TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T76198	Thromboxane A2 receptor	D06EYC	BI-671800	Phase 2	45270144	C25H26F3N5O3	501.5	CN(C)C1=C(C(=NC(=N1)CC2=CC=C(C=C2)NC(=O)C3=CC=C(C=C3)C(F)(F)F)N(C)C)CC(=O)O	IC50 = 62600 nM	Poor binder
T76198	Thromboxane A2 receptor	D0X7EG	OC-000459	Phase 2	11462174	C21H17FN2O2	348.4	CC1=C(C2=C(N1CC(=O)O)C=CC(=C2)F)CC3=NC4=CC=CC=C4C=C3	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	D0I3TU	MK-7246	Phase 1	45268455	C21H21FN2O4S	416.5	CN([C@@H]1CCC2=C(C3=CC=CC=C3N2C1)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	D0T2IH	GSK610677	Phase 1	5282440	C13H12N2O2	228.25	C1=CC(=CC=C1CN2C=CN=C2)/C=C/C(=O)O	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B0BSM9	2-((R)-8-((R)-2-(4-Fluorophenyl)-N-methylpropanamido)-6,7,8,9-tetrahydropyrido[3,2-b]indolizin-5-yl)acetic acid	Investigative	45112038	C23H24FN3O3	409.5	C[C@H](C1=CC=C(C=C1)F)C(=O)N(C)[C@@H]2CCC3=C(C4=C(N3C2)N=CC=C4)CC(=O)O	Ki ~ 71000 nM	Poor binder
T76198	Thromboxane A2 receptor	B13TJU	2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[2,3-b]indol-9-yl]acetic acid	Investigative	45270148	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C1)C3=C(N2CC(=O)O)N=CC=C3)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B1MHW6	1-(4-Chloro-benzyl)-2-(4-trifluoromethyl-benzylsulfanyl)-1H-benzoimidazole	Investigative	44338130	C22H16ClF3N2S	432.9	C1=CC=C2C(=C1)N=C(N2CC3=CC=C(C=C3)Cl)SCC4=CC=C(C=C4)C(F)(F)F	Ki ~ 73000 nM	Poor binder
T76198	Thromboxane A2 receptor	B1TD4U	6-[2-Imidazol-1-yl-1-phenyl-eth-(Z)-ylideneaminooxy]-hexanoic acid	Investigative	10380987	C17H21N3O3	315.37	C1=CC=C(C=C1)/C(=N/OCCCCCC(=O)O)/CN2C=CN=C2	IC50 = 74500 nM	Poor binder
T76198	Thromboxane A2 receptor	B1WL0H	(R)-2-(8-(4-Fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-5-yl)acetic acid	Investigative	45270983	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C1)C3=C(N2CC(=O)O)C=CC=N3)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B2IO7L	(R)-2-(3-(4-Fluoro-N-methylphenylsulfonamido)-1,2,3,4-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid	Investigative	45272700	C21H21FN2O4S	416.5	CN([C@@H]1CCC2=C(C1)N3C=CC=CC3=C2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B2UZ3G	Sodium;2-[4-[(4-chlorophenyl)sulfonylamino]butyl]-2,3-dihydro-1H-indene-5-carboxylate	Investigative	44353027	C20H21ClNNaO4S	429.9	C1C(CC2=C1C=CC(=C2)C(=O)[O-])CCCCNS(=O)(=O)C3=CC=C(C=C3)Cl.[Na+]	IC50 = 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B2VGU9	2-[1-[2-(N-Benzoyl-4-methylanilino)ethyl]piperidin-4-yl]oxyacetic acid	Investigative	127029417	C23H28N2O4	396.5	CC1=CC=C(C=C1)N(CCN2CCC(CC2)OCC(=O)O)C(=O)C3=CC=CC=C3	Ki ~ 50000 nM	Poor binder
T76198	Thromboxane A2 receptor	B2XA0R	2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[3,4-b]indol-9-yl]acetic acid	Investigative	45270987	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C1)C3=C(N2CC(=O)O)C=NC=C3)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B3QZ1G	1-[3,5-Bis(trifluoromethyl)benzyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol	Investigative	10834286	C18H15F6NO2	391.3	C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F	Ki = 83176.38 nM	Poor binder
T76198	Thromboxane A2 receptor	B4D0WJ	1-(4-Chloro-benzyl)-2-[4-(3-methyl-[1,2,4]oxadiazol-5-yl)-benzylsulfanyl]-1H-benzoimidazole	Investigative	44338264	C24H19ClN4OS	447	CC1=NOC(=N1)C2=CC=C(C=C2)CSC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)Cl	Ki ~ 74000 nM	Poor binder
T76198	Thromboxane A2 receptor	B5ER7C	Sodium;2-[2-[(pyridin-3-ylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]acetate	Investigative	44353289	C17H17N2NaO4S	368.4	C1C(CC2=C1C=CC(=C2)CC(=O)[O-])CNS(=O)(=O)C3=CN=CC=C3.[Na+]	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B5LI6Y	5-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-ylsulfanylmethyl]-isophthalic acid diethyl ester	Investigative	44338402	C27H25ClN2O4S	509	CCOC(=O)C1=CC(=CC(=C1)CSC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl)C(=O)OCC	Ki ~ 71000 nM	Poor binder
T76198	Thromboxane A2 receptor	B61ZFO	1-(4-Aminobenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol	Investigative	10683471	C16H18N2O2	270.33	C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)N	IC50 = 89125.09 nM	Poor binder
T76198	Thromboxane A2 receptor	B68SHV	Sodium;2-[2-[3-[(4-chlorophenyl)sulfonylamino]propyl]-2,3-dihydro-1H-inden-5-yl]acetate	Investigative	44353301	C20H21ClNNaO4S	429.9	C1C(CC2=C1C=CC(=C2)CC(=O)[O-])CCCNS(=O)(=O)C3=CC=C(C=C3)Cl.[Na+]	IC50 = 72300 nM	Poor binder
T76198	Thromboxane A2 receptor	B7ELX8	4-[[[(E)-1-Cyclohexyl-2-(1H-imidazol-1-yl)ethylidene]amino]oxy]butanoic acid	Investigative	9971633	C15H23N3O3	293.36	C1CCC(CC1)/C(=N/OCCCC(=O)O)/CN2C=CN=C2	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	B7PLR3	1-(4-Chloro-benzyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzylsulfanyl]-1H-benzoimidazole	Investigative	9981035	C24H19ClN4OS	447	CC1=NC(=NO1)C2=CC=C(C=C2)CSC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)Cl	Ki ~ 74000 nM	Poor binder
T76198	Thromboxane A2 receptor	B8KE1W	(Z)-7-[3-[[2-Oxo-2-(propylamino)ethyl]sulfanylmethyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid	Investigative	44387045	C19H31NO4S	369.5	CCCNC(=O)CSCC1C2CCC(C1C/C=C\\CCCC(=O)O)O2	IC50 = 72000 nM	Poor binder
T76198	Thromboxane A2 receptor	B8PV2Q	5-[[(Z)-(2-Pyrimidinyl)[3-(trifluoromethyl)phenyl]methylene]aminooxy]valeric acid	Investigative	44353162	C17H16F3N3O3	367.32	C1=CC(=CC(=C1)C(F)(F)F)/C(=N\\OCCCCC(=O)O)/C2=NC=CC=N2	IC50 = 99000 nM	Poor binder
T76198	Thromboxane A2 receptor	B9MC2I	5-[[[(Alphae)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid	Investigative	10518243	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N/OCCCCC(=O)O)/C2=NN=CC=C2	IC50 = 71000 nM	Poor binder
T76198	Thromboxane A2 receptor	B9ZA1M	2-[(3R)-3-[(4-Fluorophenyl)sulfonyl-methylamino]-1,2,3,4,4b,8a-hexahydrocarbazol-9-yl]acetic acid	Investigative	45269307	C21H23FN2O4S	418.5	CN([C@@H]1CCC2=C(C1)C3C=CC=CC3N2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BAGX92	2-[3-[2-[[Ethyl(methoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid	Investigative	44159411	C21H22F3NO5	425.4	CCN(CC1=C(C=CC(=C1)C(F)(F)F)C2=C(C=CC(=C2)CC(=O)O)OC)C(=O)OC	IC50 = 67400 nM	Poor binder
T76198	Thromboxane A2 receptor	BB9Y0C	4-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-ylsulfanylmethyl]-benzenesulfonamide	Investigative	44338224	C21H18ClN3O2S2	444	C1=CC=C2C(=C1)N=C(N2CC3=CC=C(C=C3)Cl)SCC4=CC=C(C=C4)S(=O)(=O)N	Ki ~ 70000 nM	Poor binder
T76198	Thromboxane A2 receptor	BD7E3G	1-(4-Chloro-benzyl)-2-(4-methylsulfanyl-benzylsulfanyl)-1H-benzoimidazole	Investigative	44338186	C22H19ClN2S2	411	CSC1=CC=C(C=C1)CSC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl	Ki ~ 73000 nM	Poor binder
T76198	Thromboxane A2 receptor	BDL4K7	Sodium;2-[2-[(benzylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]acetate	Investigative	44353319	C19H20NNaO4S	381.4	C1C(CC2=C1C=CC(=C2)CC(=O)[O-])CNS(=O)(=O)CC3=CC=CC=C3.[Na+]	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BFP68A	1-(3,4,5-Trimethoxyanilino)-3,4-dihydroisoquinoline-6,7-diol	Investigative	135528684	C18H20N2O5	344.4	COC1=CC(=CC(=C1OC)OC)NC2=NCCC3=CC(=C(C=C32)O)O	Ki = 120226.44 nM	Poor binder
T76198	Thromboxane A2 receptor	BGU3J8	Sodium;2-[2-[(pentylsulfonylamino)methyl]-2,3-dihydro-1H-inden-5-yl]acetate	Investigative	44353307	C17H24NNaO4S	361.4	CCCCCS(=O)(=O)NCC1CC2=C(C1)C=C(C=C2)CC(=O)[O-].[Na+]	IC50 = 77600 nM	Poor binder
T76198	Thromboxane A2 receptor	BIL2X6	4-[(E)-(2-Imidazol-1-yl-1-phenylethylidene)amino]oxybutanoic acid	Investigative	10016908	C15H17N3O3	287.31	C1=CC=C(C=C1)/C(=N/OCCCC(=O)O)/CN2C=CN=C2	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BIZ02V	4-{(E)-2-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-vinyl}-benzoic acid methyl ester	Investigative	44338310	C24H19ClN2O2	402.9	COC(=O)C1=CC=C(C=C1)/C=C/C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl	Ki ~ 75000 nM	Poor binder
T76198	Thromboxane A2 receptor	BKR32P	5-[[[(E)-1-Cyclohexyl-2-(1H-imidazol-1-yl)ethylidene]amino]oxy]pentanoic acid	Investigative	10244704	C16H25N3O3	307.39	C1CCC(CC1)/C(=N/OCCCCC(=O)O)/CN2C=CN=C2	IC50 = 53100 nM	Poor binder
T76198	Thromboxane A2 receptor	BL3K0W	5-[[[(Z)-1-Phenyl-2-(1H-imidazol-1-yl)propylidene]amino]oxy]pentanoic acid	Investigative	9973005	C17H21N3O3	315.37	CC(/C(=N/OCCCCC(=O)O)/C1=CC=CC=C1)N2C=CN=C2	IC50 = 73000 nM	Poor binder
T76198	Thromboxane A2 receptor	BM56JK	[2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid sodium salt	Investigative	50901657	C29H31N2NaO5	510.6	CCN(CC1=C(C=CC(=C1)C2=CN=C(C=C2)OCC)C3=C(C=CC(=C3)CC(=O)[O-])OC)C(=O)C4CC4.[Na+]	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BO25BW	(Z)-7-[(1R,2S,3R)-3-(Hexylsulfanylmethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid	Investigative	118718127	C20H34O3S	354.5	CCCCCCSC[C@@H]1[C@@H]([C@H]2CCC1O2)C/C=C\\CCCC(=O)O	IC50 = 83000 nM	Poor binder
T76198	Thromboxane A2 receptor	BOD8P4	2-[1-[2-[N-(1,3-Benzodioxole-5-carbonyl)-4-methylanilino]ethyl]piperidin-4-yl]oxyacetic acid;hydrate;hydrochloride	Investigative	127047381	C24H31ClN2O7	495	CC1=CC=C(C=C1)N(CCN2CCC(CC2)OCC(=O)O)C(=O)C3=CC4=C(C=C3)OCO4.O.Cl	Ki ~ 50000 nM	Poor binder
T76198	Thromboxane A2 receptor	BQ3V8E	(Z)-7-[3-(Hexylsulfinylmethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid	Investigative	44385450	C20H34O4S	370.5	CCCCCCS(=O)CC1C2CCC(C1C/C=C\\CCCC(=O)O)O2	IC50 = 63000 nM	Poor binder
T76198	Thromboxane A2 receptor	BQ9LA1	CID 44205724	Investigative	44205724	C27H24F3NO5	499.5	C[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=C(C=CC(=C3)CC(=O)O)OC)C4=CC=CC=C4	IC50 = 63700 nM	Poor binder
T76198	Thromboxane A2 receptor	BQH75S	2-[3-[2-[[Benzyl(methoxycarbonyl)amino]methyl]-4-(trifluoromethyl)phenyl]-4-methoxyphenyl]acetic acid	Investigative	56924869	C26H24F3NO5	487.5	COC1=C(C=C(C=C1)CC(=O)O)C2=C(C=C(C=C2)C(F)(F)F)CN(CC3=CC=CC=C3)C(=O)OC	IC50 = 62400 nM	Poor binder
T76198	Thromboxane A2 receptor	BS1J4G	5-[2-Imidazol-1-yl-1-pyridin-2-yl-eth-(E)-ylideneaminooxy]-pentanoic acid	Investigative	44346027	C15H18N4O3	302.33	C1=CC=NC(=C1)/C(=N/OCCCCC(=O)O)/CN2C=CN=C2	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BT3DB5	Sodium;2-[2-[4-[(4-chlorophenyl)sulfonylamino]butyl]-2,3-dihydro-1H-inden-5-yl]acetate	Investigative	44353185	C21H23ClNNaO4S	443.9	C1C(CC2=C1C=CC(=C2)CC(=O)[O-])CCCCNS(=O)(=O)C3=CC=C(C=C3)Cl.[Na+]	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BTN7J2	5-[[[(Alphaz)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid	Investigative	10756560	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N\\OCCCCC(=O)O)/C2=NN=CC=C2	IC50 = 104000 nM	Poor binder
T76198	Thromboxane A2 receptor	BTWN48	5-[[(E)-(2-Pyrimidinyl)[3-(trifluoromethyl)phenyl]methylene]aminooxy]valeric acid	Investigative	23276769	C17H16F3N3O3	367.32	C1=CC(=CC(=C1)C(F)(F)F)/C(=N/OCCCCC(=O)O)/C2=NC=CC=N2	IC50 = 52000 nM	Poor binder
T76198	Thromboxane A2 receptor	BW1F4A	2-[(8R)-8-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrazino[2,3-b]indol-5-yl]acetic acid	Investigative	45272704	C19H19FN4O4S	418.4	CN([C@@H]1CCC2=C(C1)C3=NC=CN=C3N2CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BXC50J	2-[(7R)-7-[(4-Fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[2,3-b]indolizin-10-yl]acetic acid	Investigative	45273637	C20H20FN3O4S	417.5	CN([C@@H]1CCC2=C(C3=C(N2C1)C=CC=N3)CC(=O)O)S(=O)(=O)C4=CC=C(C=C4)F	IC50 ~ 100000 nM	Poor binder
T76198	Thromboxane A2 receptor	BZJ67X	1-[3,4,5-Triiodobenzyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol	Investigative	9917280	C16H14I3NO2	633	C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC(=C(C(=C3)I)I)I	Ki = 60255.96 nM	Poor binder
T76198	Thromboxane A2 receptor	BZJ6K1	(Z)-7-[3-[[(E)-3-Phenylprop-2-enyl]sulfanylmethyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid	Investigative	44386253	C23H30O3S	386.5	C1CC2C(C(C1O2)C/C=C\\CCCC(=O)O)CSC/C=C/C3=CC=CC=C3	IC50 = 86000 nM	Poor binder