TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T72458	Melanocortin receptor 4	B0BM4I	N-(2-Aminoethyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide	Investigative	44434570	C22H25N3O	347.5	C1=CC=C(C=C1)/C=C/CN(CCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 106000 nM	Poor binder
T72458	Melanocortin receptor 4	B0HN7X	N-(3-Aminopropyl)-1H-indole-3-methanamine	Investigative	44265489	C12H17N3	203.28	C1=CC=C2C(=C1)C(=CN2)CNCCCN	Ki = 104000 nM	Poor binder
T72458	Melanocortin receptor 4	B0QHJ6	N-(2-Guanidino-ethyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide	Investigative	44434797	C26H29N5O	427.5	C1=CC=C2C=C(C=CC2=C1)CN(CCN=C(N)N)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 179000 nM	Poor binder
T72458	Melanocortin receptor 4	B13SDC	(R)-4-Amino-4-(naphthalen-2-ylmethyl-naphthalen-1-ylmethyl-carbamoyl)-butyric acid	Investigative	44265351	C27H26N2O3	426.5	C1=CC=C2C=C(C=CC2=C1)CN(CC3=CC=CC4=CC=CC=C43)C(=O)[C@@H](CCC(=O)O)N	Ki = 89000 nM	Poor binder
T72458	Melanocortin receptor 4	B1KU8L	(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(4-nitrophenyl)propanamide	Investigative	44434659	C21H28N4O3	384.5	C1=CC=C(C=C1)CN(CCCCCN)C(=O)[C@@H](CC2=CC=C(C=C2)[N+](=O)[O-])N	Ki = 96000 nM	Poor binder
T72458	Melanocortin receptor 4	B1LZI6	(E)-N-(5-Aminopentyl)-N-((E)-2-chloro-3-phenylallyl)-3-(1H-indol-3-yl)acrylamide	Investigative	44434654	C25H28ClN3O	422	C1=CC=C(C=C1)/C=C(\\CN(CCCCCN)C(=O)/C=C/C2=CNC3=CC=CC=C32)/Cl	Ki = 59000 nM	Poor binder
T72458	Melanocortin receptor 4	B1MB7R	1-[3-[(1H-Indole-3-ylmethyl)amino]propyl]guanidine	Investigative	44265472	C13H19N5	245.32	C1=CC=C2C(=C1)C(=CN2)CNCCCN=C(N)N	Ki = 107000 nM	Poor binder
T72458	Melanocortin receptor 4	B1NSR6	(2S)-2-Acetamido-N-[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-iodophenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide	Investigative	90643805	C32H45I2N11O5	917.6	CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CC1=CC=C(C=C1)I)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC=C(C=C2)I)C(=O)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	B20DLM	(E)-N-(5-Aminopentyl)-3-(1H-indol-3-yl)-N-((Z)-2-methyl-3-phenylallyl)acrylamide	Investigative	44434656	C26H31N3O	401.5	C/C(=C/C1=CC=CC=C1)/CN(CCCCCN)C(=O)/C=C/C2=CNC3=CC=CC=C32	Ki = 99000 nM	Poor binder
T72458	Melanocortin receptor 4	B2TNJ4	N-[(2R)-3-(4-Chlorophenyl)-1-(4-cyclohexyl-4-oxidopiperazin-4-ium-1-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide	Investigative	44393430	C29H37ClN4O3	525.1	C1CCC(CC1)[N+]2(CCN(CC2)C(=O)[C@@H](CC3=CC=C(C=C3)Cl)NC(=O)C4CC5=CC=CC=C5CN4)[O-]	Ki = 57000 nM	Poor binder
T72458	Melanocortin receptor 4	B2ZLW1	N-(4-Guanidino-butyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide	Investigative	44434828	C26H29N5O	427.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN=C(N)N)C(=O)CC3=CNC4=CC=CC=C43	Ki = 182000 nM	Poor binder
T72458	Melanocortin receptor 4	B36BPE	4-(2-Naphthylmethyl)-1-piperazinecarboxamidine	Investigative	44265479	C16H20N4	268.36	C1CN(CCN1CC2=CC3=CC=CC=C3C=C2)C(=N)N	Ki = 68000 nM	Poor binder
T72458	Melanocortin receptor 4	B3B6WF	2-(1H-Indol-3-yl)-N-(naphthalen-2-ylmethyl)ethanamine	Investigative	2852098	C21H20N2	300.4	C1=CC=C2C=C(C=CC2=C1)CNCCC3=CNC4=CC=CC=C43	Ki = 118000 nM	Poor binder
T72458	Melanocortin receptor 4	B3C0MX	Nalpha-(2-Naphthylmethyl)-L-Arg-L-Trp-NH2	Investigative	44265589	C28H33N7O2	499.6	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 105000 nM	Poor binder
T72458	Melanocortin receptor 4	B42WUF	(1H-Indol-3-ylmethyl)-naphthalen-1-ylmethyl-amine	Investigative	44265312	C20H18N2	286.4	C1=CC=C2C(=C1)C=CC=C2CNCC3=CNC4=CC=CC=C43	Ki = 161000 nM	Poor binder
T72458	Melanocortin receptor 4	B4GUO7	N-(4-(Diethylamino)benzyl)-4-(1H-indol-3-yl)-N-pentylbutanamide	Investigative	44434561	C28H39N3O	433.6	CCCCCN(CC1=CC=C(C=C1)N(CC)CC)C(=O)CCCC2=CNC3=CC=CC=C32	Ki = 78000 nM	Poor binder
T72458	Melanocortin receptor 4	B5BML7	N-(2-Carbamimidamidoethyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide	Investigative	44434794	C25H27N5O	413.5	C1=CC=C2C=C(C=CC2=C1)CN(CCN=C(N)N)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 149000 nM	Poor binder
T72458	Melanocortin receptor 4	B5UI2Z	(2R)-1-[2-(1H-Indol-3-yl)ethyl]-N-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide	Investigative	71449140	C26H27N3O	397.5	C1C[C@@H](N(C1)CCC2=CNC3=CC=CC=C32)C(=O)NCC4=CC5=CC=CC=C5C=C4	Ki = 166000 nM	Poor binder
T72458	Melanocortin receptor 4	B5WK7Y	N-Benzyl-N-{[carbamoylmethyl-((R)-1-phenyl-ethyl)-carbamoyl]-methyl}-2-(3-guanidino-propylamino)-acetamide	Investigative	44279630	C25H35N7O3	481.6	C[C@H](C1=CC=CC=C1)N(CC(=O)N)C(=O)CN(CC2=CC=CC=C2)C(=O)CNCCCN=C(N)N	IC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	B6U3TF	(2S,4R)-N,4-Dibenzyl-1-[(2R)-5-(diaminomethylideneamino)-2-[(2-naphthalen-2-ylacetyl)amino]pentanoyl]pyrrolidine-2-carboxamide	Investigative	44401421	C37H42N6O3	618.8	C1[C@H](CN([C@@H]1C(=O)NCC2=CC=CC=C2)C(=O)[C@@H](CCCN=C(N)N)NC(=O)CC3=CC4=CC=CC=C4C=C3)CC5=CC=CC=C5	Ki ~ 50000 nM	Poor binder
T72458	Melanocortin receptor 4	B6Y0TA	N-(3-Aminopropyl)-N-(1,2,3,4-tetrahydronaphthalen-2-yl)-1H-indole-3-carboxamide	Investigative	10269187	C22H25N3O	347.5	C1CC2=CC=CC=C2CC1N(CCCN)C(=O)C3=CNC4=CC=CC=C43	Ki = 74000 nM	Poor binder
T72458	Melanocortin receptor 4	B7B6EH	N-(2-Aminoethyl)-N-(naphthalen-2-ylmethyl)-1H-indole-3-carboxamide	Investigative	10132207	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)CN(CCN)C(=O)C3=CNC4=CC=CC=C43	Ki = 66000 nM	Poor binder
T72458	Melanocortin receptor 4	B83LOY	N-(2-Aminoethyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	9924916	C23H23N3O	357.4	C1=CC=C2C=C(C=CC2=C1)CN(CCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 140000 nM	Poor binder
T72458	Melanocortin receptor 4	B8A4TJ	N-(3-Aminopropyl)-N-cinnamyl-3-(1H-indol-3-yl)propanamide	Investigative	44434600	C23H27N3O	361.5	C1=CC=C(C=C1)/C=C/CN(CCCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 81000 nM	Poor binder
T72458	Melanocortin receptor 4	B8GA3H	(R)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide	Investigative	44265711	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)CN[C@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 64000 nM	Poor binder
T72458	Melanocortin receptor 4	B8JI7Q	N-Benzyl-N-[(benzyl-carbamoylmethyl-carbamoyl)-methyl]-2-(3-guanidino-propylamino)-acetamide	Investigative	44279606	C24H33N7O3	467.6	C1=CC=C(C=C1)CN(CC(=O)N(CC2=CC=CC=C2)CC(=O)N)C(=O)CNCCCN=C(N)N	IC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	B9UES7	N-(3-Aminopropyl)-4-(1H-indol-3-yl)-N-phenethylbutanamide	Investigative	44434597	C23H29N3O	363.5	C1=CC=C(C=C1)CCN(CCCN)C(=O)CCCC2=CNC3=CC=CC=C32	Ki = 164000 nM	Poor binder
T72458	Melanocortin receptor 4	B9UT2W	CID 90643809	Investigative	90643809	C32H45ClIN11O5	826.1	CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CC1=CC=C(C=C1)Cl)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC2=CC=C(C=C2)I)C(=O)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BA56HP	CID 90643803	Investigative	90643803	C32H40I2N10O5	898.5	CC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC=C(C=C2)I)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CC=C(C=C3)I)C(=O)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BAM32O	(2R)-2-Amino-N-[(2R)-1-cyclohexyl-5-(diaminomethylideneamino)pentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	44453902	C21H34FN5O	391.5	C1CCC(CC1)C[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	EC50 ~ 50000 nM	Poor binder
T72458	Melanocortin receptor 4	BD23CF	(S)-5-Guanidino-2-[(1,2,3,4-tetrahydro-naphthalen-2-ylmethyl)-amino]-pentanoic acid amide	Investigative	44265590	C17H27N5O	317.4	C1CC2=CC=CC=C2CC1CN[C@@H](CCCN=C(N)N)C(=O)N	Ki = 134000 nM	Poor binder
T72458	Melanocortin receptor 4	BD40RE	N-(4-Aminobutyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	10200110	C25H27N3O	385.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 111000 nM	Poor binder
T72458	Melanocortin receptor 4	BE46XJ	2-[(1R,4S,7S,13S,16S,19S,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid	Investigative	137645567	C79H107N23O17S2	1715	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N1)CC4=CNC5=CC=CC=C54)CCCNC(=N)N)CC6=CC=CC=C6)CC7=CN=CN7)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC2=O)CC9=CC=CC=C9)CC(=O)O)CCCNC(=N)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BE83VC	N-(2-Guanidino-ethyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide	Investigative	44434790	C24H25N5O	399.5	C1=CC=C2C=C(C=CC2=C1)CN(CCN=C(N)N)C(=O)CC3=CNC4=CC=CC=C43	Ki = 179000 nM	Poor binder
T72458	Melanocortin receptor 4	BF2CN7	N-(4-Guanidino-butyl)-3-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-propionamide	Investigative	44434839	C27H31N5O	441.6	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN=C(N)N)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 116000 nM	Poor binder
T72458	Melanocortin receptor 4	BGUX81	N-(4-Aminobutyl)-3-(1H-indol-3-yl)-N-(1-phenylpropyl)propanamide	Investigative	44434616	C24H31N3O	377.5	CCC(C1=CC=CC=C1)N(CCCCN)C(=O)CCC2=CNC3=CC=CC=C32	Ki = 158000 nM	Poor binder
T72458	Melanocortin receptor 4	BH4I2E	N-[(2R)-3-(4-Chlorophenyl)-1-(4-oxido-4-phenylpiperazin-4-ium-1-yl)-1-oxopropan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide	Investigative	44393450	C29H31ClN4O3	519	C1C[N+](CCN1C(=O)[C@@H](CC2=CC=C(C=C2)Cl)NC(=O)C3CC4=CC=CC=C4CN3)(C5=CC=CC=C5)[O-]	Ki = 169000 nM	Poor binder
T72458	Melanocortin receptor 4	BH5YD6	Nalpha-(2-Naphthylmethyl)-D-Arg-L-Trp-NH2	Investigative	44265591	C28H33N7O2	499.6	C1=CC=C2C=C(C=CC2=C1)CN[C@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 56000 nM	Poor binder
T72458	Melanocortin receptor 4	BH91QP	Nalpha-(2-Naphthylmethyl)-L-arginine	Investigative	44265658	C17H22N4O2	314.4	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CCCN=C(N)N)C(=O)O	Ki = 66000 nM	Poor binder
T72458	Melanocortin receptor 4	BIHT70	(E)-N-(3-Aminopropyl)-2-(1H-indol-3-yl)-N-(2-methyl-3-phenylallyl)acetamide	Investigative	10155513	C23H27N3O	361.5	C/C(=C\\C1=CC=CC=C1)/CN(CCCN)C(=O)CC2=CNC3=CC=CC=C32	Ki = 67000 nM	Poor binder
T72458	Melanocortin receptor 4	BIUL40	(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	44453826	C20H33FN6O	392.5	C1CCN(CC1)C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BJ3GQ5	N-((1R,2R)-2-Aminocyclohexyl)-N-cinnamyl-4-(1H-indol-3-yl)butanamide	Investigative	44434853	C27H33N3O	415.6	C1CC[C@H]([C@@H](C1)N)N(C/C=C/C2=CC=CC=C2)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 116000 nM	Poor binder
T72458	Melanocortin receptor 4	BJ4AI5	1-[3-[(2-Naphthylmethyl)amino]propyl]guanidine	Investigative	44265487	C15H20N4	256.35	C1=CC=C2C=C(C=CC2=C1)CNCCCN=C(N)N	Ki = 56000 nM	Poor binder
T72458	Melanocortin receptor 4	BK30ZL	(2R)-2-Amino-N-[(2R)-5-(diaminomethylideneamino)-1-phenylpentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	24882666	C21H28FN5O	385.5	C1=CC=C(C=C1)C[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BK3J7N	(2S,4S)-N,4-Dibenzyl-1-[(2S)-5-(diaminomethylideneamino)-2-[(2-naphthalen-2-ylacetyl)amino]pentanoyl]pyrrolidine-2-carboxamide	Investigative	44401462	C37H42N6O3	618.8	C1[C@@H](CN([C@@H]1C(=O)NCC2=CC=CC=C2)C(=O)[C@H](CCCN=C(N)N)NC(=O)CC3=CC4=CC=CC=C4C=C3)CC5=CC=CC=C5	Ki ~ 50000 nM	Poor binder
T72458	Melanocortin receptor 4	BK4C7R	N-(5-Aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide	Investigative	10158674	C27H31N3O	413.6	C1=CC=C2C=C(C=CC2=C1)CN(CCCCCN)C(=O)CCC3=CNC4=CC=CC=C43	Ki = 62000 nM	Poor binder
T72458	Melanocortin receptor 4	BK9Y1T	2-(1H-Indol-3-yl)-N-(1H-indol-3-ylmethyl)ethanamine	Investigative	2163781	C19H19N3	289.4	C1=CC=C2C(=C1)C(=CN2)CCNCC3=CNC4=CC=CC=C43	Ki = 161000 nM	Poor binder
T72458	Melanocortin receptor 4	BL69PQ	(2R)-2-Amino-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-piperidin-1-ylpentan-2-yl]-3-(4-fluorophenyl)propanamide	Investigative	44453850	C20H31FN6O2	406.5	C1CCN(CC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](CC2=CC=C(C=C2)F)N	EC50 ~ 50000 nM	Poor binder
T72458	Melanocortin receptor 4	BLE6M1	N-(4-Guanidino-butyl)-4-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-butyramide	Investigative	44434841	C28H33N5O	455.6	C1=CC=C2C=C(C=CC2=C1)CN(CCCCN=C(N)N)C(=O)CCCC3=CNC4=CC=CC=C43	Ki = 96000 nM	Poor binder
T72458	Melanocortin receptor 4	BM0O9X	N2-(2-Naphthylmethyl)-L-ornithine allyl ester	Investigative	44265722	C19H24N2O2	312.4	C=CCOC(=O)[C@H](CCCN)NCC1=CC2=CC=CC=C2C=C1	Ki = 127000 nM	Poor binder
T72458	Melanocortin receptor 4	BMAN65	2-[2-[(2R)-2-[(2-Acetyl-3,4-dihydro-1H-isoquinoline-3-carbonyl)amino]-3-(4-chlorophenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	90643839	C41H40ClN5O5	718.2	CC(=O)N1CC2=CC=CC=C2CC1C(=O)N[C@H](CC3=CC=C(C=C3)Cl)C(=O)N4CC5=CC=CC=C5CC4C(=O)N6CC7=CC=CC=C7CC6C(=O)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BPFW56	N-(5-Aminopentyl)-2-(1H-indol-3-yl)-N-(3-phenylpropyl)acetamide	Investigative	44434637	C24H31N3O	377.5	C1=CC=C(C=C1)CCCN(CCCCCN)C(=O)CC2=CNC3=CC=CC=C32	Ki = 77000 nM	Poor binder
T72458	Melanocortin receptor 4	BPNU43	(R)-2-Amino-N-(5-aminopentyl)-N-benzyl-3-(1H-indol-3-yl)propanamide	Investigative	44434664	C23H30N4O	378.5	C1=CC=C(C=C1)CN(CCCCCN)C(=O)[C@@H](CC2=CNC3=CC=CC=C32)N	Ki = 87000 nM	Poor binder
T72458	Melanocortin receptor 4	BR7X9O	(S)-3-(1H-Indol-3-yl)-2-[(naphthalen-2-ylmethyl)-amino]-propionamide	Investigative	44265749	C22H21N3O	343.4	C1=CC=C2C=C(C=CC2=C1)CN[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N	Ki = 139000 nM	Poor binder
T72458	Melanocortin receptor 4	BS12VX	Tert-butyl 3-(2-(4-acetylphenylamino)-6-(diisopentylcarbamoyl)-1H-benzo[d]imidazol-1-yl)propylcarbamate	Investigative	44432918	C34H49N5O4	591.8	CC(C)CCN(CCC(C)C)C(=O)C1=CC2=C(C=C1)N=C(N2CCCNC(=O)OC(C)(C)C)NC3=CC=C(C=C3)C(=O)C	Ki = 85113.8 nM	Poor binder
T72458	Melanocortin receptor 4	BSPW75	2-[Benzyl-(2-{[2-(3-guanidino-propylamino)-acetyl]-phenethyl-amino}-acetyl)-amino]-2-methyl-propionamide	Investigative	44279793	C27H39N7O3	509.6	CC(C)(C(=O)N)N(CC1=CC=CC=C1)C(=O)CN(CCC2=CC=CC=C2)C(=O)CNCCCN=C(N)N	IC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BV6I0Q	2-(4-Hydroxybenzyl)-N-(4-aminobutyl)-N-isopropyl-1H-indole-3-carboxamide	Investigative	44434631	C23H29N3O2	379.5	CC(C)N(CCCCN)C(=O)C1=C(NC2=CC=CC=C21)CC3=CC=C(C=C3)O	Ki = 165000 nM	Poor binder
T72458	Melanocortin receptor 4	BVJF16	2-[(1R,4S,7S,13S,16S,19R,22S,25S,28R,31S,37S,40S,46S)-19,46-Dibenzyl-4-[(2S)-butan-2-yl]-16,31-bis(3-carbamimidamidopropyl)-25-[(1R)-1-hydroxyethyl]-22-(1H-imidazol-5-ylmethyl)-13-(1H-indol-3-ylmethyl)-14,17,23-trimethyl-3,6,12,15,18,21,24,27,30,33,36,39,45,48-tetradecaoxo-50,51-dithia-2,5,11,14,17,20,23,26,29,32,35,38,44,47-tetradecazatetracyclo[26.20.4.07,11.040,44]dopentacontan-37-yl]acetic acid	Investigative	137646333	C82H113N23O17S2	1757.1	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N3CCC[C@H]3C(=O)N1)CC4=CNC5=CC=CC=C54)C)CCCNC(=N)N)C)CC6=CC=CC=C6)CC7=CN=CN7)C)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC2=O)CC9=CC=CC=C9)CC(=O)O)CCCNC(=N)N	Ki = 69183.1 nM	Poor binder
T72458	Melanocortin receptor 4	BW4ZO0	CID 90643804	Investigative	90643804	C36H42IN9O7	839.7	CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CC1=CC=C(C=C1)I)C(=O)N2CC3=CC=CC=C3CC2C(=O)N[C@H](CC4=CC=C(C=C4)[N+](=O)[O-])C(=O)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BW79MI	N-(3-Aminopropyl)-2-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)acetamide	Investigative	10177247	C24H25N3O	371.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCN)C(=O)CC3=CNC4=CC=CC=C43	Ki = 161000 nM	Poor binder
T72458	Melanocortin receptor 4	BWV15X	1-[3-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,37S,40S,43S,46S)-43-Benzyl-4,19-bis[(2S)-butan-2-yl]-34-(3-carbamimidamidopropyl)-28-[(1S)-1-hydroxyethyl]-22-(hydroxymethyl)-46-(1H-imidazol-5-ylmethyl)-37-(1H-indol-3-ylmethyl)-25-methyl-3,6,12,18,21,24,27,30,33,36,39,42,45,48-tetradecaoxo-50,51-dithia-2,5,11,17,20,23,26,29,32,35,38,41,44,47-tetradecazatetracyclo[29.17.4.07,11.013,17]dopentacontan-40-yl]propyl]guanidine	Investigative	137655905	C76H111N23O16S2	1667	CC[C@H](C)[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N4CCC[C@H]4C(=O)N1)[C@@H](C)CC)CO)C)[C@H](C)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC2=O)CC5=CN=CN5)CC6=CC=CC=C6)CCCNC(=N)N)CC7=CNC8=CC=CC=C87)CCCNC(=N)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BX8DU5	N-(3-Aminopropyl)-2-naphthalenemethanamine	Investigative	44265309	C14H18N2	214.31	C1=CC=C2C=C(C=CC2=C1)CNCCCN	Ki = 94000 nM	Poor binder
T72458	Melanocortin receptor 4	BY2KW3	2-[(2S)-2-[[(2R)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxamide	Investigative	90643820	C33H42N10O5	658.8	CC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N3CC4=CC=CC=C4CC3C(=O)N	EC50 ~ 100000 nM	Poor binder
T72458	Melanocortin receptor 4	BYUO85	(2S,4S)-4-Hydroxy-N-[2-(1H-imidazol-5-yl)ethyl]-1-(naphthalen-2-ylmethyl)pyrrolidine-2-carboxamide	Investigative	44265713	C21H24N4O2	364.4	C1[C@@H](CN([C@@H]1C(=O)NCCC2=CN=CN2)CC3=CC4=CC=CC=C4C=C3)O	Ki = 150000 nM	Poor binder
T72458	Melanocortin receptor 4	BYV3T9	(2R)-2-Amino-N-[3-cyclohexyl-4-(1,2,4-triazol-1-yl)butyl]-3-(4-fluorophenyl)propanamide	Investigative	44453903	C21H30FN5O	387.5	C1CCC(CC1)C(CCNC(=O)[C@@H](CC2=CC=C(C=C2)F)N)CN3C=NC=N3	Ki ~ 50000 nM	Poor binder
T72458	Melanocortin receptor 4	BZ3SP7	N-(3-Guanidino-propyl)-2-(1H-indol-3-yl)-N-naphthalen-2-ylmethyl-acetamide	Investigative	44434799	C25H27N5O	413.5	C1=CC=C2C=C(C=CC2=C1)CN(CCCN=C(N)N)C(=O)CC3=CNC4=CC=CC=C43	Ki = 150000 nM	Poor binder
T72458	Melanocortin receptor 4	BZH02D	N-(1H-Indole-3-ylmethyl)-N-(1-naphthylmethyl)-L-argininamide	Investigative	71461662	C26H30N6O	442.6	C1=CC=C2C(=C1)C=CC=C2CN(CC3=CNC4=CC=CC=C43)C(=O)[C@H](CCCN=C(N)N)N	Ki = 70000 nM	Poor binder