TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T73756	Ephrin type-B receptor 2	D06CIJ	ISIS-CRP	Phase 1	4878	C15H16ClN5	301.77	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)Cl)N	IC50 = 52000 nM	Poor binder
T73756	Ephrin type-B receptor 2	B0NB4P	N-{5-[1-(2-Amino-4-methyl-thiazol-5-yl)-eth-(E)-ylidene-hydrazinocarbonyl]-4-methyl-thiazol-2-yl}-benzenesulfonamide	Investigative	9605612	C17H18N6O3S3	450.6	CC1=C(SC(=N1)N)/C(=N/NC(=O)C2=C(N=C(S2)NS(=O)(=O)C3=CC=CC=C3)C)/C	IC50 = 94000 nM	Poor binder
T73756	Ephrin type-B receptor 2	B2S1BT	N-(Pyridin-2-ylmethyl)-7H-purin-6-amine	Investigative	2155046	C11H10N6	226.24	C1=CC=NC(=C1)CNC2=NC=NC3=C2NC=N3	IC50 = 106000 nM	Poor binder
T73756	Ephrin type-B receptor 2	B2ST5D	3-(4-Chloro-phenyl)-1-[2-(5-fluoro-2-methyl-1H-indol-3-yl)-ethyl]-1-pyridin-4-ylmethyl-thiourea	Investigative	2157978	C24H22ClFN4S	453	CC1=C(C2=C(N1)C=CC(=C2)F)CCN(CC3=CC=NC=C3)C(=S)NC4=CC=C(C=C4)Cl	IC50 = 65000 nM	Poor binder
T73756	Ephrin type-B receptor 2	BFZ07X	N-(2-Methoxyphenyl)-2-[(5-methyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]acetamide	Investigative	3132097	C19H17N5O2S	379.4	CN1C2=CC=CC=C2C3=C1N=C(N=N3)SCC(=O)NC4=CC=CC=C4OC	IC50 = 136000 nM	Poor binder
T73756	Ephrin type-B receptor 2	BH6EK1	4-Chloro-N-(2-phenylimidazo[1,2-a]pyrimidin-3-yl)benzamide	Investigative	876381	C19H13ClN4O	348.8	C1=CC=C(C=C1)C2=C(N3C=CC=NC3=N2)NC(=O)C4=CC=C(C=C4)Cl	IC50 = 88000 nM	Poor binder
T73756	Ephrin type-B receptor 2	BP4LA7	2-{3-[(5E)-5-{[(2,3-Dichlorophenyl)carbamoyl]imino}-3-thiophen-2-yl-2,5-dihydro-1H-pyrazol-1-yl]phenyl}acetamide	Investigative	11533187	C22H17Cl2N5O2S	486.4	C1=CC(=CC(=C1)N2C(=CC(=N2)C3=CC=CS3)NC(=O)NC4=C(C(=CC=C4)Cl)Cl)CC(=O)N	IC50 ~ 50000 nM	Poor binder
T73756	Ephrin type-B receptor 2	BX5HN2	3-(4-Fluoro-phenyl)-1-[2-(2-methyl-1H-indol-3-yl)-ethyl]-1-pyridin-4-ylmethyl-thiourea	Investigative	2157774	C24H23FN4S	418.5	CC1=C(C2=CC=CC=C2N1)CCN(CC3=CC=NC=C3)C(=S)NC4=CC=C(C=C4)F	IC50 = 104000 nM	Poor binder
T73756	Ephrin type-B receptor 2	D02XWJ	AG 1296	Investigative	2049	C16H14N2O2	266.29	COC1=C(C=C2C(=C1)N=CC(=N2)C3=CC=CC=C3)OC	IC50 = 110000 nM	Poor binder
T73756	Ephrin type-B receptor 2	D03XDN	PD-174265	Investigative	4709	C17H15BrN4O	371.2	CCC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Br	IC50 = 180000 nM	Poor binder
T73756	Ephrin type-B receptor 2	D0U2QT	Src kinase inhibitor I	Investigative	1474853	C22H19N3O3	373.4	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=C(C=C3)OC4=CC=CC=C4)OC	IC50 = 86000 nM	Poor binder