TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T62820	Metabotropic glutamate receptor 2	B0YI4S	(1S,3R)-1-Amino-3-(carboxymethyl)cyclopentane-1-carboxylic Acid	Investigative	10012681	C8H13NO4	187.19	C1C[C@](C[C@@H]1CC(=O)O)(C(=O)O)N	Ki = 122000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B1VT5M	Iflwvshrwaivqf-sgihwfkdsa-	Investigative	9991661	C12H13NO4	235.24	C1=CC=C(C=C1)[C@H]2[C@H]([C@@H]2C(=O)O)[C@H](C(=O)O)N	EC50 = 122000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B4PCS2	(S)-2-Amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-5-yl)propanoic acid	Investigative	52947499	C7H10N4O4	214.18	C1=C(N(N=N1)CC(=O)O)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B4WA0S	(S)-2-Amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-5-yl)propanoic acid	Investigative	52947232	C14H16N4O4	304.3	C1=CC=C(C=C1)C[C@@H](C(=O)O)N2C(=CN=N2)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B50DKL	1-Oxo-2-propyl-6-pyridin-3-ylisoquinoline-8-carbonitrile	Investigative	53320176	C18H15N3O	289.3	CCCN1C=CC2=CC(=CC(=C2C1=O)C#N)C3=CN=CC=C3	EC50 ~ 50118.72 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B54BWE	(2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302609	C17H18N2O4	314.34	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC3=CC=CC=C3C=C2)C(=O)O	IC50 = 50000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B6X9QI	(S)-1-(2-Amino-2-carboxyethyl)-1H-1,2,3-triazole-4-carboxylic acid	Investigative	52941386	C6H8N4O4	200.15	C1=C(N=NN1C[C@@H](C(=O)O)N)C(=O)O	EC50 ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B7VM5K	trans-ACPD	Investigative	73537	C7H11NO4	173.17	C1C[C@@](C[C@H]1C(=O)O)(C(=O)O)N	EC50 = 110000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	B8K6VC	(S)-4-(Amino(carboxy)methyl)cubane-1-carboxylic acid	Investigative	10198359	C11H11NO4	221.21	C12C3C4C1(C5C2C3(C45)C(=O)O)[C@@H](C(=O)O)N	Ki = 55000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BB6KT7	(2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302930	C14H18N2O4	278.3	C1[C@@H](N(C[C@]1(C(=O)O)N)CCC2=CC=CC=C2)C(=O)O	IC50 = 61000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BGI1S7	alpha-Methyl-4-carboxyphenylglycine	Investigative	1222	C10H11NO4	209.2	CC(C1=CC=C(C=C1)C(=O)O)(C(=O)O)N	IC50 = 50000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BIGT98	(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10775369	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 = 54000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BOE38X	5-[Benzyl(chloro)amino]-2-propylisoquinolin-1-one	Investigative	90668104	C19H19ClN2O	326.8	CCCN1C=CC2=C(C1=O)C=CC=C2N(CC3=CC=CC=C3)Cl	EC50 = 50118.72 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BPWR93	(1R,2R,4S,5S,6R)-2-Amino-4-methyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid	Investigative	11481048	C9H13NO4	199.2	C[C@H]1C[C@@]([C@@H]2[C@H]1[C@H]2C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BTN92G	(S)-2-Amino-3-(1-((S)-1-carboxy-2-phenylethyl)-1H-1,2,3-triazol-4-yl)propanoic acid	Investigative	52948863	C14H16N4O4	304.3	C1=CC=C(C=C1)C[C@@H](C(=O)O)N2C=C(N=N2)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BV5UC8	(1S,2S,3R)-2-[(S)-Amino(carboxy)methyl]-3-cyclohexylcyclopropane-1-carboxylic acid	Investigative	52944782	C12H19NO4	241.28	C1CCC(CC1)[C@@H]2[C@@H]([C@H]2C(=O)O)[C@@H](C(=O)O)N	IC50 = 62000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BX7V5M	(7S)-5-[4-(1-Hydroxyethyl)phenyl]-7-methyl-3-(2-methylpyridin-4-yl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4-one	Investigative	117821189	C21H22N4O2	362.4	C[C@H]1CN(C(=O)C2=C(C=NN12)C3=CC(=NC=C3)C)C4=CC=C(C=C4)C(C)O	IC50 ~ 50118.72 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BY3AD0	(S)-2-Amino-3-(1-(carboxymethyl)-1H-1,2,3-triazol-4-yl)propanoic acid	Investigative	52941387	C7H10N4O4	214.18	C1=C(N=NN1CC(=O)O)C[C@@H](C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	BZ5HB6	(2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302819	C13H15ClN2O4	298.72	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2Cl)C(=O)O	IC50 = 75000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D01EVA	CPCCOEt	Investigative	6278000	C13H13NO4	247.25	CCOC(=O)C12CC1/C(=N\\O)/C3=CC=CC=C3O2	Ki ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D01YEN	ibotenate	Investigative	1233	C5H6N2O4	158.11	C1=C(ONC1=O)C(C(=O)O)N	Ki = 110000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D05TFE	SIB-1757	Investigative	5218788	C12H11N3O	213.23	.	Ki ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D0IO8J	2-methyl-6-(phenylethynyl)pyridine	Investigative	3025961	C14H11N	193.24	CC1=NC(=CC=C1)C#CC2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D0N0NJ	1-benzyl-APDC	Investigative	15508178	C13H16N2O4	264.28	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC=CC=C2)C(=O)O	IC50 = 121000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D0OV2V	LY307452	Investigative	6324634	C21H25NO4	355.4	C1=CC=C(C=C1)C(CCC[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2	Ki = 50000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D0PN6Z	L-AP4	Investigative	179394	C4H10NO5P	183.1	C(CP(=O)(O)O)[C@@H](C(=O)O)N	Ki = 129000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D0Q6VH	SIB-1893	Investigative	5311432	C14H13N	195.26	CC1=NC(=CC=C1)/C=C/C2=CC=CC=C2	Ki ~ 100000 nM	Poor binder
T62820	Metabotropic glutamate receptor 2	D0YO8B	MCCG	Investigative	5311457	C7H11NO4	173.17	C[C@]([C@H]1C[C@@H]1C(=O)O)(C(=O)O)N	Ki = 84000 nM	Poor binder