TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T67684	Muscarinic acetylcholine receptor M3	D01AZG	Risperidone	Approved	5073	C23H27FN4O2	410.5	CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	D0H3HM	Aripiprazole	Approved	60795	C23H27Cl2N3O2	448.4	C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	D0U7BW	Carbachol	Approved	2551	C6H15N2O2+	147.2	C[N+](C)(C)CCOC(=O)N	Ki = 51000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	D07EFM	Arecoline	Phase 1	2230	C8H13NO2	155.19	CN1CCC=C(C1)C(=O)OC	IC50 = 58000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B01URL	N-Cyclohexyl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853778	C15H27N3O2	281.39	CCC(=O)N1CCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B0UJY6	N-[2-(Dimethylamino)ethyl]-N-methyl-1-(3-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274432	C21H23N3O	333.4	CN(C)CCN(C)C(=O)C1=C/C(=C\\C2=CN=CC=C2)/C3=CC=CC=C31	Ki = 72443.6 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B12LNH	Trimethyl-[[(2S,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44422698	C9H20INO2	301.17	C[C@@H]1COC[C@@H](O1)C[N+](C)(C)C.[I-]	EC50 = 50118.72 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B1ELB7	Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2R)-	Investigative	24894515	C9H13NO	151.21	CN1CCC[C@@H]1C2=CC=CO2	Ki = 81283.05 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B1Z0TB	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5beta-yl)methaneaminium	Investigative	73349591	C7H15N2O2+	159.21	C[N+](C)(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B27QAO	6-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579457	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B2DOR6	6,7,8,9-Tetrahydro-[1,2,5]thiadiazolo[3,4-h]isoquinoline	Investigative	14660293	C9H9N3S	191.26	C1CNCC2=C1C=CC3=NSN=C23	IC50 = 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B2GD9K	N-[(3R)-1-Azabicyclo[2.2.2]octan-3-yl]-2-(1-methyl-3-indolyl)-2-oxoacetamide	Investigative	6604789	C18H21N3O2	311.4	CN1C=C(C2=CC=CC=C21)C(=O)C(=O)N[C@H]3CN4CCC3CC4	Ki = 50118.72 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B2U1BJ	3-Phenylmethoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621560	C13H15ClN2O2	266.72	C1CNCC2=C1ON=C2OCC3=CC=CC=C3.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B2V7EP	2-[[4-[4-(2-Oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44578978	C25H29N5O	415.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B2ZV7A	3-[(E)-But-2-enoxy]-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621558	C10H15ClN2O2	230.69	C/C=C/COC1=NOC2=C1CNCC2.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B31EOD	Schembl21373245	Investigative	122195454	C23H27N3O2	377.5	CN(CCN1CCOCC1)CC(=O)C2=C(NC3=CC=CC=C32)C4=CC=CC=C4	IC50 = 51286.14 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B3K8HA	Pyrrolidine, 2-(2-furanyl)-1-methyl-, (2S)-	Investigative	24894514	C9H13NO	151.21	CN1CCC[C@H]1C2=CC=CO2	Ki = 52480.75 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B3UR9B	3-[(1-Methylpyrrolidin-3-yl)methoxymethyl]pyridine	Investigative	137644950	C12H18N2O	206.28	CN1CCC(C1)COCC2=CN=CC=C2	Ki = 75000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B40KXW	Trimethyl-[[(2R,3R)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706052	C9H20INO2	301.17	C[C@@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B40WHA	(4R)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545091	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B45RCD	Chembl4286717	Investigative	145993117	C24H33N3O2S	427.6	CCC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=C4C=CSC4=CC=C3)C	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B4BM5X	N-Pentan-3-yl-2-(4-propanoylpiperazin-1-yl)acetamide	Investigative	49853777	C14H27N3O2	269.38	CCC(CC)NC(=O)CN1CCN(CC1)C(=O)CC	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B4SWH0	6-Chloro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578928	C25H28ClF3N4O	493	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B50PAD	3-[1-(1-Benzylpiperidin-4-yl)piperidin-4-yl]-6-chloro-1H-benzimidazol-2-one	Investigative	44579417	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B57EKA	7-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579418	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C(=CC=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B57PVF	7-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579419	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C(=CC=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B5ER0C	(5S)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	58653718	C7H14N2O2	158.2	CN1C[C@@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B5HRN9	Trimethyl-[(6-methyl-1,4-dioxan-2-yl)methyl]azanium;iodide	Investigative	44422691	C9H20INO2	301.17	CC1COCC(O1)C[N+](C)(C)C.[I-]	EC50 = 56234.13 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B5J4WP	N,N,N-Trimethyl-alpha-(2-oxooxazolidine-5alpha-yl)methaneaminium	Investigative	73349592	C7H15N2O2+	159.21	C[N+](C)(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B5ONL2	Trimethyl-[[(5S)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545329	C8H17N2O2+	173.23	CN1C[C@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B5PXN9	1-Ethyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide	Investigative	11545844	C22H28BrNO	402.4	CC[N+]12CCC(CC1)(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]	IC50 = 104000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B68VPY	3-[1-[1-[(2-Chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10251795	C24H29ClN4O	425	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B6IUM0	3-[1-[1-[(2-Nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578976	C24H29N5O3	435.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B6LW3I	2-(3,4-Dimethoxyphenyl)ethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575552	C23H27NO4	381.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC=CC=C3	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B7U0WO	Schembl21373240	Investigative	122195453	C26H29N3O3	431.5	C1CC(CN(C1)CC(=O)C2=C(NC3=CC=CC=C32)C4=CC=CC=C4)C(=O)N5CCOCC5	IC50 = 51300 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B8ACZ5	(5R)-5-[(Dimethylamino)methyl]-3-methyl-1,3-oxazolidin-2-one	Investigative	72545094	C7H14N2O2	158.2	CN1C[C@H](OC1=O)CN(C)C	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B8CRU7	(5S,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44571572	C8H14N2O2	170.21	CN1CCC[C@H]1[C@@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B8FM1A	Trimethyl-[[(2R)-2-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118706050	C9H20INO2	301.17	C[C@]1(COCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B8GY1Q	[(2R,5S,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227416	C10H22INO2	315.19	C[C@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B8YUV4	N-[2-(Dimethylamino)ethyl]-N-methyl-1-(2-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274417	C21H23N3O	333.4	CN(C)CCN(C)C(=O)C1=C/C(=C\\C2=CC=CC=N2)/C3=CC=CC=C31	Ki = 63095.73 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B93OWZ	1-Ethyl-4-phenyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid 4-methoxyphenethyl ester	Investigative	10595006	C23H27NO3	365.5	CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3	IC50 = 52496 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B93RWT	2-(4-Methoxyphenyl)ethyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate;oxalic acid	Investigative	44346640	C25H29NO7	455.5	CCN1CCC(=C(C1)C(=O)OCCC2=CC=C(C=C2)OC)C3=CC=CC=C3.C(=O)(C(=O)O)O	IC50 = 52495.5 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B94YBT	(2-Methoxyphenyl)-N,N,N-trimethylmethanaminium iodide	Investigative	12586122	C11H18INO	307.17	C[N+](C)(C)CC1=CC=CC=C1OC.[I-]	Ki ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B9LTS0	Pyrrolidine, 2-(5-methyl-2-furanyl)-, (2S)-	Investigative	7141654	C9H13NO	151.21	CC1=CC=C(O1)[C@@H]2CCCN2	Ki = 147910.84 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	B9M3LY	6-Chloro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579375	C25H31ClN4O	439	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)Cl)NC4=O	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BAF32L	2-(3-Methoxyphenyl)ethyl-trimethylazanium;formate	Investigative	137655796	C13H21NO3	239.31	C[N+](C)(C)CCC1=CC(=CC=C1)OC.C(=O)[O-]	Ki ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BB30RM	Esaprazole	Investigative	68835	C12H23N3O	225.33	C1CCC(CC1)NC(=O)CN2CCNCC2	IC50 = 87000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BB47ZS	4-Fluoro-N-[3-[1-[7-[4-[5-[(4-fluorobenzoyl)amino]-1H-indol-3-yl]piperidin-1-yl]heptyl]piperidin-4-yl]-1H-indol-5-yl]benzamide	Investigative	24882193	C47H52F2N6O2	770.9	C1CN(CCC1C2=CNC3=C2C=C(C=C3)NC(=O)C4=CC=C(C=C4)F)CCCCCCCN5CCC(CC5)C6=CNC7=C6C=C(C=C7)NC(=O)C8=CC=C(C=C8)F	IC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BB4IT7	2-(3,4-Dimethoxyphenyl)ethyl 4-(3-fluorophenyl)-1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71574174	C23H26FNO4	399.5	CN1CCC(=C(C1)C(=O)OCCC2=CC(=C(C=C2)OC)OC)C3=CC(=CC=C3)F	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BB9YX3	N-Isopropyl-1-piperazineacetamide	Investigative	100826	C9H19N3O	185.27	CC(C)NC(=O)CN1CCNCC1	IC50 = 83000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BBS6Q0	4,5,6,7-Tetrahydro-[1,2]oxazolo[4,5-c]pyridin-3-one;hydrobromide	Investigative	13621534	C6H9BrN2O2	221.05	C1CNCC2=C1ONC2=O.Br	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BC5Y0W	(S)-5beta-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	73351145	C6H12N2O2	144.17	CN(C)C[C@@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BCJ98E	Trimethyl-[[(2R,5R)-5-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	46227554	C9H20INO2	301.17	C[C@@H]1CO[C@@H](CO1)C[N+](C)(C)C.[I-]	Ki = 66069.34 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BDPT63	[(2S)-1-Methylpyrrolidin-2-yl]methyl carbamate	Investigative	72545089	C7H14N2O2	158.2	CN1CCC[C@H]1COC(=O)N	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BDQ19Z	3-Propoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621548	C9H15ClN2O2	218.68	CCCOC1=NOC2=C1CNCC2.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BE2OY8	5-Fluoro-3-[1-[1-[[2-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44579458	C25H28F4N4O	476.5	C1CN(CCC1N2CCC(CC2)N3C4=C(C=CC(=C4)F)NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BEHS61	5-Benzyl-3-methoxy-6,7-dihydro-4H-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621575	C14H17ClN2O2	280.75	COC1=NOC2=C1CN(CC2)CC3=CC=CC=C3.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BF85HL	3-(2-Methylpropoxy)-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621554	C10H17ClN2O2	232.71	CC(C)COC1=NOC2=C1CNCC2.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BF9OW8	3-(2-Bromoprop-2-enoxy)-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621564	C9H12BrClN2O2	295.56	C=C(COC1=NOC2=C1CNCC2)Br.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BG3P0I	2-[[4-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]piperidin-1-yl]methyl]benzonitrile	Investigative	44579416	C25H28ClN5O	450	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5C#N	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BG5E7Y	1,4-Dimethyl-3-(4-methylthio-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydropyridine	Investigative	10354348	C10H15N3S2	241.4	CC1=C(CN(CC1)C)C2=NSN=C2SC	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BGM1F0	2-[(8Ar)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853883	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@@H]3C2	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BGU8H2	Chembl4294617	Investigative	145993493	C25H33N3O2S	439.6	C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=C5C=CSC5=CC=C4	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BH7I2B	N-[2-(Dimethylamino)ethyl]-3-(pyridin-4-ylmethyl)-1H-indene-2-carboxamide	Investigative	11110049	C20H23N3O	321.4	CN(C)CCNC(=O)C1=C(C2=CC=CC=C2C1)CC3=CC=NC=C3	Ki = 134896.29 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BI25BD	5-(1-Azabicyclo[2.2.1]heptan-3-yl)-1,2,4-oxadiazol-3-amine	Investigative	163938	C8H12N4O	180.21	C1CN2CC1C(C2)C3=NC(=NO3)N	EC50 = 104000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BI6DN8	5-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110765	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=CC(=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BI6V1L	Schembl21373237	Investigative	122195446	C24H27N3O4	421.5	CN(CC(=O)C1=C(NC2=CC=CC=C21)C3=CC=C(C=C3)OC)CC(=O)N4CCOCC4	IC50 = 57543.99 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BI85JF	[(2R,6R)-6-Ethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	57326141	C10H22INO2	315.19	CC[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki = 81283.05 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BI98QR	1-Butyl-4-[hydroxy(diphenyl)methyl]-1-azoniabicyclo[2.2.2]octane bromide	Investigative	11539228	C24H32BrNO	430.4	CCCC[N+]12CCC(CC1)(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O.[Br-]	IC50 = 135000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BIO5L9	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)-2-methylpropanamide	Investigative	49853987	C19H35N3O	321.5	CC(C)(C(=O)NC1CCCCC1)N2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BK21QC	Chembl4284346	Investigative	145990794	C25H31N3O2S	437.6	C1C[C@H]2C[C@@H]1[C@H]3[C@@H]2C(=O)N(C3=O)CCCCN4CCN(CC4)C5=C6C=CSC6=CC=C5	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BKR16E	Trimethyl-[[(2R,6R)-6-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	44446840	C9H20INO2	301.17	C[C@@H]1COC[C@H](O1)C[N+](C)(C)C.[I-]	Ki = 61659.5 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BL2FW7	Chembl4277101	Investigative	145983928	C25H29N3O2S	435.6	C1CN(CCN1CCCCN2C(=O)[C@@H]3[C@@H]4C[C@H]([C@@H]3C2=O)C=C4)C5=C6C=CSC6=CC=C5	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BL86PX	[(2R,5R,6S)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227454	C10H22INO2	315.19	C[C@@H]1[C@@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BL8PA0	2-(1-Azabicyclo[2.2.2]octan-3-yl)-1,1-diphenylethanol;hydrobromide	Investigative	49797558	C21H26BrNO	388.3	C1CN2CCC1C(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)O.Br	IC50 = 145000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BLI42P	Methyl 1-ethyl-4-phenyl-3,6-dihydro-2H-pyridine-3-carboxylate;oxalic acid	Investigative	14182317	C17H21NO6	335.4	CCN1CC=C(C(C1)C(=O)OC)C2=CC=CC=C2.C(=O)(C(=O)O)O	IC50 = 88401.3 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BM5FV4	2-(4-Cyclohexylpiperazin-1-yl)-2-methyl-N-propan-2-ylpropanamide	Investigative	49853885	C17H33N3O	295.5	CC(C)NC(=O)C(C)(C)N1CCN(CC1)C2CCCCC2	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BM6K7R	4-[Hydroxy(diphenyl)methyl]-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octane Bromide	Investigative	11691470	C28H32BrNO	478.5	C1C[N+]2(CCC1(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCC5=CC=CC=C5.[Br-]	IC50 = 87000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BO3YC0	6-Chloro-3-[1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578975	C24H28Cl2N4O	459.4	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BR8NT5	2-Naphthalen-1-ylethyl 1-methyl-4-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate	Investigative	71575553	C25H25NO2	371.5	CN1CCC(=C(C1)C(=O)OCCC2=CC=CC3=CC=CC=C32)C4=CC=CC=C4	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BT0EO7	2-[(8As)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-N-cyclohexylacetamide	Investigative	49853884	C15H27N3O	265.39	C1CCC(CC1)NC(=O)CN2CCN3CCC[C@H]3C2	IC50 = 57000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BT9N1V	3-Propan-2-yloxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621552	C9H15ClN2O2	218.68	CC(C)OC1=NOC2=C1CNCC2.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BTF8M9	(5R,2''S)-5-(1-Methyl-2-pyrrolidinyl)oxazolidinone	Investigative	44419370	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2CNC(=O)O2	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BTFJ39	3-Butoxy-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine;hydrochloride	Investigative	13621550	C10H17ClN2O2	232.71	CCCCOC1=NOC2=C1CNCC2.Cl	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BTH09U	Trimethyl-[[(2R,3S)-3-methyl-1,4-dioxan-2-yl]methyl]azanium;iodide	Investigative	118723724	C9H20INO2	301.17	C[C@H]1[C@H](OCCO1)C[N+](C)(C)C.[I-]	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BTHE57	Trimethyl-[[(5R)-3-methyl-2-oxo-1,3-oxazolidin-5-yl]methyl]azanium	Investigative	72545096	C8H17N2O2+	173.23	CN1C[C@@H](OC1=O)C[N+](C)(C)C	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BTZ9Y2	6-Fluoro-3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	25110764	C25H31FN4O	422.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=C(C=C(C=C5)F)NC4=O	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BU4GJ8	N-[2-(Dimethylamino)ethyl]-1-(2-pyridinylmethylene)-1H-indene-3-carboxamide	Investigative	44274317	C20H21N3O	319.4	CN(C)CCNC(=O)C1=C/C(=C\\C2=CC=CC=N2)/C3=CC=CC=C31	Ki = 61659.5 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BU4J8L	Tbpb	Investigative	10092649	C25H32N4O	404.5	CC1=CC=CC=C1CN2CCC(CC2)N3CCC(CC3)N4C5=CC=CC=C5NC4=O	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BWB3G2	(4-Methylpiperazin-1-yl)-[(3E)-3-(pyridin-4-ylmethylidene)inden-1-yl]methanone	Investigative	44274477	C21H21N3O	331.4	CN1CCN(CC1)C(=O)C2=C/C(=C\\C3=CC=NC=C3)/C4=CC=CC=C42	Ki = 97723.72 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BWBH45	[(2S)-1,1-Dimethylpyrrolidin-1-ium-2-yl]methyl carbamate	Investigative	72545098	C8H17N2O2+	173.23	C[N+]1(CCC[C@H]1COC(=O)N)C	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BWF9Y6	[(2R)-5,5-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227458	C10H22INO2	315.19	CC1(CO[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki = 77624.71 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BWOC41	1,1-Diphenyl-2-[1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octan-3-yl]ethanol;bromide	Investigative	42625860	C29H34BrNO	492.5	C1C[N+]2(CCC1C(C2)CC(C3=CC=CC=C3)(C4=CC=CC=C4)O)CCC5=CC=CC=C5.[Br-]	IC50 = 122000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BYC1I9	3-[1-[1-[[2-(Trifluoromethyl)phenyl]methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	10027177	C25H29F3N4O	458.5	C1CN(CCC1N2CCC(CC2)N3C4=CC=CC=C4NC3=O)CC5=CC=CC=C5C(F)(F)F	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BYTO08	N-Cyclohexyl-2-(4-cyclopentylpiperazin-1-yl)acetamide	Investigative	49853881	C17H31N3O	293.4	C1CCC(CC1)NC(=O)CN2CCN(CC2)C3CCCC3	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BYX70W	N-Cyclohexyl-2-(4-methyl-1,4-diazepan-1-yl)acetamide	Investigative	49855131	C14H27N3O	253.38	CN1CCCN(CC1)CC(=O)NC2CCCCC2	IC50 ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BYXU78	(R)-5alpha-[(Dimethylamino)methyl]oxazolidine-2-one	Investigative	57558000	C6H12N2O2	144.17	CN(C)C[C@H]1CNC(=O)O1	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BZ3UC8	6-Chloro-3-[1-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one	Investigative	44578977	C24H28ClN5O3	470	C1CN(CCC1N2CCC(CC2)N3C4=C(C=C(C=C4)Cl)NC3=O)CC5=CC=CC=C5[N+](=O)[O-]	EC50 ~ 50000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BZ4I0N	(4S)-4-[(2S)-1-Methylpyrrolidin-2-yl]-1,3-oxazolidin-2-one	Investigative	72545326	C8H14N2O2	170.21	CN1CCC[C@H]1[C@H]2COC(=O)N2	Ki ~ 100000 nM	Poor binder
T67684	Muscarinic acetylcholine receptor M3	BZP0V3	[(2R,5R,6R)-5,6-Dimethyl-1,4-dioxan-2-yl]methyl-trimethylazanium;iodide	Investigative	46227414	C10H22INO2	315.19	C[C@@H]1[C@H](O[C@@H](CO1)C[N+](C)(C)C)C.[I-]	Ki ~ 100000 nM	Poor binder