TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T64765	Histamine H3 receptor	B0K4YO	1-Phenyl-3-[4-(2-pyrrolidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145630	C19H23N3O4S	389.5	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 88600 nM	Poor binder
T64765	Histamine H3 receptor	B3Q0MI	1-[7-(3-Chlorophenoxy)heptyl]azepane;oxalic acid	Investigative	127042504	C21H32ClNO5	413.9	C1CCCN(CC1)CCCCCCCOC2=CC(=CC=C2)Cl.C(=O)(C(=O)O)O	Ki ~ 150000 nM	Poor binder
T64765	Histamine H3 receptor	B4LT9B	1-[4-(2-Piperidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60145773	C21H24F3N3O4S	471.5	C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 82000 nM	Poor binder
T64765	Histamine H3 receptor	B4MBG1	N-(3-Bromo-4-(2-morpholinoethoxy)phenethyl)-5-bromofuran-2-carboxamide	Investigative	45267022	C19H22Br2N2O4	502.2	C1COCCN1CCOC2=C(C=C(C=C2)CCNC(=O)C3=CC=C(O3)Br)Br	IC50 = 73200 nM	Poor binder
T64765	Histamine H3 receptor	B80OPE	Ethyl 1-[2-[4-(phenylcarbamoylsulfamoyl)phenoxy]ethyl]piperidine-4-carboxylate	Investigative	60145774	C23H29N3O6S	475.6	CCOC(=O)C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 77900 nM	Poor binder
T64765	Histamine H3 receptor	BBG4O2	Ethyl 1-[3-[4-(phenylcarbamoylsulfamoyl)phenoxy]propyl]piperidine-4-carboxylate	Investigative	60143590	C24H31N3O6S	489.6	CCOC(=O)C1CCN(CC1)CCCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=CC=C3	IC50 = 91100 nM	Poor binder
T64765	Histamine H3 receptor	BE9W0I	1-Cyclohexyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145771	C20H31N3O4S	409.5	C1CCC(CC1)NC(=O)NS(=O)(=O)C2=CC=C(C=C2)OCCN3CCCCC3	IC50 = 53800 nM	Poor binder
T64765	Histamine H3 receptor	BOQK19	1-(2,5-Dichlorophenyl)-3-[4-(2-piperidin-1-ylethoxy)phenyl]sulfonylurea	Investigative	60145772	C20H23Cl2N3O4S	472.4	C1CCN(CC1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=C(C=CC(=C3)Cl)Cl	IC50 = 93600 nM	Poor binder
T64765	Histamine H3 receptor	BP6IN4	N-(3-Bromo-4-(2-morpholinoethoxy)phenethyl)-1H-pyrrole-2-carboxamide	Investigative	45266943	C19H24BrN3O3	422.3	C1COCCN1CCOC2=C(C=C(C=C2)CCNC(=O)C3=CC=CN3)Br	IC50 = 59200 nM	Poor binder
T64765	Histamine H3 receptor	BV21SP	1-Cyano-3-[[(2S,5S)-5-(1H-imidazol-5-yl)oxolan-2-yl]methyl]-2-methylguanidine	Investigative	10879463	C11H16N6O	248.28	CN=C(NC[C@@H]1CC[C@H](O1)C2=CN=CN2)NC#N	EC50 ~ 100000 nM	Poor binder
T64765	Histamine H3 receptor	BXS9L4	1-[4-(2-Pyrrolidin-1-ylethoxy)phenyl]sulfonyl-3-[4-(trifluoromethyl)phenyl]urea	Investigative	60145633	C20H22F3N3O4S	457.5	C1CCN(C1)CCOC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3=CC=C(C=C3)C(F)(F)F	IC50 = 107000 nM	Poor binder
T64765	Histamine H3 receptor	BXZ17O	6-(4-Fluorophenyl)-4-piperazin-1-yl-7H-pyrrolo[2,3-d]pyrimidin-2-amine	Investigative	71519012	C16H17FN6	312.34	C1CN(CCN1)C2=NC(=NC3=C2C=C(N3)C4=CC=C(C=C4)F)N	Ki = 84660 nM	Poor binder