TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T70176	Cyclin-dependent kinase 2	D07POC	Erlotinib	Approved	176870	C22H23N3O4	393.4	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	D08MXP	LEE011	Phase 3	44631912	C23H30N8O	434.5	CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5	IC50 = 76000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	D0A3MV	AR-A014418	Patented	448014	C12H12N4O4S	308.32	COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B08UKS	3-Naphthalen-2-yl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-5-amine	Investigative	59662448	C22H17N5	351.4	C1=CC=C2C=C(C=CC2=C1)C3=C4N=C(C=CN4N=C3)NCC5=CN=CC=C5	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B0JF6B	(4Z)-4-({[4-(Piperidin-1-ylmethyl)phenyl]amino}methylene)-6-thien-3-ylisoquinoline-1,3(2H,4H)-dione	Investigative	135939782	C27H26N4O2	438.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CN=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B0LM1Y	(4Z)-4-({[4-(3,4-Dimethylpiperazin-1-yl)phenyl]amino}methylene)-6-iodoisoquinoline-1,3(2H,4H)-dione	Investigative	135939835	C22H23IN4O2	502.3	CC1CN(CCN1C)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)I)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B0N7JR	5-Fluoro-3-(2-indol-1-yl-ethyl)-1H-indole	Investigative	11265905	C18H15FN2	278.3	C1=CC=C2C(=C1)C=CN2CCC3=CNC4=C3C=C(C=C4)F	IC50 = 200000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B0VP1T	(4Z)-6-(4-Fluorophenyl)-4-({[4-(piperidin-1-ylmethyl)phenyl]-amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939827	C28H26FN3O2	455.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=C(C=C5)F)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B0WLH8	N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide	Investigative	58056356	C17H12N4O2S	336.4	COC1=C(C=C2C=CC=NC2=C1)NC(=O)C3=CSC4=CN=CN=C43	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B0ZEA6	14,16-Dihydroxy-3,5-dioxa-10-azapentacyclo[9.7.1.02,6.08,19.013,18]nonadeca-1(18),2(6),7,11(19),12,14,16-heptaen-9-one	Investigative	46232477	C16H9NO5	295.25	C1OC2=C(O1)C3=C4C=C(C=C(C4=CC5=C3C(=C2)C(=O)N5)O)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B1EU9D	(4Z)-6-(3-Furyl)-4-({[5-(4-methylpiperazin-1-yl)pyrazin-2-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939788	C23H22N6O3	430.5	CN1CCN(CC1)C2=NC=C(N=C2)/N=C/C3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B1H4FN	3-Hydroxy-4-[[4-(piperidin-1-ylmethyl)phenyl]iminomethyl]-6-pyrrol-1-yl-2H-isoquinolin-1-one	Investigative	135939817	C26H26N4O2	426.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)N5C=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B1JQS2	4,6-Bis anilino pyrimidine deriv. 8	Investigative	6538978	C22H27N5O3	409.5	CN(C)CC(COC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=CC=CC=C3OC)O	IC50 = 85000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B1K3WE	4,6-Bis anilino pyrimidine deriv. 1	Investigative	6538972	C21H23F2N5O2	415.4	CN(C)CC(COC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=C(C=C(C=C3)F)F)O	IC50 = 93000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B1O4NA	(4Z)-6-Nitro-4-{[(4-piperidin-1-ylmethyl)phenyl]amino}methyleneisoquinoline-1,3(2H,4H)-dione	Investigative	135939815	C22H22N4O4	406.4	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)[N+](=O)[O-])O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B20NZX	4,6-Bis anilino pyrimidine deriv. 6	Investigative	6538976	C21H24ClN5O2	413.9	CN(C)CC(COC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=CC=CC=C3Cl)O	IC50 = 95000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B2QF5I	(4Z)-6-(4-Methoxyphenyl)-4-({[4-(piperidin-1-ylmethyl)phenyl]-amino}methylene)-isoquinoline-1,3(2H,4H)-dione	Investigative	135939830	C29H29N3O3	467.6	COC1=CC=C(C=C1)C2=CC3=C(C=C2)C(=O)NC(=C3C=NC4=CC=C(C=C4)CN5CCCCC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B2R0HD	Corytuberine	Investigative	160500	C19H21NO4	327.4	CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=C3C(=C(C=C4)OC)O)O)OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B2UCY1	(4Z)-6-Iodo-4-[({4-[(2S,5R)-2,4,5-trimethylpiperazin-1-yl]phenyl}amino)methylene]-isoquinoline-1,3(2H,4H)-dione	Investigative	135939836	C23H25IN4O2	516.4	C[C@H]1CN([C@@H](CN1C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)I)O)C)C	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B2VP3O	N-(2-(1H-Indol-3-yl)ethyl)-N,4''-dimethylbiphenyl-4-carboxamide	Investigative	44587519	C25H24N2O	368.5	CC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)N(C)CCC3=CNC4=CC=CC=C43	IC50 = 70000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B2YJP3	Indazole-benzimidazole, 15	Investigative	135928482	C26H27N7	437.5	CNC1=CC=C(C=C1)C2=CC3=C(C=C2)C(=NN3)C4=NC5=C(N4)C=CC=C5N6CCN(CC6)C	IC50 = 109000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B2ZF3S	(4Z)-6-Phenyl-4-({[4-piperidin-1-ylmethyl]phenyl}amino)-methylene)}isoquinoline-1,3(2H,4H)-dione	Investigative	135939825	C28H27N3O2	437.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B34WHP	4,6 Bis anilino pyrimidine deriv. 9	Investigative	6539013	C22H27N5O3	409.5	CN(C)CC(COC1=CC=C(C=C1)NC2=NC=NC(=C2)NC3=CC=C(C=C3)OC)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3A9GH	(3r)-1-{2-[4-(4-Acetylphenyl)piperazin-1-Yl]-2-Oxoethyl}-N-(3-Chloro-4-Hydroxyphenyl)pyrrolidine-3-Carboxamide	Investigative	58985201	C25H29ClN4O4	485	CC(=O)C1=CC=C(C=C1)N2CCN(CC2)C(=O)CN3CC[C@H](C3)C(=O)NC4=CC(=C(C=C4)O)Cl	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3HX6M	N-(2-(1H-Indol-3-yl)ethyl)-4''-phenyl-N-methylbiphenyl-4-carboxamide	Investigative	44587539	C30H26N2O	430.5	CN(CCC1=CNC2=CC=CC=C21)C(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CC=CC=C5	IC50 = 91000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3ILX6	1-(6-Aminopyrimidin-4-yl)pyrrolo[2,3-b]pyridine-6-carbonitrile	Investigative	71553522	C12H8N6	236.23	C1=CC(=NC2=C1C=CN2C3=NC=NC(=C3)N)C#N	IC50 ~ 83000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3NS1V	Salutaridine	Investigative	5408233	C19H21NO4	327.4	CN1CC[C@]23C=C(C(=O)C=C2[C@H]1CC4=C3C(=C(C=C4)OC)O)OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3P8KI	6-Bromo-4-[(4-piperidin-1-ylmethyl-phenylamino)methylene]-4H-isoquinoline-1,3-dione	Investigative	135875716	C22H22BrN3O2	440.3	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)Br)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3Q9GA	Pyrazole amide, 17	Investigative	24971314	C10H9FN4O	220.2	C1=CC(=CC=C1NC(=O)C2=C(C=NN2)N)F	IC50 = 85000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B3T9QN	Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44219749	C24H29N7O5	495.5	COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B43WPI	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2R)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325478	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B4C2AW	(4Z)-6-(4-Chlorophenyl)-4-({[4-(piperidin-1-ylmethyl)phenyl]-amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939783	C28H26ClN3O2	472	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=C(C=C5)Cl)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B4EDW2	Isocorydine	Investigative	10143	C20H23NO4	341.4	CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC)OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B4G2QZ	Methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605035	C22H27N7O3	437.5	COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B54BZL	Benzamide, 4-[[4-amino-6-(cyclohexylmethoxy)-2-pyrimidinyl]amino]-	Investigative	5329598	C18H23N5O2	341.4	C1CCC(CC1)COC2=NC(=NC(=C2)N)NC3=CC=C(C=C3)C(=O)N	IC50 = 59000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B58TMC	[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamate	Investigative	24753787	C21H22ClN3O6S	479.9	CC1=C(C(=O)OC2=CC(=C(C=C12)Cl)OC(=O)N(C)C)CC3=CC(=CC=C3)NS(=O)(=O)NC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B59BPN	(4Z)-6-(4-Hydroxyphenyl)-4-({[4-piperidin-1-ylmethyl]phenyl}-amino)methylene)}isoquinoline-1,3(2H,4H)-dione	Investigative	135939829	C28H27N3O3	453.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=C(C=C5)O)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B5BFO0	(4Z)-4-[[4-(Piperidin-1-ylmethyl)anilino]methylidene]-6-thiophen-3-ylisoquinoline-1,3-dione	Investigative	135939826	C26H25N3O2S	443.6	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CSC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B5FSP8	(4Z)-6-(4-Phenoxyphenyl)-(4-({[4-piperidin-1-ylmethyl]phenyl}-amino)methylene)}isoquinoline-1,3(2H,4H)-dione	Investigative	135939831	C34H31N3O3	529.6	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=C(C=C5)OC6=CC=CC=C6)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B5LUX3	7-N-(4-Ethoxyphenyl)-6-methyl-5-N-[(3R)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60200408	C20H26N6O	366.5	CCOC1=CC=C(C=C1)NC2=C(C(=NC3=CC=NN32)N[C@@H]4CCCNC4)C	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B5MCJ0	1-(2-Aminopyrimidin-4-yl)pyrrolo[3,2-b]pyridine-6-carbonitrile	Investigative	71580829	C12H8N6	236.23	C1=CN=C(N=C1N2C=CC3=C2C=C(C=N3)C#N)N	IC50 ~ 83000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B5RA4H	N-[(4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-6-yl]acetamide	Investigative	135939813	C23H25N5O3	419.5	CC(=O)NC1=CC2=C(C=C1)C(=O)NC(=C2C=NC3=CC=C(C=C3)N4CCN(CC4)C)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B5TYH4	(4Z)-6-(3-Furyl)-4-({[4-(4-methylpiperazin-1-yl)phenyl]amino}-methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939822	C25H24N4O3	428.5	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B60CAW	(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide	Investigative	46232555	C20H15Cl2FN2O2	405.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)/C=C/C(=O)N	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B6N4KU	4,6-Bis anilino pyrimidine deriv. 2	Investigative	6538931	C21H25N5O2	379.5	CN(C)CC(COC1=CC=C(C=C1)NC2=NC=NC(=C2)NC3=CC=CC=C3)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B6XA4Z	6-Bromo-4-{[4-(4-methyl-piperazin-1-yl)-phenylamino]-methylene}-4H-isoquinoline-1,3-dione	Investigative	135939807	C21H21BrN4O2	441.3	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)Br)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B7MO4E	4-[6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide	Investigative	24959046	C21H26N6O	378.5	CN(C)CCNC(=O)C1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NCC4CC4	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B7N1WR	3-[(E)-2-(4-Chlorophenyl)ethenyl]-N-[(2S)-2,3-dihydroxypropyl]-4-methoxybenzamide	Investigative	57325479	C19H20ClNO4	361.8	COC1=C(C=C(C=C1)C(=O)NC[C@@H](CO)O)/C=C/C2=CC=C(C=C2)Cl	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B7OEI6	N-(5-(Dibutylamino)-1H-indazol-3-yl)-2-phenylacetamide	Investigative	44447905	C23H30N4O	378.5	CCCCN(CCCC)C1=CC2=C(C=C1)NN=C2NC(=O)CC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B7W2NM	Stephanine	Investigative	160501	C19H19NO3	309.4	CN1CCC2=CC3=C(C4=C2[C@H]1CC5=C4C=CC=C5OC)OCO3	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B7YZS1	(4Z)-6-(2-Furyl)-4-({[4-(4-methylpiperazin-1-yl)phenyl]amino}-methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939821	C25H24N4O3	428.5	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=CO5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B7ZDB8	(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline	Investigative	46232443	C17H12Cl2FNO	336.2	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=C(C=C2)N=CC=C3	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B87BVH	(4Z)-6-Iodo-4-({[4-(4-methylpiperazin-1-yl)phenyl]amino}-methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939811	C21H21IN4O2	488.3	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)I)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B87KWG	3-(5-Fluoro-6-Iodo-1-Methyl-1h-Indol-3-Yl)-4-(7-Methoxy-1-Benzofuran-3-Yl)-1h-Pyrrole-2,5-Dione	Investigative	24825779	C22H14FIN2O4	516.299	CN1C=C(C2=CC(=C(C=C21)I)F)C3=C(C(=O)NC3=O)C4=COC5=C4C=CC=C5OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B8G6DZ	AZ-Dyrk1B-33	Investigative	118735338	C19H16N4	300.4	CC1=NC=CC(=N1)C2=CN(C3=C2C=CN=C3)CC4=CC=CC=C4	IC50 = 56703 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B8OQ9N	4-Nitro-2-{[4-(methylsulfanyl)benzylidene]amino}phenol	Investigative	832258	C14H12N2O3S	288.32	CSC1=CC=C(C=C1)C=NC2=C(C=CC(=C2)[N+](=O)[O-])O	IC50 = 52120 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B8R9BM	5-[6-(5-Difluoromethyl-[1,3,4]oxadiazol-2-yl)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-2,4-difluoro-N-methoxy-benzamide	Investigative	10073832	C20H17F4N7O3	479.4	CC(C)C1=C2C(=NC=NN2C=C1C3=NN=C(O3)C(F)F)NC4=C(C=C(C(=C4)C(=O)NOC)F)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B8USB7	3-Hydroxy-2-methyl-2-(2-methyl-4-oxo-6-phenyl-1,5,6,7-tetrahydroindol-3-yl)-6-phenyl-6,7-dihydro-5H-indol-4-one	Investigative	136845708	C30H28N2O3	464.6	CC1=C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3)C4(C(=C5C(=N4)CC(CC5=O)C6=CC=CC=C6)O)C	IC50 ~ 91000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B94XNG	(4Z)-6-(3-Furyl)-4-({[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939786	C23H22N6O3	430.5	CN1CCN(CC1)C2=NN=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B95ETX	(4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)-6-thien-3-ylisoquinoline-1,3(2H,4H)-dione	Investigative	135939780	C25H24N4O2S	444.6	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CSC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B9D0FM	(4Z)-6-(3-Furyl)-4-({[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939768	C24H23N5O3	429.5	CN1CCN(CC1)C2=CN=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B9JS2Z	4-{[(4-Hydroxy-5-methoxy-pyrimidin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione	Investigative	135922731	C16H13IN4O4	452.2	COC1=CN=C(NC1=O)CN=CC2=C(NC(=O)C3=C2C=C(C=C3)I)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B9LSF5	2,4-Difluoro-5-[5-isopropyl-6-(5-methyl-[1,3,4]oxadiazol-2-yl)-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino]-N-methoxy-benzamide	Investigative	10478569	C20H19F2N7O3	443.4	CC1=NN=C(O1)C2=CN3C(=C2C(C)C)C(=NC=N3)NC4=C(C=C(C(=C4)C(=O)NOC)F)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	B9O5JW	Canadine	Investigative	34458	C20H21NO4	339.4	COC1=C(C2=C(CC3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BAL94P	4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-5-indolyl]amino]-4-pyrimidinyl]amino]-1-cyclohexanol	Investigative	24825971	C27H32N6O	456.6	CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BBV6Y7	1-[4-[4-[(4-Imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]ethanone	Investigative	56659843	C24H25N7O2	443.5	CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN=C5N4C=CC=C5)OC	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BBW85N	(4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)-6-(phenylethynyl)-isoquinoline-1,3(2H,4H)-dione	Investigative	135939781	C29H26N4O2	462.5	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C#CC5=CC=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BC0D6Y	3-(6-Chloro-5-fluoro-1-methyl-1H-indol-3-yl)-4-(7-methoxybenzofuran-3-yl)pyrrole-2,5-dione	Investigative	44582716	C22H14ClFN2O4	424.8	CN1C=C(C2=CC(=C(C=C21)Cl)F)C3=C(C(=O)NC3=O)C4=COC5=C4C=CC=C5OC	IC50 = 99000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BC75NS	N-(4-(N-(4,6-Dimethylpyrimidin-2-yl)sulfamoyl)phenyl)-3,4,5-triethoxybenzamide	Investigative	1187348	C25H30N4O6S	514.6	CCOC1=CC(=CC(=C1OCC)OCC)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC(=CC(=N3)C)C	IC50 = 105100 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BD1RI5	4-[(3-Hydroxy-4-pyridin-4-yl-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dione	Investigative	135863112	C22H16IN3O3	497.3	C1=CC(=C(C=C1CN=CC2=C(NC(=O)C3=C2C=C(C=C3)I)O)O)C4=CC=NC=C4	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BD2JP3	(4Z)-6-(3-Methoxyphenyl)-4-[[4-(piperidin-1-ylmethyl)anilino]methylidene]isoquinoline-1,3-dione	Investigative	135939784	C29H29N3O3	467.6	COC1=CC=CC(=C1)C2=CC3=C(C=C2)C(=O)NC(=C3C=NC4=CC=C(C=C4)CN5CCCCC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BF03QX	2,2,2-Trifluoro-N-[4-(2-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]acetamide	Investigative	6539007	C14H10F3N5O	321.26	CC1=C(N2C=CC=CC2=N1)C3=NC(=NC=C3)NC(=O)C(F)(F)F	IC50 = 95000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BF41MS	(4Z)-6-(3-Furyl)-4-({[6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939769	C24H23N5O3	429.5	CN1CCN(CC1)C2=NC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BFJ3P7	(4Z)-6-Piperidin-1-yl-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939819	C27H32N4O2	444.6	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)N5CCCCC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BFT1P4	N-(2-(1H-Indol-3-yl)ethyl)-N-methyl-4-(pyridin-4-yl)benzamide	Investigative	44587808	C23H21N3O	355.4	CN(CCC1=CNC2=CC=CC=C21)C(=O)C3=CC=C(C=C3)C4=CC=NC=C4	IC50 = 92000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BG40KU	[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid tetrahydro-furan-2-ylmethyl ester	Investigative	11477626	C23H26F2N6O5	504.5	CC(C)C1=C2C(=NC=NN2C=C1NC(=O)OCC3CCCO3)NC4=C(C=C(C(=C4)C(=O)NOC)F)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BG7CL8	4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide	Investigative	24959043	C24H24Cl2N6O	483.4	CN(C)CCNC(=O)C1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NCC4=CC(=C(C=C4)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BG83YQ	6-Methyl-7-N-[4-(2-morpholin-4-ylethoxy)phenyl]-5-N-[(3S)-piperidin-3-yl]pyrazolo[1,5-a]pyrimidine-5,7-diamine	Investigative	60200900	C24H33N7O2	451.6	CC1=C(N2C(=CC=N2)N=C1N[C@H]3CCCNC3)NC4=CC=C(C=C4)OCCN5CCOCC5	IC50 = 62000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BG93DE	(4Z)-6-Nitro-4-({[4-(4-methylpiperazin-1-yl)phenyl]amino}-methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939772	C21H21N5O4	407.4	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)[N+](=O)[O-])O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BGM57R	(4Z)-4-({[3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}-methylene)-6-(3-furyl)isoquinoline-1,3(2H,4H)-dione	Investigative	135939770	C25H23FN4O3	446.5	CN1CCN(CC1)C2=C(C=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BH4TW6	7-Methyl-3-[2-(4-methylsulfonylphenyl)pyrimidin-4-yl]-1H-pyrrolo[2,3-c]pyridine	Investigative	118735335	C19H16N4O2S	364.4	CC1=NC=CC2=C1NC=C2C3=NC(=NC=C3)C4=CC=C(C=C4)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BHN9G3	(E)-3-[1-[4-(3-Ethynylanilino)quinazolin-6-yl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide	Investigative	58191961	C23H17N5O4S	459.5	C#CC1=CC(=CC=C1)NC2=NC=NC3=C2C=C(C=C3)S(=O)(=O)N4C=CC(=C4)/C=C/C(=O)NO	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BHU4O2	N-(2-(1H-Indol-3-yl)ethyl)-3-(pyridin-3-yl)benzamide	Investigative	44587809	C22H19N3O	341.4	C1=CC=C2C(=C1)C(=CN2)CCNC(=O)C3=CC=CC(=C3)C4=CN=CC=C4	IC50 = 150000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BHX3S5	1-Pyrimidin-4-ylindole-6-carbonitrile	Investigative	71580638	C13H8N4	220.23	C1=CC(=CC2=C1C=CN2C3=NC=NC=C3)C#N	IC50 ~ 83000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BIE61Q	1-Methyl-3-[2-(4-methylsulfonylphenyl)pyrimidin-4-yl]pyrrolo[2,3-c]pyridine	Investigative	118735334	C19H16N4O2S	364.4	CN1C=C(C2=C1C=NC=C2)C3=NC(=NC=C3)C4=CC=C(C=C4)S(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BIH9J6	(4Z)-6-(3-Furyl)-4-({[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939771	C23H22N6O3	430.5	CN1CCN(CC1)C2=NC=C(C=N2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BJU4Y3	CID 56673689	Investigative	56673689	C25H27N7O3	473.5	CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)C4=CN=C5N4C=CC=C5)OC)OC	IC50 = 53000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BK2GQ1	N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide	Investigative	27666048	C21H20N2O3S	380.5	CN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BKIX59	4-[6-Chloro-3-(2-chloropyridin-3-yl)pyrrolo[3,2-c]pyridin-1-yl]pyrimidin-2-amine	Investigative	71580917	C16H10Cl2N6	357.2	C1=CC(=C(N=C1)Cl)C2=CN(C3=CC(=NC=C32)Cl)C4=NC(=NC=C4)N	IC50 ~ 83000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BKO62B	4-[3-(3-Chlorophenyl)pyrrolo[3,2-c]pyridin-1-yl]pyrimidin-2-amine	Investigative	71580914	C17H12ClN5	321.8	C1=CC(=CC(=C1)Cl)C2=CN(C3=C2C=NC=C3)C4=NC(=NC=C4)N	IC50 ~ 83000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BKS9W8	(4Z)-6-Piperidin-1-yl-4-({[4-(methylpiperazin-1-yl)phenyl]-amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939818	C26H31N5O2	445.6	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)N5CCCCC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BL2EZ0	(4Z)-6-(Furan-3-yl)-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione	Investigative	135875746	C26H25N3O3	427.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=COC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BMP0C7	Tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate	Investigative	44605037	C25H33N7O3	479.6	CC(C)(C)OC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)N)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BN37JB	Corydine	Investigative	10153	C20H23NO4	341.4	CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=C3C(=C(C=C4)OC)OC)O)OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BN3Y0E	3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide	Investigative	11235063	C21H21N7O2	403.4	CC1=C(C=C(C=C1)C(=O)NC2=NOC=C2)NC3=C(C(=NC=N3)NC4CCCC4)C#N	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BN6O5J	3-Hydroxy-6-(4-methylpiperazin-1-yl)-4-[[4-(piperidin-1-ylmethyl)phenyl]iminomethyl]-2H-isoquinolin-1-one	Investigative	135939820	C27H33N5O2	459.6	CN1CCN(CC1)C2=CC3=C(C=C2)C(=O)NC(=C3C=NC4=CC=C(C=C4)CN5CCCCC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BND2I0	1-(6-Aminopyrimidin-4-yl)indole-6-carbonitrile	Investigative	71580636	C13H9N5	235.24	C1=CC(=CC2=C1C=CN2C3=NC=NC(=C3)N)C#N	IC50 ~ 83000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BO9HF5	(5Z)-2-Imino-5-[[5-(4-morpholin-4-ylsulfonylphenyl)furan-2-yl]methylidene]-1,3-thiazolidin-4-one	Investigative	137628992	C18H17N3O5S2	419.5	C1COCCN1S(=O)(=O)C2=CC=C(C=C2)C3=CC=C(O3)/C=C\\4/C(=O)NC(=N)S4	IC50 = 150000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BOE96M	Crebanine	Investigative	159999	C20H21NO4	339.4	CN1CCC2=CC3=C(C4=C2C1CC5=C4C=CC(=C5OC)OC)OCO3	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BOY29H	4,6-Bis anilino pyrimidine deriv. 16	Investigative	6538984	C28H29Cl2N5O2	538.5	CN(C)CC(COC1=CC=C(C=C1)NC2=CC(=NC=N2)N(CC3=CC=CC=C3)C4=C(C=CC(=C4)Cl)Cl)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BPO9D8	4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-(2-pyrrolidin-1-ylethyl)benzamide	Investigative	49864785	C26H26Cl2N6O	509.4	C1CCN(C1)CCNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5=CC(=C(C=C5)Cl)Cl	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BPV4H6	2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide	Investigative	46232556	C21H17Cl2FN2O2	419.3	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC3=CC(=CN=C3C=C2)C4CC4C(=O)N	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BQ1GT4	(4Z)-6-Anilino-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135875719	C28H28N4O2	452.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)NC5=CC=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BQUZ09	4-[6-[(3-Chlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide	Investigative	49865153	C25H25ClN6O	461	C1C[C@H](NC1)CNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5=CC(=CC=C5)Cl	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BRN8J1	N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide	Investigative	24822704	C25H16F3N5O	459.4	C1=CC(=CC(=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC=NC4=CC(=NN34)C5=CC=NC=C5	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BROK46	4,6 Bis anilino pyrimidine deriv. 12	Investigative	6539015	C22H26FN5O2	411.5	CC1=CC(=C(C=C1)F)NC2=NC=NC(=C2)NC3=CC=C(C=C3)OCC(CN(C)C)O	IC50 = 81000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BRXD64	Indigo	Investigative	10215	C16H10N2O2	262.26	C1=CC=C2C(=C1)C(=C(N2)C3=NC4=CC=CC=C4C3=O)O	IC50 = 70000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BS97QD	Roemerine HBr	Investigative	46232561	C18H18BrNO2	360.2	CN1CCC2=CC3=C(C4=C2[C@H]1CC5=CC=CC=C54)OCO3.Br	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BSW76L	2-Amino-6-methoxypurine	Investigative	65275	C6H7N5O	165.15	COC1=NC(=NC2=C1NC=N2)N	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BT42EV	6-Iodo-4-{[4-(5-methyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-phenylamino]-methylene}-4H-isoquinoline-1,3-dione	Investigative	136045789	C22H21IN4O2	500.3	CN1CC2CC1CN2C3=CC=C(C=C3)N=CC4=C(NC(=O)C5=C4C=C(C=C5)I)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BT5D6F	(4Z)-6-Morpholin-4-yl-4-({[4-(piperidin-1-ylmethyl)phenyl]-amino}methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939778	C26H30N4O3	446.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)N5CCOCC5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BT7JF9	1H-Indazole	Investigative	9221	C7H6N2	118.14	C1=CC=C2C(=C1)C=NN2	IC50 = 185000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BTCQ17	[4-(2,4-Difluoro-5-methoxycarbamoyl-phenylamino)-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamic acid 3-methanesulfonyl-propyl ester	Investigative	9893493	C22H26F2N6O6S	540.5	CC(C)C1=C2C(=NC=NN2C=C1NC(=O)OCCCS(=O)(=O)C)NC3=C(C=C(C(=C3)C(=O)NOC)F)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BTNA47	10-Bromo-11H-indolo[3,2-c]quinoline-6-carboxylic acid	Investigative	122181014	C16H9BrN2O2	341.16	C1=CC=C2C(=C1)C3=C(C4=C(N3)C(=CC=C4)Br)C(=N2)C(=O)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BTO92W	(4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)-6-(1H-pyrrol-1-yl)isoquinoline-1,3(2H,4H)-dione	Investigative	135939773	C25H25N5O2	427.5	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)N5C=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BUMF97	(4Z)-4-({[4-(3,5-Dimethylpiperazin-1-yl)phenyl]amino}methylene)-6-iodoisoquinoline-1,3(2H,4H)-dione	Investigative	135939833	C22H23IN4O2	502.3	C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)I)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BV45SY	(4Z)-6-Chloro-4-({[4-(piperidin-1-ylmethyl)phenyl]amino}-methylene)isoquinoline-1,3(2H,4H)-dione	Investigative	135939775	C22H22ClN3O2	395.9	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)Cl)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BV5S3F	6-(Cyclohexylmethoxy)-9-methyl-9h-purin-2-amine	Investigative	398149	C13H19N5O	261.32	CN1C=NC2=C1N=C(N=C2OCC3CCCCC3)N	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BVDF78	(S)-4-(6-(Cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide	Investigative	46933384	C22H26N6O	390.5	C1C[C@H](NC1)CNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5CC5	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BVW0E5	4,6-Bis anilino pyrimidine deriv. 5	Investigative	6538975	C21H24FN5O2	397.4	CN(C)CC(COC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=CC=CC=C3F)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BW05DU	(4Z)-4-({[4-(4-Methylpiperazin-1-yl)phenyl]amino}methylene)-6-phenylisoquinoline-1,3(2H,4H)-dione	Investigative	135939779	C27H26N4O2	438.5	CN1CCN(CC1)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC=CC=C5)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BW8AH4	6-(Adamantylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine	Investigative	10524103	C21H32N6O	384.5	CC(C)N1C=NC2=C(N=C(N=C21)NCCCO)NC34CC5CC(C3)CC(C5)C4	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BW8M7X	6-Methoxy-4-[(4-piperidin-1-ylmethyl-phenylamino)-methylene]-4H-isoquinoline-1,3-dione	Investigative	135939814	C23H25N3O3	391.5	COC1=CC2=C(C=C1)C(=O)NC(=C2C=NC3=CC=C(C=C3)CN4CCCCC4)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BWF61X	Dicentrine	Investigative	101300	C20H21NO4	339.4	CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC(=C(C=C54)OC)OC)OCO3	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BWM8T7	4-[3-[[4-(Dimethylamino)benzoyl]amino]-2-fluorophenyl]-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide	Investigative	122191637	C34H33FN6O3	592.7	CN1CCN(CC1)C(=O)C2=CC3=C(C=C2)C4=C(C=CC(=C4N3)C(=O)N)C5=C(C(=CC=C5)NC(=O)C6=CC=C(C=C6)N(C)C)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BWY3P1	4-[6-[(3,4-Dichlorophenyl)methylamino]imidazo[1,2-b]pyridazin-3-yl]-N-[[(2S)-pyrrolidin-2-yl]methyl]benzamide	Investigative	49864850	C25H24Cl2N6O	495.4	C1C[C@H](NC1)CNC(=O)C2=CC=C(C=C2)C3=CN=C4N3N=C(C=C4)NCC5=CC(=C(C=C5)Cl)Cl	IC50 = 95000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BXF62Y	5-{6-[5-(Difluoro-methanesulfonyl-methyl)-[1,3,4]oxadiazol-2-yl]-5-isopropyl-pyrrolo[2,1-f][1,2,4]triazin-4-ylamino}-2,4-difluoro-N-methoxy-benzamide	Investigative	11432911	C21H19F4N7O5S	557.5	CC(C)C1=C2C(=NC=NN2C=C1C3=NN=C(O3)C(F)(F)S(=O)(=O)C)NC4=C(C=C(C(=C4)C(=O)NOC)F)F	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BXZ3A8	(4Z)-6-Iodo-4-[({4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl]phenyl}amino)methylene]-isoquinoline-1,3(2H,4H)-dione	Investigative	135939834	C23H25IN4O2	516.4	C[C@@H]1CN(C[C@@H](N1C)C)C2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)I)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BY4DI6	4,6 Bis anilino pyrimidine deriv. 10	Investigative	6539014	C22H27N5O2	393.5	CC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=CC=C(C=C3)OCC(CN(C)C)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BYFE78	(4Z)-6-(3-Hydroxyphenyl)-4-({[4-piperidin-1-ylmethyl]phenyl}-amino)methylene)}isoquinoline-1,3(2H,4H)-dione	Investigative	135939828	C28H27N3O3	453.5	C1CCN(CC1)CC2=CC=C(C=C2)N=CC3=C(NC(=O)C4=C3C=C(C=C4)C5=CC(=CC=C5)O)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BYI4C1	4,6 Bis anilino pyrimidine deriv. 8	Investigative	6539012	C21H24ClN5O2	413.9	CN(C)CC(COC1=CC=C(C=C1)NC2=CC(=NC=N2)NC3=CC=C(C=C3)Cl)O	IC50 ~ 100000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BYL0Z6	4-[(3-Hydroxy-4-pyridin-2-yl-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dione	Investigative	135863111	C22H16IN3O3	497.3	C1=CC=NC(=C1)C2=C(C=C(C=C2)CN=CC3=C(NC(=O)C4=C3C=C(C=C4)I)O)O	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	BYUE71	Sinomenine	Investigative	5459308	C19H23NO4	329.4	CN1CC[C@@]23CC(=O)C(=C[C@@H]2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC	IC50 ~ 50000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	D06LJL	PMID16451062C46	Investigative	9916282	C29H33FN6O4S	580.7	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=NC=C(S3)CC(=O)NC4=CC(=CC=C4)F)OCCCN5CCC(CC5)CO	IC50 = 62000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	D0O1KD	1-Anilino-8-Naphthalene Sulfonate	Investigative	1369	C16H13NO3S	299.3	C1=CC=C(C=C1)NC2=CC=CC3=C2C(=CC=C3)S(=O)(=O)O	IC50 = 91000 nM	Poor binder
T70176	Cyclin-dependent kinase 2	D0W7TU	NSC-73306	Investigative	947057	C16H14N4O2S	326.4	.	IC50 ~ 50000 nM	Poor binder