TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T78356	Thromboxane-A synthase	D0R1RS	Indomethacin	Approved	3715	C19H16ClNO4	357.8	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	D0OO6A	Isbogrel	Discontinued in Preregistration	6450501	C18H19NO2	281.3	C1=CC=C(C=C1)/C(=C/CCCCC(=O)O)/C2=CC=NC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	D07JSK	Sulotroban	Terminated	51550	C16H17NO5S	335.4	C1=CC=C(C=C1)S(=O)(=O)NCCC2=CC=C(C=C2)OCC(=O)O	IC50 = 94100 nM	Poor binder
T78356	Thromboxane-A synthase	B2MJE6	1-[2-(4-Sulphamoylphenoxy)ethyl]imidazole	Investigative	13569205	C11H13N3O3S	267.31	C1=CC(=CC=C1OCCN2C=CN=C2)S(=O)(=O)N	IC50 ~ 50000 nM	Poor binder
T78356	Thromboxane-A synthase	B38TAS	5-[[(E)-(4-Pyrimidinyl)phenylmethylene]aminooxy]valeric acid	Investigative	10827996	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N/OCCCCC(=O)O)/C2=NC=NC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	B76JLU	(6-{2-[(E)-Phenyl-pyridin-3-yl-methoxyimino]-pentyl}-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid	Investigative	44267574	C29H32N2O4	472.6	CCC/C(=N\\OC(C1=CC=CC=C1)C2=CN=CC=C2)/CC3CCC4=C(C3)C=CC=C4OCC(=O)O	IC50 = 85000 nM	Poor binder
T78356	Thromboxane-A synthase	B7K6BT	5-[[(E)-alpha-(4-Pyrimidinyl)-3-(trifluoromethyl)benzylidene]aminooxy]pentanoic acid	Investigative	23276770	C17H16F3N3O3	367.32	C1=CC(=CC(=C1)C(F)(F)F)/C(=N/OCCCCC(=O)O)/C2=NC=NC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	B9MC2I	5-[[[(Alphae)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid	Investigative	10518243	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N/OCCCCC(=O)O)/C2=NN=CC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BF8L2K	1-[2-(4-Nitrophenoxy)ethyl]imidazole	Investigative	13569186	C11H11N3O3	233.22	C1=CC(=CC=C1[N+](=O)[O-])OCCN2C=CN=C2	IC50 ~ 50000 nM	Poor binder
T78356	Thromboxane-A synthase	BGZ01I	5-[[(Z)-(2-Pyrimidinyl)phenylmethylene]aminooxy]valeric acid	Investigative	10494367	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N\\OCCCCC(=O)O)/C2=NC=CC=N2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BIC60G	1-[5-Chloro-6-(4-chlorophenyl)-2-benzoxazolyl]-N-[(1S,3S)-3-(hydroxymethyl)cyclohexyl]-4-piperidinecarboxamide	Investigative	53252516	C26H29Cl2N3O3	502.4	C1C[C@@H](C[C@H](C1)NC(=O)C2CCN(CC2)C3=NC4=C(O3)C=C(C(=C4)Cl)C5=CC=C(C=C5)Cl)CO	IC50 ~ 50000 nM	Poor binder
T78356	Thromboxane-A synthase	BLO1B6	7-Phenyl-7-pyridin-2-yl-hept-6-enoic acid	Investigative	13417269	C18H19NO2	281.3	C1=CC=C(C=C1)/C(=C/CCCCC(=O)O)/C2=CC=CC=N2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BORW68	N-(3',4'-Dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide	Investigative	54728414	C21H14Cl2N2O4S	461.3	C1=CC=C2C(=C1)C(=C(NS2(=O)=O)C(=O)NC3=CC=C(C=C3)C4=CC(=C(C=C4)Cl)Cl)O	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BR4PG9	5-[Pyridazin-3-yl-(3-trifluoromethyl-phenyl)-methyleneaminooxy]-pentanoic acid	Investigative	44353269	C17H16F3N3O3	367.32	C1=CC(=CC(=C1)C(F)(F)F)/C(=N\\OCCCCC(=O)O)/C2=NN=CC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BTN7J2	5-[[[(Alphaz)-alpha-(3-Pyridazinyl)benzylidene]amino]oxy]valeric acid	Investigative	10756560	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N\\OCCCCC(=O)O)/C2=NN=CC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BX81VE	5-[[(Z)-(4-Pyrimidinyl)phenylmethylene]aminooxy]valeric acid	Investigative	10518244	C16H17N3O3	299.32	C1=CC=C(C=C1)/C(=N\\OCCCCC(=O)O)/C2=NC=NC=C2	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BXA47I	(Z)-6-[(2S,4S,5R)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid	Investigative	6604763	C22H23ClO5	402.9	C1[C@H]([C@H](O[C@H](O1)C2=CC=CC=C2Cl)C3=CC=CC=C3O)C/C=C\\CCC(=O)O	IC50 ~ 100000 nM	Poor binder
T78356	Thromboxane-A synthase	BY10ST	3-[1-(2,2-Dimethyl-propyl)-5-pyridin-3-ylmethyl-1H-pyrrol-2-yl]-2-methyl-acrylic acid	Investigative	44383251	C19H24N2O2	312.4	C/C(=C/C1=CC=C(N1CC(C)(C)C)CC2=CN=CC=C2)/C(=O)O	IC50 = 78000 nM	Poor binder