TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T71081 GTPase HRas B0PVH6 Benzoic acid (2S,5R)-5-(4-chloro-6-methoxy-3-methyl-pyrazolo[3,4-b]quinolin-1-yl)-2,5-dihydro-furan-2-ylmethyl ester Investigative 44303262 C24H20ClN3O4 449.9 CC1=NN(C2=NC3=C(C=C(C=C3)OC)C(=C12)Cl)[C@H]4C=C[C@H](O4)COC(=O)C5=CC=CC=C5 IC50 = 80000 nM Poor binder T71081 GTPase HRas BEA67K N-[(3R,4R,5S,6R)-2-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Investigative 90665526 C22H28N2O8 448.5 CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](OC1N(CC2=CC(=C(C=C2)O)O)OCC3=CC=CC=C3)CO)O)O IC50 = 80000 nM Poor binder T71081 GTPase HRas BJ1SA8 (3R,4S,5S,6R)-2-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-6-(hydroxymethyl)oxane-3,4,5-triol Investigative 90665525 C20H25NO8 407.4 C1=CC=C(C=C1)CON(CC2=CC(=C(C=C2)O)O)C3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O IC50 = 80000 nM Poor binder T71081 GTPase HRas BQO86C Tert-butyl-[[(2S,6R)-6-(4-chloro-6-methoxy-3-methylpyrazolo[3,4-b]quinolin-1-yl)-4-(4-nitrophenyl)sulfanylmorpholin-2-yl]methoxy]-dimethylsilane Investigative 44303334 C29H36ClN5O5SSi 630.2 CC1=NN(C2=NC3=C(C=C(C=C3)OC)C(=C12)Cl)[C@H]4CN(C[C@H](O4)CO[Si](C)(C)C(C)(C)C)SC5=CC=C(C=C5)[N+](=O)[O-] IC50 = 50000 nM Poor binder T71081 GTPase HRas BTC82Y (2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R)-6-[(3,4-Dihydroxyphenyl)methyl-phenylmethoxyamino]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Investigative 90665527 C26H35NO13 569.6 C1=CC=C(C=C1)CON(CC2=CC(=C(C=C2)O)O)C3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)O IC50 = 100000 nM Poor binder