TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T64205	Signal transducer and activator of transcription 1	D0Y0OQ	PMID26394986-Compound-13	Patented	24767791	C30H34N2O6S	550.7	CC1=CC=C(C=C1)S(=O)(=O)N(C)CC(=O)N(CC2=CC=C(C=C2)C3CCCCC3)C4=CC(=C(C=C4)C(=O)O)O	Ki ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B1MF2Y	6-Methyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	665524	C14H12N6S	296.35	CC1=NN2C(=NN=C2SC1)C3=CC(=NN3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B3L7PJ	3-(1,4,5,6-Tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044052	C10H10N6S	246.29	C1CC2=C(C1)NN=C2C3=NN=C4N3N=CCS4	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B59EOC	2-[(7-Methoxy-4-methylquinazolin-2-yl)amino]-6-methylpyrimidin-4-ol	Investigative	135463175	C15H15N5O2	297.31	CC1=CC(=O)NC(=N1)NC2=NC(=C3C=CC(=CC3=N2)OC)C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B5Y0DG	6-(3,4-Dichlorophenyl)-7-(2-methylpropyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044627	C20H20Cl2N6S	447.4	CC(C)CC1C(=NN2C(=NN=C2S1)C3=NNC4=C3CCC4)C5=CC(=C(C=C5)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B6K0IP	6-Pyridin-4-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044001	C15H13N7S	323.4	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(CS4)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B70RZP	6-(3,4-Dichlorophenyl)-7-propan-2-yl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044626	C19H18Cl2N6S	433.4	CC(C)C1C(=NN2C(=NN=C2S1)C3=NNC4=C3CCC4)C5=CC(=C(C=C5)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B83DEP	6-Cyclohexyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127043538	C16H20N6S	328.4	C1CCC(CC1)C2=NN3C(=NN=C3SC2)C4=NNC5=C4CCC5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B8FLB5	6-(5-Chlorothiophen-2-yl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127043886	C17H11ClN6S2	398.9	C1C(=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4)C5=CC=C(S5)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	B97NJF	7-Benzyl-6-(3,4-dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044628	C23H18Cl2N6S	481.4	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(C(S4)CC5=CC=CC=C5)C6=CC(=C(C=C6)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BAW5X7	6-(4-Methoxyphenyl)-7-(2-methylpropyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044476	C24H24N6OS	444.6	CC(C)CC1C(=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BB10KC	6-(4-Methoxyphenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	122417980	C18H18N6OS	366.4	CC1C(=NN2C(=NN=C2S1)C3=NNC4=C3CCC4)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BFP4R6	6-(3,4-Dichlorophenyl)-7,7-dimethyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044631	C18H16Cl2N6S	419.3	CC1(C(=NN2C(=NN=C2S1)C3=NNC4=C3CCC4)C5=CC(=C(C=C5)Cl)Cl)C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BFX64O	6-(4-Chlorophenyl)-3-(2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	665421	C16H13ClN6S	356.8	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(CS4)C5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BGF76W	6-Methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	665766	C11H12N6S	260.32	CC1=NN2C(=NN=C2SC1)C3=NNC4=C3CCC4	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BH5P8I	6-Ethoxy-4-methyl-N-(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)quinazolin-2-amine	Investigative	4378002	C18H23N5O	325.4	CCOC1=CC2=C(N=C(N=C2C=C1)NC3=NC(C=C(N3)C)(C)C)C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BI8PD4	6-Phenyl-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	665426	C19H14N6S	358.4	C1C(=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BJ51PQ	Schembl20866490	Investigative	127044282	C20H22N6OS	394.5	CC(C)C1C(=NN2C(=NN=C2S1)C3=NNC4=C3CCC4)C5=CC=C(C=C5)OC	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BJFK20	6-(3,4-Dichlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	665910	C16H12Cl2N6S	391.3	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(CS4)C5=CC(=C(C=C5)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BK3UH5	[(5R,5As,9R,9aR,9bR)-9,9b-dihydroxy-6,6,9a-trimethyl-1-oxo-3,5,5a,7,8,9-hexahydrobenzo[e][2]benzofuran-5-yl] hexanoate	Investigative	90643507	C21H32O6	380.5	CCCCCC(=O)O[C@@H]1C=C2COC(=O)[C@@]2([C@@]3([C@@H]1C(CC[C@H]3O)(C)C)C)O	IC50 = 50700 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BK46MI	4,6-Dimethyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine	Investigative	4744091	C17H21N5	295.4	CC1=CC2=C(N=C(N=C2C=C1)NC3=NC(C=C(N3)C)(C)C)C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BK7U8X	6-(4-Chlorophenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	1400670	C19H13ClN6S	392.9	C1C(=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4)C5=CC=C(C=C5)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BLM90K	6-(3-Chlorophenyl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127044345	C16H13ClN6S	356.8	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(CS4)C5=CC(=CC=C5)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BLN46Z	5,6-Dimethyl-2-[(4,6,8-trimethylquinazolin-2-yl)amino]pyrimidin-4(1H)-one	Investigative	135402276	C17H19N5O	309.4	CC1=CC(=C2C(=C1)C(=NC(=N2)NC3=NC(=C(C(=O)N3)C)C)C)C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BLSX05	6-(5-Chlorothiophen-2-yl)-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127043885	C14H11ClN6S2	362.9	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(CS4)C5=CC=C(S5)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BN78IW	3-(3-Phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127043537	C13H10N6S	282.33	C1C=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BR71XT	6-(3,4-Dichlorophenyl)-7-methyl-3-(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	121485603	C17H14Cl2N6S	405.3	CC1C(=NN2C(=NN=C2S1)C3=NNC4=C3CCC4)C5=CC(=C(C=C5)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BT9PS5	6-(3,4-Dichlorophenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	3592521	C19H12Cl2N6S	427.3	C1C(=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BVBL67	6-Phenyl-3-(2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	665706	C16H14N6S	322.4	C1CC2=C(C1)NN=C2C3=NN=C4N3N=C(CS4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BVI9H6	6-(4-Methoxyphenyl)-3-(5-phenyl-1H-pyrazol-3-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	1383290	C20H16N6OS	388.4	COC1=CC=C(C=C1)C2=NN3C(=NN=C3SC2)C4=CC(=NN4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BWXZ06	(1S,3R,4S,5R,6R,8R,9S,12R,13R)-13-Ethenyl-5-hydroxy-4,9,12-trimethyl-7-oxapentacyclo[7.6.0.01,12.03,8.06,8]pentadecan-11-one	Investigative	134148443	C19H26O3	302.4	C[C@H]1[C@H]2C[C@]34CC[C@@H]([C@]3(C(=O)C[C@@]4([C@@]25[C@@H]([C@@H]1O)O5)C)C)C=C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BX4L6Z	(7-Ethoxy-4-methylquinazolin-2-yl)(4,4,6-trimethyl-1,4-dihydropyrimidin-2-yl)amine	Investigative	658668	C18H23N5O	325.4	CCOC1=CC2=NC(=NC(=C2C=C1)C)NC3=NC(C=C(N3)C)(C)C	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BX9D1I	3-(3-Phenyl-1H-pyrazol-5-yl)-6-pyridin-4-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127043884	C18H13N7S	359.4	C1C(=NN2C(=NN=C2S1)C3=CC(=NN3)C4=CC=CC=C4)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BZ8S5M	6-Cyclohexyl-3-(3-phenyl-1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	Investigative	127043708	C19H20N6S	364.5	C1CCC(CC1)C2=NN3C(=NN=C3SC2)C4=CC(=NN4)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T64205	Signal transducer and activator of transcription 1	BZP29S	STAT5 Inhibitor	Investigative	9566174	C16H11N3O3	293.28	C1=CC=C2C(=C1)C(=O)C(=CO2)/C=N/NC(=O)C3=CN=CC=C3	IC50 = 130000 nM	Poor binder