TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T65200	Corticosteroid 11-beta-dehydrogenase 1	B0GI5M	3-Chloro-2-methyl-N-(4-methyl-oxazol-2-yl)-benzenesulfonamide	Investigative	44402437	C11H11ClN2O3S	286.74	CC1=COC(=N1)NS(=O)(=O)C2=C(C(=CC=C2)Cl)C	IC50 = 58700 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B0OLM6	1-Benzoyl-4-ethylpiperazine	Investigative	4119853	C13H18N2O	218.29	CCN1CCN(CC1)C(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B1T8NI	(1S,5R)-1-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042099	C25H28N4O3S	464.6	CCN1C2=CC=CC=C2C3=C1N=C(N=N3)S(=O)(=O)C[C@H]4CC=C([C@@]45CCC(=O)C=C5)C(C)C	IC50 = 74000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B2E0WV	1-(4-(2-(p-Toluidino)-2-oxoethoxy)-2,3-dibromo-5-ethoxybenzylidene)semicarbazide	Investigative	6874186	C19H20Br2N4O4	528.2	CCOC1=C(C(=C(C(=C1)/C=N/NC(=O)N)Br)Br)OCC(=O)NC2=CC=C(C=C2)C	IC50 ~ 50000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B2OXL3	(4-Benzenesulfonyl-piperazin-1-yl)-(3-p-tolyl-adamantan-1-yl)-methanone	Investigative	42908115	C28H34N2O3S	478.6	CC1=CC=C(C=C1)C23CC4CC(C2)CC(C4)(C3)C(=O)N5CCN(CC5)S(=O)(=O)C6=CC=CC=C6	IC50 = 64000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B46GEJ	1-(Adamantane-1-carbonyl)-4-benzoylpiperazine	Investigative	2999452	C22H28N2O2	352.5	C1CN(CCN1C(=O)C2=CC=CC=C2)C(=O)C34CC5CC(C3)CC(C5)C4	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B5C2TU	2-Cyclohexyl-1-(4-ethylpiperazin-1-yl)ethanone	Investigative	36054272	C14H26N2O	238.37	CCN1CCN(CC1)C(=O)CC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B6Q4AD	(4-Ethyl-piperazin-1-yl)-(3-hydroxy-adamantan-1-yl)-methanone	Investigative	42918799	C17H28N2O2	292.4	CCN1CCN(CC1)C(=O)C23CC4CC(C2)CC(C4)(C3)O	IC50 = 53000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	B8RT9Z	N-(Phenylsulfonyl)-4-(trifluoromethyl)benzamide	Investigative	44437635	C14H10F3NO3S	329.3	C1=CC=C(C=C1)S(=O)(=O)NC(=O)C2=CC=C(C=C2)C(F)(F)F	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BBZ12D	1-(4-Ethylpiperazin-1-yl)-2,2-dimethylpropan-1-one	Investigative	4570352	C11H22N2O	198.31	CCN1CCN(CC1)C(=O)C(C)(C)C	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BC85HA	(1S,5R)-N-[5-(4-Chlorophenyl)-1,3-thiazol-2-yl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127041810	C23H23ClN2O2S	427	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NC3=NC=C(S3)C4=CC=C(C=C4)Cl	IC50 = 122000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BDG1E2	Cyclohexyl(4-ethylpiperazin-1-yl)methanone	Investigative	798754	C13H24N2O	224.34	CCN1CCN(CC1)C(=O)C2CCCCC2	IC50 = 53000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BE7YJ0	N-(Benzenesulfonyl)-3-chlorobenzamide	Investigative	777284	C13H10ClNO3S	295.74	C1=CC=C(C=C1)S(=O)(=O)NC(=O)C2=CC(=CC=C2)Cl	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BETF70	(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042100	C22H32N2O3S3	468.7	CCCCCCSC1=NN=C(S1)S(=O)(=O)C[C@H]2CC=C([C@@]23CCC(=O)C=C3)C(C)C	IC50 = 121000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BEY3H5	2-(Phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanol	Investigative	44437666	C15H13F3O3S	330.3	C1=CC=C(C=C1)S(=O)(=O)CC(C2=CC=C(C=C2)C(F)(F)F)O	IC50 = 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BF84MG	N-(Benzenesulfonyl)benzamide	Investigative	229604	C13H11NO3S	261.3	C1=CC=C(C=C1)C(=O)NS(=O)(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BH8V5T	Benzamide, N-[(4-methylphenyl)sulfonyl]-	Investigative	81439	C14H13NO3S	275.32	CC1=CC=C(C=C1)S(=O)(=O)NC(=O)C2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BKL70Z	Adamantan-1-yl-(4-phenyl-piperazin-1-yl)-methanone	Investigative	656335	C21H28N2O	324.5	C1CN(CCN1C2=CC=CC=C2)C(=O)C34CC5CC(C3)CC(C5)C4	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BLP01H	[2-Chloro-6-(4-methyl-oxazol-2-ylsulfamoyl)-phenyl]-acetic acid	Investigative	44402330	C12H11ClN2O5S	330.74	CC1=COC(=N1)NS(=O)(=O)C2=C(C(=CC=C2)Cl)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BM4RA6	[2-Chloro-6-(4-methyl-oxazol-2-ylsulfamoyl)-phenyl]-acetic acid methyl ester	Investigative	44402659	C13H13ClN2O5S	344.77	CC1=COC(=N1)NS(=O)(=O)C2=C(C(=CC=C2)Cl)CC(=O)OC	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BMGO03	(1S,5R)-N-[(6,6-Dimethyl-2-bicyclo[3.1.1]heptanyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127037831	C24H35NO2	369.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NCC3CCC4CC3C4(C)C	IC50 = 94000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BN9XO0	N-(4-Chlorophenyl)sulfonylbenzamide	Investigative	286220	C13H10ClNO3S	295.74	C1=CC=C(C=C1)C(=O)NS(=O)(=O)C2=CC=C(C=C2)Cl	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BQ1H9T	1-(Benzenesulfonyl)-3,3-dimethylbutan-2-one	Investigative	4592745	C12H16O3S	240.32	CC(C)(C)C(=O)CS(=O)(=O)C1=CC=CC=C1	IC50 = 90000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BU7WN0	Cyclopropyl(4-ethylpiperazin-1-yl)methanone	Investigative	5151632	C10H18N2O	182.26	CCN1CCN(CC1)C(=O)C2CC2	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BU7ZM0	(1S,5R)-N-[1-(1-Adamantyl)ethyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127042781	C26H37NO2	395.6	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NC(C)C34CC5CC(C3)CC(C5)C4	IC50 = 85000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BW0YJ1	N-[4-(4,5-Dimethyl-oxazol-2-ylsulfamoyl)-phenyl]-N-methyl-acetamide	Investigative	44402662	C14H17N3O4S	323.37	CC1=C(OC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N(C)C(=O)C)C	IC50 = 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BW39JN	1-(Adamantane-1-carbonyl)-4-(benzenesulfonyl)piperazine	Investigative	3502039	C21H28N2O3S	388.5	C1CN(CCN1C(=O)C23CC4CC(C2)CC(C4)C3)S(=O)(=O)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	BZ6E3K	(2R)-4-[3-Chloro-4-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)phenyl]-cis-2,6-dimethylmorpholine	Investigative	44248335	C24H28ClF4N3O3S	550	C[C@@H]1CN(CCN1S(=O)(=O)C2=C(C=C(C=C2)N3C[C@H](O[C@H](C3)C)C)Cl)C4=C(C=C(C=C4)F)C(F)(F)F	IC50 = 185000 nM	Poor binder
T65200	Corticosteroid 11-beta-dehydrogenase 1	D0IO0I	Go-Y022	Investigative	6474893	C19H18O5	326.3	COC1=C(C=CC(=C1)/C=C/C(=O)/C=C/C2=CC(=C(C=C2)O)OC)O	IC50 = 70901 nM	Poor binder