TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T72252	Caspase-7	B07OWV	4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic Acid	Investigative	4246483	C15H14O6	290.27	CCOC(=O)COC1=CC(=C(C2=CC=CC=C21)O)C(=O)O	IC50 = 84900 nM	Poor binder
T72252	Caspase-7	B0PL7X	1-Butyl-5-[(2S,4R)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	71698883	C19H23F3N2O5S	448.5	CCCCN1C2=C(C=C(C=C2)S(=O)(=O)N3C[C@@H](C[C@H]3COC)C(F)(F)F)C(=O)C1=O	IC50 = 52700 nM	Poor binder
T72252	Caspase-7	B1Q0LB	1,2-Benzisothiazol-3(2H)-one	Investigative	17520	C7H5NOS	151.19	C1=CC=C2C(=C1)C(=O)NS2	IC50 = 137400 nM	Poor binder
T72252	Caspase-7	B42ERU	3,3-Difluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-propyl-2H-indole	Investigative	44573088	C17H24F2N2O3S	374.4	CCCN1CC(C2=C1C=CC(=C2)S(=O)(=O)N3CCC[C@H]3COC)(F)F	IC50 ~ 100000 nM	Poor binder
T72252	Caspase-7	B56MJD	(S)-1-[3-(3-Fluoropropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin	Investigative	44572194	C20H27FN2O6S	442.5	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCOCCCF	IC50 ~ 100000 nM	Poor binder
T72252	Caspase-7	B9XB4R	1-Butyl-5-[(2S,4S)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	71698884	C19H23F3N2O5S	448.5	CCCCN1C2=C(C=C(C=C2)S(=O)(=O)N3C[C@H](C[C@H]3COC)C(F)(F)F)C(=O)C1=O	IC50 = 78300 nM	Poor binder
T72252	Caspase-7	BA30RU	(S)-1-[3-(3-Hydroxypropoxy)propyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin	Investigative	44573090	C20H28N2O7S	440.5	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCOCCCO	IC50 = 113000 nM	Poor binder
T72252	Caspase-7	BC0Q2G	N-(4-Morpholin-4-ylphenyl)-2-(3-oxo-1,2-benzothiazol-2-yl)acetamide	Investigative	90654536	C19H19N3O3S	369.4	C1COCCN1C2=CC=C(C=C2)NC(=O)CN3C(=O)C4=CC=CC=C4S3	IC50 = 100400 nM	Poor binder
T72252	Caspase-7	BD78KC	1-(4-Fluorobutyl)-5-[(2S,4R)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	71698885	C19H22F4N2O5S	466.4	COC[C@@H]1C[C@H](CN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCCF)C(F)(F)F	IC50 = 67700 nM	Poor binder
T72252	Caspase-7	BG76PC	1-(4-Fluorobutyl)-5-[(2S,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	71698799	C19H25FN2O6S	428.5	COC[C@@H]1C[C@H](CN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCCF)OC	IC50 = 59600 nM	Poor binder
T72252	Caspase-7	BKX43R	2-(2,3-Dihydro-1,4-benzodioxin-2-YL)-1,3-thiazole-4-carboxylic acid	Investigative	2821593	C12H9NO4S	263.27	C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C(=O)O	IC50 = 170000 nM	Poor binder
T72252	Caspase-7	BL97ET	3-[3-[5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-2,3-dioxoindol-1-yl]propoxy]propyl methanesulfonate	Investigative	44572193	C21H30N2O9S2	518.6	COC[C@@H]1CCCN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCOCCCOS(=O)(=O)C	IC50 ~ 100000 nM	Poor binder
T72252	Caspase-7	BUGY57	1-(4-Fluorobutyl)-5-[(2S,4S)-2-(methoxymethyl)-4-(trifluoromethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	71698886	C19H22F4N2O5S	466.4	COC[C@@H]1C[C@@H](CN1S(=O)(=O)C2=CC3=C(C=C2)N(C(=O)C3=O)CCCCF)C(F)(F)F	IC50 = 147000 nM	Poor binder
T72252	Caspase-7	BXI2Z0	(E,3S)-3-[[(2S,3S)-2-[[(2S)-5-Amino-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-methylsulfonylpent-4-enoic acid	Investigative	71719897	C30H45N5O10S	667.8	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1	IC50 ~ 100000 nM	Poor binder