25CS	5-Anilino-8-methyl-4-[(4-phenylphenyl)methyl]-1,3,4,8,10-pentazatricyclo[7.4.0.02,6]trideca-2,5,9-trien-7-one	Investigative	127026600	C28H26N6O	462.5	CN1C(=O)C2=C(N(N=C2N3C1=NCCC3)CC4=CC=C(C=C4)C5=CC=CC=C5)NC6=CC=CC=C6	Ki ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	BJ89QB	2-[4-[3,5-Bis(cyclopropylmethoxy)phenyl]-2-ethyl-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol	Investigative	44329633	C28H34N2O6	494.6	CCC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC(=C3)OCC4CC4)OCC5CC5)OCCO)OCCO	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	BN2WO3	5,5-Dimethyl-3-(piperazin-1-ylmethyl)imidazolidine-2,4-dione	Investigative	6501454	C10H18N4O2	226.28	CC1(C(=O)N(C(=O)N1)CN2CCNCC2)C	Ki = 131000 nM	Poor binder
T61744	Phosphodiesterase 4A	BO3YQ5	2-(Butylthio)-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2155145	C16H18N2OS2	318.5	CCCCSC1=NC2=C(C(=O)N1C3=CC=CC=C3)SCC2	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	BR5L8O	2-(Propylthio)-3-(p-tolyl)-6,7-dihydrothieno[3,2-d]pyrimidin-4(3H)-one	Investigative	2052838	C16H18N2OS2	318.5	CCCSC1=NC2=C(C(=O)N1C3=CC=C(C=C3)C)SCC2	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	BRHT84	3-Phenyl-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione	Investigative	2802078	C15H9N3O2S	295.3	C1=CC=C(C=C1)N2C(=O)N=C3N(C2=O)C4=CC=CC=C4S3	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	BSO0M8	4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid	Investigative	136132229	C29H33N5O5	531.6	CC(C)(COC1=CC=C(C=C1)C(=O)O)C2=NC3=C(N2)C(=N)N=CN3CC4=CC(=C(C=C4)OC)OC5CCCC5	Ki ~ 50000 nM	Poor binder
T61744	Phosphodiesterase 4A	BSR6U4	7-Benzyloxy-4-(3,5-bis-cyclopropylmethoxy-phenyl)-2-ethyl-6-methoxy-quinazoline	Investigative	44329482	C32H34N2O4	510.6	CCC1=NC2=CC(=C(C=C2C(=N1)C3=CC(=CC(=C3)OCC4CC4)OCC5CC5)OC)OCC6=CC=CC=C6	IC50 ~ 100000 nM	Poor binder
T61744	Phosphodiesterase 4A	BU87DA	4-[2-[4-(2-Oxo-2-hydroxyethyl)phenyl]-2-[3,4-bis(difluoromethoxy)phenyl]ethyl]pyridine 1-oxide	Investigative	44282706	C23H19F4NO5	465.4	C1=CC(=CC=C1CC(=O)O)C(CC2=CC=[N+](C=C2)[O-])C3=CC(=C(C=C3)OC(F)F)OC(F)F	IC50 = 58000 nM	Poor binder
T61744	Phosphodiesterase 4A	BWN74O	(11R,15S)-5-Anilino-3-[[4-(4-fluorophenyl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-5,9-dien-7-one	Investigative	127028161	C30H29FN6O	508.6	CN1C(=O)C2=C(NN(C2N3C1=N[C@H]4[C@@H]3CCC4)CC5=CC=C(C=C5)C6=CC=C(C=C6)F)NC7=CC=CC=C7	Ki ~ 100000 nM	Poor binder